Credille CV, et al. Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J Med Chem. 2018 Oct 16. Abstract
submitted by kickingbird at Oct, 24, 2018 from J Med Chem. 2018 Oct 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30351002)
Metalloenzymes represent an important target space for drug discovery. A limitation to the early development of metalloenzyme inhibitors has been the lack of established structure-activity relationships ... Delgadillo-Gutiérrez K, et al. Stability of retroviral pseudotypes carrying the hemagglutinin of avian influenza viruses under various storage conditions. J Virol Methods. 2018 Oct 19.. Abstract
submitted by kickingbird at Oct, 23, 2018 from J Virol Methods. 2018 Oct 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30347199)
Retroviral pseudotypes are broadly used as safe instruments to mimic the structure and surface of highly pathogenic viruses. They have been employed for the discovery of new drugs, as diagnostic tools ... Davis RL, et al. The culture of primary duck endothelial cells for the study of avian influenza. BMC Microbiol. 2018 Oct 19;18(1):138. Abstract
submitted by kickingbird at Oct, 22, 2018 from BMC Microbiol. 2018 Oct 19;18(1):138 (via https://www.ncbi.nlm.nih.gov/pubmed/30340527)
BACKGROUND: Endothelial cells play a major role in highly pathogenic avian influenza (HPAI) virus pathogenesis in gallinaceous poultry species (e.g. chicken, turkey and quail). Upon infection of gallinaceous ... Ye S, Cowled CJ, Yap CH, Stambas J. Deep sequencing of primary human lung epithelial cells challenged with H5N1 influenza virus reveals a proviral role for CEACAM1. Sci Rep. 2018 Oct 19;8(1):15468.. Abstract
submitted by kickingbird at Oct, 21, 2018 from Sci Rep. 2018 Oct 19;8(1):15468. (via https://www.ncbi.nlm.nih.gov/pubmed/30341336)
Current prophylactic and therapeutic strategies targeting human influenza viruses include vaccines and antivirals. Given variable rates of vaccine efficacy and antiviral resistance, alternative strategies ... Ge Y, et al. Detection of reassortant avian influenza A (H11N9) virus in wild birds in China. Transbound Emerg Dis. 2018 Oct 19. Abstract
submitted by kickingbird at Oct, 21, 2018 from Transbound Emerg Dis. 2018 Oct 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30338936)
Human infectious avian influenza virus (AIV) H7N9 emerged in China in 2013. The N9 gene of H7N9, which has the ability to cause death in humans, originated from an H11N9 influenza strain circulating in ... Sun Y, et al. Aflatoxin B1 Promotes Influenza Replication and Increases Virus Related Lung Damage via Activation of TLR4 Signaling. Front Immunol. 2018 Oct 4;9:2297. Abstract
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Oct 4;9:2297 (via https://www.ncbi.nlm.nih.gov/pubmed/30337931)
Aflatoxin B1 (AFB1), which alters immune responses to mammals, is one of the most common mycotoxins in feeds and food. Swine influenza virus (SIV) is a major pathogen of both animals and humans. However, ... Hughes HR, Brockmeier SL, Loving CL. Bordetella bronchiseptica Colonization Limits Efficacy, but Not Immunogenicity, of Live-Attenuated Influenza Virus Vaccine and Enhances Pathogenesis After Influenza Challenge. Front Immunol. 2018 Oct 4;9:2255. Abstract
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Oct 4;9:2255 (via https://www.ncbi.nlm.nih.gov/pubmed/30337924)
Intranasally administered live-attenuated influenza virus (LAIV) vaccines provide significant protection against heterologous influenza A virus (IAV) challenge. However, LAIV administration can modify ... Gopal R, et al. STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection. Front Immunol. 2018 Sep 25;9:2151. Abstract
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Sep 25;9:2151 (via https://www.ncbi.nlm.nih.gov/pubmed/30337919)
Influenza is a common respiratory virus that infects between 5 and 20% of the US population and results in 30,000 deaths annually. A primary cause of influenza-associated death is secondary bacterial pneumonia. ... Lisovski S, et al. The roles of migratory and resident birds in local avian influenza infection dynamics. J Appl Ecol. 2018 Nov;55(6):2963-2975.. Abstract
submitted by kickingbird at Oct, 21, 2018 from J Appl Ecol. 2018 Nov;55(6):2963-2975. (via https://www.ncbi.nlm.nih.gov/pubmed/30337766)
Migratory birds are an increasing focus of interest when it comes to infection dynamics and the spread of avian influenza viruses (AIV). However, we lack detailed understanding migratory birds' contribution ... Mohebbi A, et al. Molecular Epidemiology of the Hemagglutinin gene of prevalent influenza virus A/H1N1/pdm09 among patient in Iran. Virus Res. 2018 Oct 15. Abstract
submitted by kickingbird at Oct, 21, 2018 from Virus Res. 2018 Oct 15 (via https://www.ncbi.nlm.nih.gov/pubmed/30336188)
In 2015, the influenza virus A/H1N1/pdm09 strain outbreak became prevalent throughout the different provinces of Iran. There are relatively limited complete genetic sequences available for this virus from ... Kumar P, Gaur P, Kumari R, Lal SK. Influenza A virus neuraminidase protein interacts with Hsp90, to stabilize itself and enhance cell survival. J Cell Biochem. 2018 Oct 18.. Abstract
submitted by kickingbird at Oct, 21, 2018 from J Cell Biochem. 2018 Oct 18. (via https://www.ncbi.nlm.nih.gov/pubmed/30335904)
Neuraminidase protein (NA) of influenza A virus (IAV) is popularly known for its sialidase function to assist in the release of progeny virus. However, involvement of NA in other stages of the IAV life ... Zheng Y, et al. Canine Influenza Virus is Mildly Restricted by Canine Tetherin Protein. Viruses. 2018 Oct 16;10(10). Abstract
submitted by kickingbird at Oct, 21, 2018 from Viruses. 2018 Oct 16;10(10) (via https://www.ncbi.nlm.nih.gov/pubmed/30332780)
Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological ... Im SP, et al. Potential Use of Genetically Engineered Variable Lymphocyte Receptor B Specific to Avian Influenza Virus H9N2. J Immunol. 2018 Oct 17. Abstract
submitted by kickingbird at Oct, 21, 2018 from J Immunol. 2018 Oct 17 (via https://www.ncbi.nlm.nih.gov/pubmed/30333123)
The variable lymphocyte receptor (VLR) B of jawless vertebrates functions as a secreted Ab of jawed vertebrates and has emerged as an alternative Ab with a single polypeptide chain. After observing an ... Martínez-Sobrido L, Peersen O, Nogales A.. Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine. Viruses. 2018 Oct 15;10(10). Abstract
submitted by kickingbird at Oct, 18, 2018 from Viruses. 2018 Oct 15;10(10) (via https://www.ncbi.nlm.nih.gov/pubmed/30326610)
Live attenuated influenza vaccines (LAIV) have prevented morbidity and mortality associated with influenza viral infections for many years and represent the best therapeutic option to protect against influenza ... Mahesutihan M, et al. CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus. Virol Sin. 2018 Oct 16. Abstract
submitted by kickingbird at Oct, 18, 2018 from Virol Sin. 2018 Oct 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30328013)
Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin-proteasome-mediated ... Shirey KA, et al. Novel role of gastric releasing peptide-mediated signaling in the host response to influenza infection. Mucosal Immunol. 2018 Oct 16.. Abstract
submitted by kickingbird at Oct, 18, 2018 from Mucosal Immunol. 2018 Oct 16. (via https://www.ncbi.nlm.nih.gov/pubmed/30327535)
Gastrin-releasing peptide (GRP) is an evolutionarily well-conserved neuropeptide that was originally recognized for its ability to mediate gastric acid secretion in the gut. More recently, however, GRP ... Kissler SM, et al. Geographic transmission hubs of the 2009 influenza pandemic in the United States. Epidemics. 2018 Oct 10.. Abstract
submitted by kickingbird at Oct, 18, 2018 from Epidemics. 2018 Oct 10. (via https://www.ncbi.nlm.nih.gov/pubmed/30327253)
A key issue in infectious disease epidemiology is to identify and predict geographic sites of epidemic establishment that contribute to onward spread, especially in the context of invasion waves of emerging ... Er JZ, Koean RAG, Ding JL. Loss of T-bet confers survival advantage to influenza-bacterial superinfection. EMBO J. 2018 Oct 15.. Abstract
submitted by kickingbird at Oct, 18, 2018 from EMBO J. 2018 Oct 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30322895)
The transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. Here, we demonstrate a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection. ... Krischuns T, et al. Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Front Immunol. 2018 Sep 28;9:2229.. Abstract
submitted by kickingbird at Oct, 18, 2018 from Front Immunol. 2018 Sep 28;9:2229. (via https://www.ncbi.nlm.nih.gov/pubmed/30323812)
Human infection with highly pathogenic avian influenza viruses (HPAIV) is often associated with severe tissue damage due to hyperinduction of interferons and proinflammatory cytokines. The reasons for ... Cui X, et al. A 113-amino-acid truncation at the NS1 C-terminus is a determinant for viral replication of H5N6 avian influenza virus in vitro and in vivo. Vet Microbiol. 2018 Nov;225:6-16. Abstract
submitted by kickingbird at Oct, 18, 2018 from Vet Microbiol. 2018 Nov;225:6-16 (via https://www.ncbi.nlm.nih.gov/pubmed/30322535)
Virulence of highly pathogenic avian influenza viruses (AIV) is determined by multiple genes and their encoded proteins. In particular, the nonstructural protein 1 (NS1) of viruses is a multifunctional ... 5584 items, 20/Page, Page[144/280][|<<] [|<] [141] [142] [143] [144] [145] [146] [147] [148] [149] [150] [>|] [>>|] |
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