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Victor C. Chu and Gary R. Whittaker. Influenza virus entry and infection require host cell N-linked glycoprotein. PNAS December 28, 2004, vol. 101, no. 52, 18153-18158.  Abstract  
submitted by kickingbird at Dec, 30, 2004 from PNAS December 28, 2004, vol. 101, no. 52, 18153-18158
A widely held view of influenza virus infection is that the viral receptor consists of cell surface carbohydrate sialic acid, which can be present as glycoprotein or glycolipid. Here, we examined influenza ...

Erich Hoffmann, Aleksandr S. Lipatov, Richard J. Webby, Elena A. Govorkova and Robert G. Webster. Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus. PNAS September 6, 2005 , vol. 102, no. 36, 12915-12920.  Abstract  
submitted by kickingbird at Nov, 1, 2005 from PNAS September 6, 2005 , vol. 102, no. 36, 12915-12920
If H5N1 influenza viruses become transmissible among humans, vaccination will offer the most effective option to limit their spread. Two human vaccine candidates recently generated by reverse genetics ...

Vasiliy P. Mishin, Frederick G. Hayden, Larisa V. Gubareva. Susceptibilities of Antiviral-Resistant Influenza Viruses to Novel Neuraminidase Inhibitors. Antimicrob Agents Chemother November edition.  Abstract  
submitted by kickingbird at Oct, 11, 2005 from Antimicrob Agents Chemother November edition (via http://aac.asm.org/cgi/content/full/49/11/4515)
The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric ...

Ghedin E, Sengamalay NA, Shumway M, et al. Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature 2005 Oct 5 (advance online publication).  Full Text  
submitted by kickingbird at Oct, 7, 2005 from Nature 2005 Oct 5 (advance online publication) (via http://www.nature.com/nature/journal/vaop/ncurrent/full/natu)
Influenza viruses are remarkably adept at surviving in the human population over a long timescale. The human influenza A virus continues to thrive even among populations with widespread access to vaccines, ...

National Institute of Allergy and Infectious Diseases (NIAID). Statement-Unmasking the 1918 Influenza Virus:An Important Step Toward Pandemic Influenza Preparedness. National Institute of Allergy and Infectious Diseases (NIAID).  Full Text  
submitted by kickingbird at Oct, 6, 2005 from National Institute of Allergy and Infectious Diseases (NIAID) (via http://www3.niaid.nih.gov/news/newsreleases/2005/0510state.h)
STATEMENT Unmasking the 1918 Influenza Virus:An Important Step Toward Pandemic Influenza PreparednessAnthony S. Fauci, M.D., Director, National Institute of Allergy and Infectious Diseases, National ...

Anne Moscona. Neuraminidase Inhibitors for Influenza. NEJM Volume 353:1363-1373.  Full Text  
submitted by kickingbird at Oct, 2, 2005 from NEJM Volume 353:1363-1373 (via http://content.nejm.org/cgi/content/full/353/13/1363)
The impact of influenza infection is felt globally each year when the disease develops in approximately 20 percent of the world´s population. In the United States, influenza infections occur in epidemics ...

Pushko P, Tumpey TM, Bu F, Knell J, Robinson R, Smith G. Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice. Vaccine. 2005 Sep 2; [Epub ahead of print].  Abstract  
submitted by kickingbird at Sep, 14, 2005 from Vaccine. 2005 Sep 2; [Epub ahead of print]
Avian influenza viruses represent a growing threat for an influenza pandemic. To develop recombinant vaccine for avian influenza of the H9N2 subtype, we expressed in insect cells virus-like particles (VLPs) ...

Jin A Kim, Si Yun Ryu, and Sang Heui Seo. Cells in the Respiratory and Intestinal Tracts of Chickens Have Different Proportions of both Human and Avian Influenza Virus Receptors. The Journal of Microbiology, 43(4),366-369, 2005,.  Full Text  
submitted by kickingbird at Sep, 14, 2005 from The Journal of Microbiology, 43(4),366-369, 2005,
Avian influenza viruses play a crucial role in the creation of human pandemic viruses. In this study, we have demonstrated that both human and avian influenza receptors exist in cells in the respiratory ...

Markovic-Plese S, Hemmer B, Zhao Y, Simon R, Pinilla C, Martin R. High level of cross-reactivity in influenza virus hemagglutinin-specific CD4+ T-cell response: Implications for the initiation of autoimmune response in multiple sclerosis. J Neuroimmunol. 2005 Sep 5; [Epub ahead of print].  Abstract  
submitted by kickingbird at Sep, 14, 2005 from J Neuroimmunol. 2005 Sep 5; [Epub ahead of print]
Viral infections play a role in shaping and maintaining the peripheral T-cell repertoire, as well as in the initiation of autoimmune response via mechanisms of molecular mimicry. In this study, we addressed ...

Iki S, Yokota SI, Okabayashi T, Yokosawa N, Nagata K, Fujii N. Serum-dependent expression of promyelocytic leukemia protein suppresses propagation of influenza virus. Virology. 2005 Sep 8; [Epub ahead of print].  Abstract  
submitted by kickingbird at Sep, 14, 2005 from Virology. 2005 Sep 8; [Epub ahead of print]
The rate of propagation of influenza virus in human adenocarcinoma Caco-2 cells was found to negatively correlate with the concentration of fetal bovine serum (FBS) in the culture medium. Virus replicated ...

Oxford JS. Zanamivir. IDrugs. 2000 Apr;3(4):447-59.  Abstract [Primary member] 
submitted by kickingbird at Aug, 23, 2005 from IDrugs. 2000 Apr;3(4):447-59
Zanamivir, a neuraminidase inhibitor under license from Biota, has been developed and launched by Glaxo Wellcome for the treatment of influenza virus infection [277127]. While registered as drugs, neuraminidase ...

Brydon EW, Morris SJ, Sweet C. Role of apoptosis and cytokines in influenza virus morbidity. FEMS Microbiol Rev. 2005 Sep;29(4):837-50. Epub 2004 Dec 24.  Abstract  
submitted by kickingbird at Aug, 23, 2005 from FEMS Microbiol Rev. 2005 Sep;29(4):837-50. Epub 2004 Dec 24
Influenza virus is a major human pathogen that causes epidemics and pandemics with increased morbidity and, especially in the elderly and those with pre-existing medical conditions, increased mortality. ...

Lee CW, Swayne DE, Linares JA, Senne DA, Suarez DL. H5N2 Avian Influenza Outbreak in Texas in 2004: the First Highly Pathogenic Strain in the United States in 20 Years?. J Virol. 2005 Sep;79(17):11412-21.  Abstract  
submitted by kickingbird at Aug, 23, 2005 from J Virol. 2005 Sep;79(17):11412-21
In early 2004, an H5N2 avian influenza virus (AIV) that met the molecular criteria for classification as a highly pathogenic AIV was isolated from chickens in the state of Texas in the United States. However, ...

The World Health Organization Global Influenza Program Surveillance Network. Evolution of H5N1 avian influenza viruses in Asia. Emerg Infect Dis. 2005 Oct.  Full Text  
submitted by kickingbird at Aug, 23, 2005 from Emerg Infect Dis. 2005 Oct (via http://www.cdc.gov/ncidod/EID/vol11no10/05-0644.htm)
An outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused >52 human deaths in Vietnam, Thailand, and Cambodia from ...

Munster VJ, Wallensten A, Baas C, Rimmelzwaan GF, Schutten M, Olsen B, et al. Mallards and Highly Pathogenic Avian Influenza Ancestral Viruses, Northern Europe. Emerg Infect Dis. 2005 Oct.  Full Text  
submitted by kickingbird at Aug, 13, 2005 from Emerg Infect Dis. 2005 Oct (via http://www.cdc.gov/ncidod/EID/vol11no10/05-0546.htm)
Outbreaks of highly pathogenic avian influenza (HPAI), which originate in poultry upon transmission of low pathogenic viruses from wild birds, have occurred relatively frequently in the last decade. ...

Cooksley CD, Avritscher EB, Bekele BN, Rolston KV, Geraci JM, Elting LS. Epidemiology and outcomes of serious influenza-related infections in the cancer population. Cancer. 2005 Aug 1;104(3):618-28.  Abstract  
submitted by kickingbird at Aug, 10, 2005 from Cancer. 2005 Aug 1;104(3):618-28 (via http://www3.interscience.wiley.com/cgi-bin/abstract/11054680)
BACKGROUND: Although patients with cancer generally respond favorably to vaccination, they may not receive annual influenza vaccinations. The current population-based study described the epidemiology and ...

XUE Feng, ZHANG Pin-hu, LIU Xiao-Wen, TANG Ying-hua, LONG Jin-xue,GAO Song, LIU Xiu-fan. Monitoring of law of rise and decline of AI hemagglutination inhibition antibody in broiler chickens and waterfowl induced by H5 subtype vaccines against avian influenza. Journal of Yangzhou University(Agriculture and Life Science Edition) Vol 26,No.2 Jun 2005.  Full Text [Primary member] 
submitted by kickingbird at Aug, 9, 2005 from Journal of Yangzhou University(Agriculture and Life Science Edition) Vol 26,No.2 Jun 2005
Monitoring of law of rise and decline of AI hemagglutination inhibition antibody in broiler chickens and waterfowl induced by H5 subtype vaccines against avian influenza XUE Feng, ZHANG Pin-hu, LIU Xiao-Wen, ...

The National Immunization Program of US CDC. US CDC:Influenza Vaccine Bulletin No.1. The National Immunization Program of US CDC.  Full Text  
submitted by kickingbird at Aug, 4, 2005 from The National Immunization Program of US CDC
flubulletin1.pdf

Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD. An Evaluation of Echinacea angustifolia in Experimental Rhinovirus Infections. N Engl J Med. 2005 Jul 28;353(4):341-8.  Full Text  
submitted by kickingbird at Aug, 2, 2005 from N Engl J Med. 2005 Jul 28;353(4):341-8 (via http://content.nejm.org/cgi/content/abstract/353/4/341)
ABSTRACT Background Echinacea has been widely used as an herbal remedy for the common cold, but efficacy studies have produced conflicting results, and there are a variety of echinacea products on the ...

Yen HL, Monto AS, Webster RG, Govorkova EA. Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic a/vietnam/1203/04 influenza virus in mice. J Infect Dis. 2005 Aug 15;192(4):665-72. Epub 2005 Jul 15.  Abstract  
submitted by kickingbird at Jul, 22, 2005 from J Infect Dis. 2005 Aug 15;192(4):665-72. Epub 2005 Jul 15
Background. Control of highly pathogenic avian H5N1 influenza viruses is a major public-health concern. Antiviral drugs could be the only option early in the pandemic.Methods. BALB/c mice were given oseltamivir ...

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