Yang L, et al. Tandem mass tag-based quantitative proteomic analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection. PeerJ. 2019 Oct 2;7:e7697.. Abstract
submitted by kickingbird at Oct, 11, 2019 from PeerJ. 2019 Oct 2;7:e7697. (via https://peerj.com/articles/7697/)
Highly pathogenic H5N1 influenza viruses (HPAIV) cause rapid systemic illness and death in susceptible animals, leading to a disease with high morbidity and mortality rates. Although vaccines and drugs ...
Buffin S, et al. Influenza A and B virus-like particles produced in mammalian cells are highly immunogenic and induce functional antibodies. Vaccine. 2019 Oct 4.. Abstract
submitted by kickingbird at Oct, 11, 2019 from Vaccine. 2019 Oct 4. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Influenza virus-like particles (VLPs) represent an attractive alternative to traditional influenza vaccine formulations. Influenza VLPs mimic the natural virus while lacking the genetic material, are easily ...
Chastagner A, et al. Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus. Vet Res. 2019 Oct 7;50(1):77. Abstract
submitted by kickingbird at Oct, 11, 2019 from Vet Res. 2019 Oct 7;50(1):77 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
This report describes the detection of a triple reassortant swine influenza A virus of H1avN2 subtype. It evolved from an avian-like swine H1avN1 that first acquired the N2 segment from a seasonal H3N2, ...
Butler J, et al. Insights into the Acquisition of Virulence of Avian Influenza Viruses during a Single Passage in Ferrets. Viruses. 2019 Oct 4;11(10). Abstract
submitted by kickingbird at Oct, 11, 2019 from Viruses. 2019 Oct 4;11(10) (via https://www.mdpi.com/1999-4915/11/10/915)
Circulating avian influenza viruses pose a significant threat, with human infections occurring infrequently but with potentially severe consequences. To examine the dynamics and locale of the adaptation ...
Buthelezi NM, et al. Exploring the impact of H5N1 neuraminidase (H274Y) mutation on Peramivir: A bio-computational study from a molecular perspective. J Biomol Struct Dyn. 2019 Oct 6:1-11.. Abstract
submitted by kickingbird at Oct, 9, 2019 from J Biomol Struct Dyn. 2019 Oct 6:1-11. (via https://www.tandfonline.com/doi/abs/10.1080/07391102.2019.16)
List of Abbreviations ARDS Acute Respiratory Distress Syndrome HA Haemagglutinin GAFF General Amber force field MD Molecular Dynamic NA Neuraminidase NAI Neuraminidase Inhibitor PCA Principal Component ...
Soda K, Sakita M, Usui T, Ito H, Ito T. H5N8 avian influenza virus acquires enhanced pathogenicity after a single passage in chicken. Vet Microbiol. 2019 Oct;237:108381. Abstract
submitted by kickingbird at Oct, 7, 2019 from Vet Microbiol. 2019 Oct;237:108381 (via https://www.sciencedirect.com/science/article/pii/S037811351)
The H5N8 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during the 2014-2015 winter differed in their pathogenicity in chickens. In the present study, we examined the possibility ...
Cantan B, Luyt CE, Martin-Loeches I. Influenza Infections and Emergent Viral Infections in Intensive Care Unit. Semin Respir Crit Care Med. 2019 Aug;40(4):488-497. Abstract
submitted by kickingbird at Oct, 7, 2019 from Semin Respir Crit Care Med. 2019 Aug;40(4):488-497 (via https://www.thieme-connect.de/products/ejournals/abstract/10)
Critically ill patients are admitted to an intensive care unit (ICU) for multiple reasons. In this study, we aim to analyze the current evidence and findings associated with influenza and other emergent ...
Huang S, et al. Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection. PLoS One. 2019 Oct 4;14(10):e0223430.. Abstract
submitted by kickingbird at Oct, 6, 2019 from PLoS One. 2019 Oct 4;14(10):e0223430. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Influenza virus causes a heterogeneous respiratory infectious disease ranging from self-limiting symptoms to non-resolving pathology in the lungs. Worldwide, seasonal influenza infections claim ~500,000 ...
Park YH, et al. Host-specific restriction of avian influenza virus caused by differential dynamics of ANP32 family members. J Infect Dis. 2019 Oct 3.. Abstract
submitted by kickingbird at Oct, 5, 2019 from J Infect Dis. 2019 Oct 3. (via https://academic.oup.com/jid/article-abstract/doi/10.1093/in)
Influenza viruses must utilize host factors to complete their lifecycle. Species-specific differences in host factors between birds and mammals mean that avian influenza viruses (AIVs) replicate well in ...
Chen KY, et al. Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer. PLoS Pathog. 2019 Oct 3;15(10). Abstract
submitted by kickingbird at Oct, 5, 2019 from PLoS Pathog. 2019 Oct 3;15(10) (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The influenza A virus RNA-dependent RNA polymerase complex consists in three subunits, PB2, PB1 and PA, that perform transcription and replication of the viral genome through very distinct mechanisms. ...
Sun J, et al. Novel H5N6 Avian Influenza Virus Reassortants with European H5N8 Isolated in Migratory Birds, China. Transbound Emerg Dis. 2019 Oct 3. Abstract
submitted by kickingbird at Oct, 5, 2019 from Transbound Emerg Dis. 2019 Oct 3 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13380)
Five novel H5N6 influenza viruses, including four highly pathogenic avian influenza viruses and one low pathogenic avian influenza virus, were isolated from migratory birds in Ningxia, China in November ...
Gao J, Pasion J, Sanchez-Petitto G, Law J. Influenza virus B-associated hemophagocytic lymphohistiocytosis. Hematol Rep. 2019 Sep 18;11(3):8268.. Abstract
submitted by kickingbird at Oct, 5, 2019 from Hematol Rep. 2019 Sep 18;11(3):8268. (via https://www.pagepress.org/journals/index.php/hr/article/view)
This original report describes the diagnosis and management of a male with hemophagocytic lymphohistiocytosis (HLH) triggered by influenza B virus infection. The patient was diagnosed with HLH- 2004 clinical ...
Popova AV, et al. Allele-specific nonstationarity in evolution of influenza A virus surface proteins. Proc Natl Acad Sci U S A. 2019 Oct 2.. Abstract
submitted by kickingbird at Oct, 5, 2019 from Proc Natl Acad Sci U S A. 2019 Oct 2. (via https://www.pnas.org/content/early/2019/10/01/1904246116)
Influenza A virus (IAV) is a major public health problem and a pandemic threat. Its evolution is largely driven by diversifying positive selection so that relative fitness of different amino acid variants ...
Nogales A, L DeDiego M. Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans. Pathogens. 2019 Sep 30;8(4).. Abstract
submitted by kickingbird at Oct, 3, 2019 from Pathogens. 2019 Sep 30;8(4). (via https://www.mdpi.com/2076-0817/8/4/168)
A large number of human genes associated with viral infections contain single nucleotide polymorphisms (SNPs), which represent a genetic variation caused by the change of a single nucleotide in the DNA ...
Furusawa Y, et al. Influenza Virus Polymerase Mutation Stabilizes a Foreign Gene Inserted into the Virus Genome by Enhancing the Transcription/Replication Efficiency of the Modified Segment. MBio. 2019 Oct 1;10(5).. Abstract
submitted by kickingbird at Oct, 3, 2019 from MBio. 2019 Oct 1;10(5). (via https://mbio.asm.org/content/10/5/e01794-19)
We previously attempted to establish a reporter influenza virus by inserting the gene for the Venus fluorescent protein into the NS segment of influenza A/Puerto Rico/8/34 (PR8, H1N1) virus to yield WT-Venus-PR8. ...
Kim GS, et al. The difference of detection rate of avian influenza virus in the wild bird surveillance using various methods. J Vet Sci. 2019 Sep;20(5):e56. Abstract
submitted by kickingbird at Oct, 1, 2019 from J Vet Sci. 2019 Sep;20(5):e56 (via http://mr.crossref.org/iPage?doi=10.4142%2Fjvs.2019.20.e56)
Korea is located within the East Asian-Australian flyway of wild migratory birds during the fall and winter seasons. Consequently, the likelihood of introduction of numerous subtypes and pathotypes of ...
Tsai CH, et al. Generation of Stable Influenza Virus Hemagglutinin through Structure-Guided Recombination. ACS Synth Biol. 2019 Sep 30.. Abstract
submitted by kickingbird at Oct, 1, 2019 from ACS Synth Biol. 2019 Sep 30. (via https://www.ncbi.nlm.nih.gov/pubmed/31565926)
Hemagglutinin (HA) is the major surface antigen of influenza virus and the most promising influenza vaccine immunogen. In 2013, the devastating H7N9 influenza virus was identified in China, which induced ...
Tsang TK, et al. Association between the respiratory microbiome and susceptibility to influenza virus infection. Clin Infect Dis. 2019 Sep 28. Abstract
submitted by kickingbird at Sep, 30, 2019 from Clin Infect Dis. 2019 Sep 28 (via https://www.ncbi.nlm.nih.gov/pubmed/31562814)
BACKGROUND: Previous studies suggest that the nose/throat microbiome may play an important role in shaping host immunity and modifying the risk of respiratory infection. Our aim is to quantify the association ...
Wong HH, Fung K, Nicholls JM. MDCK-B4GalNT2 cells disclose a α2,3-sialic acid requirement for the 2009 pandemic H1N1 A/California/04/2009 and NA aid entry of A/WSN/33. Emerg Microbes Infect. 2019;8(1):1428-1437. Abstract
submitted by kickingbird at Sep, 30, 2019 from Emerg Microbes Infect. 2019;8(1):1428-1437 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Switching of receptor binding preference has been widely considered as one of the necessary mutations for avian influenza viruses, enabling efficient transmissions between human hosts. By stably overexpressing ...
Le KP, et al. Molecular Docking of Broad-Spectrum Antibodies on Hemagglutinins of Influenza A Virus. Evol Bioinform Online. 2019 Sep 16;15:117693431987. Abstract
submitted by kickingbird at Sep, 29, 2019 from Evol Bioinform Online. 2019 Sep 16;15:117693431987 (via https://journals.sagepub.com/doi/10.1177/1176934319876938)
AbstractInfluenza A has caused several deadly pandemics throughout human history. The virus is often resistant to developed treatments because of its genetic drift or shift property. Broad-spectrum antibodies ...
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