Ikematsu H, Hayden FG, Kawaguchi K, et al. Baloxavir Marboxil for Prophylaxis Against Influenza in Household Contacts. N Engl J Med. 2020;10.1056/NEJMoa1915341. Abstract
submitted by kickingbird at Jul, 10, 2020 from N Engl J Med. 2020;10.1056/NEJMoa1915341 (via https://pubmed.ncbi.nlm.nih.gov/32640124/)
Background: Baloxavir marboxil (baloxavir) is a polymerase acidic protein (PA) endonuclease inhibitor with clinical efficacy in the treatment of uncomplicated influenza, including in outpatients at increased ...
Dong X, Xiong J, Huang C, et al. Human H9N2 Avian Influenza Infection: Epidemiological and Clinical Characterization of 16 Cases in China. Virol Sin. 2020;10.1007/s12250-020-00248-9. Abstract
submitted by kickingbird at Jul, 9, 2020 from Virol Sin. 2020;10.1007/s12250-020-00248-9 (via https://link.springer.com/article/10.1007/s12250-020-00248-9)
The first human infections with avian influenza virus (AIV) H9N2 were reported in 1998 (Guo et al. 1999). As of October 18th, 2019, 59 cases of human infection with H9N2 have been reported globally, including ...
Chen C, Liu Z, Liu L, Wang J, Jin Q. Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design. Front Microbiol. 2020;11:1313. Abstract
submitted by kickingbird at Jul, 9, 2020 from Front Microbiol. 2020;11:1313 (via https://pubmed.ncbi.nlm.nih.gov/32636820/)
H7N9 influenza virus was first isolated in 2013 and has caused five epidemic waves among humans to date. Treatment opinions are currently limited. Previously, we characterized a human neutralizing antibody, ...
Feng Z, Zhu W, Yang L, et al. Epidemiology and Genotypic Diversity of Eurasian Avian-Like H1N1 Swine Influenza Viruses in China. Virol Sin. 2020;10.1007/s12250-020-00257-8. Abstract
submitted by kickingbird at Jul, 9, 2020 from Virol Sin. 2020;10.1007/s12250-020-00257-8 (via https://pubmed.ncbi.nlm.nih.gov/32638231/)
Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) outside European countries was first detected in Hong Kong Special Administrative Region (Hong Kong, SAR) of China in 2001. Afterwards, EA ...
Gupta SD, Hoque MA, Fournié G, Henning J. Patterns of Avian Influenza A (H5) and A (H9) Virus Infection in Backyard, Commercial Broiler and Layer Chicken Farms in Bangladesh. ransbound Emerg Dis. 2020;10.1111/tbed.13657. Abstract
submitted by kickingbird at Jul, 9, 2020 from ransbound Emerg Dis. 2020;10.1111/tbed.13657 (via https://pubmed.ncbi.nlm.nih.gov/32639112/)
In order to control Highly Pathogenic Avian Influenza (HPAI) H5N1 and Low Pathogenic Avian Influenza (LPAI) H9N2 virus spread in endemically infected countries, a detailed understanding of infection patterns ...
Sieben C, Sezgin E, Eggeling C, Manley S. Influenza A Viruses Use Multivalent Sialic Acid Clusters for Cell Binding and Receptor Activation. PLoS Pathog. 2020;16(7):e1008656. Abstract
submitted by kickingbird at Jul, 9, 2020 from PLoS Pathog. 2020;16(7):e1008656 (via https://pubmed.ncbi.nlm.nih.gov/32639985/)
Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment ...
Arevalo P, McLean HQ, Belongia EA, Cobey S. Earliest Infections Predict the Age Distribution of Seasonal Influenza A Cases. Elife. 2020;9:e50060. Abstract
submitted by kickingbird at Jul, 8, 2020 from Elife. 2020;9:e50060 (via https://pubmed.ncbi.nlm.nih.gov/32633233/)
Seasonal variation in the age distribution of influenza A cases suggests that factors other than age shape susceptibility to medically attended infection. We ask whether these differences can be partly ...
Phipps KL, Ganti K, Jacobs NT, et al. Collective Interactions Augment Influenza A Virus Replication in a Host-Dependent Manner. Nat Microbiol. 2020;10.1038/s41564-020-0749-2. Abstract
submitted by kickingbird at Jul, 8, 2020 from Nat Microbiol. 2020;10.1038/s41564-020-0749-2 (via https://pubmed.ncbi.nlm.nih.gov/32632248/)
Infection with a single influenza A virus (IAV) is only rarely sufficient to initiate productive infection. Instead, multiple viral genomes are often required in a given cell. Here, we show that the reliance ...
Arevalo CP, Le Sage V, Bolton MJ, et al. Original Antigenic Sin Priming of Influenza Virus Hemagglutinin Stalk Antibodies. Proc Natl Acad Sci U S A . 2020 Jul 6;201920321. Abstract
submitted by kickingbird at Jul, 8, 2020 from Proc Natl Acad Sci U S A . 2020 Jul 6;201920321 (via https://pubmed.ncbi.nlm.nih.gov/32631992/)
Immunity to influenza viruses can be long-lived, but reinfections with antigenically distinct viral strains and subtypes are common. Reinfections can boost antibody responses against viral strains first ...
Müller NF, Stolz U, Dudas G, Stadler T, Vaughan TG. Bayesian Inference of Reassortment Networks Reveals Fitness Benefits of Reassortment in Human Influenza Viruses. Proc Natl Acad Sci U S A. 2020;201918304. Abstract
submitted by kickingbird at Jul, 8, 2020 from Proc Natl Acad Sci U S A. 2020;201918304 (via https://pubmed.ncbi.nlm.nih.gov/32631984/)
Reassortment is an important source of genetic diversity in segmented viruses and is the main source of novel pathogenic influenza viruses. Despite this, studying the reassortment process has been constrained ...
Kim HM, Lee N, Kim MS, Kang C, Chung YS. Characterization of Neuraminidase Inhibitor-Resistant Influenza Virus Isolates From Immunocompromised Patients in the Republic of Korea. Virol J. 2020;17(1):94. Abstract
submitted by kickingbird at Jul, 8, 2020 from Virol J. 2020;17(1):94 (via https://pubmed.ncbi.nlm.nih.gov/32631440/)
Background: The emergence of influenza viruses resistant to anti-influenza drugs is a threat to global public health. The Korea Centers for Disease Control and Prevention operates the Korea Influenza and ...
Tsai SK, Shih CH, Chang HW, et al. Replication of a Dog-Origin H6N1 Influenza Virus in Cell Culture and Mice. Viruses. 2020;12(7):E704. Abstract
submitted by kickingbird at Jul, 8, 2020 from Viruses. 2020;12(7):E704 (via https://pubmed.ncbi.nlm.nih.gov/32629810/)
The world's first natural avian-origin H6N1 influenza A virus infection case in dogs was confirmed in Taiwan in 2014. The H6N1 virus in chickens has been endemic in Taiwan since 1972. Whether the dog H6N1 ...
Scolamacchia F, Mulatti P, Mazzucato M, et al. Different Environmental Gradients Associated to the Spatiotemporal and Genetic Pattern of the H5N8 Highly Pathogenic Avian Influenza Outbreaks in Poultry in Italy. Transbound Emerg Dis. 2020;10.1111/tbed.13661. Abstract
submitted by kickingbird at Jul, 3, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13661 (via https://pubmed.ncbi.nlm.nih.gov/32613724/)
Comprehensive understanding of the patterns and drivers of avian influenza outbreaks is pivotal to inform surveillance systems and heighten nations' ability to quickly detect and respond to the emergence ...
Zeng Z, Yau LF, Lin Z, et al. Characterization and Evolutionary Analysis of a Novel H3N2 Influenza A Virus Glycosylation Motif in Southern China. Front Microbiol. 2020;11:1318. Abstract
submitted by kickingbird at Jul, 3, 2020 from Front Microbiol. 2020;11:1318 (via https://pubmed.ncbi.nlm.nih.gov/32612596/)
An influenza A (H3N2) virus epidemic occurred in China in 2017 and the causative strain failed to bind red blood cells (RBCs), which may affect receptor binding and antibody recognition. The objective ...
Belser JA, Sun X, Brock N, et al. Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models. J Virol. 2020;JVI.00451-20. Abstract
submitted by kickingbird at Jul, 3, 2020 from J Virol. 2020;JVI.00451-20 (via https://pubmed.ncbi.nlm.nih.gov/32611751/)
Low pathogenicity avian influenza A(H9N2) viruses, enzootic in poultry populations in Asia, are associated with fewer confirmed human infections but higher rates of seropositivity compared to A(H5) or ...
Zhang RH, Li PY, Xu MJ, et al. Molecular Characterization and Pathogenesis of H9N2 Avian Influenza Virus Isolated From a Racing Pigeon. Vet Microbiol. 2020;246:108747. Abstract
submitted by kickingbird at Jul, 2, 2020 from Vet Microbiol. 2020;246:108747 (via https://pubmed.ncbi.nlm.nih.gov/32605760/)
H9N2 avian influenza viruses (AIVs) can cross species barriers and expand from birds tomammals and humans. It usually leads to economic loss for breeding farms and poses a serious threat to human health.This ...
Chen Z, Wang Z, Zhao X, et al. Pathogenicity of Different H5N6 Highly Pathogenic Avian Influenza Virus Strains and Host Immune Responses in Chickens. Vet Microbiol. 2020;246:108745. Abstract
submitted by kickingbird at Jul, 2, 2020 from Vet Microbiol. 2020;246:108745 (via https://pubmed.ncbi.nlm.nih.gov/32605756/)
The H5N6 highly pathogenic avian influenza virus (HPAIV) has been circulating in China since 2013. In this report, we describe our recent chicken experimental studies investigating the pathogenicity and ...
Ruan BY, Yao Y, Wang SY, et al. Protective Efficacy of a Bivalent Inactivated Reassortant H1N1 Influenza Virus Vaccine Against European Avian-Like and Classical Swine Influenza H1N1 Viruses in Mice. Vet Microbiol. 2020;246:108724. Abstract
submitted by kickingbird at Jul, 2, 2020 from Vet Microbiol. 2020;246:108724 (via https://pubmed.ncbi.nlm.nih.gov/32605742/)
The classical swine (CS) H1N1 swine influenza virus (SIVs) emerged in humans as a reassortant virus that caused the H1N1 influenza virus pandemic in 2009, and the European avian-like (EA) H1N1 SIVs has ...
Dos Anjos Borges LG, Pisanelli G, Khatun O, García. Live Visualization of Hemagglutinin Dynamics During Infection by Using a Novel Reporter Influenza A Virus. Viruses. 2020;12(6):E687. Abstract
submitted by kickingbird at Jul, 2, 2020 from Viruses. 2020;12(6):E687 (via https://pubmed.ncbi.nlm.nih.gov/32604762/)
Live visualization of influenza A virus (IAV) structural proteins during viral infection in cells is highly sought objective to study different aspects of the viral replication cycle. To achieve this, ...
Hu M, Yang G, DeBeauchamp J, et al. HA Stabilization Promotes Replication and Transmission of Swine H1N1 Gamma Influenza Viruses in Ferrets. Elife. 2020;9:e56236.. Abstract
submitted by kickingbird at Jul, 2, 2020 from Elife. 2020;9:e56236. (via https://pubmed.ncbi.nlm.nih.gov/32602461/)
Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface antigen. Other HA traits ...
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