Pawestri HA, Nugraha AA, Han AX, et al. Genetic and Antigenic Characterization of Influenza A/H5N1 Viruses Isolated From Patients in Indonesia, 2008-2015. Virus Genes. 2020;10.1007/s11262-020-01765-1. Abstract
submitted by kickingbird at Jun, 3, 2020 from Virus Genes. 2020;10.1007/s11262-020-01765-1 (via https://pubmed.ncbi.nlm.nih.gov/32483655)
Since the initial detection in 2003, Indonesia has reported 200 human cases of highly pathogenic avian influenza H5N1 (HPAI H5N1), associated with an exceptionally high case fatality rate (84%) compared ...
Jallow MM, Fall A, Barry MA, et al. Genetic Characterization of the First Detected Human Case of Low Pathogenic Avian Influenza A/H9N2 in sub-Saharan Africa, Senegal. Emerg Microbes Infect. 2020;9(1):1092‐1095. Abstract
submitted by kickingbird at Jun, 2, 2020 from Emerg Microbes Infect. 2020;9(1):1092‐1095 (via https://pubmed.ncbi.nlm.nih.gov/32471335)
The H9N2 influenza virus has become one of the dominant subtypes of influenza virus circulating in poultry, wild birds, and can occasionally cross the mammalian species barrier. Here, we report the first ...
Belser JA, Sun X, Brock N, et al. Mammalian Pathogenicity and Transmissibility of Low Pathogenic Avian Influenza H7N1 and H7N3 Viruses Isolated From North America in 2018. Emerg Microbes Infect. 2020;9(1):1037‐1045. Abstract
submitted by kickingbird at May, 27, 2020 from Emerg Microbes Infect. 2020;9(1):1037‐1045 (via https://pubmed.ncbi.nlm.nih.gov/32449503)
ABSTRACTLow pathogenic avian influenza (LPAI) H7 subtype viruses are infrequently, but persistently, associated with outbreaks in poultry in North America. These LPAI outbreaks provide opportunities for ...
Li YH, Hu CY, Cheng LF, et al. Highly Pathogenic H7N9 Avian Influenza Virus Infection Associated With Up-Regulation of PD-1/PD-Ls Pathway-Related Molecules. Int Immunopharmacol. 2020;85:106558. Abstract
submitted by kickingbird at May, 27, 2020 from Int Immunopharmacol. 2020;85:106558 (via https://pubmed.ncbi.nlm.nih.gov/32450532)
To investigate the main transcriptional and biological changes of human host during low and highly pathogenic avian H7N9 influenza virus infection and to analyze the possible causes of escalated virulence ...
Li L, Dai H, Nguyen AP, Hai R, Gu W. Influenza A Virus Utilizes Non-Canonical Cap-Snatching to Diversify Its mRNA/ncRNA. RNA. 2020;rna.073866.119.. Abstract
submitted by kickingbird at May, 25, 2020 from RNA. 2020;rna.073866.119. (via https://pubmed.ncbi.nlm.nih.gov/32444459)
Influenza A virus (IAV) utilizes cap-snatching to obtain host capped small RNAs for priming viral mRNA synthesis, generating capped hybrid mRNAs for translation. Previous studies have been focusing on ...
Chen Y, Cheng J, Xu Z, Hu W, Lu J. Live Poultry Market Closure and Avian Influenza A (H7N9) Infection in Cities of China, 2013-2017: An Ecological Study. BMC Infect Dis. 2020;20(1):369. Abstract
submitted by kickingbird at May, 25, 2020 from BMC Infect Dis. 2020;20(1):369 (via https://pubmed.ncbi.nlm.nih.gov/32448137)
Background: Previous studies have proven that the closure of live poultry markets (LPMs) was an effective intervention to reduce human risk of avian influenza A (H7N9) infection, but evidence is limited ...
Fukuyama S, Iwatsuki-Horimoto K, Kiso M, et al. Pathogenesis of Influenza A(H7N9) Virus in Aged Non-Human Primates. J Infect Dis. 2020;jiaa267. Abstract
submitted by kickingbird at May, 23, 2020 from J Infect Dis. 2020;jiaa267 (via https://pubmed.ncbi.nlm.nih.gov/32433769)
The avian influenza A(H7N9) virus has caused high mortality in humans, especially in the elderly; however, little is known about the mechanistic basis for this. In this study, we employed non-human primates ...
Sch?n J, Ran W, Gorka M, Schwemmle M, Beer M, Hoff. A Modified Live Bat Influenza A Virus-Based Vaccine Prototype Provides Full Protection Against HPAIV H5N1. NPJ Vaccines. 2020;5:40. Abstract
submitted by kickingbird at May, 23, 2020 from NPJ Vaccines. 2020;5:40 (via https://pubmed.ncbi.nlm.nih.gov/32435514)
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5 are a major threat for poultry holdings worldwide, here especially the zoonotic Asian H5N1 viruses. These HPAIVs have caused more than 500 ...
Zhang N, Zhu L, Zhang Y, et al. Circulating Rather Than Alveolar Extracellular DNA Levels Predict Outcomes in Influenza. J Infect Dis. 2020;jiaa241. Abstract
submitted by kickingbird at May, 23, 2020 from J Infect Dis. 2020;jiaa241 (via https://pubmed.ncbi.nlm.nih.gov/32436580)
Background: High levels of circulating neutrophil extracellular traps (NETs) are associated with a poor prognosis in influenza A infection. It remains unclear whether NETs in the plasma or bronchoalveolar ...
Willgert K, Meyer A, Tung DX, et al. Transmission of Highly Pathogenic Avian Influenza in the Nomadic Free-Grazing Duck Production System in Viet Nam. Sci Rep. 2020;10(1):8432. Abstract
submitted by kickingbird at May, 23, 2020 from Sci Rep. 2020;10(1):8432 (via https://pubmed.ncbi.nlm.nih.gov/32439997)
The presence of free-grazing ducks (FGD) has consistently been shown to be associated with highly pathogenic avian influenza virus (HPAIV) H5N1 outbreaks in South-East Asia. However, the lack of knowledge ...
Kaul D, Rathnasinghe R, Ferres M, et al. Microbiome Disturbance and Resilience Dynamics of the Upper Respiratory Tract During Influenza A Virus Infection. Nat Commun. 2020;11(1):2537. Abstract
submitted by kickingbird at May, 23, 2020 from Nat Commun. 2020;11(1):2537 (via https://pubmed.ncbi.nlm.nih.gov/32439901)
Infection with influenza can be aggravated by bacterial co-infections, which often results in disease exacerbation. The effects of influenza infection on the upper respiratory tract (URT) microbiome are ...
Laconi A, Fortin A, Bedendo G, et al. Detection of Avian Influenza Virus: A Comparative Study of the in Silico and in Vitro Performances of Current RT-qPCR Assays. Sci Rep. 2020;10(1):8441.. Abstract
submitted by kickingbird at May, 23, 2020 from Sci Rep. 2020;10(1):8441. (via https://pubmed.ncbi.nlm.nih.gov/32439885)
Avian influenza viruses (AIV) are negative sense RNA viruses posing a major threat to the poultry industry worldwide, with the potential to spread to mammals, including humans; hence, an accurate and rapid ...
Kato Y, et al. Novel oseltamivir-resistant mutations distant from the active site of influenza B neuraminidase. J Biomol Struct Dyn. 2020 May 14:1-17.. Abstract
submitted by kickingbird at May, 17, 2020 from J Biomol Struct Dyn. 2020 May 14:1-17. (via https://www.ncbi.nlm.nih.gov/pubmed/32406800)
We performed a neuraminidase sequence analysis of thirty-two pediatric patients with influenza B who visited Teikyo University Hospital from January 2016 to March 2017, and found oseltamivir-resistant ...
Banerjee A, Mossman KL, Miller MS. Bat Influenza Viruses: Making a Double Agent of MHC Class II. Trends Microbiol. 2020 Apr 20.. Abstract
submitted by kickingbird at May, 17, 2020 from Trends Microbiol. 2020 Apr 20. (via https://www.ncbi.nlm.nih.gov/pubmed/32409145)
MHC class II (MHCII) has recently been identified as a cellular receptor for bat influenza viruses. Here, we discuss the possible implications of viral exploitation of this critical host defense molecule ...
Liu T, et al. Discovery of dihydropyrrolidones as novel inhibitors against influenza A virus. Eur J Med Chem. 2020 May 4;199:. Abstract
submitted by kickingbird at May, 17, 2020 from Eur J Med Chem. 2020 May 4;199: (via https://www.ncbi.nlm.nih.gov/pubmed/32408213)
More effective prophylactic and therapeutic strategies to combat influenza viruses are urgently required worldwide because the conventional anti-influenza drugs are facing drug resistance. Here, dihydropyrrolidones ...
Xie XT, et al. A within-host mathematical model of H9N2 avian influenza infection and type-I interferon response pathways in chickens. J Theor Biol. 2020 May 11:110320.. Abstract
submitted by kickingbird at May, 17, 2020 from J Theor Biol. 2020 May 11:110320. (via https://www.ncbi.nlm.nih.gov/pubmed/32407720)
Chickens infected with avian influenza virus (AIV) transmit the virus via respiratory and cloacal shedding. While previous mathematical models have shown that the innate immune response is necessary for ...
de Jonge J, et al. H7N9 influenza split vaccine with SWE oil-in-water adjuvant greatly enhances cross-reactive humoral immunity and protection against severe pneumonia in ferrets. NPJ Vaccines. 2020 May 11;5:38. Abstract
submitted by kickingbird at May, 17, 2020 from NPJ Vaccines. 2020 May 11;5:38 (via https://www.nature.com/articles/s41541-020-0187-4)
Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE ...
Hu C, et al. Co-circulation of multiple reassortant H6 subtype avian influenza viruses in wild birds in eastern China, 2016-2017. Virol J. 2020 Apr 29;17(1):62.. Abstract
submitted by kickingbird at May, 3, 2020 from Virol J. 2020 Apr 29;17(1):62. (via https://www.ncbi.nlm.nih.gov/pubmed/32349760)
BACKGROUND: H6 subtype influenza viruses were prevalent in domestic poultry and wild birds, which also could pose potential threat to humans. However, little is known about the prevalence of H6 subtype ...
Mine J, Uchida Y, Takemae N, Saito T. Genetic characterization of influenza A viruses in Japanese swine during 2015-2019. J Virol. 2020 Apr 29. pii: JVI.02169-19.. Abstract
submitted by kickingbird at May, 3, 2020 from J Virol. 2020 Apr 29. pii: JVI.02169-19. (via https://www.ncbi.nlm.nih.gov/pubmed/32350072)
To assess the current status of influenza A viruses of swine (IAVs-S) throughout Japan and to investigate how these viruses persisted and evolve on pig farms, we genetically characterized IAVs-S isolated ...
Kesavardhana S, et al. The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.. J Biol Chem. 2020 Apr 29.. Abstract
submitted by kickingbird at May, 3, 2020 from J Biol Chem. 2020 Apr 29. (via https://www.jbc.org/content/early/2020/04/29/jbc.RA120.01375)
Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor of nucleic acids that regulates both host defense responses and development. ZBP1 activation triggers inflammation and pyroptosis, necroptosis, ...
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