Eickhoff CS, et al. Highly conserved influenza T cell epitopes induce broadly protective immunity. Vaccine. 2019 Jul 19. Abstract
submitted by kickingbird at Jul, 27, 2019 from Vaccine. 2019 Jul 19 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Influenza world-wide causes significant morbidity and mortality annually, and more severe pandemics when novel strains evolve to which humans are immunologically na?ve. Because of the high viral mutation ...
Dadonaite B, et al. The structure of the influenza A virus genome. Nat Microbiol. 2019 Jul 22. Abstract
submitted by kickingbird at Jul, 27, 2019 from Nat Microbiol. 2019 Jul 22 (via https://www.nature.com/articles/s41564-019-0513-7)
Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes ...
Schar D, et al. New frontiers in applied veterinary point-of-capture diagnostics: Toward early detection and control of zoonotic influenza. Influenza Other Respir Viruses. 2019 Jul 23. Abstract
submitted by kickingbird at Jul, 27, 2019 from Influenza Other Respir Viruses. 2019 Jul 23 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12648)
Among the chief limitations in achieving early detection and control of animal-origin influenza of pandemic potential in high-risk livestock populations is the existing lag time between sample collection ...
Li J, et al. Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient. Antiviral Res. 2019 Jul 20;170:104564. Abstract
submitted by kickingbird at Jul, 27, 2019 from Antiviral Res. 2019 Jul 20;170:104564 (via https://www.sciencedirect.com/science/article/pii/S016635421)
Influenza virus A H7N9 remains a serious threat to public health due to the lack of effective vaccines and drugs. In this study, a neutralizing human antibody named 3L11 was rapidly isolated from the switched ...
Sangkachai N, et al. Serological evidence of influenza virus infection in captive wild felids, Thailand. J Vet Med Sci. 2019 Jul 23.. Abstract
submitted by kickingbird at Jul, 27, 2019 from J Vet Med Sci. 2019 Jul 23. (via https://www.ncbi.nlm.nih.gov/pubmed/31341136)
Influenza virus is known to affect wild felids. To explore the prevalence of influenza viruses in these animal species, 196 archival sera from 5 felid species including Panthera tigris (N=147), Prionailurus ...
Jakubcová L, et al. Biological properties of influenza A virus mutants with amino acid substitutions in the HA2 glycoprotein of the HA1/HA2 interaction region. J Gen Virol. 2019 Jul 22.. Abstract
submitted by kickingbird at Jul, 24, 2019 from J Gen Virol. 2019 Jul 22. (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
Influenza A viruses (IAVs) enter into cells by receptor-dependent endocytosis. Subsequently, conformational changes of haemagglutinin are triggered by low environmental pH and the N terminus of HA2 glycoprotein ...
Xu L, et al. A Higher Rate of Pulmonary Fungal Infection in Chronic Obstructive Pulmonary Disease Patients with Influenza in a Large Tertiary Hospital. Respiration. 2019 Jul 22:1-10. Abstract
submitted by kickingbird at Jul, 24, 2019 from Respiration. 2019 Jul 22:1-10 (via https://www.karger.com/Article/Abstract/501410)
BACKGROUND: Influenza is considered a self-limiting disease. However, in patients with chronic obstructive pulmonary disease (COPD), it may result in serious outcomes during the flu season.OBJECTIVES: ...
Sun X, et al. Identification of key hemagglutinin residues responsible for cleavage, acid stability, and virulence of fifth-wave highly pathogenic avian influenza A(H7N9) viruses. Virology. 2019 Jul 12;535:232-240. Abstract
submitted by kickingbird at Jul, 22, 2019 from Virology. 2019 Jul 12;535:232-240 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
We previously demonstrated that despite no airborne transmissibility increase compared to low pathogenic avian influenza viruses, select human isolates of highly pathogenic avian influenza A(H7N9) virus ...
Hao X, et al. The PB2 and M genes of genotype S H9N2 virus contribute to the enhanced fitness of H5Nx and H7N9 avian influenza viruses in chickens. Virology. 2019 Jul 8;535:218-226. Abstract
submitted by kickingbird at Jul, 22, 2019 from Virology. 2019 Jul 8;535:218-226 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Genotype S H9N2 viruses frequently donate their internal genes to facilitate the generation of novel influenza viruses, e.g., H5N6, H7N9, and H10N8, which have caused human infection. Genotype S was originated ...
AlIbrahim M, et al. Molecular epidemiology and genetic characterization of influenza B virus in Lebanon during 2016~2018. Infect Genet Evol. 2019 Jul 17:103969. Abstract
submitted by kickingbird at Jul, 22, 2019 from Infect Genet Evol. 2019 Jul 17:103969 (via https://www.sciencedirect.com/science/article/pii/S156713481)
BACKGROUND: Influenza B viruses are a major cause of serious acute respiratory infections in humans.METHODS: Nasopharyngeal swabs were collected from subjects with influenza-like illness during October ...
Dahmani I, Ludwig K, Chiantia S. Influenza A matrix protein M1 induces lipid membrane deformation via protein multimerization. Biosci Rep. 2019 Jul 19. Abstract
submitted by kickingbird at Jul, 22, 2019 from Biosci Rep. 2019 Jul 19 (via http://bioscirep.org/lookup/doi/10.1042/BSR20191024)
The matrix protein M1 of the Influenza A virus is supposed to mediate viral assembly and budding at the plasma membrane (PM) of infected cells. In order for a new viral particle to form, the PM lipid bilayer ...
An J, Li J, Wang Y, Wang J, Li Q, Zhou H, et al. A Homeostasis Hypothesis of Avian Influenza Resistance in Chickens. Genes (Basel). 2019 Jul 17;10(7).. Abstract
submitted by kickingbird at Jul, 21, 2019 from Genes (Basel). 2019 Jul 17;10(7). (via https://www.mdpi.com/2073-4425/10/7/543)
Avian influenza has caused significant damage to the poultry industry globally. Consequently, efforts have been made to elucidate the disease mechanisms as well as the mechanisms of disease resistance. ...
Abed Y, et al. The Val430Ile neuraminidase (NA) substitution, identified in influenza B virus isolates, impacts the catalytic 116Arg residue causing reduced susceptibility to NA inhibitors. Antiviral Res. 2019 Jul 16:104561. Abstract
submitted by kickingbird at Jul, 21, 2019 from Antiviral Res. 2019 Jul 16:104561 (via https://www.sciencedirect.com/science/article/pii/S016635421)
As part of a 2015-2018 clinical trial of peramivir treatment for acute influenza infections in the elderly, an influenza B/Yamagata/16/1988-like isolate harbouring a Val430Ile neuraminidase (NA) substitution ...
Sedeyn K, Saelens X. New antibody-based prevention and treatment options for influenza. Antiviral Res. 2019 Jul 16:104562. Abstract
submitted by kickingbird at Jul, 21, 2019 from Antiviral Res. 2019 Jul 16:104562 (via https://www.sciencedirect.com/science/article/pii/S016635421)
The antigenic diversity of human influenza viruses represents a challenge to the development of vaccines with durable immune protection. In addition, small molecule anti-influenza viral drugs can bring ...
Shi N, et al. Interventions in live poultry markets for the control of avian influenza: A systematic review and meta-analysis. J Infect Dis. 2019 Jul 17.. Abstract
submitted by kickingbird at Jul, 21, 2019 from J Infect Dis. 2019 Jul 17. (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
BACKGROUND: This review aimed to provide constructive suggestions for the control and management of avian influenza through quantitative and qualitative evaluation of the impact of different live poultry ...
Cao Z, et al. Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China. PLoS One. 2019 Jul 19;14(7):e0217607. Abstract
submitted by kickingbird at Jul, 21, 2019 from PLoS One. 2019 Jul 19;14(7):e0217607 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Southern China is considered an important source of influenza virus pandemics because of the large, diverse viral reservoirs in poultry and swine. To examine the trend in influenza A virus of swine (IAV-S), ...
Pawestri HA, et al. Viral Factors Associated With the High Mortality Related to Human Infections With Clade 2.1 Influenza A/H5N1 Virus in Indonesia. Clin Infect Dis. 2019 Apr 26. Abstract
submitted by kickingbird at Jul, 21, 2019 from Clin Infect Dis. 2019 Apr 26 (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: Since their emergence in Indonesia in 2005, 200 human infections with clade 2.1 highly pathogenic avian influenza A/H5N1 virus have been reported, associated with exceptionally high mortality ...
Chen Y, Zhang Y, Xu Z, Wang X, Lu J, Hu W. Avian Influenza A (H7N9) and related Internet search query data in China. Sci Rep. 2019 Jul 18;9(1):10434. Abstract
submitted by kickingbird at Jul, 21, 2019 from Sci Rep. 2019 Jul 18;9(1):10434 (via https://www.nature.com/articles/s41598-019-46898-y)
The use of Internet-based systems for infectious disease surveillance has been increasingly explored in recent years. However, few studies have used Internet search query or social media data to monitor ...
Music N, et al. Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets. NPJ Vaccines. 2019 Jul 9;4:28.. Abstract
submitted by kickingbird at Jul, 19, 2019 from NPJ Vaccines. 2019 Jul 9;4:28. (via https://www.nature.com/articles/s41541-019-0123-7)
Epidemiological studies suggest that humans who receive repeated annual immunization with influenza vaccine are less well protected against influenza than those who receive vaccine in the current season ...
Minagawa Y, Ueno H, Tabata KV, Noji H. Mobile imaging platform for digital influenza virus counting. Lab Chip. 2019 Jul 17. Abstract
submitted by kickingbird at Jul, 19, 2019 from Lab Chip. 2019 Jul 17 (via https://pubs.rsc.org/en/content/articlelanding/2019/LC/C9LC0)
Droplet-based digital bioassays enable highly sensitive and quantitative analysis of biomolecules, and are thought to be suitable for point-of-care diagnosis. However, digital bioassays generally require ...
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