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2025-12-18 15:33:23
Article

Luca Bordes, etc.,al. [preprint]Mathematical modelling of in vitro replication dynamics for multiple highly pathogenic avian influenza clade 2.3.4.4 viruses in chicken and duck cells. https://doi.org/10.1101/2025.04.22.649950.  Abstract  
submitted by kickingbird at Apr, 23, 2025 from https://doi.org/10.1101/2025.04.22.649950 (via https://www.biorxiv.org/content/10.1101/2025.04.22.649950v1)
The introduction and subsequent detection of highly pathogenic avian influenza (HPAI) in poultry is influenced by the virus replication fitness, transmission fitness, and virulence in poultry. These viral ...

Rachel Phillips, etc.,al. [preprint]Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue. https://doi.org/10.1101/2025.04.16.649193.  Abstract  
submitted by kickingbird at Apr, 22, 2025 from https://doi.org/10.1101/2025.04.16.649193 (via https://www.biorxiv.org/content/10.1101/2025.04.16.649193v2)
The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus among dairy cattle illustrates the adaptability of influenza A viruses (IAV) to infect non-traditional species. While IAV-specific ...

Manon Couty, etc.,al. [preprint]The role of wild birds in the global highly pathogenic avian influenza H5 panzootic. https://doi.org/10.48550/arXiv.2504.11910.  Abstract  
submitted by kickingbird at Apr, 22, 2025 from https://doi.org/10.48550/arXiv.2504.11910 (via https://arxiv.org/abs/2504.11910)
The highly pathogenic avian influenza (HPAI) H5 clade 2.3.4.4b has triggered an unprecedented global panzootic. As the frequency and scale of HPAI H5 outbreaks continue to rise, understanding how wild ...

de Bruin, A.C.M., Lamers, M.M., Haagmans, B.L. et. Long-term culture of chicken tracheal organoids for the purpose of avian influenza virus research. Virol J 22, 99 (2025).  Abstract  
submitted by kickingbird at Apr, 21, 2025 from Virol J 22, 99 (2025) (via https://link.springer.com/article/10.1186/s12985-025-02714-w)
There is an increasing need for reproducible long-term in vitro primary cell culture systems that are representative of the avian respiratory tract to study pathogens like highly pathogenic avian influenza ...

Chen N, Jin J, Qiao B, Gao Z, Tian Y, Ping J. JNK kinase promotes inflammatory responses by inducing the expression of the inflammatory amplifier TREM1 during influenza A virus infection. Virus Res. 2025 Apr 17:199577.  Abstract  
submitted by kickingbird at Apr, 21, 2025 from Virus Res. 2025 Apr 17:199577 (via https://www.sciencedirect.com/science/article/pii/S016817022)
Since the twentieth century, four influenza pandemics caused by IAV have killed millions of people worldwide. IAV infection could induce acute lung injury mediated by cytokine storms, which is an essential ...

Lambert S, Godard C, Vergne T. Effective mortality thresholds for reporting suspicion of highly pathogenic avian influenza in mule ducks. Vet Res. 2025 Apr 19;56(1):85.  Abstract  
submitted by kickingbird at Apr, 21, 2025 from Vet Res. 2025 Apr 19;56(1):85 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
Effective mortality thresholds are critical for timely reporting and management of highly pathogenic avian influenza. Using standard modelling techniques, we evaluated the performance of different mortality ...

Peng X, Wen X, Deng J, Yuan M, Liu Y, Zhou Y, Du X. Emerging zoonotic potential of H4N1 avian influenza virus: enhanced human receptor binding and replication via novel mutations. Virol J. 2025 Apr 18;22(1):106.  Abstract  
submitted by kickingbird at Apr, 20, 2025 from Virol J. 2025 Apr 18;22(1):106 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Avian influenza virus (AIV), a zoonotic pathogen found worldwide, includes multiple subtypes, one of which is the H4 subtype frequently detected in wild birds and poultry. Despite its prevalence, ...

Zhang S, Tang J, Liu L, Wei H, Xin L, Xiao K, Xiao. Construction and Immune Strategy Optimization of a Vaccine Strain for Influenza A (H5N8) Subtype. Viruses. 2025; 17(4):544.  Abstract  
submitted by kickingbird at Apr, 20, 2025 from Viruses. 2025; 17(4):544 (via https://www.mdpi.com/1999-4915/17/4/544)
Multiple subtypes of avian influenza virus (AIV), including H5N1, H5N6, and H5N8 viruses, are currently co-circulating in wild birds and poultry and causing sporadic human infections. Vaccine development ...

Cui N, Wang P, Huang Q, Yuan Z, Su S, Xu C, Qi L. Detection of Avian Influenza Virus in Pigeons. Viruses. 2025; 17(4):585..  Abstract  
submitted by kickingbird at Apr, 20, 2025 from Viruses. 2025; 17(4):585. (via https://www.mdpi.com/1999-4915/17/4/585)
Pigeons (Columba livia) are usually kept as free-ranging or racing birds, and they have direct contact with livestock, poultry, and humans. Therefore, they may have an important role in the ecology of ...

Simon B.Z. Gorta, etc.,al. [preprint]Impacts of high pathogenicity avian influenza H5N1 2.3.4.4b south of the Antarctic Circle. https://doi.org/10.1101/2025.04.13.648652.  Abstract  
submitted by kickingbird at Apr, 20, 2025 from https://doi.org/10.1101/2025.04.13.648652 (via https://www.biorxiv.org/content/10.1101/2025.04.13.648652v1)
High pathogenicity avian influenza (HPAI) H5N1 2.3.4.4b poses a substantial conservation threat to ecosystems, populations, and species globally, with its continued spread into new regions increasing concern ...

Abenova AZ, Mukhanbetkaliyev YY, Kadyrov AS, Sytni. Environmental Suitability of Kazakhstan to Highly Pathogenic Avian Influenza Using Data on Eurasian Outbreaks, 2020~2024. Viruses. 2025; 17(4):574.  Abstract  
submitted by kickingbird at Apr, 18, 2025 from Viruses. 2025; 17(4):574 (via https://www.mdpi.com/1999-4915/17/4/574)
Highly pathogenic avian influenza (HPAI) is a highly contagious disease of domestic, synanthropic, and wild birds that has demonstrated a sharp rise globally since 2020. This study intends to examine environmental ...

Jiahui Zou, etc.,al. Pre-mRNA cleavage complex II protein Pcf11 facilitates swine influenza virus replication by interacting with viral NP and promoting polymerase activity. Microbiological Research.  Abstract  
submitted by kickingbird at Apr, 18, 2025 from Microbiological Research (via https://www.sciencedirect.com/science/article/abs/pii/S09445)
Swine influenza virus (SIV) poses a significant threat to the pig industry and public health safety due to rapid viral evolution and potential interspecies transmission. Identifying the key host factors ...

Qinzhe Li, etc.,al. Highly pathogenic avian influenza H5N1 clade 2.3.4.4b hemagglutinin and/or neuraminidase elicit immunity in a recombinant nanoparticle vaccine. Cell Biomaterials.  Abstract  
submitted by kickingbird at Apr, 18, 2025 from Cell Biomaterials (via https://www.sciencedirect.com/science/article/abs/pii/S30505)
The widespread transmission of highly pathogenic avian H5N1 influenza, clade 2.3.4.4b, in wild and livestock mammals with isolated human cases has heightened concerns for zoonotic outbreak, necessitating ...

Facciuolo, A., Aubrey, L., Barron-Castillo, U. et. Dairy cows develop protective immunity against reinfection with bovine H5N1 influenza virus. Nat Microbiol (2025).  Abstract  
submitted by kickingbird at Apr, 18, 2025 from Nat Microbiol (2025) (via https://www.nature.com/articles/s41564-025-01998-6)
Infection of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in dairy cows causes severe mastitis and milk production losses. Whether cows can develop protective immunity is unclear. Here ...

Qin SL, Bai HJ, Deng P, Wang YW, Ma SM, Zhang Y, J. Spatial-temporal evolution patterns of influenza incidence in plateau regions from 2009 to 2023. Front Public Health. 2025 Apr 2;13:1553715.  Abstract  
submitted by kickingbird at Apr, 18, 2025 from Front Public Health. 2025 Apr 2;13:1553715 (via https://www.frontiersin.org/journals/public-health/articles/)
Objectives: This study used (Geographic Information System) GIS technology to analyze the spatiotemporal distribution of influenza incidence in Qinghai from 2009 to 2023, based on influenza surveillance ...

Leda Bassit, etc.,al. [preprint]Towards diagnostic preparedness: detection of highly pathogenic avian influenza A(H5N1) in contrived nasal swab specimens using rapid antigen and point-of-care molecular tests. https://doi.org/10.1101/2025.04.15.25325613.  Abstract  
submitted by kickingbird at Apr, 18, 2025 from https://doi.org/10.1101/2025.04.15.25325613 (via https://www.medrxiv.org/content/10.1101/2025.04.15.25325613v)
Highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b was first detected in birds in the United States in 2021 and an ongoing outbreak in dairy cattle began in early 2024. At least 70 U.S. cases ...

Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, S. Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography. PNAS 2025 Apr 22;122(16):e2426427122.  Abstract  
submitted by kickingbird at Apr, 18, 2025 from PNAS 2025 Apr 22;122(16):e2426427122 (via https://www.pnas.org/doi/10.1073/pnas.2426427122)
Influenza viruses are enveloped, negative-sense single-stranded RNA viruses covered in a dense layer of glycoproteins. Hemagglutinin (HA) accounts for 80 to 90% of influenza glycoprotein and plays a role ...

Chengyao Zhang, Vicky J Fang, Kwok-Hung Chan, Gabr. Interplay Between Viral Shedding, Age, and Symptoms in Individual Infectiousness of Influenza Cases in Households. he Journal of Infectious Diseases, Volume 231.  Abstract  
submitted by kickingbird at Apr, 18, 2025 from he Journal of Infectious Diseases, Volume 231 (via https://academic.oup.com/jid/article-abstract/231/2/462/7743)
BackgroundUnderstanding factors affecting the infectiousness of influenza cases is crucial for disease prevention and control. Viral shedding is expected to correlate with infectiousness of cases, but ...

Mao J, Chu KB, Eom GD, Yoon KW, Heo SI, Kang HJ, K. Influenza A hemagglutinin virus-like particles confer protection against influenza B virus infection. Emerg Microbes Infect. 2025 Apr 15:2494702.  Abstract  
submitted by kickingbird at Apr, 17, 2025 from Emerg Microbes Infect. 2025 Apr 15:2494702 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Influenza A hemagglutinin (HA), neuraminidase, and/or M2e-containing virus-like particles (VLPs) induce immune responses that contribute to protection against multiple influenza A virus subtypes. In this ...

Moon J, Shim J, Kim E, Hwang E. MIFlu: Large Language Model-based Multimodal Influenza Forecasting Scheme. IEEE J Biomed Health Inform. 2025 Apr 15;PP.  Abstract  
submitted by kickingbird at Apr, 17, 2025 from IEEE J Biomed Health Inform. 2025 Apr 15;PP (via https://ieeexplore.ieee.org/document/10965883)
In order to minimize the impact of influenza on public health, accurate early forecasting is essential. Various deep-learning-based models have been proposed to predict future influenza occurrences by ...

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