Martinot M, et al. Analysis of delays in the prescription of oseltamivir in hospitals and potential for improvement. Med Mal Infect. 2018 Nov 13. Abstract
submitted by kickingbird at Nov, 19, 2018 from Med Mal Infect. 2018 Nov 13 (via https://www.ncbi.nlm.nih.gov/pubmed/30446349)
OBJECTIVES: Patients hospitalized for influenza should receive early treatment with a neuraminidase inhibitor.PATIENTS AND METHODS: We conducted a retrospective study of the prescription of oseltamivir ...
Zaraket H, et al. Review of seasonal influenza vaccination in the Eastern Mediterranean Region: Policies, use and barriers. J Infect Public Health. 2018 Nov 13.. Abstract
submitted by kickingbird at Nov, 19, 2018 from J Infect Public Health. 2018 Nov 13. (via https://www.ncbi.nlm.nih.gov/pubmed/30446255)
Vaccination is the main control measure for influenza and its severe complications. To better understand the influenza vaccination situation in the Eastern Mediterranean Region, we conducted an extensive ...
Ratanakorn P, et al. Satellite telemetry tracks flyways of Asian Openbill storks in relation to H5N1 avian influenza spread and ecological change. BMC Vet Res. 2018 Nov 16;14(1):349. Abstract
submitted by kickingbird at Nov, 19, 2018 from BMC Vet Res. 2018 Nov 16;14(1):349 (via https://www.ncbi.nlm.nih.gov/pubmed/30445946)
BACKGROUND: Asian Openbills, Anastomus oscitans, have long been known to migrate from South to Southeast Asia for breeding and nesting. In Thailand, the first outbreak of H5N1 highly pathogenic avian influenza ...
Yasuhara A, et al. Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses. Front Microbiol. 2018 Nov 1;9:2660. Abstract
submitted by kickingbird at Nov, 19, 2018 from Front Microbiol. 2018 Nov 1;9:2660 (via https://www.ncbi.nlm.nih.gov/pubmed/30443246)
The influenza A virus rapidly mutates to escape from antibodies. Here, we isolated and characterized three human monoclonal antibodies (mAbs) that neutralize A(H1N1)pdm09 viruses. Generation of escape ...
Lee YN, etc.,al. Pathogenesis and genetic characteristics of novel reassortant low-pathogenic avian influenza H7 viruses isolated from migratory birds in the Republic of Korea in the winter of 2016~2017. Emerg Microbes Infect. 2018 Nov 15;7(1):182. Abstract
submitted by kickingbird at Nov, 19, 2018 from Emerg Microbes Infect. 2018 Nov 15;7(1):182 (via https://www.ncbi.nlm.nih.gov/pubmed/30442892)
In this study, we characterized H7 subtype low-pathogenicity (LP) influenza A viruses (IAVs) isolated from wild bird habitats in the Republic of Korea from 2010 to early 2017. Through national surveillance, ...
Yoon SJ, et al. Optimized Expression, Purification, and Rapid Detection of Recombinant Influenza Nucleoproteins Expressed in Sf9 Insect Cells. J Microbiol Biotechnol. 2018 Oct 28;28(10):1683-16. Abstract
submitted by kickingbird at Nov, 19, 2018 from J Microbiol Biotechnol. 2018 Oct 28;28(10):1683-16 (via https://www.ncbi.nlm.nih.gov/pubmed/30441884)
Accurate and rapid diagnosis of influenza infection is essential to enable early antiviral treatment and reduce the mortality associated with seasonal and epidemic infections. Immunochromatography is one ...
Miyagawa T, et al. A Novel Diagnostic System for Infectious Diseases Using Solid-State Nanopore Devices. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:283. Abstract
submitted by kickingbird at Nov, 19, 2018 from Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:283 (via https://www.ncbi.nlm.nih.gov/pubmed/30440991)
Nanopore-based diagnostic systems are a promising tool for counting viruses in a specimen one by one. However, despite intensive R&D efforts, it remains difficult to recognize virus subtypes by nanopore ...
Zhao H, et al. A neuraminidase activity-based microneutralization assay for evaluating antibody responses to influenza H5 and H7 vaccines. PLoS One. 2018 Nov 15;13(11):e0207431. Abstract
submitted by kickingbird at Nov, 19, 2018 from PLoS One. 2018 Nov 15;13(11):e0207431 (via https://www.ncbi.nlm.nih.gov/pubmed/30440054)
Outbreaks of the highly pathogenic avian influenza H5N1 and H7N9 viruses have spurred an unprecedented research effort to develop antivirals and vaccines against influenza. Standardized methods for vaccine ...
Tsedenbal N, et al. Influenza B viruses circulated during last 5 years in Mongolia. PLoS One. 2018 Nov 15;13(11):e0206987. Abstract
submitted by kickingbird at Nov, 17, 2018 from PLoS One. 2018 Nov 15;13(11):e0206987 (via https://www.ncbi.nlm.nih.gov/pubmed/30439983)
Influenza B virus-caused illness has recently been considered as an urgent public health problem due to substantial morbidity, mortality and life-threatening medical complications. In this study, we have ...
Desirò D, H?lzer M, Ibrahim B, Marz M. SilentMutations (SIM): a tool for analyzing long-range RNA-RNA interactions in viral genomes and structured RNAs. Virus Res. 2018 Nov 12.. Abstract
submitted by kickingbird at Nov, 17, 2018 from Virus Res. 2018 Nov 12. (via https://www.ncbi.nlm.nih.gov/pubmed/30439394)
A single nucleotide change in the coding region can alter the amino acid sequence of a protein. In consequence, natural or artificial sequence changes in viral RNAs may have various effects not only on ...
Barbezange C, et al. Seasonal Genetic Drift of Human Influenza A Virus Quasispecies Revealed by Deep Sequencing. Front Microbiol. 2018 Oct 31;9:2596.. Abstract
submitted by kickingbird at Nov, 17, 2018 from Front Microbiol. 2018 Oct 31;9:2596. (via https://www.ncbi.nlm.nih.gov/pubmed/30429836)
After a pandemic wave in 2009 following their introduction in the human population, the H1N1pdm09 viruses replaced the previously circulating, pre-pandemic H1N1 virus and, along with H3N2 viruses, are ...
Allen JD, et al. Elicitation of protective antibodies against 20 years of future H3N2 co-ciruculating influenza virus variants in ferrets preimmune to historical H3N2 influenza viruses. J Virol. 2018 Nov 14.. Abstract
submitted by kickingbird at Nov, 17, 2018 from J Virol. 2018 Nov 14. (via https://www.ncbi.nlm.nih.gov/pubmed/30429350)
The vast majority of people already have pre-existing immune responses to influenza viruses from one or more subtypes. However, almost all preclinical studies evaluate new influenza vaccine candidates ...
Beyleveld G, et al. Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein. mSphere. 2018 Nov 14;3(6).. Abstract
submitted by kickingbird at Nov, 17, 2018 from mSphere. 2018 Nov 14;3(6). (via https://www.ncbi.nlm.nih.gov/pubmed/30429226)
Viruses utilize a number of host factors in order to carry out their replication cycles. Influenza A virus (IAV) and human respiratory syncytial virus (RSV) both infect the tissues of the respiratory tract, ...
Ye F, et al. Analysis of influenza B virus lineages and the HA1 domain of its hemagglutinin gene in Guangzhou, southern China, during 2016. Virol J. 2018 Nov 14;15(1):175. Abstract
submitted by kickingbird at Nov, 17, 2018 from Virol J. 2018 Nov 14;15(1):175 (via https://www.ncbi.nlm.nih.gov/pubmed/30428893)
BACKGROUND: Few studies have analyzed influenza B virus lineages based on hemagglutinin A (HA) gene sequences in southern China. The present study analyzed the HA gene and the lineages of influenza B virus ...
Souty C, et al. Influenza epidemics observed in primary care from 1984 to 2017 in France: a decrease of epidemic size over time. Influenza Other Respir Viruses. 2018 Nov 14.. Abstract
submitted by kickingbird at Nov, 17, 2018 from Influenza Other Respir Viruses. 2018 Nov 14. (via https://www.ncbi.nlm.nih.gov/pubmed/30428158)
BACKGROUND: Epidemiological analysis of past influenza epidemics remains essential to understand the evolution of the disease and optimize control and prevention strategies. Here, we aimed to use data ...
Hilton SK, Bloom JD. Modeling site-specific amino-acid preferences deepens phylogenetic estimates of viral sequence divergence. Virus Evol. 2018 Nov 6;4(2):vey033. Abstract
submitted by kickingbird at Nov, 17, 2018 from Virus Evol. 2018 Nov 6;4(2):vey033 (via https://www.ncbi.nlm.nih.gov/pubmed/30425841)
Molecular phylogenetics is often used to estimate the time since the divergence of modern gene sequences. For highly diverged sequences, such phylogenetic techniques sometimes estimate surprisingly recent ...
Song L, Xiong D, Kang X, Jiao Y, et al.. The optimized fusion protein HA1-2-FliC△D2D3 promotes mixed Th1/Th2 immune responses to influenza H7N9 with low induction of systemic proinflammatory cytokines in mice. Antiviral Res 2018 Oct 30. Abstract
submitted by kickingbird at Nov, 15, 2018 from Antiviral Res 2018 Oct 30 (via https://www.ncbi.nlm.nih.gov/pubmed/30389471)
H7N9 influenza virus has an unusually high fatality rate of approximately 40%, and a safe and effective vaccine against this subtype is urgently needed. Flagellin, a Toll-like receptor (TLR) 5 agonist, ...
Jia X, et al. Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration. PLoS Pathog. 2018 Nov 13;14(11):. Abstract
submitted by kickingbird at Nov, 15, 2018 from PLoS Pathog. 2018 Nov 13;14(11): (via https://www.ncbi.nlm.nih.gov/pubmed/30422993)
Severe influenza A virus infection causes high mortality and morbidity worldwide due to delayed antiviral treatment and inducing overwhelming immune responses, which contribute to immunopathological lung ...
Butler AM, et al. Assessing Residual Bias in Estimating Influenza Vaccine Effectiveness: Comparison of High-dose Versus Standard-dose Vaccines. Med Care. 2018 Nov 12.. Abstract
submitted by kickingbird at Nov, 15, 2018 from Med Care. 2018 Nov 12. (via https://www.ncbi.nlm.nih.gov/pubmed/30422840)
BACKGROUND: Estimating influenza vaccine effectiveness using an unvaccinated comparison group may result in biased effect estimates.OBJECTIVES: To explore the reduction of confounding bias in an active ...
Chen T, Xiao M, Yang J, Chen YK, Bai T, et al. Association between rs12252 and influenza susceptibility and severity: an updated meta-analysis. Epidemiol Infect. 2018 Nov 13:1-9. Abstract
submitted by kickingbird at Nov, 15, 2018 from Epidemiol Infect. 2018 Nov 13:1-9 (via https://www.ncbi.nlm.nih.gov/pubmed/30421689)
In several lately published studies, the association between single-nucleotide polymorphism (SNP, rs12252) of IFITM3 and the risk of influenza is inconsistent. To further understand the association between ...
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