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Braun KM, Haddock Iii LA, Crooks CM, Barry GL, Lal. Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals. Virus Evol. 2023 Jan 19;9(1):vead004.  Abstract  
submitted by kickingbird at Feb, 24, 2023 from Virus Evol. 2023 Jan 19;9(1):vead004 (via https://academic.oup.com/ve/article/9/1/vead004/6991850)
H7N9 avian influenza viruses (AIVs) have caused over 1,500 documented human infections since emerging in 2013. Although wild-type H7N9 AIVs can be transmitted by respiratory droplets in ferrets, they have ...

Nie J, Wang Q, Jin S, Yao X, Xu L, Chang Y, Ding F. Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus. Nano Res. 2023 Feb 16:1-10.  Abstract  
submitted by kickingbird at Feb, 24, 2023 from Nano Res. 2023 Feb 16:1-10 (via https://link.springer.com/article/10.1007/s12274-023-5395-6)
Current seasonal influenza vaccines confer only limited coverage of virus strains due to the frequent genetic and antigenic variability of influenza virus (IV). Epitope vaccines that accurately target ...

Aznar E, Casas I, González Praetorius A, Ruano Ram. Influenza A(H5N1) detection in two asymptomatic poultry farm workers in Spain, September to October 2022: suspected environmental contamination. Euro Surveill. 2023 Feb;28(8).  Abstract  
submitted by kickingbird at Feb, 24, 2023 from Euro Surveill. 2023 Feb;28(8) (via https://pubmed.ncbi.nlm.nih.gov/36820643/)
In autumn 2022, the Spanish Influenza National Reference Laboratory (NRL) confirmed the detection of influenza A(H5N1) in samples from two asymptomatic workers linked to an outbreak in a poultry farm in ...

Gu M, Jiao J, Liu S, Zhao W, Ge Z, Cai K, Xu L, He. Monoclonal antibody targeting a novel linear epitope on nucleoprotein confers pan-reactivity to influenza A virus. Appl Microbiol Biotechnol. 2023 Feb 23:1–14..  Abstract  
submitted by kickingbird at Feb, 24, 2023 from Appl Microbiol Biotechnol. 2023 Feb 23:1–14. (via https://link.springer.com/article/10.1007/s00253-023-12433-3)
Nucleoprotein (NP) functions crucially in the replicative cycle of influenza A virus (IAV) via forming the ribonucleoprotein complex together with PB2, PB1, and PA proteins. As its high conservation, NP ...

McLean HQ, Petrie JG, Hanson KE, Meece JK, Rolfes. Interim Estimates of 2022-23 Seasonal Influenza Vaccine Effectiveness - Wisconsin, October 2022-February 2023. MMWR Morb Mortal Wkly Rep. 2023 Feb 24;72(8):201-2.  Abstract  
submitted by kickingbird at Feb, 24, 2023 from MMWR Morb Mortal Wkly Rep. 2023 Feb 24;72(8):201-2 (via https://www.cdc.gov/mmwr/volumes/72/wr/mm7208a1.htm?s_cid=mm)
In the United States, 2022-23 influenza activity began earlier than usual, increasing in October 2022, and has been associated with high rates of hospitalizations among children*. Influenza A(H3N2) represented ...

Liu Y, Zeng Q, Hu X, Xu Z, Pan C, Liu Q, Yu J, Wu. Natural variant R246K in hemagglutinin increased zoonotic characteristics and renal inflammation in mice infected with H9N2 influenza virus. Vet Microbiol. 2023 Feb 3;279:109667.  Abstract  
submitted by kickingbird at Feb, 23, 2023 from Vet Microbiol. 2023 Feb 3;279:109667 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Considered a potential pandemic candidate, the widespread among poultry of H9N2 avian influenza viruses across Asia and North Africa pose an increasing threat to poultry and human health. The massive epidemic ...

Yin Y, Liu Y, Fen J, Liu K, Qin T, Chen S, Peng D,. Characterization of an H7N9 Influenza Virus Isolated from Camels in Inner Mongolia, China. Microbiol Spectr. 2023 Feb 21:e0179822.  Abstract  
submitted by kickingbird at Feb, 23, 2023 from Microbiol Spectr. 2023 Feb 21:e0179822 (via https://journals.asm.org/doi/10.1128/spectrum.01798-22)
The H7N9 subtype of influenza virus can infect birds and humans, causing great losses in the poultry industry and threatening public health worldwide. However, H7N9 infection in other mammals has not been ...

Wang T, Zhang J, Wang Y, Li Y, Wang L, Yu Y, Yao Y. Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs. Nat Immunol. 2023 Feb 20.  Abstract  
submitted by kickingbird at Feb, 23, 2023 from Nat Immunol. 2023 Feb 20 (via https://www.nature.com/articles/s41590-023-01428-x)
Respiratory viral infections reprogram pulmonary macrophages with altered anti-infectious functions. However, the potential function of virus-trained macrophages in antitumor immunity in the lung, a preferential ...

Nemoto M, Reedy SE, Yano T, Suzuki K, Fukuda S, Ga. Antigenic comparison of H3N8 equine influenza viruses belonging to Florida sublineage clade 1 between vaccine strains and North American strains isolated in 2021-2022. Arch Virol. 2023 Feb 19;168(3):94.  Abstract  
submitted by kickingbird at Feb, 23, 2023 from Arch Virol. 2023 Feb 19;168(3):94 (via https://pubmed.ncbi.nlm.nih.gov/36806782/)
Equine influenza virus strains of Florida sublineage clade 1 (Fc1) have been circulating in North America. In this study, virus neutralization assays were performed to evaluate antigenic differences between ...

Zhang Y, Zhu T, Xu S, Gu P, Cai G, Peng S, Liu Z,. Cationic Nanoparticle-Stabilized Vaccine Delivery System for the H9N2 Vaccine to Promote Immune Response in Chickens. Mol Pharm. 2023 Feb 16.  Abstract  
submitted by kickingbird at Feb, 19, 2023 from Mol Pharm. 2023 Feb 16 (via https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.2c00805)
Chinese yam polysaccharides (CYPs) have received wide attention for their immunomodulatory activity. Our previous studies had discovered that the Chinese yam polysaccharide PLGA-stabilized Pickering emulsion ...

Vatzia E, Feest K, McNee A, Manjegowda T, Carr BV,. Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs. NPJ Vaccines. 2023 Feb 15;8(1):19.  Abstract  
submitted by kickingbird at Feb, 17, 2023 from NPJ Vaccines. 2023 Feb 15;8(1):19 (via https://pubmed.ncbi.nlm.nih.gov/36792640/)
There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization of the human population. We investigated the efficacy of heterologous prime ...

Chien YA, Alford BK, Wasik BR, Weichert WS, Parris. Single Particle Analysis of H3N2 Influenza Entry Differentiates the Impact of the Sialic Acids (Neu5Ac and Neu5Gc) on Virus Binding and Membrane Fusion. J Virol. 2023 Feb 13:e0146322.  Abstract  
submitted by kickingbird at Feb, 17, 2023 from J Virol. 2023 Feb 13:e0146322 (via https://journals.asm.org/doi/10.1128/jvi.01463-22)
Entry of influenza A viruses (IAVs) into host cells is initiated by binding to sialic acids (Sias), their primary host cell receptor, followed by endocytosis and membrane fusion to release the viral genome ...

Yang L, Li G, Yang J, Zhang T, Du J, Liu T, Zhang. Deep-Learning Model for Influenza Prediction From Multisource Heterogeneous Data in a Megacity: Model Development and Evaluation. J Med Internet Res. 2023 Feb 13;25:e44238.  Abstract  
submitted by kickingbird at Feb, 17, 2023 from J Med Internet Res. 2023 Feb 13;25:e44238 (via https://www.jmir.org/2023/1/e44238)
Background: In megacities, there is an urgent need to establish more sensitive forecasting and early warning methods for acute respiratory infectious diseases. Existing prediction and early warning models ...

He D, Gu M, Wang X, Yan Y, Li Y, Wang X, Hu S, Liu. Reintroduction of highly pathogenic avian influenza A H7N9 virus in southwestern China. Virus Genes. 2023 Feb 13:1–5.  Abstract  
submitted by kickingbird at Feb, 17, 2023 from Virus Genes. 2023 Feb 13:1–5 (via https://link.springer.com/article/10.1007/s11262-023-01974-4)
Highly pathogenic (HP) avian influenza A H7N9 virus has emerged in China since 2016. In recent years, it has been most prevalent in northern China. However, several strains of HP H7N9 reappeared in southwestern ...

Wang S, Zhuang Q, Jiang N, Zhang F, Chen Q, Zhao R. Reverse transcription recombinase-aided amplification assay for avian influenza virus. Virus Genes. 2023 Feb 13.  Abstract  
submitted by kickingbird at Feb, 17, 2023 from Virus Genes. 2023 Feb 13 (via https://link.springer.com/article/10.1007/s11262-023-01979-z)
Avian influenza virus (AIV) infection can lead to severe economic losses in the poultry industry and causes a serious risk for humans. A rapid and simple test for suspected viral infection cases is crucial. ...

Günl F, Krischuns T, Schreiber JA, Henschel L, Wah. The ubiquitination landscape of the influenza A virus polymerase. Nat Commun. 2023 Feb 11;14(1):787.  Abstract  
submitted by kickingbird at Feb, 13, 2023 from Nat Commun. 2023 Feb 11;14(1):787 (via https://www.nature.com/articles/s41467-023-36389-0)
During influenza A virus (IAV) infections, viral proteins are targeted by cellular E3 ligases for modification with ubiquitin. Here, we decipher and functionally explore the ubiquitination landscape of ...

Chen C, Jiang D, Yan D, Pi L, Zhang X, Du Y, Liu X. The global region-specific epidemiologic characteristics of influenza: WHO FluNet data from 1996 to 2021. Int J Infect Dis. 2023 Feb 9:S1201-9712(23)00052-8.  Abstract  
submitted by kickingbird at Feb, 13, 2023 from Int J Infect Dis. 2023 Feb 9:S1201-9712(23)00052-8 (via https://www.ijidonline.com/article/S1201-9712(23)00052-8/ful)
Background: This study aimed to investigate region-specific epidemiologic characteristics of influenza and influenza transmission zones (ITZs).Methods: Weekly influenza surveillance data of 156 countries ...

Aslam S, Rajendran M, Kriti D, Kurland A, Johnson. Generation of a high yield vaccine backbone for influenza B virus in embryonated chicken eggs. NPJ Vaccines. 2023 Feb 10;8(1):12.  Abstract  
submitted by kickingbird at Feb, 12, 2023 from NPJ Vaccines. 2023 Feb 10;8(1):12 (via https://www.nature.com/articles/s41541-023-00603-3)
Influenza B virus (IBV) strains are one of the components of seasonal influenza vaccines in both trivalent and quadrivalent formulations. The vast majority of these vaccines are produced in embryonated ...

Heinemann AS, Stalp JL, Bonifacio JPP, Silva F, Wi. Silent neonatal influenza A virus infection primes systemic antimicrobial immunity. Front Immunol. 2023 Jan 24;14:1072142.  Abstract  
submitted by kickingbird at Feb, 11, 2023 from Front Immunol. 2023 Jan 24;14:1072142 (via https://www.frontiersin.org/articles/10.3389/fimmu.2023.1072)
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majority of these infections remain asymptomatic, especially among children below five years of age. Importantly, ...

Vo V, Harrington A, Chang CL, Baker H, Moshi M, Gh. Identification and genome sequencing of an influenza H3N2 variant in wastewater from elementary schools during a surge of influenza A cases in Las Vegas, Nevada. Nevada. Sci Total Environ. 2023 Feb 7:162058.  Abstract  
submitted by kickingbird at Feb, 11, 2023 from Nevada. Sci Total Environ. 2023 Feb 7:162058 (via https://www.sciencedirect.com/science/article/pii/S004896972)
Real-time surveillance of infectious diseases at schools or in communities is often hampered by delays in reporting due to resource limitations and infrastructure issues. By incorporating quantitative ...

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