Sha TW, Weber M, Kasumba DM, et al. Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner. Virol J. 2020;17(1):107. Abstract
submitted by kickingbird at Jul, 18, 2020 from Virol J. 2020;17(1):107 (via https://pubmed.ncbi.nlm.nih.gov/32677963/)
Background: The non-structural protein 1 (NS1) of influenza A virus (IAV) is a key player in inhibiting antiviral response in host cells, thereby facilitating its replication. However, other roles of NS1, ...
Paillot R, Regourd E, Behr-Gross ME. Establishment of a candidate equine influenza Florida Clade 2 strain A/eq/Richmond/1/07 horse antiserum as Ph. Eur. Biological Reference Preparation/OIE International Reference Reagent. Bio Sci Notes. 2020;2020:125-140. Abstract
submitted by kickingbird at Jul, 18, 2020 from Bio Sci Notes. 2020;2020:125-140 (via https://pubmed.ncbi.nlm.nih.gov/32677612/)
Equine influenza (EI) is an important respiratory disease of horses, with welfare and economic consequences. Vaccination remains one of the most efficient prevention methods available. Equine influenza ...
Sultankulova K, Orynbayev M, Kozhabergenov N, et a. Complete Coding Genome Sequence of an Avian Influenza A/H3N8 Virus Strain Detected in North Kazakhstan in 2018. Microbiol Resour Announc. 2020;9(29):e00441-20. Abstract
submitted by kickingbird at Jul, 18, 2020 from Microbiol Resour Announc. 2020;9(29):e00441-20 (via https://pubmed.ncbi.nlm.nih.gov/32675181/)
We report the complete coding genome sequence of the influenza A/H3N8 virus, isolated from Anas querquedula in northern Kazakhstan in 2018. Phylogenetic analysis of the surface antigens of strain A/garganey/North-Kazakhstan/45/2018 ...
Zhou X, Liu Y, Jin Y, et al. Immune responses after influenza vaccination in patients of primary Sj?gren´s syndrome. Rheumatology (Oxford). 2020;keaa243. Abstract
submitted by kickingbird at Jul, 18, 2020 from Rheumatology (Oxford). 2020;keaa243 (via https://pubmed.ncbi.nlm.nih.gov/32671409/)
Objectives: Influenza vaccination is effective in preventing infections in most people. This study aimed to assess the changes of immune responses in primary Sj?gren's Syndrome (pSS) patients after influenza ...
Horwood PF, Fabrizio T, Horm SV, et al. Transmission experiments support clade-level differences in the transmission and pathogenicity of Cambodian influenza A/H5N1 viruses. Emerg Microbes Infect. 2020;1-36. Abstract
submitted by kickingbird at Jul, 16, 2020 from Emerg Microbes Infect. 2020;1-36 (via https://pubmed.ncbi.nlm.nih.gov/32666894/)
Influenza A/H5N1 has circulated in Asia since 2003 and is now enzootic in many countries in that region. In Cambodia, the virus has circulated since 2004 and has intermittently infected humans. During ...
Tricoche AD, Wagner AL, Balmaseda A, et al. Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections. J Infect Dis. 2020;jiaa426. Abstract
submitted by kickingbird at Jul, 16, 2020 from J Infect Dis. 2020;jiaa426 (via https://pubmed.ncbi.nlm.nih.gov/32668454/)
Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses. This study examines the relationship between influenza symptoms and serological response. Influenza-positive ...
Yang G, Wang X, Yang Y, Yang R, Gowetski DB, Paula. Quantitation of residual valproic acid in flu vaccine drug substance. J Chromatogr B Analyt Technol Biomed Life Sci. 202. Abstract
submitted by kickingbird at Jul, 16, 2020 from J Chromatogr B Analyt Technol Biomed Life Sci. 202 (via https://pubmed.ncbi.nlm.nih.gov/32668376/)
Quantitative measurement of process-related impurities is a critical safety requirement for the production of drug substances of vaccine and therapeutic biologics. A simple and sensitive HPLC method has ...
Li YT, Chen CC, Chang AM, Chao DY, Smith GJD. Co-circulation of both low and highly pathogenic avian influenza H5 viruses in current poultry epidemics in Taiwan. Virus Evol. 2020;6(1):veaa037. Abstract
submitted by kickingbird at Jul, 15, 2020 from Virus Evol. 2020;6(1):veaa037 (via https://pubmed.ncbi.nlm.nih.gov/32661493/)
Highly pathogenic avian influenza (HPAI) A(H5) viruses belonging to clade 188.8.131.52c of the A/goose/Guangdong/1/96-like (Gs/GD) lineage caused severe global outbreaks in domestic birds from 2014 to 2015, ...
Ellebedy AH, Nachbagauer R, Jackson KJL, et al. Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans. Proc Natl Acad Sci U S A. 2020;201906613. Abstract
submitted by kickingbird at Jul, 15, 2020 from Proc Natl Acad Sci U S A. 2020;201906613 (via https://pubmed.ncbi.nlm.nih.gov/32661157/)
There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus nonadjuvanted H5N1 avian influenza virus inactivated ...
Wang M, Huang Y, Gu W, Wang H. Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice. J Vis Exp. 2020;(160):10.3791/60523. Abstract
submitted by kickingbird at Jul, 15, 2020 from J Vis Exp. 2020;(160):10.3791/60523 (via https://pubmed.ncbi.nlm.nih.gov/32658200/)
T Follicular Helper (Tfh) cells are an independent CD4+ T cell subset specialized in providing help for germinal center (GC) development and generation of high-affinity antibodies. In influenza virus infection, ...
Nguyen-Van-Tam JS, Killingley B, Enstone J, et al. Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment. PLoS Pathog. 2020;16(7):e1008704. Abstract
submitted by kickingbird at Jul, 14, 2020 from PLoS Pathog. 2020;16(7):e1008704 (via https://pubmed.ncbi.nlm.nih.gov/32658939/)
Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising ...
Yang F, Xiao Y, Liu F, Yao H, Wu N, Wu H. Development of a Monoclonal Antibody-Based Antigen Capture Enzyme-Linked Immunosorbent Assay for Detection of H7N9 Subtype Avian Influenza Virus. J Med Virol. 2020;10.1002/jmv.26292. Abstract
submitted by kickingbird at Jul, 12, 2020 from J Med Virol. 2020;10.1002/jmv.26292 (via https://pubmed.ncbi.nlm.nih.gov/32648948/)
In order to establish a rapid detection method for H7N9 avian influenza virus (AIV), monoclonal antibodies (mAbs) against hemagglutinin (HA) of H7N9 were developed to establish an antigen capture enzyme-linked ...
Guk K, Kim H, Lee M, et al.. Development of A4 Antibody for Detection of Neuraminidase I223R/H275Y-associated Antiviral Multidrug-Resistant Influenza Virus. Nat Commun. 2020;11(1):3418. Published 2020 Jul 9.. Abstract
submitted by kickingbird at Jul, 12, 2020 from Nat Commun. 2020;11(1):3418. Published 2020 Jul 9. (via https://pubmed.ncbi.nlm.nih.gov/32647286/)
The emergence and spread of antiviral drug-resistant viruses have been a worldwide challenge and a great concern for patient care. We report A4 antibody specifically recognizing and binding to the mutant ...
Cheng C, Li J, Liu W, Xu L, Zhang Z. Modelling Analysis Revealed the Distinct Global Transmission Patterns of Influenza A Viruses and Their Influencing Factors. Integr Zool. 2020;10.1111/1749-4877.12469. Abstract
submitted by kickingbird at Jul, 11, 2020 from Integr Zool. 2020;10.1111/1749-4877.12469 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/1749-4877.12)
Influenza A virus has caused huge damage to human health and poultry production worldwide, but its global transmission patterns and influencing factors remains unclear. Here, by using the Nearest Genetic ...
Mo J, Spackman E, Stephens CB. Identification of Optimal Sample Collection Devices and Sampling Locations for the Detection Environmental Viral Contamination in Wire Poultry Cages. Transbound Emerg Dis. 2020;10.1111/tbed.13721. Abstract
submitted by kickingbird at Jul, 10, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13721 (via https://pubmed.ncbi.nlm.nih.gov/32643291/)
Environmental testing of poultry premises after an outbreak of an infectious disease like avian influenza (AI) or Newcastle disease, is essential to promptly verify virus-free status and subsequently return ...
Li L, Wu H, Li Q, et al. SOCS3-deficient Lung Epithelial Cells Uptaking Neutrophil-Derived SOCS3 Worsens Lung Influenza Infection. Mol Immunol. 2020;125:51-62. Abstract
submitted by kickingbird at Jul, 10, 2020 from Mol Immunol. 2020;125:51-62 (via https://pubmed.ncbi.nlm.nih.gov/32645550/)
Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether ...
Maier HE, Kuan G, Gresh L, et al. Obesity Is Associated With Increased Susceptibility to Influenza A (H1N1pdm) but Not H3N2 Infection. Clin Infect Dis. 2020;ciaa928. Abstract
submitted by kickingbird at Jul, 10, 2020 from Clin Infect Dis. 2020;ciaa928 (via https://pubmed.ncbi.nlm.nih.gov/32642771/)
Background: Obesity has been shown to increase the risk of severe outcomes and death for influenza virus infections. However, we don't understand the influence of obesity on susceptibility to infection ...
Scarpino SV, Scott JG, Eggo RM, Clements B, Dimitr. Socioeconomic Bias in Influenza Surveillance. PLoS Comput Biol. 2020;16(7):e1007941. Abstract
submitted by kickingbird at Jul, 10, 2020 from PLoS Comput Biol. 2020;16(7):e1007941 (via https://pubmed.ncbi.nlm.nih.gov/32644990/)
Individuals in low socioeconomic brackets are considered at-risk for developing influenza-related complications and often exhibit higher than average influenza-related hospitalization rates. This disparity ...
Arai Y, Elgendy EM, Daidoji T, et al. H9N2 Influenza Virus Infections in Human Cells Require a Balance Between NA Sialidase Activity and HA Receptor Affinity. J Virol. 2020;JVI.01210-20.. Abstract
submitted by kickingbird at Jul, 10, 2020 from J Virol. 2020;JVI.01210-20. (via https://pubmed.ncbi.nlm.nih.gov/32641475/)
Some avian influenza (AI) viruses have a deletion of up to 20-30 amino acids in their NA stalk. This has been associated with changes in virus replication and host range. Currently prevalent H9N2 AI viruses ...
Zanin M, DeBeauchamp J, Vangala G, Webby RJ, Husai. Histone Deacetylase 6 Knockout Mice Exhibit Higher Susceptibility to Influenza A Virus Infection. Viruses. 2020;12(7):E728. Abstract
submitted by kickingbird at Jul, 10, 2020 from Viruses. 2020;12(7):E728 (via https://pubmed.ncbi.nlm.nih.gov/32640546/)
The host innate defence against influenza virus infection is an intricate system with a plethora of antiviral factors involved. We have identified host histone deacetylase 6 (HDAC6) as an anti-influenza ...
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