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2019-3-21 8:21:24
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Gooch KE, et al. Heterosubtypic cross-protection correlates with cross-reactive interferon-gamma-secreting lymphocytes in the ferret model of influenza. Sci Rep. 2019 Feb 22;9(1):2617.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Sci Rep. 2019 Feb 22;9(1):2617 (via https://www.nature.com/articles/s41598-019-38885-0)
An effective universal vaccine for influenza will likely need to induce virus-specific T-cells, which are the major mediator of heterosubtypic cross-protection between different subtypes of influenza A ...

Henry C, et al. Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell Host Microbe. 2019 Jan 24.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Cell Host Microbe. 2019 Jan 24 (via https://www.sciencedirect.com/science/article/pii/S193131281)
Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction of this population. A key aspect of antibody-mediated anti-influenza virus immunity is adaptation to antigenically ...

Lee J, et al. Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations. Cell Host Microbe. 2019 Feb 6..  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Cell Host Microbe. 2019 Feb 6. (via https://www.sciencedirect.com/science/article/pii/S193131281)
Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact antibody responses is essential for vaccine development. ...

Wang SH, et al. Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge. Vaccine. 2019 Feb 19..  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Vaccine. 2019 Feb 19. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: Highly pathogenic H5N1 influenza viruses remain a pandemic risk to the world population. Although vaccines are the best solution to prevent this threat, a more effective vaccine for H5 strains ...

Awadalla M, et al. Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors. J Immunother Cancer. 2019 Feb 22;7(1):53.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from J Immunother Cancer. 2019 Feb 22;7(1):53 (via https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0)
BACKGROUND: Influenza vaccination (FV) is recommended for patients with cancer. Recent data suggested that the administration of the FV was associated with an increase in immune-related adverse events ...

Kim JW, et al. An optimized molecular method for detection of influenza A virus using improved generic primers and concentration of the viral genomic RNA and nucleoprotein complex. J Vet Diagn Invest. 2019 Feb 22.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from J Vet Diagn Invest. 2019 Feb 22 (via https://journals.sagepub.com/doi/abs/10.1177/104063871983076)
For reported primer sets used to detect influenza A viruses (IAVs), we verified the nucleotide identities with 9,103 complete sequences of matrix (M) genes. At best, only 93.2% and 85.3% of the sequences ...

Wang Q, et al. Host cell interactome of PB1 N40 protein of H5N1 influenza A virus in chicken cells. J Proteomics. 2019 Feb 18.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from J Proteomics. 2019 Feb 18 (via https://www.sciencedirect.com/science/article/pii/S187439191)
H5N1 influenza A virus (IAV) causes seasonal epidemics that represent a worldwide threat to public health. IAV relies on host factors for viral replication. PB1 N40 is translated from the fifth starting ...

Nielsen J, et al. European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?. Clin Microbiol Infect. 2019 Feb 18..  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Clin Microbiol Infect. 2019 Feb 18. (via https://www.clinicalmicrobiologyandinfection.com/article/S11)
OBJECTIVES: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among ...

Njouom R, et al. Detection of Influenza C Virus Infection among Hospitalized Patients, Cameroon. Emerg Infect Dis. 2019 Mar;25(3):607-609.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Emerg Infect Dis. 2019 Mar;25(3):607-609 (via https://wwwnc.cdc.gov/eid/article/25/3/18-1213_article)
We report 3 cases of influenza C virus in children hospitalized with severe acute respiratory infection in Cameroon. Two of these case-patients had grave clinical manifestations, but all 3 recovered. The ...

Han L, et al. Smoking and influenza-associated morbidity and mortality: a systematic review and meta-analysis. Epidemiology. 2019 Feb 15.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Epidemiology. 2019 Feb 15 (via https://insights.ovid.com/crossref?an=00001648-900000000-985)
BACKGROUND: Although smoking has been recognized as risk factor for many respiratory diseases, its effects on influenza-associated morbidity and mortality remain controversial. We conducted a systematic ...

Thornton AC, et al. Human exposures to H5N6 Avian influenza, England, 2018. J Infect Dis. 2019 Feb 21.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from J Infect Dis. 2019 Feb 21 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
The human risk following exposure to the European reassortant avian influenza A (H5N6) is unknown. We used routine data collected as part of public health follow-up to assess outcomes of individuals exposed ...

Byrd-Leotis L, et al. Influenza binds phosphorylated glycans from human lung. Sci Adv. 2019 Feb 13;5(2):eaav2554.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Sci Adv. 2019 Feb 13;5(2):eaav2554 (via http://advances.sciencemag.org/content/5/2/eaav2554)
Influenza A viruses can bind sialic acid-terminating glycan receptors, and species specificity is often correlated with sialic acid linkage with avian strains recognizing α2,3-linked sialylated glycans ...

Nieto A, et al. Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model. Front Immunol. 2019 Feb 6;10:132..  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Front Immunol. 2019 Feb 6;10:132. (via https://www.ncbi.nlm.nih.gov/pubmed/30787926)
Characterization of a pandemic 2009 H1N1 influenza virus isolated from a fatal case patient (F-IAV), showed the presence of three different mutations; potential determinants of its high pathogenicity that ...

To EE, et al. Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice. Sci Rep. 2019 Feb 20;9(1):2366.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Sci Rep. 2019 Feb 20;9(1):2366 (via https://www.nature.com/articles/s41598-019-38864-5)
Toll-like receptor 7 (TLR7) is a pattern recognition receptor that recognizes viral RNA following endocytosis of the virus and initiates a powerful immune response characterized by Type I IFN production ...

Meineke R, Rimmelzwaan GF, Elbahesh H. Influenza Virus Infections and Cellular Kinases. Viruses. 2019 Feb 20;11(2).  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Viruses. 2019 Feb 20;11(2) (via https://www.mdpi.com/1999-4915/11/2/171)
Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs may cause pandemic outbreaks ...

Turgeon N, et al. Design and Validation with Influenza A Virus of an Aerosol Transmission Chamber for Ferrets. Int J Environ Res Public Health. 2019 Feb 19;16(4).  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Int J Environ Res Public Health. 2019 Feb 19;16(4) (via https://www.mdpi.com/1660-4601/16/4/609)
Background: The importance of aerosols in the spread of viruses like influenza is still a subject of debate. Indeed, most viruses can also be transmitted through direct contact and droplets. Therefore, ...

Kandula S, Shaman J. Near-term forecasts of influenza-like illness: An evaluation of autoregressive time series approaches. Epidemics. 2019 Jan 17.  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Epidemics. 2019 Jan 17 (via https://www.ncbi.nlm.nih.gov/pubmed/30792135)
Seasonal influenza in the United States is estimated to cause 9-35 million illnesses annually, with resultant economic burden amounting to $47-$150 billion. Reliable real-time forecasts of influenza can ...

Lei N, et al. Molecular evolution of influenza B virus during 2011-2017 in Chaoyang, Beijing, suggesting the free influenza vaccine policy. Sci Rep. 2019 Feb 21;9(1):2432..  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Sci Rep. 2019 Feb 21;9(1):2432. (via https://www.nature.com/articles/s41598-018-38105-1)
Two influenza B virus lineages, B/Victoria and B/Yamagata, are co-circulating in human population. While the two lineages are serologically distinct and TIV only contain one lineage. It is important to ...

Zhang W, et al. Genetic Evolution and Molecular Selection of the HE Gene of Influenza C Virus. Viruses. 2019 Feb 19;11(2).  Abstract  
submitted by kickingbird at Feb, 24, 2019 from Viruses. 2019 Feb 19;11(2) (via https://www.mdpi.com/1999-4915/11/2/167)
Influenza C virus (ICV) was first identified in humans and swine, but recently also in cattle, indicating a wider host range and potential threat to both the livestock industry and public health than was ...

Jiao H, et al. MicroRNA expression profiles from HEK293 cells expressing H5N1 avian influenza virus non-structural protein 1. Innate Immun. 2019 Feb;25(2):110-117.  Abstract  
submitted by kickingbird at Feb, 22, 2019 from Innate Immun. 2019 Feb;25(2):110-117 (via https://journals.sagepub.com/doi/full/10.1177/17534259198263)
H5N1 avian influenza poses a serious threat to the poultry industry and human health. Non-structural protein 1 (NS1) plays an important role in the replication and pathogenesis of avian influenza virus ...

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