Magnusson SE, Reimer JM, Karlsson KH, Lilja L, et. Immune enhancing properties of the novel Matrix-M adjuvant leads to potentiated immune responses to an influenza vaccine in mice. Vaccine 2013 Feb 2. pii: S0264-410X(13)00107. Abstract
submitted by kickingbird at Feb, 14, 2013 from Vaccine 2013 Feb 2. pii: S0264-410X(13)00107 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23384754/)
The novel saponin based adjuvant Matrix-M? was recently used in a Phase I study of seasonal influenza in elderly. The present study is a pre-clinical evaluation of the efficacy and mode-of-action of Matrix-M? ... Bischoff WE, Swett K, Leng I, Peters TR, et al. Exposure to Influenza Virus Aerosols During Routine Patient Care. Bischoff WE, Swett K, Leng I, Peters TR, et al. Abstract
submitted by kickingbird at Feb, 14, 2013 from Bischoff WE, Swett K, Leng I, Peters TR, et al (via http://www.ncbi.nlm.nih.gov/m/pubmed/23372182/)
Background.?Defining dispersal of influenza virus via aerosol is essential for the development of prevention measures.Methods.?During the 2010-2011 influenza season, subjects with influenza-like illness ... Zhang F, Fang F, Chang H, Peng B, et al. Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine. Arch Virol 2013. Abstract
submitted by kickingbird at Feb, 14, 2013 from Arch Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23385327/)
H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. ... Lau LL, Ip DK, Nishiura H, Fang VJ, et al. Heterogeneity in virus shedding among medically-attended influenza A virus infections. J Infect Dis 2013.. Abstract
submitted by kickingbird at Feb, 14, 2013 from J Infect Dis 2013. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23382573/)
Compared with the average transmissibility of human influenza A virus infection, much less attention has been paid to its potential variability. Considering viral shedding as a proxy for infectiousness, ... Nicola Principi, Alessia Scala, Cristina Daleno, S. Influenza C virus–associated community-acquired pneumonia in children. Influenza and Other Respiratory Viruses. Abstract
submitted by kickingbird at Feb, 11, 2013 from Influenza and Other Respiratory Viruses (via http://onlinelibrary.wiley.com/doi/10.1111/irv.12062/abstrac)
To evaluate the impact of influenza C (ICV) infection in children with community-acquired pneumonia (CAP), all of the children consecutively seen during 4 influenza seasons with respiratory symptoms and ... Bragstad K, Emborg HD, K?lsen Fischer T, Voldstedl. Low vaccine effectiveness against influenza A(H3N2) virus among elderly people in Denmark in 2012/13 – a rapid epidemiological and virological assessment. Eurosurveillance, Volume 18, Issue 6, 07 February. Abstract
submitted by kickingbird at Feb, 11, 2013 from Eurosurveillance, Volume 18, Issue 6, 07 February (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
In Denmark, the 2012/13 influenza season has been dominated by influenza A(H3N2). We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine by linking national registers in a test-negative ... Hause BM, Ducatez M, Collin EA, Ran Z, Liu R, et a. Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses. PLoS Pathog 9(2): e1003176. doi:10.1371/journal.pp. Abstract
submitted by kickingbird at Feb, 11, 2013 from PLoS Pathog 9(2): e1003176. doi:10.1371/journal.pp (via http://www.plospathogens.org/article/info:doi/10.1371/journa)
Abstract
Of the Orthomyxoviridae family of viruses, only influenza A viruses are thought to exist as multiple subtypes and has non-human maintenance hosts. In April 2011, nasal swabs were collected ... Huang SS, Banner D, Degousee N, Leon AJ, et al.. Differential pathological and immune responses in newly weaned ferrets are associated with a mild clinical outcome of pandemic 2009 H1N1 infection. J Virol 2012;86:13187-201. Abstract
submitted by kickingbird at Feb, 3, 2013 from J Virol 2012;86:13187-201 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23055557/)
Young children are typically considered a high-risk group for disease associated with influenza virus infection. Interestingly, recent clinical reports suggested that young children were the smallest group ... Chen L, Li F. Structural analysis of evolutionary origins of influenza hemagglutinin and other viral lectins. J Virol 2013. Abstract
submitted by kickingbird at Feb, 3, 2013 from J Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23365425/)
Influenza and other viruses use host-cell-surface sugars as receptors. Here we show that the sugar-binding domains in influenza hemagglutinin and other viral lectins share the same structural fold as human ... Ince WL, Mbaye A, Bennink JR, Yewdell JW, et al.. Reassortment Complements Spontaneous Mutation in Influenza A Virus NP and M1 genes to Accelerate Adaptation to a New Host. J Virol 2013. Abstract
submitted by kickingbird at Feb, 3, 2013 from J Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23365443/)
Influenza A virus (IAV) infects a remarkably wide variety of avian and mammalian hosts. Evolution finely hones IAV genes to optimally infect and transmit in a particular host species. Sporadically, IAV ... Beaulieu A, Gravel E, Cloutier A, Marois I, et al. Matriptase Proteolytically Activates Influenza Virus and Promotes Multicycle Replication in the Human Airway Epithelium. J Virol 2013. Abstract
submitted by kickingbird at Feb, 3, 2013 from J Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23365447/)
Influenza viruses do not encode any proteases and must rely on host proteases for the proteolytic activation of their surface hemagglutinin protein in order to fuse with the infected host cell. Recent ... Job ER, Deng YM, Barfod KK, Tate MD, et al.. Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses. J Immunol 2013. Abstract
submitted by kickingbird at Feb, 3, 2013 from J Immunol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23365085/)
Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including addition of glycans to the viral hemagglutinin (HA). Glycans on the head of HA ... Yong-Hong Zhang, etc.,al. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat. Commun. 4 : 1418 doi: 10.1038/ncomms2433 (2013). Full Text
submitted by kickingbird at Feb, 1, 2013 from Nat. Commun. 4 : 1418 doi: 10.1038/ncomms2433 (2013) (via http://www.nature.com/ncomms/journal/v4/n1/full/ncomms2433.h)
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C ... Said A, Lange E, Beer M, Damiani A, et al. Recombinant equine herpes virus 1 (EHV-1) vaccine protects pigs against challenge with influenza A(H1N1)pmd09. Virus Res 2013 Jan 17. pii: S0168-1702(13)00005. Abstract
submitted by kickingbird at Jan, 30, 2013 from Virus Res 2013 Jan 17. pii: S0168-1702(13)00005 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23333290/)
Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a threat to human health. The pandemic influenza A(H1N1)pdm09 virus likely originated in swine through reassortment ... Lee YN, Lee DH, Park JK, Yuk SS, et al.. Experimental infection and natural contact exposure of ferrets with canine influenza virus (H3N2). J Gen Virol 2013;94.. Abstract
submitted by kickingbird at Jan, 30, 2013 from J Gen Virol 2013;94. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23329681/)
Epidemics of H3N2 canine influenza virus (CIV) among dogs in South Korea and southern China have raised concern over the potential for zoonotic transmission of these viruses. Here, we analysed the pathogenesis ... Terrier O, Textoris J, Carron C, Marcel V, et al.. Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a. J Gen Virol 2013. Abstract
submitted by kickingbird at Jan, 30, 2013 from J Gen Virol 2013 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23343627/)
While post-transcriptional regulation of gene expression by miRNAs have been shown to be involved in influenza virus replication cycle, only a few studies have further investigated this aspect in a human ... Gao R, Du N, Liu D, Zhou J, et al.. Oseltamivir inhibits both viral entry and release but enhances apoptosis of cells infected with influenza A H1N1. Biochem Biophys Res Commun 2013 Jan 17. pii: S0006. Abstract
submitted by kickingbird at Jan, 30, 2013 from Biochem Biophys Res Commun 2013 Jan 17. pii: S0006 (via http://www.ncbi.nlm.nih.gov/m/pubmed/23333739/)
Oseltamivir (Tamiflu) has been shown to be effective as a treatment and chemoprophylaxis for influenza virus infections. However, the safety consideration of oseltamivir should not be overlooked because ... Siboonnan N, Wiriyarat W, Boonarkart C, Chakritbud. A serine-to-asparagine mutation at position 314 of H5N1 avian influenza virus NP is a temperature-sensitive mutation that interferes with nuclear localization of NP. Arch Virol 2013.. Abstract
submitted by kickingbird at Jan, 25, 2013 from Arch Virol 2013. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23307364/)
We have generated a temperature-sensitive (ts) mutant from a human isolate of the H5N1 avian influenza virus by classical adaptation in cell culture. After 20 passages at low temperature, the virus showed ... Jegaskanda S, Job ER, Kramski M, Laurie K, et al.. Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies.. J Immunol 2013.. Abstract
submitted by kickingbird at Jan, 25, 2013 from J Immunol 2013. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23319732/)
Abstract
A better understanding of immunity to influenza virus is needed to generate cross-protective vaccines. Engagement of Ab-dependent cellular cytotoxicity (ADCC) Abs by NK cells leads to killing ... Zhang AJ, To KK, Li C, Lau CC, et al.. Leptin mediates the pathogenesis of severe influenza A(H1N1)pdm09 associated with cytokine dysregulation is preventable by anti-leptin antibody in diet-induced obese mice.. J Infect Dis 2013.. Abstract
submitted by kickingbird at Jan, 25, 2013 from J Infect Dis 2013. (via http://www.ncbi.nlm.nih.gov/m/pubmed/23325916/)
Abstract
Background.?Obesity is associated with a high circulating leptin level and severe influenza A(H1N1)pdm09 infection. The mechanism for severe lung injury in obese patients and the specific treatment ... 5584 items, 20/Page, Page[214/280][|<<] [|<] [211] [212] [213] [214] [215] [216] [217] [218] [219] [220] [>|] [>>|] |
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