de Vries RD, et al. Analysis Of The Vaccine-Induced Influenza B Virus Hemagglutinin-Specific Antibody Dependent Cellular Cytotoxicity Response. Virus Res. 2019 Dec 11:197839.. Abstract
submitted by kickingbird at Dec, 16, 2019 from Virus Res. 2019 Dec 11:197839. (via https://www.ncbi.nlm.nih.gov/pubmed/31837382)
Influenza A virus (IAV) and influenza B virus (IBV) cause substantial morbidity and mortality during seasonal epidemics. On basis of variation in the surface glycoprotein hemagglutinin, two antigenically ...
Kiso M, Yamayoshi S, Murakami J, Kawaoka Y. Baloxavir marboxil treatment of nude mice infected with influenza A virus. J Infect Dis. 2019 Dec 14. Abstract
submitted by kickingbird at Dec, 16, 2019 from J Infect Dis. 2019 Dec 14 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Immunocompromised patients infected with influenza virus require prolonged treatment with neuraminidase inhibitors, because these patients are not able to eradicate the virus from the respiratory tract, ...
Krammer F, et al. Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines. Influenza Other Respir Viruses. 2019 Dec 13.. Abstract
submitted by kickingbird at Dec, 16, 2019 from Influenza Other Respir Viruses. 2019 Dec 13. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12706)
BACKGROUND: This report summarizes the discussions and conclusions from the "Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines" meeting which took place in Siena, ...
Luckey D, et al. Immunity to Influenza is dependent on MHC II polymorphism: study with 2 HLA transgenic strains. Sci Rep. 2019 Dec 13;9(1):19061. Abstract
submitted by kickingbird at Dec, 16, 2019 from Sci Rep. 2019 Dec 13;9(1):19061 (via https://www.nature.com/articles/s41598-019-55503-1)
Major histocompatibility complex II (MHC II) molecules are involved in antigen presentation and the development of a functional adaptive immune response. Evolutionary selection for MHC molecules that effectively ...
Matos ADR, et al. Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities. Emerg Microbes Infect. 2019;8(1):1763-1776. Abstract
submitted by kickingbird at Dec, 15, 2019 from Emerg Microbes Infect. 2019;8(1):1763-1776 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza is an acute respiratory infection causing high morbidity and mortality in annual outbreaks worldwide. Antiviral drugs are limited and pose the risk of resistance development, calling for new ...
Traxler S, et al. Volatile scents of influenza A and S. pyogenes (co-)infected cells. Sci Rep. 2019 Dec 11;9(1):18894. Abstract
submitted by kickingbird at Dec, 15, 2019 from Sci Rep. 2019 Dec 11;9(1):18894 (via https://www.nature.com/articles/s41598-019-55334-0)
Influenza A is a serious pathogen itself, but often leads to dangerous co-infections in combination with bacterial species such as Streptococcus pyogenes. In comparison to classical biochemical methods, ...
Qiu Y, et al. Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth. J Virol. 2019 Dec 11. Abstract
submitted by kickingbird at Dec, 15, 2019 from J Virol. 2019 Dec 11 (via https://jvi.asm.org/content/early/2019/12/05/JVI.01035-19)
The discovery of potent and broadly protective influenza epitopes could lead to improved vaccines that are resistant to antigenic drift. Here, we describe human antibody C585, isolated from a vaccinee ...
Parsons L, et al. Influenza Hemagglutinins H2, H5, H6, and H11 are not Targets of Pulmonary Surfactant Protein D: N-glycan subtypes in host-pathogen interactions. J Virol. 2019 Dec 11. pii: JVI.01951-19.. Abstract
submitted by kickingbird at Dec, 15, 2019 from J Virol. 2019 Dec 11. pii: JVI.01951-19. (via https://jvi.asm.org/content/early/2019/12/05/JVI.01951-19)
Seasonal influenza carrying key hemagglutinin (HA) head region glycosylation sites can be removed from the lung by pulmonary surfactant protein D (SP-D). Little is known about HA head glycosylation of ...
Hallmann-Szelińska E, et al. Virological and Epidemiological Situation in the Influenza Epidemic Seasons 2016/2017 and 2017/2018 in Poland. Adv Exp Med Biol. 2019 Dec 13.. Abstract
submitted by kickingbird at Dec, 15, 2019 from Adv Exp Med Biol. 2019 Dec 13. (via https://link.springer.com/chapter/10.1007%2F5584_2019_454)
The World Health Organization estimates that influenza virus infects 3-5 million people worldwide every year, of whom 290,000 to 650,000 die. In the 2016/2017 epidemic season in Poland, the incidence of ...
Abolnik C. Outbreaks of Clade 126.96.36.199 H5N8 highly pathogenic avian influenza in 2018 in the northern regions of South Africa were unrelated to those of 2017. Transbound Emerg Dis. 2019 Dec 13.. Abstract
submitted by kickingbird at Dec, 15, 2019 from Transbound Emerg Dis. 2019 Dec 13. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13448)
Asian-origin H5N8 highly pathogenic avian influenza (HPAI) viruses of the H5 Goose/Guangdong/96 lineage, clade 188.8.131.52 group B reached South Africa by June 2017. By the end of that year, 5.4 million layers ...
Babakazo P, et al. Evaluation of the influenza sentinel surveillance system in the Democratic Republic of Congo, 2012-2015. BMC Public Health. 2019 Dec 10;19(1):1652.. Abstract
submitted by kickingbird at Dec, 15, 2019 from BMC Public Health. 2019 Dec 10;19(1):1652. (via https://bmcpublichealth.biomedcentral.com/articles/10.1186/s)
BACKGROUND: The World Health Organization recommends periodic evaluations of influenza surveillance systems to identify areas for improvement and provide evidence of data reliability for policymaking. ...
Zhu YL, et al. Reversible Parkinsonism caused by Influenza B-associated encephalitis affecting bilateral basal ganglia: A case report. CNS Neurosci Ther. 2019 Dec 10.. Abstract
submitted by kickingbird at Dec, 15, 2019 from CNS Neurosci Ther. 2019 Dec 10. (via https://onlinelibrary.wiley.com/doi/full/10.1111/cns.13278)
Influenza viruses are important human pathogens that often cause respiratory tract infections, while neurological complications are rare.1 Secondary Parkinsonism following viral infections usually occur ...
Suttie A, et al. The evolution and genetic diversity of avian influenza A(H9N2) viruses in Cambodia, 2015-2016. PLoS One. 2019 Dec 9;14(12):e0225428.. Abstract
submitted by kickingbird at Dec, 11, 2019 from PLoS One. 2019 Dec 9;14(12):e0225428. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Low pathogenic A(H9N2) subtype avian influenza viruses (AIVs) were originally detected in Cambodian poultry in 2013, and now circulate endemically. We sequenced and characterised 64 A(H9N2) AIVs detected ...
Suttie A, et al. Diversity of A(H5N1) clade 184.108.40.206c avian influenza viruses with evidence of reassortment in Cambodia, 2014-2016. PLoS One. 2019 Dec 9;14(12):e0226108.. Abstract
submitted by kickingbird at Dec, 11, 2019 from PLoS One. 2019 Dec 9;14(12):e0226108. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
In Cambodia, highly pathogenic avian influenza A(H5N1) subtype viruses circulate endemically causing poultry outbreaks and zoonotic human cases. To investigate the genomic diversity and development of ...
Suehiro Sakaguchi, Junji Chida. Prion Protein is a Novel Modulator of Influenza: Potential Implications for Anti-Influenza Therapeutics. Curr. Issues Mol. Biol. (2020) 37: 21-32. Abstract
submitted by kickingbird at Dec, 11, 2019 from Curr. Issues Mol. Biol. (2020) 37: 21-32 (via https://www.caister.com/cimb/abstracts/v37/21.html)
Worldwide spread of influenza A virus (IAV) strains, which are resistant to currently available anti- influenza agents such as viral neuraminidase inhibitors, has encouraged identification of new target ...
Fatima U, et al. Equine Mx1 Restricts Influenza A Virus Replication by Targeting at Distinct Site of its Nucleoprotein. Viruses. 2019 Dec 2;11(12).. Abstract
submitted by kickingbird at Dec, 10, 2019 from Viruses. 2019 Dec 2;11(12). (via https://www.mdpi.com/1999-4915/11/12/1114)
Interferon-mediated host factors myxovirus (Mx) proteins are key features in regulating influenza A virus (IAV) infections. Viral polymerases are essential for viral replication. The Mx1 protein has been ...
Shehata MM, et al. A Recombinant Influenza A/H1N1 Carrying A Short Immunogenic Peptide of MERS-CoV as Bivalent Vaccine in BALB/c Mice. Pathogens. 2019 Dec 2;8(4).. Abstract
submitted by kickingbird at Dec, 10, 2019 from Pathogens. 2019 Dec 2;8(4). (via https://www.mdpi.com/2076-0817/8/4/281)
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) became a global human health threat since its first documentation in humans in 2012. An efficient vaccine for the prophylaxis of humans in hotspots ...
Van Poelvoorde LAE, Saelens X, Thomas I, Roosen NH. Next-Generation Sequencing: An Eye-Opener for the Surveillance of Antiviral Resistance in Influenza. Trends Biotechnol. 2019 Dec. Abstract
submitted by kickingbird at Dec, 10, 2019 from Trends Biotechnol. 2019 Dec (via https://www.cell.com/trends/biotechnology/fulltext/S0167-779)
Next-generation sequencing (NGS) can enable a more effective response to a wide range of communicable disease threats, such as influenza, which is one of the leading causes of human morbidity and mortality ...
van de Sandt CE, et al. Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph. Nat Commun. 2019 Dec 6;10(1):557. Abstract
submitted by kickingbird at Dec, 10, 2019 from Nat Commun. 2019 Dec 6;10(1):557 (via https://www.nature.com/articles/s41467-019-13346-4)
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic ...
Xu C, Shu Y. The heterogeneity of influenza seasonality by subtype and lineage in China. J Infect. 2019 Nov 29.. Abstract
submitted by kickingbird at Dec, 8, 2019 from J Infect. 2019 Nov 29. (via https://www.journalofinfection.com/article/S0163-4453(19)303)
Recently, a notable pattern of synchrony of influenza A and B virus, and respiratory syncytial virus incidence peaks globally was reported in this journal. A previous study characterized seasonal pattern ...
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