Din GU, Wu C, Tariq Z, Hasham K, Amjad MN, Shen B,. Unlocking influenza B: exploring molecular biology and reverse genetics for epidemic control and vaccine innovation. Virol J. 2024 Aug 23;21(1):196. Abstract
submitted by kickingbird at Aug, 27, 2024 from Virol J. 2024 Aug 23;21(1):196 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Influenza is a highly contagious acute viral illness that affects the respiratory system, posing a significant global public health concern. Influenza B virus (IBV) causes annual seasonal epidemics. The ... Gao Y, Guyatt G, Uyeki TM, Liu M, Chen Y, Zhao Y,. Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials. Lancet. 2024 Aug 24;404(10454):753-763. Abstract
submitted by kickingbird at Aug, 27, 2024 from Lancet. 2024 Aug 24;404(10454):753-763 (via https://www.thelancet.com/journals/lancet/article/PIIS0140-6)
Background: The optimal antiviral drug for treatment of severe influenza remains unclear. To support updated WHO influenza clinical guidelines, this systematic review and network meta-analysis evaluated ... Zhao Y, Gao Y, Guyatt G, Uyeki TM, Liu P, Liu M, S. Antivirals for post-exposure prophylaxis of influenza: a systematic review and network meta-analysis. Lancet. 2024 Aug 24;404(10454):764-772. Abstract
submitted by kickingbird at Aug, 27, 2024 from Lancet. 2024 Aug 24;404(10454):764-772 (via https://www.thelancet.com/journals/lancet/article/PIIS0140-6)
Background: Antiviral post-exposure prophylaxis with neuraminidase inhibitors can reduce the incidence of influenza and the risk of symptomatic influenza, but the efficacy of the other classes of antiviral ... Kelsey M. Rayment, etc.,al. [preprint]Exposure and Survival of Wild Raptors During the 2022-2023 Highly Pathogenic Influenza A Virus Outbreak. https://doi.org/10.21203/rs.3.rs-4759859/v1. Abstract
submitted by kickingbird at Aug, 27, 2024 from https://doi.org/10.21203/rs.3.rs-4759859/v1 (via https://www.researchsquare.com/article/rs-4759859/v1)
The global outbreak of clade 2.3.4.4b H5N1 highly pathogenic influenza A virus (HP H5N1) has had an unprecedented impact on wild birds including raptors, but long-term population impacts have not been ... David Hawman, etc.,al. [preprint]Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge. https://doi.org/10.21203/rs.3.rs-4946897/v1. Abstract
submitted by kickingbird at Aug, 27, 2024 from https://doi.org/10.21203/rs.3.rs-4946897/v1 (via https://www.researchsquare.com/article/rs-4946897/v1)
The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared ... Luise Hohensee, etc.,al. PB1-F2 of low pathogenicity H7N7 restricts apoptosis in avian cells. Virus Research, Volume 349 , November 2024. Abstract
submitted by kickingbird at Aug, 25, 2024 from Virus Research, Volume 349 , November 2024 (via https://www.sciencedirect.com/science/article/pii/S016817022)
Avian influenza viruses (AIV) pose a continuous challenge to global health and economy. While countermeasures exist to control outbreaks in poultry, the persistent circulation of AIV in wild aquatic and ... Li Y, Yin Z, Wang J, Xu Y, Huo S, Wu Y, Dou D, Han. Surveillance of avian influenza viruses in Hebei Province of China from 2021 to 2023: identification of a novel reassortant H3N3. J Infect. 2024 Aug 20:106240. Abstract
submitted by kickingbird at Aug, 24, 2024 from J Infect. 2024 Aug 20:106240 (via https://www.journalofinfection.com/article/S0163-4453(24)001)
Avian influenza remains a global public health concern for its well-known point mutation and genomic segment reassortment, through which plenty of serum serotypes are generated to escape existing immune ... Liping Wang, etc.,al. Incompatible packaging signals and impaired protein functions hinder reassortment of bat H17N10 or H18N11 segment 7 with human H1N1 influenza A viruses. Journal of Virology, 20 August 2024. Abstract
submitted by kickingbird at Aug, 21, 2024 from Journal of Virology, 20 August 2024 (via https://journals.asm.org/doi/10.1128/jvi.00864-24)
Novel bat H17N10 and H18N11 influenza A viruses (IAVs) are incapable of reassortment with conventional IAVs during co-infection. To date, the underlying mechanisms that inhibit bat and conventional IAV ... Sougat Misra, etc.,al. [preprint]Enhanced Diversifying Selection on Polymerase Genes in H5N1 Clade 2.3.4.4b: A Key Driver of Altered Species Tropism and Host Range Expansion. https://doi.org/10.1101/2024.08.19.606826. Abstract
submitted by kickingbird at Aug, 21, 2024 from https://doi.org/10.1101/2024.08.19.606826 (via https://www.biorxiv.org/content/10.1101/2024.08.19.606826v1)
Highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses have shown unprecedented host range and pathogenicity, including infections in cattle, previously not susceptible to H5N1.We investigated whether ... Thomas Tipih, etc.,al. [preprint]Recent Bovine HPAI H5N1 Isolate is Highly Virulent for Mice, Rapidly Causing Acute Pulmonary and Neurologic Disease. https://doi.org/10.1101/2024.08.19.608652. Abstract
submitted by kickingbird at Aug, 21, 2024 from https://doi.org/10.1101/2024.08.19.608652 (via https://www.biorxiv.org/content/10.1101/2024.08.19.608652v1)
The highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses, responsible for the current outbreak in dairy cows in the United States, pose a significant animal and public health threat. ... Alexander Helmut Rotsch, etc.,al. [preprint]Mechanism of Co-Transcriptional Cap-Snatching by Influenza Polymerase. https://doi.org/10.1101/2024.08.11.607481. Abstract
submitted by kickingbird at Aug, 20, 2024 from https://doi.org/10.1101/2024.08.11.607481 (via https://www.biorxiv.org/content/10.1101/2024.08.11.607481v1)
Influenza virus mRNA is stable and competent for nuclear export and translation because it receives a 5′ cap(1) structure in a process called cap-snatching1. During cap-snatching, the viral RNA-dependent ... Yu H, Sun Y, Zhang J, Zhang W, Liu W, Liu P, Liu K. Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination. Cell Mol Life Sci. 2024 Aug 19;81(1):355. Abstract
submitted by kickingbird at Aug, 20, 2024 from Cell Mol Life Sci. 2024 Aug 19;81(1):355 (via https://link.springer.com/article/10.1007/s00018-024-05392-z)
Caspase-8, an aspartate-specific cysteine protease that primarily functions as an initiator caspase to induce apoptosis, can downregulate innate immunity in part by cleaving RIPK1 and IRF3. However, patients ... Zhang, Y., Cui, P., Shi, J. et al. A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes. npj Vaccines 9, 152 (2024). Abstract
submitted by kickingbird at Aug, 20, 2024 from npj Vaccines 9, 152 (2024) (via https://www.nature.com/articles/s41541-024-00947-4)
The global spread of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses threatens poultry and public health. The continuous circulation of these viruses has led to their considerable genetic ... Arragain, B., Krischuns, T., Pelosse, M. et al. Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun 15, 6910 (2024). Abstract
submitted by kickingbird at Aug, 20, 2024 from Nat Commun 15, 6910 (2024) (via https://www.nature.com/articles/s41467-024-51007-3)
Replication of influenza viral RNA depends on at least two viral polymerases, a parental replicase and an encapsidase, and cellular factor ANP32. ANP32 comprises an LRR domain and a long C-terminal low ... Qitao Jia and others. MetaFluAD: meta-learning for predicting antigenic distances among influenza viruses. Briefings in Bioinformatics, Volume 25, Issue 5. Abstract
submitted by kickingbird at Aug, 20, 2024 from Briefings in Bioinformatics, Volume 25, Issue 5 (via https://academic.oup.com/bib/article/25/5/bbae395/7731492)
Influenza viruses rapidly evolve to evade previously acquired human immunity. Maintaining vaccine efficacy necessitates continuous monitoring of antigenic differences among strains. Traditional serological ... Liu L, Li Z, Liu J, Li X, Zhou J, Xiao N, Yang L,. Effects of different HA and NA gene combinations on the growth characteristics of the H3N8 influenza candidate vaccine virus. Vaccine X. 2024 Jul 18;19:100531. Abstract
submitted by kickingbird at Aug, 20, 2024 from Vaccine X. 2024 Jul 18;19:100531 (via https://www.sciencedirect.com/science/article/pii/S259013622)
Since 2022, three human cases of a novel H3N8 avian influenza virus infection have been reported in three provinces in China. Specific vaccines are important means of preparing for the potential influenza ... Colby T Ford, etc.,al. [preprint]Large-Scale Computational Modeling of H5 Influenza Variants Against HA1-Neutralizing Antibodies. https://doi.org/10.1101/2024.07.14.603367. Abstract
submitted by kickingbird at Aug, 20, 2024 from https://doi.org/10.1101/2024.07.14.603367 (via https://www.biorxiv.org/content/10.1101/2024.07.14.603367v3)
In June 2024, the United States Department of Agriculture released a report that showed over 300 samples from 2022-2024 of highly pathogenic avian influenza have been detected in mammals. To date, the ... Shohaimi SA, Leow BL, Mohd Yusop FF, Sidik MR, Bar. Sequence analysis and molecular characterization of low pathogenic avian influenza H9N2 virus isolated from chickens in Sabah. Trop Biomed. 2024 Jun 1;41(2):183-189. Abstract
submitted by kickingbird at Aug, 19, 2024 from Trop Biomed. 2024 Jun 1;41(2):183-189 (via https://msptm.org/files/Vol41No2/tb-41-2-008-Shohaimi-S-A.pd)
Low pathogenic avian influenza (LPAI) subtype H9N2 is a causative agent that has raised increasing concern about its impact on poultry and potential public health threats. Even though H9N2 is endemic in ... Owuor DC, de Laurent ZR, Oketch JW, Murunga N, Oti. Phylogeography and reassortment patterns of human influenza A viruses in sub-Saharan Africa. Sci Rep. 2024 Aug 16;14(1):18987. Abstract
submitted by kickingbird at Aug, 18, 2024 from Sci Rep. 2024 Aug 16;14(1):18987 (via https://www.nature.com/articles/s41598-024-70023-3)
The role of sub-Saharan Africa in the global spread of influenza viruses remains unclear due to insufficient spatiotemporal sequence data. Here, we analyzed 222 codon-complete sequences of influenza A ... Du L, Hou YN, Fu DD, Li J, Ao J, Ma AX, Wan QQ, Wa. Revealing Different Pathways for Influenza A Virus To Reach Microtubules after Endocytosis by Quantum Dot-Based Single-Virus Tracking. ACS Nano. 2024 Aug 14. Abstract
submitted by kickingbird at Aug, 15, 2024 from ACS Nano. 2024 Aug 14 (via https://pubs.acs.org/doi/10.1021/acsnano.4c05261)
Actin- and microtubule (MT)-based transport systems are essential for intracellular transport. During influenza A virus (IAV) infection, MTs provide long tracks for virus trafficking toward the nucleus. ... 5584 items, 20/Page, Page[10/280][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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