Pereira CF, Read EKC, Wise HM, Amorim MJ, et al. The influenza A virus NS1 protein promotes efficient nuclear export of unspliced viral M1 mRNA. Virol 2017 May 17. pii: JVI.00528-17. Abstract
submitted by kickingbird at May, 22, 2017 from Virol 2017 May 17. pii: JVI.00528-17 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28515301/)
Influenza A virus mRNAs are transcribed by the viral RNA-dependent RNA polymerase in the cell nucleus before being exported to the cytoplasm for translation. Segment 7 produces two major transcripts: an ... Lee N, Cao B, Ke C, Lu H, et al. IFITM3, TLR3, and CD55 Genes SNPs and Cumulative Ge-netic Risks for Severe Outcomes in Chinese Patients with H7N9 / H1N1pdm09 Influenza. J Infect Dis 2017 May 16. Abstract
submitted by kickingbird at May, 22, 2017 from J Infect Dis 2017 May 16 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28510725/)
Background: We examined associations between SNPs (single-nucleotide-polymorphisms) of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese patients. Methods: A multicenter-study was ... Root JJ, Shriner SA, Ellis JW, VanDalen KK, et al. Transmission of H6N2 wild bird-origin influenza A virus among multiple bird species in a stacked-cage setting. Arch Virol 2017 May 16. Abstract
submitted by kickingbird at May, 22, 2017 from Arch Virol 2017 May 16 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28508987/)
Live bird markets are common in certain regions of the U.S. and in other regions of the world. We experimentally tested the ability of a wild bird influenza A virus to transmit from index animals to na?ve ... Liu S, Zhang L, Yao Z, Xing L, et al. In vitro and in vivo characterization of a novel H1N1/2009 influenza virus reassortant with an NS gene from a highly pathogenic H5N1 virus, isolated from a human. Arch Virol 2017 May 18. Abstract
submitted by kickingbird at May, 22, 2017 from Arch Virol 2017 May 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28523521/)
The triple-reassortant H1N1/2009 influenza A virus, which caused the first influenza pandemic of the 21(st) century, is generally associated with mild disease and a relatively low mortality rate comparable ... JA Besler,etc.,al. A novel A(H7N2) influenza virus isolated from a veterinarian caring for cats in a New York City animal shelter causes mild disease and transmits poorly in the ferret model. J Virol May 17. Abstract
submitted by kickingbird at May, 19, 2017 from J Virol May 17 (via http://jvi.asm.org/content/early/2017/05/12/JVI.00672-17.abs)
In December 2016, a low pathogenic avian influenza (LPAI) A(H7N2) virus was identified as the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters ... Bahl K. et al.. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses. Mol Ther. 2017 Apr 11. pii: S1525-0016(17)30156-9.. Abstract
submitted by kickingbird at May, 15, 2017 from Mol Ther. 2017 Apr 11. pii: S1525-0016(17)30156-9. (via http://www.cell.com/molecular-therapy-family/molecular-thera)
Recently, the World Health Organization confirmed 120 new human cases of avian H7N9 influenza in China resulting in 37 deaths, highlighting the concern for a potential pandemic and the need for an ... Bui CM. et al.. Influenza A H5N1 and H7N9 in China: A spatial risk analysis. PLoS One. 2017 Apr 4;12(4):e0174980.. Abstract
submitted by kickingbird at May, 15, 2017 from PLoS One. 2017 Apr 4;12(4):e0174980. (via http://journals.plos.org/plosone/article?id=10.1371/journal.)
Background
Zoonotic avian influenza poses a major risk to China, and other parts of the world. H5N1 has remained endemic in China and globally for nearly two decades, and in 2013, a novel zoonotic influenza ... Hussain M, Galvin HD, Haw TY, Nutsford AN, Husain. Drug resistance in influenza A virus: the epidemiology and management. Infection and Drug Resistance 20 April 2017 Volum. Abstract
submitted by kickingbird at May, 15, 2017 from Infection and Drug Resistance 20 April 2017 Volum (via https://www.dovepress.com/drug-resistance-in-influenza-a-vir)
Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual influenza epidemics in ... HOFT DF, Lottenbach K, Goll JB, Hill H, et al. Priming Vaccination With Influenza Virus H5 Hemagglutinin Antigen Significantly Increases the Duration of T cell Responses Induced by a Heterologous H5 Booster Vaccination. J Infect Dis. 2016 Oct. Abstract
submitted by kickingbird at May, 14, 2017 from J Infect Dis. 2016 Oct (via https://www.ncbi.nlm.nih.gov/pubmed/27443611)
BACKGROUND: Influenza A(H5N1) virus and other avian influenza virus strains represent major pandemic threats. Like all influenza A virus strains, A(H5N1) viruses evolve rapidly. Innovative immunization ... HIROSE R, Nakaya T, Naito Y, Daidoji T, et al.. Mechanism of human influenza virus RNA persistence and virion survival in feces: mucus protects virions from acid and digestive juices. J Infect Dis. 2017 May 11. Abstract
submitted by kickingbird at May, 14, 2017 from J Infect Dis. 2017 May 11 (via https://www.ncbi.nlm.nih.gov/pubmed/28498998)
Although viral RNA or infectious virions have been detected in the feces of individuals infected with human influenza A/B virus (IAV/IBV), the mechanism of viral survival in the gastrointestinal tract ... Zhu W, Zhou J, Li Z, Yang L, Li X, Huang W, Zou S,. Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017. Euro Surveill. 2017;22(19):pii=30533.. Abstract
submitted by kickingbird at May, 12, 2017 from Euro Surveill. 2017;22(19):pii=30533. (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 ... José Carlos Mancera Gracia, etc.,al. A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine. Scientific Reports 7, Article number: 1323 (2017). Abstract
submitted by kickingbird at May, 4, 2017 from Scientific Reports 7, Article number: 1323 (2017) (via http://www.nature.com/articles/s41598-017-01512-x)
Avian H9N2 and 2009 pandemic H1N1 (pH1N1) influenza viruses can infect pigs and humans, raising the concern that H9N2:pH1N1 reassortant viruses could emerge. Such reassortants demonstrated increased replication ... Nakatsukasa A, Kuruma K, Okamatsu M, Hiono T, et a. Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice. Vaccine 2017 Apr 18.. Abstract
submitted by kickingbird at May, 4, 2017 from Vaccine 2017 Apr 18. (via https://www.ncbi.nlm.nih.gov/m/pubmed/28446669/)
Transdermal vaccination using a microneedle (MN) confers enhanced immunity compared with subcutaneous (SC) vaccination. Here we developed a novel dissolving MN patch for the influenza vaccine. The potencies ... Ivinson K, Deliyannis G, McNabb L, Grollo L, et al. Salivary blockade protects the lower respiratory tract of mice from lethal influenza. J Virol 2017 Apr 26.. Abstract
submitted by kickingbird at May, 4, 2017 from J Virol 2017 Apr 26. (via https://www.ncbi.nlm.nih.gov/m/pubmed/28446669/)
It is possible to model progression of influenza virus from the upper respiratory tract to the lower respiratory tract in the mouse using viral inoculum delivered in a restricted manner to the nose. In ... IZZARD L, Dlugolenski D, Xia Y, McMahon M, et al.. Enhanced immunogenicity following miR-155 incorporation into the influenza A virus genome. Virus Res. 2017 Apr 6. pii: S0168-1702(16)30814. Abstract
submitted by kickingbird at Apr, 20, 2017 from Virus Res. 2017 Apr 6. pii: S0168-1702(16)30814 (via https://www.ncbi.nlm.nih.gov/pubmed/28392443)
Influenza A vaccine efficacy in the elderly is generally poor and so identification of novel molecular adjuvants to improve immunogenicity is important to reduce the overall burden of disease. Short non-coding ... CHUTIWITOONCHAI N, Mano T, Kakisaka M, Sato H, et. Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development. Virology. 2017;507:32-39. Abstract
submitted by kickingbird at Apr, 20, 2017 from Virology. 2017;507:32-39 (via https://www.ncbi.nlm.nih.gov/pubmed/28399435)
An anti-influenza compound, DP2392-E10 based on inhibition of the nuclear export function of the viral nucleoprotein-nuclear export signal 3 (NP-NES3) domain was successfully identified by our previous ... HENDIN HE, Pillet S, Lara AN, Wu CY, et al. Plant-made virus-like particle vaccines bearing the hemagglutinin of either seasonal (H1) or avian (H5) influenza have distinct patterns of interaction with human immune cells in vitro. Vaccine. 2017 May 2;35(19):2592-2599.. Abstract
submitted by kickingbird at Apr, 20, 2017 from Vaccine. 2017 May 2;35(19):2592-2599. (via https://www.ncbi.nlm.nih.gov/pubmed/28389100)
INTRODUCTION: The recent emergence of avian influenza strains has fuelled concern about pandemic preparedness since vaccines targeting these viruses are often poorly immunogenic. Weak antibody responses ... TZARUM N, McBride R, Nycholat CM, Paulson JC, et a. Unique structural features of influenza H15 HA. J Virol. 2017 Apr 12. Abstract
submitted by kickingbird at Apr, 20, 2017 from J Virol. 2017 Apr 12 (via https://www.ncbi.nlm.nih.gov/pubmed/28404848)
Influenza A H15 viruses are members of a subgroup (H7-H10-H15) of group 2 hemagglutinin (HA) subtypes that include H7N9 and H10N8 viruses that were isolated from humans during 2013. The isolation of avian ... Gronsang D, Bui AN, Trinh DQ, Bui VN, et al.. Characterization of cross-clade monoclonal antibodies against H5N1 highly pathogenic avian influenza virus and their application to the antigenic analysis of diverse H5 subtype viruses. Arch Virol 2017 Apr 12. doi: 10.1007/s00705-017-33. Abstract
submitted by kickingbird at Apr, 20, 2017 from Arch Virol 2017 Apr 12. doi: 10.1007/s00705-017-33 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28405766/)
H5N1 highly pathogenic avian influenza viruses (HPAIVs) are a threat to both animal and public health and require specific and rapid detection for prompt disease control. We produced three neutralizing ... Wang Y, Wu J, Xue C, Wu Z, et al. A recombinant H7N9 influenza vaccine with the H7 hemagglutinin transmembrane domain replaced by the H3 domain induces increased cross-reactive antibodies and improved interclade protection in mice. Antiviral Res 2017 Apr 10. pii: S0166-3542(16)3079. Abstract
submitted by kickingbird at Apr, 20, 2017 from Antiviral Res 2017 Apr 10. pii: S0166-3542(16)3079 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28408133/)
Influenza A H7N9 virus is the latest emerging pandemic threat, and has rapidly diverged into three clades, demanding a H7N9 virus vaccine with broadened protection against unmatched strains. Hemagglutinin ... 5584 items, 20/Page, Page[178/280][|<<] [|<] [171] [172] [173] [174] [175] [176] [177] [178] [179] [180] [>|] [>>|] |
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