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2024-11-24 18:18:12
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Galeone V, Lee C, Monaghan MT, Bauer DC, Wilson LO. Evolutionary Insights from Association Rule Mining of Co-Occurring Mutations in Influenza Hemagglutinin and Neuraminidase. Viruses. 2024; 16(10):1515.  Abstract  
submitted by kickingbird at Oct, 22, 2024 from Viruses. 2024; 16(10):1515 (via https://www.mdpi.com/1999-4915/16/10/1515)
Seasonal influenza viruses continuously evolve via antigenic drift. This leads to recurring epidemics, globally significant mortality rates, and the need for annually updated vaccines. Co-occurring mutations ...

Hailiang Sun, etc.,al. Genetic evolution, phylodynamic and phylogeographic of H5Ny AIVs in mammals. Animals and Zoonoses.  Abstract  
submitted by kickingbird at Oct, 22, 2024 from Animals and Zoonoses (via https://www.sciencedirect.com/science/article/pii/S295024892)
The growing incidence of H5Ny virus infection in humans and mammals causes an increasing public health concern. To date, H5Ny virus infection in humans and mammals has been reported in 46 countries around ...

Miyu Moriyama, etc.,al. [preprint]Intranasal hemagglutinin protein boosters induce robust mucosal immunity and cross-protection against influenza A viral challenge. https://doi.org/10.1101/2024.10.10.616291.  Abstract  
submitted by kickingbird at Oct, 20, 2024 from https://doi.org/10.1101/2024.10.10.616291 (via https://www.biorxiv.org/content/10.1101/2024.10.10.616291v1)
Licensed parenteral influenza vaccines induce systemic antibody responses and alleviate disease severity but do not efficiently prevent viral entry and transmission due to the lack of local mucosal immune ...

Qiu Yu Huang, etc.,al. [preprint]Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryo-electron tomography. https://doi.org/10.1101/2024.10.15.618557.  Abstract  
submitted by kickingbird at Oct, 20, 2024 from https://doi.org/10.1101/2024.10.15.618557 (via https://www.biorxiv.org/content/10.1101/2024.10.15.618557v1)
Influenza viruses are enveloped, negative sense single-stranded RNA viruses covered in a dense layer of glycoproteins. Hemagglutinin (HA) accounts for 80-90% of influenza glycoprotein and plays a role ...

Zhang M, Zeng Y, Liu Q, Li F, Zhao J, Liu Z, Liu H. The H5N1-NS1 protein affects the host cell cycle and apoptosis through interaction with the host lncRNA PIK3CD-AS2. Virus Genes. 2024 Oct 18.  Abstract  
submitted by kickingbird at Oct, 20, 2024 from Virus Genes. 2024 Oct 18 (via https://link.springer.com/article/10.1007/s11262-024-02118-y)
Long noncoding RNAs (lncRNAs) are involved in the host antiviral response, but how host lncRNAs interact with viral proteins remains unclear. The NS1 protein of avian influenza viruses can affect the interferon-dependent ...

Huajuan Feng, etc.,al. A Case Report of Gibbon Infection with H9N2 Avian Influenza Virus. Chinese Journal of Wildlife.  Abstract  
submitted by kickingbird at Oct, 19, 2024 from Chinese Journal of Wildlife
In January 2022, 6 gibbons (Nomascus spp.) in the same enclosure of a zoo successively showed symptoms of runny nose and cough. We separately collected six nasal swabs from the six gibbons, detected the ...

Richard Webby, etc.,al. [preprint] Efficacy of oseltamivir and baloxavir against A(H5N1)-contaminated bovine milk in mice. https://doi.org/10.21203/rs.3.rs-5119512/v1.  Abstract  
submitted by kickingbird at Oct, 19, 2024 from https://doi.org/10.21203/rs.3.rs-5119512/v1 (via https://www.researchsquare.com/article/rs-5119512/v1)
Understanding the reliability of FDA-approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species including dairy cows is critical to public health and pre-pandemic planning, ...

Lamb C, Pitre E, Ajufo S, Rigby C, Bisht K, Oade M. Quantification of influenza virus mini viral RNAs using Cas13. RNA. 2024 Oct 17:rna.080174.124.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from RNA. 2024 Oct 17:rna.080174.124 (via https://rnajournal.cshlp.org/content/early/2024/10/17/rna.08)
Influenza A virus (IAV) RNA synthesis produces full-length and deletion-containing RNA molecules, which include defective viral genomes (DVG) and mini viral RNAs (mvRNA). Sequencing approaches have shown ...

Lisovski S, Günther A, Dewar M, Ainley D, Aldunate. Unexpected Delayed Incursion of Highly Pathogenic Avian Influenza H5N1 (Clade 2.3.4.4b) Into the Antarctic Region. Influenza Other Respir Viruses. 2024 Oct;18(10):e7.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from Influenza Other Respir Viruses. 2024 Oct;18(10):e7 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70010)
The current highly pathogenic avian influenza H5N1 panzootic is having substantial impacts on wild birds and marine mammals. Following major and widespread outbreaks in South America, an incursion to Antarctica ...

Vergne T, Paul MC, Guinat C, Delpont M, Hayes BH,. Highly pathogenic avian influenza management policy in domestic poultry: from reacting to preventing. Euro Surveill. 2024 Oct;29(42).  Abstract  
submitted by kickingbird at Oct, 18, 2024 from Euro Surveill. 2024 Oct;29(42) (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
The emergence of clade 2.3.4.4b H5N1 highly pathogenic avian influenza (HPAI) viruses in 2021 has led to unprecedented epidemics in poultry, changing epidemiological patterns of year-round infections in ...

Alessandro Zulli, etc.,al. [preprint]Infectivity and persistence of influenza viruses in raw milk. https://doi.org/10.1101/2024.10.10.24315269.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from https://doi.org/10.1101/2024.10.10.24315269 (via https://www.medrxiv.org/content/10.1101/2024.10.10.24315269v)
Influenza A viruses present a significant public health risk, with recent outbreaks of highly pathogenic avian influenza (HPAI) H5N1 in dairy cattle raising concerns about potential transmission through ...

Jennifer Schrock, etc.,al. Survivability of low pathogenic avian influenza virus in aqueous poultry manure fertilizer. Journal of Applied Poultry Research, 17 Oct 2024.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from Journal of Applied Poultry Research, 17 Oct 2024 (via https://www.sciencedirect.com/science/article/pii/S105661712)
Avian influenza has been a growing problem in the United States for decades. Low pathogenic avian influenza (LPAI) virus causes low morbidity, while highly pathogenic avian influenza (HPAI) has a devastating ...

Mohamed H. Elhusseiny, etc.,al. Genetic features of avian influenza (A/H5N8) clade 2.3.4.4b isolated from quail in Egypt. Virus Research, December 2024, 199482.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from Virus Research, December 2024, 199482 (via https://www.sciencedirect.com/science/article/pii/S016817022)
Several genotypes of the highly pathogenic avian influenza (HPAI) virus H5N8 subtype within clade 2.3.4.4b continue to circulate in different species of domestic birds across Egypt. It is believed that ...

Klim, H., William, T., Mellors, J. et al. Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats. Nat Commun 15, 8863 (2024).  Abstract  
submitted by kickingbird at Oct, 18, 2024 from Nat Commun 15, 8863 (2024) (via https://www.nature.com/articles/s41467-024-53058-y)
Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 ...

Li, R., Gao, J., Wang, L. et al. Multivalent interactions between fully glycosylated influenza virus hemagglutinins mediated by glycans at distinct N-glycosylation sites. npj Viruses 2, 48 (2024).  Abstract  
submitted by kickingbird at Oct, 18, 2024 from npj Viruses 2, 48 (2024) (via https://www.nature.com/articles/s44298-024-00059-9)
The hemagglutinin (HA) glycoprotein of influenza virus binds host cell receptors and mediates viral entry. Here we present cryo-EM structures of fully glycosylated HAs from H5N1 and H5N8 influenza viruses. ...

Song X, Tian J, Li M, Bai X, Zhao Z, Shi J, Zeng X. Epidemiology and Biological Characteristics of Influenza A (H4N6) Viruses from Wild Birds. Emerg Microbes Infect. 2024 Oct 17:2418909.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from Emerg Microbes Infect. 2024 Oct 17:2418909 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
During the active surveillance, we isolated nine H4N6 subtype influenza A viruses from wild birds in China. To reveal the epidemiology and biology characteristics of H4 subtype influenza A virus from wild ...

Li F, Sun Z, Tao M, Song K, Wang Z, Ren X. Epidemiological characterization of human infection with H5N6 avian influenza. Front Public Health. 2024 Oct 2;12:1398365.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from Front Public Health. 2024 Oct 2;12:1398365 (via https://www.frontiersin.org/journals/public-health/articles/)
Background: In recent years, there have been frequent reports of human infection with H5N6 avian influenza. However, the fundamental characteristics of the disease remain unclear. This paper conducts a ...

Wille M, Broz I, Cherrington T, Crawley A, Farrugi. Contrasting dynamics of two incursions of low-pathogenicity avian influenza virus into Australia. Virus Evol. 2024 Sep 10;10(1):veae076.  Abstract  
submitted by kickingbird at Oct, 18, 2024 from Virus Evol. 2024 Sep 10;10(1):veae076 (via https://academic.oup.com/ve/article/10/1/veae076/7754475)
The current panzootic of high pathogenicity avian influenza virus H5N1 demonstrates how viral incursions can have major ramifications for wildlife and domestic animals. Herein, we describe the recent incursion ...

Gross J, Volmer R, Bessière P. High pathogenicity avian influenza virus emergence: Blame it on chickens or on humans raising chickens?. PLoS Pathog. 2024 Oct 16;20(10):e1012608.  Abstract  
submitted by kickingbird at Oct, 17, 2024 from PLoS Pathog. 2024 Oct 16;20(10):e1012608 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Low pathogenicity avian influenza viruses (LPAIV) of H5 and H7 subtypes can naturally evolve to replicate systemically in birds, acquiring a high pathogenicity avian influenza virus (HPAIV) phenotype. ...

Michalska-Smith M, Clements E, Rasmussen E, Culhan. Location, Age, and Antibodies Predict Avian Influenza Virus Shedding in Ring-Billed and Franklin´s Gulls in Minnesota. Animals (Basel). 2024 Sep 26;14(19):2781.  Abstract  
submitted by kickingbird at Oct, 17, 2024 from Animals (Basel). 2024 Sep 26;14(19):2781 (via https://www.mdpi.com/2076-2615/14/19/2781)
Influenza A virus (IAV) is a multi-host pathogen maintained in water birds and capable of spillover into humans, wildlife, and livestock. Prior research has focused on dabbling ducks as a known IAV reservoir ...

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