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2024-4-27 0:02:24
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ZHU X, Guo YH, Jiang T, Wang YD, et al. A Unique and Conserved Neutralization Epitope in H5N1 Influenza Viruses Identified by a Murine Antibody against the A/goose/Guangdong/1/96 Hemagglutinin. J Virol. 2013 Sep 18.  Abstract  
submitted by kickingbird at Sep, 30, 2013 from J Virol. 2013 Sep 18 (via http://www.ncbi.nlm.nih.gov/pubmed/24049169)
Despite substantial efforts to control and contain influenza H5N1 viruses, 'bird flu' viruses continue to spread and evolve. Neutralizing antibodies against conserved epitopes on the viral hemagglutinin ...

SUGITA Y, Sagara H, Noda T, Kawaoka Y, et al. The configuration of viral ribonucleoprotein complexes within the influenza A virion. J Virol. 2013 Sep 25.  Abstract  
submitted by kickingbird at Sep, 30, 2013 from J Virol. 2013 Sep 25 (via http://www.ncbi.nlm.nih.gov/pubmed/24067952)
The influenza A virus possesses an eight-segmented, negative-sense, single-stranded RNA genome (vRNA). Each vRNA segment binds to multiple copies of viral nucleoproteins and a small number of heterotrimeric ...

MCNALLY B, Ye F, Willette M, Flano E, et al. Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection. J Virol. 2013 Sep 25..  Abstract  
submitted by kickingbird at Sep, 30, 2013 from J Virol. 2013 Sep 25. (via http://www.ncbi.nlm.nih.gov/pubmed/24067957)
In order to maintain the gas exchange function of the lung following influenza virus infection, a delicate orchestration of positive and negative regulatory pathways must be maintained to attain viral ...

SU S, Chen J, Cao Z, Lai A, et al. Detection of antibodies against avian influenza virus subtypes H7 and H9 among veterinarians in Guangdong province, China.. J Clin Microbiol. 2013 Sep 18.  Abstract  
submitted by kickingbird at Sep, 30, 2013 from J Clin Microbiol. 2013 Sep 18 (via http://www.ncbi.nlm.nih.gov/pubmed/24048542)
Zoonotic transmission of pathogenic avian influenza virus is a potential public health threat (1, 2), as the virus may acquire human to human transmissibility through mutations or by reassortment with ...

DENISON AM, Deleon-Carnes M, Blau DM, Shattuck EC,. Molecular Characterization of Staphylococcus aureus and Influenza Virus Coinfections in Patients with Fatal Pneumonia. J Clin Microbiol. 2013 Sep 25.  Abstract  
submitted by kickingbird at Sep, 30, 2013 from J Clin Microbiol. 2013 Sep 25 (via http://www.ncbi.nlm.nih.gov/pubmed/24068016)
Molecular techniques were used to characterize genetic features of Staphylococcus aureus in 66 fatal cases of pneumonia caused by S. aureus and influenza A or B viruses. Nucleic acids were extracted from ...

WOO HM, Kim KS, Lee JM, Shim HS, et al. Single-stranded DNA aptamer that specifically binds to the influenza virus NS1 protein suppresses interferon antagonism. Antiviral Res. 2013 Sep 19.  Abstract  
submitted by kickingbird at Sep, 30, 2013 from Antiviral Res. 2013 Sep 19 (via http://www.ncbi.nlm.nih.gov/pubmed/24055449)
Non-structural protein 1 (NS1) of the influenza A virus (IAV) inhibits the host's innate immune response by suppressing the induction of interferons (IFNs). Therefore, blocking NS1 activity can be a potential ...

Pan P, Li L, Li Y, Li D, Hou T.. Insights into susceptibility of antiviral drugs against the E119G mutant of 2009 influenza A (H1N1) neuraminidase by molecular dynamics simulations and free energy calculations. Antiviral Res. 2013 Sep 19.  Abstract  
submitted by kickingbird at Sep, 30, 2013 from Antiviral Res. 2013 Sep 19 (via http://www.ncbi.nlm.nih.gov/pubmed/24055835)
Neuraminidase inhibitors (NAIs) play vital roles in controlling human influenza epidemics and pandemics. However, the emergence of new human influenza virus mutant strains resistant to existing antiviral ...

Saranya Sridhar,etc.,al. Cellular immune correlates of protection against symptomatic pandemic influenza. Nature Medicine Year published: (2013) DOI: doi:10.  Abstract  
submitted by kickingbird at Sep, 23, 2013 from Nature Medicine Year published: (2013) DOI: doi:10 (via http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3350.)
The role of T cells in mediating heterosubtypic protection against natural influenza illness in humans is uncertain. The 2009 H1N1 pandemic (pH1N1) provided a unique natural experiment to determine whether ...

ESSERE B, Yver M, Gavazzi C, Terrier O, et al. Critical role of segment-specific packaging signals in genetic reassortment of influenza A viruses. Proc Natl Acad Sci U S A. 2013.  Abstract  
submitted by kickingbird at Sep, 22, 2013 from Proc Natl Acad Sci U S A. 2013 (via http://www.ncbi.nlm.nih.gov/pubmed/24043788)
The fragmented nature of the influenza A genome allows the exchange of gene segments when two or more influenza viruses infect the same cell, but little is known about the rules underlying this process. ...

DONG J, Harada M, Yoshida S, Kato Y, et al. Expression and purification of bioactive hemagglutinin protein of highly pathogenic avian influenza A (H5N1) in silkworm larvae. J Virol Methods. 2013 Sep 13.  Abstract  
submitted by kickingbird at Sep, 22, 2013 from J Virol Methods. 2013 Sep 13 (via http://www.ncbi.nlm.nih.gov/pubmed/24041500)
The hemagglutinin (HA) of avian influenza viruses plays a very important role in the infection of host cells. In this study, the HA gene of the highly pathogenic avian influenza H5N1 virus was cloned and ...

Daihai He, etc.,al. Patterns of spread of influenza A in Canada. Proc. R. Soc. B November 7, 2013 280.  Abstract  
submitted by kickingbird at Sep, 13, 2013 from Proc. R. Soc. B November 7, 2013 280 (via http://rspb.royalsocietypublishing.org/content/280/1770/2013)
Understanding spatial patterns of influenza transmission is important for designing control measures. We investigate spatial patterns of laboratory-confirmed influenza A across Canada from October 1999 ...

Yi Shi, etc.,al. Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses. Science DOI: 10.1126/science.1242917.  Abstract  
submitted by kickingbird at Sep, 11, 2013 from Science DOI: 10.1126/science.1242917 (via http://www.sciencemag.org/content/early/2013/09/04/science.1)
An avian-origin human-infecting influenza (H7N9) virus has recently been identified in China. Here, we have evaluated the viral hemagglutinin (HA) receptor binding properties from two human H7N9 isolates, ...

XU L, Bao L, Deng W, Dong L, et al. The Novel Avian-Origin Human A (H7N9) Influenza Virus Could be Transmitted between Ferrets via Respiratory Droplets. J Infect Dis. 2013 Aug 29..  Abstract  
submitted by kickingbird at Sep, 8, 2013 from J Infect Dis. 2013 Aug 29. (via http://www.ncbi.nlm.nih.gov/pubmed/23990570)
The outbreak of human infections caused by the novel avian-origin H7N9 subtype influenza viruses in China since March 2013 underscores the need to better understand the pathogenicityand transmissibility ...

CHI Y, Zhu Y, Wen T, Cui L, et al. Cytokine and Chemokine Levels in Patients Infected with the Novel Avian Influenza A (H7N9) Virus in China. J Infect Dis. 2013 Aug 29.  Abstract  
submitted by kickingbird at Sep, 8, 2013 from J Infect Dis. 2013 Aug 29 (via http://www.ncbi.nlm.nih.gov/pubmed/23990573)
H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A H7N9 virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead ...

YANG G, Li S, Blackmon S, Ye J, et al. Mutation tryptophan to leucine at the position 222 of hemagglutinin could facilitate H3N2 influenza A virus infection in dogs. J Gen Virol. 2013 Sep 1.  Abstract  
submitted by kickingbird at Sep, 8, 2013 from J Gen Virol. 2013 Sep 1 (via http://www.ncbi.nlm.nih.gov/pubmed/23994833)
An avian-like H3N2 influenza A virus (IAV) has recently caused sporadic canine influenza outbreaks in China and Korea, but the molecular mechanisms involved in the interspecies transmission of H3N2 IAV ...

ZHANG J, Feng Y, Hu D, Lv H, et al. Rapid and sensitive detection of H7N9 avian influenza virus using reverse transcription loop-mediated isothermal amplification. J Clin Microbiol. 2013 Sep 4.  Abstract  
submitted by kickingbird at Sep, 8, 2013 from J Clin Microbiol. 2013 Sep 4 (via http://www.ncbi.nlm.nih.gov/pubmed/24006004)
An epidemic of human H7N9 influenza virus infection has recently emerged in China, which was clinically featuring with high mortality and while also resulting in serious economic loss. The novel reassortant ...

Adegboye OA, Kotze D.. Epidemiological analysis of spatially misaligned data: a case of highly pathogenic avian influenza virus outbreak in Nigeria. Epidemiol Infect. 2013 Sep 4:1-10.  Abstract  
submitted by kickingbird at Sep, 8, 2013 from Epidemiol Infect. 2013 Sep 4:1-10 (via http://www.ncbi.nlm.nih.gov/pubmed/24001574)
SUMMARY This research is focused on the epidemiological analysis of the transmission of the highly pathogenic avian influenza (HPAI) H5N1 virus outbreak in Nigeria. The data included 145 outbreaks together ...

THARAKARAMAN K, Raman R, Viswanathan K, Stebbins N. Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity. Cell. 2013 Jun 20;153(7):1475-85..  Abstract  
submitted by kickingbird at Sep, 8, 2013 from Cell. 2013 Jun 20;153(7):1475-85. (via http://www.ncbi.nlm.nih.gov/pubmed/23746829)
Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to "quantitatively ...

Jason Buehler, etc.,al. Influenza A Virus PB1-F2 Protein Expression Is Regulated in a Strain-Specific Manner by Sequences Located Downstream of the PB1-F2 Initiation Codon. J. Virol. October 2013 vol. 87 no. 19 10687-10699.  Abstract  
submitted by kickingbird at Sep, 8, 2013 from J. Virol. October 2013 vol. 87 no. 19 10687-10699 (via http://jvi.asm.org/content/87/19/10687.abstract)
Translation of influenza A virus PB1-F2 occurs in a second open reading frame (ORF) of the PB1 gene segment. PB1-F2 has been implicated in regulation of polymerase activity, immunopathology, susceptibility ...

Metzger DW, Sun K.. Immune Dysfunction and Bacterial Coinfections following Influenza. J Immunol. 2013;191:2047-52.  Abstract  
submitted by kickingbird at Aug, 26, 2013 from J Immunol. 2013;191:2047-52 (via http://www.ncbi.nlm.nih.gov/pubmed/23964104)
Secondary pulmonary infections by encapsulated bacteria including Streptococcus pneumoniae and Staphylococcus aureus following influenza represent a common and challenging clinical problem. The reasons ...

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