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2020-3-31 18:46:10
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Xiong FF, et al. Protective efficacy of anti-neuraminidase monoclonal antibodies against H7N9 influenza virus infection. Emerg Microbes Infect. 2020 Dec;9(1):78-87.  Abstract  
submitted by kickingbird at Jan, 3, 2020 from Emerg Microbes Infect. 2020 Dec;9(1):78-87 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The H7N9 influenza virus has been circulating in China for more than six years. The neuraminidase (NA) has gained great concern for the development of antiviral drugs, therapeutic antibodies, and new vaccines. ...

Thomaston JL, et al. X-ray crystal structures of the influenza M2 proton channel drug-resistant V27A mutant bound to a spiro-adamantyl amine inhibitor reveal the mechanism of adamantane resistance. Biochemistry. 2020 Jan 2.  Abstract  
submitted by kickingbird at Jan, 3, 2020 from Biochemistry. 2020 Jan 2 (via https://pubs.acs.org/doi/10.1021/acs.biochem.9b00971)
The V27A mutation confers adamantane resistance to the influenza A matrix 2 (M2) proton channel and is becoming more prevalent in circulating populations of influenza A virus. We have used X-ray crystallography ...

Ou J, Huang M, Chen X, Wang Z, Lu G, Li S. The potential threat of avian influenza virus to horses - recalling the Chinese 1989~1990 equine influenza outbreaks. J Infect. 2019 Dec 28. pii: S0163-4453(19)30385-8.  Abstract  
submitted by kickingbird at Jan, 3, 2020 from J Infect. 2019 Dec 28. pii: S0163-4453(19)30385-8 (via https://www.journalofinfection.com/article/S0163-4453(19)303)
Recently, several studies in this journal have highlighted the threat of avian influenza virus (AIV) to humans, poultry, and other animals.1–6 In equines, there was only one reported influenza outbreak ...

Trombetta CM, et al. Influenza D Virus: Serological Evidence in the Italian Population from 2005 to 2017. Viruses. 2019 Dec 27;12(1)..  Abstract  
submitted by kickingbird at Jan, 3, 2020 from Viruses. 2019 Dec 27;12(1). (via https://www.mdpi.com/1999-4915/12/1/30)
Influenza D virus is a novel influenza virus, which was first isolated from an ailing swine in 2011 and later detected in cattle, suggesting that these animals may be a primary natural reservoir. To date, ...

Liu H, et al. An Internet-Based Survey of Influenza Vaccination Coverage in Healthcare Workers in China, 2018/2019 Season. Vaccines (Basel). 2019 Dec 26;8(1)..  Abstract  
submitted by kickingbird at Jan, 3, 2020 from Vaccines (Basel). 2019 Dec 26;8(1). (via https://www.mdpi.com/2076-393X/8/1/6)
Influenza vaccination coverage was low among healthcare workers (HCWs) in China. In October 2018, the National Health Commission of China began to require all hospitals to provide free influenza vaccination ...

Zhang X, Wang J, Zeng Q, Wu X, Jiang S, Shen J. Spontaneous pneumomediastinum and subcutaneous emphysema in avian influenza A (H5N6) human pneumonia. Clin Case Rep. 2019 Nov 11;7(12):2594-2595.  Abstract  
submitted by kickingbird at Jan, 3, 2020 from Clin Case Rep. 2019 Nov 11;7(12):2594-2595 (via https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.2519)
The pneumomediastinum and subcutaneous emphysema can repetitively occur in human H5N6 virus pneumonia. Prompt treatment of this uncommon complication is important for successful rescue of patients with ...

Yu Z, Gu Q, Zhang B, Chen X, Tang J, Hou Y, Yu W. Clinical Features of Fatal Pandemic Influenza A/H1N1 Infection Complicated by Invasive Pulmonary Fungal Infection. Mycopathologia. 2019 Dec 27..  Abstract  
submitted by kickingbird at Jan, 1, 2020 from Mycopathologia. 2019 Dec 27. (via https://link.springer.com/article/10.1007%2Fs11046-019-00421)
BACKGROUND: Severe pneumonia caused by influenza virus infection can be secondary to invasive pulmonary fungal (IPF) infection.OBJECTIVES: This study aimed to summarize the incidence of IPF infection secondary ...

Xiao G, Chen B, He M, Hu B. Dual-mode detection of avian influenza virions (H9N2) by ICP-MS and fluorescence after quantum dot labeling with immuno-rolling circle amplification. Anal Chim Acta. 2020 Feb 1;1096:18-25..  Abstract  
submitted by kickingbird at Jan, 1, 2020 from Anal Chim Acta. 2020 Feb 1;1096:18-25. (via https://www.sciencedirect.com/science/article/pii/S000326701)
Avian influenza virus (AIVs), hosted in poultry, are the pathogens of many poultry diseases and human infections, which bring huge losses to the poultry breeding industry and huge panic to society. Therefore, ...

Hill A, et al. Quantifying the spatial risk of Avian Influenza introduction into British poultry by wild birds. Sci Rep. 2019 Dec 27;9(1):19973..  Abstract  
submitted by kickingbird at Dec, 31, 2019 from Sci Rep. 2019 Dec 27;9(1):19973. (via http://www.nature.com/articles/s41598-019-56165-9)
The transmission of pathogens across the interface between wildlife and livestock presents a challenge to the development of effective surveillance and control measures. Wild birds, especially waterbirds ...

Gorin S, et al. Assessment of Influenza D Virus in Domestic Pigs and Wild Boars in France: Apparent Limited Spread within Swine Populations Despite Serological Evidence of Breeding Sow Exposure. Viruses. 2019 Dec 24;12(1).  Abstract  
submitted by kickingbird at Dec, 29, 2019 from Viruses. 2019 Dec 24;12(1) (via https://www.mdpi.com/1999-4915/12/1/25)
In order to assess influenza D virus (IDV) infections in swine in France, reference reagents were produced in specific pathogen free pigs to ensure serological and virological analyses. Hemagglutination ...

Chae W, et al. Hemagglutinin Quantitative ELISA-based Potency Assay for Trivalent Seasonal Influenza Vaccine Using Group-Specific Universal Monoclonal Antibodies. Sci Rep. 2019 Dec 23;9(1):19675..  Abstract  
submitted by kickingbird at Dec, 27, 2019 from Sci Rep. 2019 Dec 23;9(1):19675. (via https://www.nature.com/articles/s41598-019-56169-5)
The assurance of vaccine potency is important for the timely release and distribution of influenza vaccines. As an alternative to Single Radial Immunodiffusion (SRID), we report a new quantitative enzyme-linked ...

Ivan FX, Kwoh CK. Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice. BMC Genomics. 2019 Dec 24.  Abstract  
submitted by kickingbird at Dec, 27, 2019 from BMC Genomics. 2019 Dec 24 (via https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286)
BACKGROUND: Influenza A virus (IAV) poses threats to human health and life. Many individual studies have been carried out in mice to uncover the viral factors responsible for the virulence of IAV infections. ...

Lina L, et al. Adaptive amino acid substitutions enable transmission of an H9N2 avian influenza virus in guinea pigs. Sci Rep. 2019 Dec 24;9(1):19734.  Abstract  
submitted by kickingbird at Dec, 27, 2019 from Sci Rep. 2019 Dec 24;9(1):19734 (via https://www.nature.com/articles/s41598-019-56122-6)
H9N2 is the most prevalent low pathogenic avian influenza virus (LPAIV) in domestic poultry in the world. Two distinct H9N2 poultry lineages, G1-like (A/quail/Hong Kong/G1/97) and Y280-like (A/Duck/Hong ...

Galli C, et al. In-depth phylogenetic analysis of the hemagglutinin gene of influenza A(H3N2) viruses circulating during the 2016-2017 season revealed egg-adaptive mutations of vaccine strains. Expert Rev Vaccines. 2019 Dec 25..  Abstract  
submitted by kickingbird at Dec, 27, 2019 from Expert Rev Vaccines. 2019 Dec 25. (via https://www.tandfonline.com/doi/abs/10.1080/14760584.2020.17)
Objectives: The authors conducted an in-depth phylogenetic analysis of the hemagglutinin (HA) gene of A(H3N2) identified during the 2016-2017 season to compare the circulating strains with both the egg-derived ...

Zost SJ, et al. Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans. Cell Rep. 2019 Dec 24;29(13):4460-4470.e8..  Abstract  
submitted by kickingbird at Dec, 27, 2019 from Cell Rep. 2019 Dec 24;29(13):4460-4470.e8. (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)315)
Antibodies targeting the receptor binding site (RBS) of the influenza virus hemagglutinin (HA) protein are usually not broadly reactive because their footprints are typically large and extend to nearby ...

Lin X, Yu S, Ren P, Sun X, Jin M. Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4. Cell Microbiol. 2019 Dec 26:e13150..  Abstract  
submitted by kickingbird at Dec, 27, 2019 from Cell Microbiol. 2019 Dec 26:e13150. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13150)
Influenza A virus (IAV) has evolved multiple mechanisms to compromise type I interferon (IFN) responses. The antiviral function of IFN is mainly exerted by activating the JAK/STAT signalling and subsequently ...

Honce R, et al. Influenza in High-Risk Hosts-Lessons Learned from Animal Models. Cold Spring Harb Perspect Med. 2019 Dec 23..  Full Text  
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Factoring significantly into the global burden of influenza disease are high-risk populations that suffer the bulk of infections. Classically, the very young, very old, and pregnant women have been identified ...

Ciminski K, Schwemmle M. Bat-Borne Influenza A Viruses: An Awakening. Cold Spring Harb Perspect Med. 2019 Dec 23..  Full Text  
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Influenza A viruses (IAVs) originating from aquatic waterfowl recurrently cross interspecies barriers, which is greatly facilitated by utilizing cell surface-exposed monosaccharide sialic acids located ...

Fodor E, Te Velthuis AJW. Structure and Function of the Influenza Virus Transcription and Replication Machinery. Cold Spring Harb Perspect Med. 2019 Dec 23..  Full Text  
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Transcription and replication of the influenza virus RNA genome is catalyzed by the viral heterotrimeric RNA-dependent RNA polymerase in the context of viral ribonucleoprotein (vRNP) complexes. Atomic ...

Belser JA, Pulit-Penaloza JA, Maines TR. Ferreting Out Influenza Virus Pathogenicity and Transmissibility: Past and Future Risk Assessments in the Ferret Model. Cold Spring Harb Perspect Med. 2019 Dec 23..  Full Text  
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
As influenza A viruses continue to jump species barriers, data generated in the ferret model to assess influenza virus pathogenicity, transmissibility, and tropism of these novel strains continues to inform ...

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