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2025-4-1 2:24:06
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Ospina-Jimenez AF, Gomez AP, Rincon-Monroy MA, Per. A novel reassorted swine H3N2 influenza virus demonstrates an undetected human-to-swine spillover in Latin America and highlights zoonotic risks. Virology. 2025 Mar 5;606:110483.  Abstract  
submitted by kickingbird at Mar, 13, 2025 from Virology. 2025 Mar 5;606:110483 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A virus (FLUAV) affects a wide range of hosts, including humans and animals, posing a threat to public health. In swine, H3N2 subtype is associated with human-to-swine spillovers of seasonal ...

Pawar SD, Keng SS, Tare DS, Balakrishnan A, S S, K. Evidence of novel reassortment in clade 2.3.4.4b avian influenza H5N1 viruses, India, 2024. Virology. 2025 Mar 5;606:110482.  Abstract  
submitted by kickingbird at Mar, 13, 2025 from Virology. 2025 Mar 5;606:110482 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
H5N1 viruses belonging to clade 2.3.4.4b have caused unprecedented outbreaks globally. Outbreaks of H5N1 virus were reported in poultry and wild birds from Kerala (India) in the year 2024. Samples from ...

Caroline Kikawa, etc.,al. [preprint]High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains. https://doi.org/10.1101/2025.03.04.641544.  Abstract  
submitted by kickingbird at Mar, 13, 2025 from https://doi.org/10.1101/2025.03.04.641544 (via https://www.biorxiv.org/content/10.1101/2025.03.04.641544v1)
Human influenza viruses rapidly acquire mutations in their hemagglutinin (HA) protein that erode neutralization by antibodies from prior exposures. Here, we use a sequencing-based assay to measure neutralization ...

Paravinja N, Herrmann L, Dzijan I, Rinder M, Neuba. Highly Pathogenic Avian Influenza Virus in Mammals: Lack of Detection in Cattle With Respiratory Tract Infections and Genetic Analysis of Sporadic Spillover Infections in Wild Mammals in Bavaria, Sout. Zoonoses Public Health. 2025 Mar 11.  Abstract  
submitted by kickingbird at Mar, 13, 2025 from Zoonoses Public Health. 2025 Mar 11 (via https://onlinelibrary.wiley.com/doi/10.1111/zph.13217)
Background: In 2021, the H5N1 clade 2.3.4.4b Avian Influenza Viruses (AIVs) emerged on the American continent. At the same time, a further global spread took place. Infections have been reported in avian ...

Zhang C, Zhao C, Huang J, Wang Y, Jiang B, Zheng H. Emergence of a novel reassortant H3N3 avian influenza virus with enhanced pathogenicity and transmissibility in chickens in China. Vet Res. 2025 Mar 11;56(1):56.  Abstract  
submitted by kickingbird at Mar, 13, 2025 from Vet Res. 2025 Mar 11;56(1):56 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
H3N3 avian influenza viruses (AIVs) are less prevalent in poultry than H3N8 viruses. However, although relatively rare, reassortant H3N3 viruses have been known to appear in both domestic poultry and wild ...

Perlas A, Reska T, Croville G, Tarrés-Freixas F, G. Improvements in RNA and DNA nanopore sequencing allow for rapid genetic characterization of avian influenza. Virus Evol. 2025 Feb 18;11(1):veaf010.  Abstract  
submitted by kickingbird at Mar, 13, 2025 from Virus Evol. 2025 Feb 18;11(1):veaf010 (via https://academic.oup.com/ve/article/11/1/veaf010/8020575)
Avian influenza virus (AIV) currently causes a panzootic with extensive mortality in wild birds, poultry, and wild mammals, thus posing a major threat to global health and underscoring the need for efficient ...

Kaiser F, Cardenas S, Yinda KC, Mukesh RK, Ochwoto. Highly Pathogenic Avian Influenza A(H5N1) Virus Stability in Irradiated Raw Milk and Wastewater and on Surfaces, United States. Emerg Infect Dis. 2025 Apr.  Abstract  
submitted by kickingbird at Mar, 13, 2025 from Emerg Infect Dis. 2025 Apr (via https://wwwnc.cdc.gov/eid/article/31/4/24-1615_article)
We measured stability of infectious influenza A(H5N1) virus in irradiated raw milk and wastewater and on surfaces. We found a relatively slow decay in milk, indicating that contaminated milk and fomites ...

Han SM, Shiino T, Masuda S, Furuse Y, Yasaka T, Ka. Phylogenetic Study of Local Patterns Influenza A(H3N2) Virus Transmission in a Semi-Isolated Population in a Remote Island in Japan Between 2011 and 2013. Influenza Other Respir Viruses. 2025 Mar;19(3):e70.  Abstract  
submitted by kickingbird at Mar, 12, 2025 from Influenza Other Respir Viruses. 2025 Mar;19(3):e70 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70089)
Background: Influenza A outbreak risk is impacted by the potential for importation and local transmission. Reconstructing transmission history with phylogenetic analysis of genetic sequences can help assess ...

Sophie George, Pia Ryt-Hansen, Anders Gorm Pederse. Evolutionary dynamics and molecular epidemiology of H1N1 pandemic 2009 influenza A viruses across swine farms in Denmark. Virus Evolution, 2025;, veaf014.  Abstract  
submitted by kickingbird at Mar, 11, 2025 from Virus Evolution, 2025;, veaf014 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
Transmission of influenza A viruses (IAVs) between pigs and humans can trigger pandemics but more often cease as isolated infections without further spread in the new host species population. In Denmark, ...

WPRO. WHO: Avian Influenza Weekly Update # 988: 7 March 2025. WHO/WPRO.  Abstract  
submitted by kickingbird at Mar, 10, 2025 from WHO/WPRO (via https://cdn.who.int/media/docs/default-source/wpro---documen)
Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. ...

Wang J, Zhang Y, Sun L, Wang Z, Hao C, Wang W. Eukaryotic RNA Binding Protein hnRNPH1 Suppresses Influenza A Virus Replication through Interaction with Virus NS1 Protein. Emerg Microbes Infect. 2025 Mar 7:2477645.  Abstract  
submitted by kickingbird at Mar, 10, 2025 from Emerg Microbes Infect. 2025 Mar 7:2477645 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The NS1 protein of influenza A virus (IAV) is a multi-functional protein which can antagonize host immune system and facilitate viral replication by interacting with host factors. However, the novel partners ...

Li, X., Li, L., Tian, J., Su, R., Sun, J., Li, Y.,. SREBP2-dependent lipid droplet formation enhances viral replication and deteriorates lung injury in mice following IAV infection. Emerging Microbes & Infections, 14(1).  Abstract  
submitted by kickingbird at Mar, 10, 2025 from Emerging Microbes & Infections, 14(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Influenza A virus (IAV) is a significant zoonotic pathogen that poses a considerable challenge to public health due to its continuous mutations. Lipid droplets (LDs) have been shown to play an important ...

Coffey, P., & Verspoor, R. S. Case study of the impact of an outbreak of high pathogenicity avian influenza (HPAI) on a seabird colony in Flintshire, Wales, United Kingdom. Bird Study, 1–9.  Abstract  
submitted by kickingbird at Mar, 10, 2025 from Bird Study, 1–9 (via https://www.tandfonline.com/doi/full/10.1080/00063657.2025.2)
CapsuleAdult Black-headed Gulls Chroicocephalus ridibundus brought the HPAI infection to a mixed gull and tern breeding colony, but were less severely affected than adult Common Terns Sterna hirundo.AimsTo ...

Pacini, M. I., Ceccherelli, R., Terregino, C., Bor. The highly pathogenic avian influenza epidemic 2021–2022 from the point of view of an Italian network of Wildlife Rescue Centres. Bird Study, 1–12.  Abstract  
submitted by kickingbird at Mar, 10, 2025 from Bird Study, 1–12 (via https://www.tandfonline.com/doi/full/10.1080/00063657.2025.2)
CapsuleLipu Birdlife Italia is a large environmental association that manages nine Wildlife Rescue Centres (WRCs) throughout Italy, where testing of large numbers of animals/birds of different species ...

Nicholas J. Chaplinski, etc.,al. A Case Study of Biosafety Considerations and Solutions for Work with Highly Pathogenic Avian Influenza Virus with Large-Scale Equipment in High Biocontainment. Applied Biosafety, Published Online: 3 March 2025.  Abstract  
submitted by kickingbird at Mar, 9, 2025 from Applied Biosafety, Published Online: 3 March 2025 (via https://www.liebertpub.com/doi/10.1089/apb.2024.0061)
Introduction: Highly pathogenic avian influenza virus (HPAIV), a potential pandemic pathogen (PPP), was discovered in a new species, cattle, in March 2024 in the United States. Soon thereafter it was discovered ...

Pascua PNQ, Chesnokov A, Nguyen HT, Di H, Cruz JDL. Antiviral Susceptibility of Influenza A(H5N1) Clade 2.3.2.1c and 2.3.4.4b Viruses from Humans, 2023~2024. Emerg Infect Dis. 2025 Apr.  Abstract  
submitted by kickingbird at Mar, 9, 2025 from Emerg Infect Dis. 2025 Apr (via https://wwwnc.cdc.gov/eid/article/31/4/24-1820_article)
During 2023~2024, highly pathogenic avian influenza A(H5N1) viruses from clade 2.3.2.1c caused human infections in Cambodia and from clade 2.3.4.4b caused human infections in the Americas. We assessed ...

Levine MZ, Liu F, Bagdasarian N, Haliday C, Jeffer. Neutralizing Antibody Response to Influenza A(H5N1) Virus in Dairy Farm Workers, Michigan, USA. Emerg Infect Dis. 2025 Apr.  Abstract  
submitted by kickingbird at Mar, 9, 2025 from Emerg Infect Dis. 2025 Apr (via https://wwwnc.cdc.gov/eid/article/31/4/25-0007_article)
Since March 2024, highly pathogenic avian influenza A(H5N1) viruses have caused outbreaks in dairy cattle and poultry in the United States, and they continue to spill over into humans. However, data on ...

Ebell MH, Rahmatullah I, Hulme C, Buhr M, Kotnik J. Accuracy of individual signs and symptoms and case definitions for the diagnosis of influenza in different age groups: a systematic review with meta-analysis. BMJ Open. 2025 Mar 3;15(3):e067574.  Abstract  
submitted by kickingbird at Mar, 8, 2025 from BMJ Open. 2025 Mar 3;15(3):e067574 (via https://pmc.ncbi.nlm.nih.gov/articles/PMC11877276/)
Objective: The objective of this study is to perform a comprehensive systematic review and meta-analysis of the accuracy of signs, symptoms and case definitions for the diagnosis of influenza.Design: Systematic ...

Xiao N, Oong XY, Chen Y, Li C, Chung HC, Wang P, Y. Reverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice. Emerg Microbes Infect. 2025 Mar 4:2475836.  Abstract  
submitted by kickingbird at Mar, 8, 2025 from Emerg Microbes Infect. 2025 Mar 4:2475836 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The newly emerged avian influenza A H5N1 Clade 2.3.4.4b can infect dairy cows and shed live virus in their milk. Sporadic cattle-to-human infections have been reported, highlighting the urgent need to ...

Branda F, Mohapatra RK, Tuglo LS, Ciccozzi M, Scar. Real-time epidemiological surveillance data: tracking the occurrences of avian influenza outbreaks around the world. BMC Res Notes. 2025 Mar 4;18(1):95.  Abstract  
submitted by kickingbird at Mar, 8, 2025 from BMC Res Notes. 2025 Mar 4;18(1):95 (via https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310)
Objectives: This study aims to provide real-time surveillance of epidemiological outbreaks of avian influenza in humans and mammals. The primary objective is to understand and track the dynamics of outbreaks ...

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