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2020-5-28 23:44:43

Imai M, et al. Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets. Nat Microbiol. 2019 Nov 25..  Abstract  
submitted by kickingbird at Dec, 7, 2019 from Nat Microbiol. 2019 Nov 25. (via https://www.nature.com/articles/s41564-019-0609-0)
Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduced susceptibility ...

Bogdanow B, et al. The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant. Nat Commun. 2019 Dec 4;10(1):5518.  Abstract  
submitted by kickingbird at Dec, 7, 2019 from Nat Commun. 2019 Dec 4;10(1):5518 (via https://www.nature.com/articles/s41467-019-13520-8)
Pandemic influenza A virus (IAV) outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular basis of this species barrier is incompletely understood. ...

Zhong G, et al. Mutations in the NA-like protein of bat influenza H18N11 virus enhance virus replication in mammalian cells, mice, and ferrets. J Virol. 2019 Dec 4.  Abstract  
submitted by kickingbird at Dec, 7, 2019 from J Virol. 2019 Dec 4 (via https://jvi.asm.org/content/early/2019/11/28/JVI.01416-19)
To characterize bat influenza H18N11 virus, we propagated a reverse genetics-generated H18N11 virus in MDCK II cells and detected two adapting mutations in the neuraminidase (NA)-like protein (NA-F144C ...

Valesano AL, et al. Influenza B viruses exhibit lower within-host diversity than influenza A viruses in human hosts. J Virol. 2019 Dec 4.  Abstract  
submitted by kickingbird at Dec, 7, 2019 from J Virol. 2019 Dec 4 (via https://jvi.asm.org/content/early/2019/11/28/JVI.01710-19)
Influenza B virus undergoes seasonal antigenic drift more slowly than influenza A, but the reasons for this difference are unclear. While the evolutionary dynamics of influenza viruses play out globally, ...

Shi L, et al. Molecular evolution and amino acid characteristics of newly isolated H9N2 avian influenza viruses from Liaoning Province, China. J Vet Med Sci. 2019 Dec 4..  Abstract  
submitted by kickingbird at Dec, 7, 2019 from J Vet Med Sci. 2019 Dec 4. (via https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_19)
H9N2 is widespread among poultry and humans. Though this subtype is not lethal to either species, it can cause considerable financial losses for farmers and threaten human health. In this study, 10 new ...

Ilyushina NA, et al. Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies. Virol J. 2019 Nov 29;16(1):149.  Abstract  
submitted by kickingbird at Dec, 2, 2019 from Virol J. 2019 Nov 29;16(1):149 (via https://www.ncbi.nlm.nih.gov/pubmed/31783761)
BACKGROUND: Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such ...

Zhang Y, Yu T, Ding Y, Li Y, Lei J, Hu B, Zhou J. Analysis of Expression Profiles of Long Noncoding RNAs and mRNAs in A549 Cells Infected with H3N2 Swine Influenza Virus by RNA Sequencing. Virol Sin. 2019 Nov 27..  Abstract  
submitted by kickingbird at Dec, 1, 2019 from Virol Sin. 2019 Nov 27. (via https://www.ncbi.nlm.nih.gov/pubmed/31777011)
Long noncoding RNAs (lncRNAs) participate in regulating many biological processes. However, their roles in influenza A virus (IAV) pathogenicity are largely unknown. Here, we analyzed the expression profiles ...

Oliva J, et al. A murine model for the study of influenza D virus. J Virol. 2019 Nov 27..  Abstract  
submitted by kickingbird at Dec, 1, 2019 from J Virol. 2019 Nov 27. (via https://jvi.asm.org/content/early/2019/11/21/JVI.01662-19)
A novel genus within the Orthomyxoviridae family was identified in the USA and named Influenza D virus (IDV). Bovine have been proposed to be the primary host and three main viral lineages (D/OK-like, ...

Rodriguez-Frandsen A, et al. Viral determinants in H5N1 influenza A virus enable productive infection of HeLa cells. J Virol. 2019 Nov 27.  Abstract  
submitted by kickingbird at Dec, 1, 2019 from J Virol. 2019 Nov 27 (via https://jvi.asm.org/content/early/2019/11/21/JVI.01410-19)
Influenza A virus (IAV) is a human respiratory pathogen that causes yearly global epidemics, and sporadic pandemics due to human adaptation of pathogenic strains. Efficient replication of IAV in different ...

Karakus U, Pohl MO, Stertz S. Breaking the convention: Sialoglycan variants, Co-receptors and Alternative Receptors for Influenza A Virus Entry. J Virol. 2019 Nov 27..  Abstract  
submitted by kickingbird at Dec, 1, 2019 from J Virol. 2019 Nov 27. (via https://jvi.asm.org/content/early/2019/11/21/JVI.01357-19)
The influenza A virus (IAV) envelope protein haemagglutinin binds α2,6- or α2,3-linked sialic acid as host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this rule and do not bind ...

Ding X, Yuan X, Mao L, Wu A, Jiang T. FluReassort: a database for the study of genomic reassortments among influenza viruses. Brief Bioinform. 2019 Nov 27.  Abstract  
submitted by kickingbird at Dec, 1, 2019 from Brief Bioinform. 2019 Nov 27 (via https://academic.oup.com/bib/advance-article-abstract/doi/10)
Genomic reassortment is an important genetic event in the generation of emerging influenza viruses, which can cause numerous serious flu endemics and epidemics within hosts or even across different hosts. ...

Hanpaibool C, et al. Source of oseltamivir resistance due to single E119D and double E119D/H274Y mutations in pdm09H1N1 influenza neuraminidase. J Comput Aided Mol Des. 2019 Nov 26.  Abstract  
submitted by kickingbird at Dec, 1, 2019 from J Comput Aided Mol Des. 2019 Nov 26 (via https://www.ncbi.nlm.nih.gov/pubmed/31773463)
Influenza epidemics are responsible for an average of 3-5 millions of severe cases and up to 500,000 deaths around the world. One of flu pandemic types is influenza A(H1N1)pdm09 virus (pdm09H1N1). Oseltamivir ...

Haller O, Kochs G. Mx genes: host determinants controlling influenza virus infection and trans-species transmission. Hum Genet. 2019 Nov 26..  Abstract  
submitted by kickingbird at Dec, 1, 2019 from Hum Genet. 2019 Nov 26. (via https://www.ncbi.nlm.nih.gov/pubmed/31773252)
The human MxA protein, encoded by the interferon-inducible MX1 gene, is an intracellular influenza A virus (IAV) restriction factor. It can protect transgenic mice from severe IAV-induced disease, indicating ...

Wang Y, Song T, Li K, Jin Y, Yue J, Ren H, Liang L. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. Biomed Res Int. 2019 Oct 22;2019:4794910.  Abstract  
submitted by kickingbird at Dec, 1, 2019 from Biomed Res Int. 2019 Oct 22;2019:4794910 (via https://www.hindawi.com/journals/bmri/2019/4794910/)
Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide ...

Shin DL, et al. Highly Pathogenic Avian Influenza A(H5N8) Virus in Gray Seals, Baltic Sea. Emerg Infect Dis. 2019 Dec;25(12):2295-2298.  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Emerg Infect Dis. 2019 Dec;25(12):2295-2298 (via https://wwwnc.cdc.gov/eid/article/25/12/18-1472_article)
We detected a highly pathogenic avian influenza A(H5N8) virus in lung samples of 2 gray seals (Halichoerus grypus) stranded on the Baltic coast of Poland in 2016 and 2017. This virus, clade B, ...

Martelli P, et al. Influenza A(H1N1)pdm09 Virus Infection in a Captive Giant Panda, Hong Kong. Emerg Infect Dis. 2019 Dec;25(12):2303-2306..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Emerg Infect Dis. 2019 Dec;25(12):2303-2306. (via https://wwwnc.cdc.gov/eid/article/25/12/19-1143_article)
We report influenza A(H1N1)pdm09 virus infection in a captive giant panda in Hong Kong. The viral load peaked on day 1 and became undetectable on day 5, and an antibody response developed. Genome analysis ...

Fusade-Boyer M, et al. Evolution of Highly Pathogenic Avian Influenza A(H5N1) Virus in Poultry, Togo, 2018. Emerg Infect Dis. 2019 Dec;25(12):2287-2289.  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Emerg Infect Dis. 2019 Dec;25(12):2287-2289 (via https://wwwnc.cdc.gov/eid/article/25/12/19-0054_article)
In 2015, highly pathogenic avian influenza A(H5N1) viruses reemerged in poultry in West Africa. We describe the introduction of a reassortant clade virus into Togo in April 2018. Our findings ...

Susloparov IM, et al. Genetic Characterization of Avian Influenza A(H5N6) Virus Clade, Russia, 2018. Emerg Infect Dis. 2019 Dec;25(12):2338-2339..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Emerg Infect Dis. 2019 Dec;25(12):2338-2339. (via https://wwwnc.cdc.gov/eid/article/25/12/19-0504_article)
Timely identification of pandemic influenza threats depends on monitoring for highly pathogenic avian influenza viruses. We isolated highly pathogenic avian influenza A(H5N6) virus clade, genotype ...

Evseenko VA, et al. Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase. Arch Virol. 2019 Nov 19..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Arch Virol. 2019 Nov 19. (via https://www.ncbi.nlm.nih.gov/pubmed/31745716)
Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation ...

Xu Y, et al. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep. 2019 Nov 19;29(8):2217-2228.e5..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Cell Rep. 2019 Nov 19;29(8):2217-2228.e5. (via https://www.ncbi.nlm.nih.gov/pubmed/31747596)
Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. ...

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