Wu Y, Gao GF. "Breathing" Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design. Cell. 2019 May 16;177(5):1086-1088.. Abstract
submitted by kickingbird at May, 20, 2019 from Cell. 2019 May 16;177(5):1086-1088. (via https://www.cell.com/cell/fulltext/S0092-8674(19)30453-2)
A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe ...
Lambertz RLO, et al. Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis. J Gen Virol. 2019 May 17.. Abstract
submitted by kickingbird at May, 20, 2019 from J Gen Virol. 2019 May 17. (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
The surface protein haemagglutinin (HA) of influenza A viruses (IAV) needs to be cleaved by a host protease to become functional. Here, we investigated if IAV of the H10 subtype also requires TMPRSS2 for ...
Warfield KL, et al. Lack of selective resistance of influenza A virus in presence of host-targeted antiviral, UV-4B. Sci Rep. 2019 May 16;9(1):7484.. Abstract
submitted by kickingbird at May, 20, 2019 from Sci Rep. 2019 May 16;9(1):7484. (via https://www.nature.com/articles/s41598-019-43030-y)
Development of antiviral drug resistance is a continuous concern for viruses with high mutation rates such as influenza. The use of antiviral drugs targeting host proteins required for viral replication ...
de Greef JC, et al. Protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation. PNAS 2019 May 16.. Abstract
submitted by kickingbird at May, 20, 2019 from PNAS 2019 May 16. (via https://www.pnas.org/content/early/2019/05/14/1904493116)
α-Dystroglycan (α-DG) is a highly glycosylated basement membrane receptor that is cleaved by the proprotein convertase furin, which releases its N-terminal domain (α-DGN). Before cleavage, α-DGN interacts ...
Bui CHT, et al. Tropism of influenza B viruses in human respiratory tract explants and airway organoids. Eur Respir J. 2019 May 16.. Abstract
submitted by kickingbird at May, 20, 2019 from Eur Respir J. 2019 May 16. (via https://erj.ersjournals.com/content/early/2019/05/08/1399300)
Despite causing regular seasonal epidemics with substantial morbidity, mortality and socioeconomic burden, there is still a lack of research on influenza B viruses (IBVs). In this study, we provide for ...
Kudo E, et al. Low ambient humidity impairs barrier function and innate resistance against influenza infection. PNAS USA. 2019 May 13. Abstract
submitted by kickingbird at May, 16, 2019 from PNAS USA. 2019 May 13 (via https://www.pnas.org/content/early/2019/05/07/1902840116)
In the temperate regions, seasonal influenza virus outbreaks correlate closely with decreases in humidity. While low ambient humidity is known to enhance viral transmission, its impact on host response ...
Walters KA, et al. Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection. MBio. 2019 May 14;10(3).. Abstract
submitted by kickingbird at May, 16, 2019 from MBio. 2019 May 14;10(3). (via https://mbio.asm.org/content/10/3/e00760-19)
In this study, we examined the relationships between anti-influenza virus serum antibody titers, clinical disease, and peripheral blood leukocyte (PBL) global gene expression during presymptomatic, acute, ...
Lui WY, et al. SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection. Emerg Microbes Infect. 2019;8(1):662-674. Abstract
submitted by kickingbird at May, 16, 2019 from Emerg Microbes Infect. 2019;8(1):662-674 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza defective interfering (DI) particles are replication-incompetent viruses carrying large internal deletion in the genome. The loss of essential genetic information causes abortive viral replication, ...
Gahan J, et al. Whole Genome Sequencing of the First H3N8 Equine Influenza Virus Identified in Malaysia. Pathogens. 2019 May 10;8(2).. Abstract
submitted by kickingbird at May, 16, 2019 from Pathogens. 2019 May 10;8(2). (via https://www.mdpi.com/2076-0817/8/2/62)
In August 2015, Malaysia experienced an outbreak of acute respiratory disease in racehorses. Clinical signs observed were consistent with equine influenza (EI) infection. The index cases were horses recently ...
Feldman RA, et al. mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials. Vaccine. 2019 May 9.. Abstract
submitted by kickingbird at May, 15, 2019 from Vaccine. 2019 May 9. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: We evaluated safety and immunogenicity of the first mRNA vaccines against potentially pandemic avian H10N8 and H7N9 influenza viruses.METHODS: Two randomized, placebo-controlled, double-blind, ...
Qin C, et al. Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection. Biomed Res Int. 2019 Apr 7;2019:2121357. Abstract
submitted by kickingbird at May, 15, 2019 from Biomed Res Int. 2019 Apr 7;2019:2121357 (via https://www.hindawi.com/journals/bmri/2019/2121357/)
Background: cIAP2 is involved in necroptosis as a key upstream regulation factor. We aimed to investigate the role of cIAP2 in ARDS/ALI induced by H7N9 virus through regulating the RIPK1/3 necroptosis ...
Xu G, et al. Mutations in PB2 and HA enhanced pathogenicity of H4N6 avian influenza virus in mice. J Gen Virol. 2019 May 13. Abstract
submitted by kickingbird at May, 15, 2019 from J Gen Virol. 2019 May 13 (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
The H4 subtype avian influenza virus (AIV) continues to circulate in both wild birds and poultry, and occasionally infects mammals (e.g. pigs). H4-specific antibodies have also been detected in poultry ...
Luo W, et al. The codon usage bias of avian influenza A viruses. J Infect. 2019 May 7. pii: S0163-4453(19)30131-8.. Abstract
submitted by kickingbird at May, 12, 2019 from J Infect. 2019 May 7. pii: S0163-4453(19)30131-8. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
A recent study in this journal revealed that avian influenza A viruses (AIVs) H5Nx (N1, N6 and N8) showed pathogenicity,1 and accordingly had different adaptation to the codon usage pattern of its hosts.2 ...
Nguyen ATV, et al. Peptide Aptamer of Complementarity-determining Region to Detect Avian Influenza Virus. J Biomed Nanotechnol. 2019 Jun 1;15(6):1185-1200. Abstract
submitted by kickingbird at May, 12, 2019 from J Biomed Nanotechnol. 2019 Jun 1;15(6):1185-1200 (via https://www.ingentaconnect.com/content/asp/jbn/2019/00000015)
Despite significant progress in the development of diagnostic methods for influenza, avian influenza (AI) infection continues to represent a substantial threat to human health. Among the subtypes of AI, ...
Ashraf U, et al. Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy. PNAS 2019 May 10. Abstract
submitted by kickingbird at May, 12, 2019 from PNAS 2019 May 10 (via https://www.pnas.org/content/early/2019/05/09/1901214116)
New therapeutic strategies targeting influenza are actively sought due to limitations in current drugs available. Host-directed therapy is an emerging concept to target host functions involved in pathogen ...
Rigby RE, Wise HM, Smith N, Digard P, Rehwinkel J. PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection. Sci Rep. 2019 May 10;9(1):7216.. Abstract
submitted by kickingbird at May, 12, 2019 from Sci Rep. 2019 May 10;9(1):7216. (via https://www.nature.com/articles/s41598-019-43632-6)
The sensing of viral nucleic acids by the innate immune system activates a potent antiviral response in the infected cell, a key component of which is the expression of genes encoding type I interferons ...
Russell AB, et al. Single-cell virus sequencing of influenza infections that trigger innate immunity. J Virol. 2019 May 8. Abstract
submitted by kickingbird at May, 12, 2019 from J Virol. 2019 May 8 (via https://www.ncbi.nlm.nih.gov/pubmed/31068418)
Influenza-infected cells vary widely in their expression of viral genes, and only occasionally activate innate immunity. Here we develop a new method to assess how the genetic variation in viral populations ...
Muscatello DJ, Leong RNF, Turner RM, Newall A. Rapid mapping of the spatial and temporal intensity of influenza. Eur J Clin Microbiol Infect Dis. 2019 May 8. Abstract
submitted by kickingbird at May, 12, 2019 from Eur J Clin Microbiol Infect Dis. 2019 May 8 (via https://www.ncbi.nlm.nih.gov/pubmed/31069558)
Surveillance of influenza epidemics is a priority for risk assessment and pandemic preparedness, yet representation of their spatiotemporal intensity remains limited. Using the epidemic of influenza type ...
Mine J, et al. Genetics and pathogenicity of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and a chicken in Japan during winter 2017~2018. Virology. 2019 May 2;533:1-11.. Abstract
submitted by kickingbird at May, 12, 2019 from Virology. 2019 May 2;533:1-11. (via https://www.ncbi.nlm.nih.gov/pubmed/31071540)
An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017~2018. Time-measured ...
Scheibner D, et al. Virulence of three European highly pathogenic H7N1 and H7N7 avian influenza viruses in Pekin and Muscovy ducks. BMC Vet Res. 2019 May 10;15(1):142.. Abstract
submitted by kickingbird at May, 12, 2019 from BMC Vet Res. 2019 May 10;15(1):142. (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
BACKGROUND: There is paucity of data on the virulence of highly pathogenic (HP) avian influenza viruses (AIV) H7 in ducks compared to HPAIV H5. Here, the virulence of HPAIV H7N1 (designated H7N1-FPV34 ...
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