Chen HD, Wang X, Yu SL, Ding YH, Wang ML, Wang JN. Clinical Effectiveness of Intravenous Peramivir Compared With Oseltamivir in Patients With Severe Influenza A With Primary Viral Pneumonia: A Randomized Controlled Study. Open Forum Infect Dis. 2020 Nov 18;8(1):ofaa562. Abstract
submitted by kickingbird at Jan, 15, 2021 from Open Forum Infect Dis. 2020 Nov 18;8(1):ofaa562 (via https://academic.oup.com/ofid/article/8/1/ofaa562/5989582)
Background: High-quality evidence confirms that the clinical efficacy of peramivir in severe influenza patients with primary viral pneumonia is lacking. To optimize clinical medication, we evaluate the ...
Park JA, Kim J, Kim SM, Sohn H, Park C, Kim TH, Le. Fabrication of Electrochemical Influenza Virus (H1N1) Biosensor Composed of Multifunctional DNA Four-Way Junction and Molybdenum Disulfide Hybrid Materia. Materials (Basel). 2021 Jan 12;14(2):E343. Abstract
submitted by kickingbird at Jan, 15, 2021 from Materials (Basel). 2021 Jan 12;14(2):E343 (via https://www.mdpi.com/1996-1944/14/2/343)
The outbreak of the influenza virus (H1N1) has symptoms such as coughing, fever, and a sore throat, and due to its high contagious power, it is fatal to humans. To detect H1N1 precisely, the present study ...
Gao R, Gu M, Shi L, Liu K, Li X, Wang X, Hu J, Liu. N-linked glycosylation at site 158 of the HA protein of H5N6 highly pathogenic avian influenza virus is important for viral biological properties and host immune responses. Vet Res. 2021 Jan 13;52(1):8. Abstract
submitted by kickingbird at Jan, 14, 2021 from Vet Res. 2021 Jan 13;52(1):8 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
Since 2014, clade 18.104.22.168 has become the dominant epidemic branch of the Asian lineage H5 subtype highly pathogenic avian influenza virus (HPAIV) in southern and eastern China, while the H5N6 subtype is ...
Suntronwong N, Klinfueng S, Korkong S, Vichaiwatta. Characterizing genetic and antigenic divergence from vaccine strain of influenza A and B viruses circulating in Thailand, 2017-2020. Sci Rep. 2021 Jan 12;11(1):735. Abstract
submitted by kickingbird at Jan, 14, 2021 from Sci Rep. 2021 Jan 12;11(1):735 (via https://www.nature.com/articles/s41598-020-80895-w)
We monitored the circulating strains and genetic variation among seasonal influenza A and B viruses in Thailand between July 2017 and March 2020. The hemagglutinin gene was amplified and sequenced. We ...
Simpson RB, Gottlieb J, Zhou B, Hartwick MA, Naumo. Completeness of open access FluNet influenza surveillance data for Pan-America in 2005-2019. Sci Rep. 2021 Jan 12;11(1):795. Abstract
submitted by kickingbird at Jan, 14, 2021 from Sci Rep. 2021 Jan 12;11(1):795 (via https://www.nature.com/articles/s41598-020-80842-9)
For several decades, the World Health Organization has collected, maintained, and distributed invaluable country-specific disease surveillance data that allow experts to develop new analytical tools for ...
Zhang S, Yu JL, He L, Gong L, Hou S, Zhu M, Wu JB,. Molecular characteristics of the H9N2 avian influenza viruses in live poultry markets in Anhui Province, China, 2013 to 2018. Health Sci Rep. 2021 Jan 6;4(1):e230. Abstract
submitted by kickingbird at Jan, 14, 2021 from Health Sci Rep. 2021 Jan 6;4(1):e230 (via https://pubmed.ncbi.nlm.nih.gov/33437876/)
Background and aims: H9N2 subtype avian influenza virus (AIV) has low-pathogenicity but causes respiratory symptoms and drop in egg production in chicken with long-term virus shedding, resulting in great ...
El Zowalaty ME, DeBeauchmp J, Jeevan T, Franks J,. Molecular detection of influenza A viruses and H5 subtype among migratory Amur falcons amurensis and captive birds of prey. Transbound Emerg Dis. 2021 Jan 11. Abstract
submitted by kickingbird at Jan, 12, 2021 from Transbound Emerg Dis. 2021 Jan 11 (via https://pubmed.ncbi.nlm.nih.gov/33428819/)
Influenza A viruses (IAV) and Newcastle disease viruses (NDV) are major human and animal health threats with geographic differences in prevalence, characteristics, and host populations. Currently, there ...
Du R, Cheng H, Cui Q, Peet NP, Gaisina IN, Rong L. Identification of a novel inhibitor targeting influenza A virus group 2 hemagglutinins. Antiviral Res. 2021 Jan 8:105013. Abstract
submitted by kickingbird at Jan, 12, 2021 from Antiviral Res. 2021 Jan 8:105013 (via https://pubmed.ncbi.nlm.nih.gov/33428962/)
Influenza A virus (IAV) causes seasonal epidemics and occasional but devastating pandemics, which are major public health concerns. The putative antiviral therapeutics are useful for the treatment of influenza, ...
Gu L, Zhou Y, Wang G, Deng H, Song X, He X, Wang T. Spatial learning and memory impaired after infection of non-neurotropic influenza virus in BALB/c male mice. Biochem Biophys Res Commun. 2021 Jan 8;540:29-36. Abstract
submitted by kickingbird at Jan, 12, 2021 from Biochem Biophys Res Commun. 2021 Jan 8;540:29-36 (via https://pubmed.ncbi.nlm.nih.gov/33429197/)
During the influenza pandemic or seasonal influenza outbreak, influenza infection can cause acute influenza-associated encephalopathy/encephalitis (IAE), even death. Patients with severe IAE will also ...
Zhu W, Dong C, Wei L, Wang BZ. Promising Adjuvants and Platforms for Influenza Vaccine Developmen. Pharmaceutics. 2021 Jan 7;13(1):E68. Abstract
submitted by kickingbird at Jan, 12, 2021 from Pharmaceutics. 2021 Jan 7;13(1):E68 (via https://www.mdpi.com/1999-4923/13/1/68)
Influenza is one of the major threats to public health. Current influenza vaccines cannot provide effective protection against drifted or shifted influenza strains. Researchers have considered two important ...
McMillan CLD, Young PR, Watterson D, Chappell KJ. The Next Generation of Influenza Vaccines: Towards a Universal Solution. Vaccines (Basel). 2021 Jan 7;9(1):E26. Abstract
submitted by kickingbird at Jan, 12, 2021 from Vaccines (Basel). 2021 Jan 7;9(1):E26 (via https://www.mdpi.com/2076-393X/9/1/26)
Influenza viruses remain a constant burden in humans, causing millions of infections and hundreds of thousands of deaths each year. Current influenza virus vaccine modalities primarily induce antibodies ...
Timofeeva TA, Sadykova GK, Lomakina NF, Gambaryan. The Effect of I155T, K156Q, K156E and N186K Mutations in Hemagglutinin on the Virulence and Reproduction of Influenza A/H5N1 Viruses. Mol Biol. 2020;54(6):861-869. Abstract
submitted by kickingbird at Jan, 12, 2021 from Mol Biol. 2020;54(6):861-869 (via https://link.springer.com/article/10.1134/S0026893320060126)
The continued circulation of influenza A virus subtype H5 may cause the emergence of new potential pandemic virus variants, which can be transmitted from person to person. The occurrence of such variants ...
An SH, Hong SM, Son SE, Song JH, Lee CY, Choi JG,. Improvement of PR8-Derived Recombinant Clade 22.214.171.124c H5N6 Vaccine Strains by Optimization of Internal Genes and H103Y Mutation of Hemagglutinin. Vaccines (Basel). 2020 Dec 20;8(4):E781. Abstract
submitted by kickingbird at Jan, 11, 2021 from Vaccines (Basel). 2020 Dec 20;8(4):E781 (via https://www.mdpi.com/2076-393X/8/4/781)
Clade 126.96.36.199c H5N6 avian influenza A viruses (AIVs) may have originally adapted to infect chickens and have caused highly pathogenic avian influenza (HPAI) in poultry and human fatalities. Although A/Puerto ...
Schweitzer KS, Crue T, Nall JM, Foster D, Sajuthi. Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells. Eur Respir J. 2021 Jan 8:2003988. Abstract
submitted by kickingbird at Jan, 11, 2021 from Eur Respir J. 2021 Jan 8:2003988 (via https://erj.ersjournals.com/content/early/2020/12/17/1399300)
Patients with COVID-19 caused by severe acute respiratory syndrome coronavirus (SARS-Co-V)-2 demonstrate high rates of co-infection with respiratory viruses, including influenza A (IAV), suggesting pathogenic ...
Zhao D, Qiu D, Qi X, Li S, Zhao Y, Dong Y, Wen X,. Generation and properties of one strain of H3N2 influenza virus with enhanced replication. Vet Microbiol. 2020 Dec 28;253:108970. Abstract
submitted by kickingbird at Jan, 11, 2021 from Vet Microbiol. 2020 Dec 28;253:108970 (via https://www.sciencedirect.com/science/article/pii/S037811352)
H3N2 canine influenza virus (CIV) has been circulating in many countries since 2008. The epidemic spread of CIV could be a concern for public health because of the close contact between humans and companion ...
Sano K, Saito S, Suzuki T, Kotani O, Ainai A, van. An influenza HA stalk reactive polymeric IgA antibody exhibits anti-viral function regulated by binary interaction between HA and the antibody. PLoS One. 2021 Jan 7;16(1):e0245244. Abstract
submitted by kickingbird at Jan, 10, 2021 from PLoS One. 2021 Jan 7;16(1):e0245244 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
IgA antibodies, which are secreted onto the mucosal surface as secretory IgA antibodies (SIgAs), play an important role in preventing influenza virus infection. A recent study reported that anti-hemagglutinin ...
Wang Q, Sun Z, Li J, Qin T, Ma H, Chen S, Peng D,. Identification of a universal antigen epitope of influenza A virus using peptide microarray. BMC Vet Res. 2021 Jan 7;17(1):22. Abstract
submitted by kickingbird at Jan, 10, 2021 from BMC Vet Res. 2021 Jan 7;17(1):22 (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
Background: Hemagglutinin is a major surface protein in influenza A virus (IAV), and HA2 is relative conserved among different IAVs. It will be meaningful to identify broad-spectrum epitopes based on the ...
Yamazaki T, Biswas M, Kosugi K, Nagashima M, Inui. A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza. Front Immunol. 2020 Dec 22;11:606518. Abstract
submitted by kickingbird at Jan, 10, 2021 from Front Immunol. 2020 Dec 22;11:606518 (via https://www.frontiersin.org/articles/10.3389/fimmu.2020.6065)
Radioprotective 105 (RP105) (also termed CD180) is an orphan and unconventional Toll-like receptor (TLR) that lacks an intracellular signaling domain. The agonistic anti-RP105 monoclonal antibody (mAb) ...
Feng M, Zhang Q, Wu W, Chen L, Gu S, Ye Y, Zhong Y. Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways. J Virol. 2021 Jan 6:JVI.02038-20. Abstract
submitted by kickingbird at Jan, 8, 2021 from J Virol. 2021 Jan 6:JVI.02038-20 (via https://jvi.asm.org/content/early/2021/01/05/JVI.02038-20)
Guanylate-binding protein 7 (GBP7) belongs to the GBP family, which plays key roles in mediating innate immune responses to intracellular pathogens. Thus far, GBP7 has been reported to be a critical cellular ...
Patil A, Anhlan D, Ferrando V, Mecate-Zambrano A,. Phosphorylation of influenza A virus NS1 at serine 205 mediates its viral polymerase-enhancing function. J Virol. 2021 Jan 6:JVI.02369-20. Abstract
submitted by kickingbird at Jan, 8, 2021 from J Virol. 2021 Jan 6:JVI.02369-20 (via https://jvi.asm.org/content/early/2021/01/05/JVI.02369-20)
Influenza A virus (IAV) non-structural protein 1 (NS1) is a protein with multiple functions that are regulated by phosphorylation. Phospho-proteomic screening of H1N1-infected cells identified NS1 to be ...
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