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2019-7-23 3:44:08
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Yang G, et al. Detection of highly pathogenic avian influenza A(H5N6) viruses in waterfowl in Bangladesh. Virology. 2019 May 28;534:36-44.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Virology. 2019 May 28;534:36-44 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Bangladesh has reported repeated outbreaks of highly pathogenic avian influenza (HPAI) A(H5) viruses in poultry since 2007. Because of the large number of live poultry markets (LPM) relative to the population ...

Jia R, et al. Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase. Eur J Med Chem. 2019 May 30;178:64-80.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Eur J Med Chem. 2019 May 30;178:64-80 (via https://www.sciencedirect.com/science/article/pii/S022352341)
Encouraged by our earlier discovery of neuraminidase inhibitors targeting 150-cavity or 430-cavity, herein, to yield more potent inhibitors, we designed, synthesized, and biologically evaluated a series ...

Wang C, et al. Infection of chicken H9N2 influenza viruses in different species of domestic ducks. Vet Microbiol. 2019 Jun;233:1-4..  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Vet Microbiol. 2019 Jun;233:1-4. (via https://www.sciencedirect.com/science/article/pii/S037811351)
Domestic ducks are considered as the interface between wild aquatic birds and terrestrial poultry and play an important role in the transmission and evolution of avian influenza viruses (AIVs). However, ...

Artarini A, et al. Regulation of influenza a virus mRNA splicing by CLK1. Antiviral Res. 2019 Jun 6.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Antiviral Res. 2019 Jun 6 (via https://www.sciencedirect.com/science/article/pii/S016635421)
Influenza A virus carries eight negative single-stranded RNAs and uses spliced mRNAs to increase the number of proteins produced from them. Several genome-wide screens for essential host factors for influenza ...

Bergmann S, Elbahesh H. Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses. Virology. 2019 Jun 1;534:54-63..  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Virology. 2019 Jun 1;534:54-63. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A virus (IAV) infections result in ~500,000 global deaths annually. Host kinases link multiple signaling pathways at various stages of infection and are attractive therapeutic target. Focal adhesion ...

Yuan B, et al. The tree shrew is a promising model for the study of influenza B virus infection. Virol J. 2019 Jun 7;16(1):77.  Abstract  
submitted by kickingbird at Jun, 10, 2019 from Virol J. 2019 Jun 7;16(1):77 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Influenza B virus is a main causative pathogen of annual influenza epidemics, however, research on influenza B virus in general lags behind that on influenza A viruses, one of the important ...

Ghafouri SA, et al. Full genome characterization of Iranian H5N8 highly pathogenic avian influenza virus from Hooded Crow (Corvus cornix), 2017: The first report. Comp Immunol Microbiol Infect Dis. 2019 Jun;64:73-.  Abstract  
submitted by kickingbird at Jun, 10, 2019 from Comp Immunol Microbiol Infect Dis. 2019 Jun;64:73- (via https://www.sciencedirect.com/science/article/pii/S014795711)
During 2014-2017 Clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses (HPAIVs) have spread worldwide. In 2016, an epidemic of HPAIV H5N8 in Iran caused mass deaths among wild birds, and several ...

Kouba T, Drncová P, Cusack S. Structural snapshots of actively transcribing influenza polymerase. Nat Struct Mol Biol. 2019 Jun;26(6):460-470.  Abstract  
submitted by kickingbird at Jun, 9, 2019 from Nat Struct Mol Biol. 2019 Jun;26(6):460-470 (via https://www.nature.com/articles/s41594-019-0232-z)
Influenza virus RNA-dependent RNA polymerase uses unique mechanisms to transcribe its single-stranded genomic viral RNA (vRNA) into messenger RNA. The polymerase is initially bound to a promoter comprising ...

Ng S, et al. Novel correlates of protection against pandemic H1N1 influenza A virus infection. Nat Med. 2019 Jun 3..  Abstract  
submitted by kickingbird at Jun, 9, 2019 from Nat Med. 2019 Jun 3. (via https://www.nature.com/articles/s41591-019-0463-x)
Influenza viruses remain a severe threat to human health, causing up to 650,000 deaths annually1,2. Seasonal influenza virus vaccines can prevent infection, but are rendered ineffective by antigenic drift. ...

Park SC, et al. Pathogenicity of clade 2.3.4.4 H5N6 highly pathogenic avian influenza virus in three chicken breeds from South Korea in 2016/2017. J Vet Sci. 2019 May;20(3):e27.  Abstract  
submitted by kickingbird at Jun, 9, 2019 from J Vet Sci. 2019 May;20(3):e27 (via https://synapse.koreamed.org/DOIx.php?id=10.4142/jvs.2019.20)
In 2016, novel H5N6 highly pathogenic avian influenza virus emerged in Korea. During the outbreak, the virus caused the largest culling, especially in brown chicken lines. We determined the pathogenicity ...

Kim JI, et al. Novel small molecule targeting the hemagglutinin stalk of influenza viruses. J Virol. 2019 Jun 5..  Abstract  
submitted by kickingbird at Jun, 9, 2019 from J Virol. 2019 Jun 5. (via https://jvi.asm.org/content/early/2019/05/30/JVI.00878-19)
Combating influenza is one of the perennial global public health issues to be managed. Antiviral drugs are useful for the treatment of influenza in the absence of an appropriate vaccine. However, the appearance ...

Nooruzzaman M, et al. A new reassortant clade 2.3.2.1a H5N1 highly pathogenic avian influenza virus causing recent outbreaks in ducks, geese, chickens and turkeys in Bangladesh. Transbound Emerg Dis. 2019 Jun 6..  Abstract  
submitted by kickingbird at Jun, 9, 2019 from Transbound Emerg Dis. 2019 Jun 6. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13264)
A total of 15 dead or sick birds from 13 clinical outbreaks of avian influenza in ducks, geese, chickens and turkeys in 2017 in Bangladesh were examined. The presence of H5N1 influenza A virus in the affected ...

Zhong W, Levine MZ. Stockpiled avian influenza A(H7N9) vaccines induce robust, non-neutralizing functional antibodies against antigenically drifted 5th wave A(H7N9) viruses. J Infect Dis. 2019 Jun 5..  Abstract  
submitted by kickingbird at Jun, 9, 2019 from J Infect Dis. 2019 Jun 5. (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Human infections caused by avian influenza A(H7N9) viruses have raised concerns of a pandemic. The capability of the current stockpiled A(H7N9) vaccines to induce cross-protective, non-neutralizing functional ...

Yu Z, Cheng K, Wang T, Ren Z, Wu J, He H, Gao Y. Two mutations in viral protein enhance the adaptation of waterfowl-origin H3N2 virus in murine model. Virus Res. 2019 Jun 4. pii: S0168-1702(19)30049-8.  Abstract  
submitted by kickingbird at Jun, 9, 2019 from Virus Res. 2019 Jun 4. pii: S0168-1702(19)30049-8 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
After serial passage of a waterfowl-origin H3N2 subtype avian influenza virus in BALB/c mice, we obtained H3N2 mouse-adapted variants and identified eight amino acid substitutions in five viral proteins ...

Huang SY, et al. Novel Role for miR-1290 in Host Species Specificity of Influenza A Virus. Mol Ther Nucleic Acids. 2019 May 15;17:10-23..  Abstract  
submitted by kickingbird at Jun, 9, 2019 from Mol Ther Nucleic Acids. 2019 May 15;17:10-23. (via https://www.cell.com/molecular-therapy-family/nucleic-acids/)
The role of microRNA (miRNA) in influenza A virus (IAV) host species specificity is not well understood as yet. Here, we show that a host miRNA, miR-1290, is induced through the extracellular signal-regulated ...

Meng W, et al. New evidence for the east-west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China. Emerg Microbes Infect. 2019;8(1):823-826..  Abstract  
submitted by kickingbird at Jun, 6, 2019 from Emerg Microbes Infect. 2019;8(1):823-826. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The spread of highly pathogenic avian influenza (HPAI) H5N1 virus is associated with wild fowl migration in East Asian-Australasian (EA) and Central Asian (CA) flyways. However, the spread of H5N1 virus ...

Cuningham W, et al. Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis. Influenza Other Respir Viruses. 2019 Jun 5..  Abstract  
submitted by kickingbird at Jun, 6, 2019 from Influenza Other Respir Viruses. 2019 Jun 5. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12649)
BACKGROUND: Pregnant women have an elevated risk of illness and hospitalisation from influenza. Pregnant women are recommended to be prioritised for influenza vaccination during any stage of pregnancy. ...

Lee ACY, et al. H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses. Cell Death Dis. 2019 Jun 5;10(6):442.  Abstract  
submitted by kickingbird at Jun, 6, 2019 from Cell Death Dis. 2019 Jun 5;10(6):442 (via https://www.nature.com/articles/s41419-019-1684-0)
We previously demonstrated that avian influenza A H7N9 virus preferentially infected CD14+ monocyte in human peripheral blood mononuclear cells (PBMCs), which led to apoptosis. To better understand H7N9 ...

Parvin R, et al. Co-subsistence of avian influenza virus subtypes of low and high pathogenicity in Bangladesh: Challenges for diagnosis, risk assessment and control. Sci Rep. 2019 Jun 5;9(1):8306..  Abstract  
submitted by kickingbird at Jun, 6, 2019 from Sci Rep. 2019 Jun 5;9(1):8306. (via https://www.nature.com/articles/s41598-019-44220-4)
Endemic co-circulation of potentially zoonotic avian influenza viruses (AIV) of subtypes H5N1 and H9N2 (G1 lineage) in poultry in Bangladesh accelerated diversifying evolution. Two clinical samples from ...

Choi WS, et al. Development of a rapid, simple and efficient one-pot cloning method for a reverse genetics system of broad subtypes of influenza A virus. Sci Rep. 2019 Jun 5;9(1):8318.  Abstract  
submitted by kickingbird at Jun, 6, 2019 from Sci Rep. 2019 Jun 5;9(1):8318 (via https://www.nature.com/articles/s41598-019-44813-z)
The reverse genetics (RG) system of influenza A viruses is well established. However, the conventional sequence-dependent method for cloning influenza genome segments is time-consuming and requires multiple ...

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