Westera L, et al. Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. Adv Virol. 2019 Mar 19;2019:8512363.. Abstract
submitted by kickingbird at Apr, 25, 2019 from Adv Virol. 2019 Mar 19;2019:8512363. (via https://www.hindawi.com/journals/av/2019/8512363/)
Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans. To ...
Salata C, et al. Antiviral treatment and virological monitoring of oseltamivir-resistant influenza virus A(H1N1)pdm09 in a patient with chronic B lymphocytic leukemia. J Infect Chemother. 2019 Apr 20.. Abstract
submitted by kickingbird at Apr, 25, 2019 from J Infect Chemother. 2019 Apr 20. (via https://www.jiac-j.com/article/S1341-321X(18)30460-4/fulltex)
We report the virological monitoring and the antiviral therapy adopted for the treatment of a patient affected by chronic B lymphocytic leukemia, who experienced a severe pneumonia with long-term shedding ...
Alfardan R, Guo C, Toth LA, Nie D. Impaired Recovery from Influenza A/X-31(H3N2) Infection in Mice with 8-Lipoxygenase Deficiency. Med Sci (Basel). 2019 Apr 12;7(4).. Abstract
submitted by kickingbird at Apr, 25, 2019 from Med Sci (Basel). 2019 Apr 12;7(4). (via https://www.mdpi.com/2076-3271/7/4/60)
Lipoxygenase-derived lipid mediators can modulate inflammation and are stimulated in response to influenza infections. We report an effect of 8-lipoxygenase (ALOX8) on the recovery of mice after infection ...
Weigel T, Soliman R, Wolff MW, Reichl U. Hydrophobic-interaction chromatography for purification of influenza A and B virus. J Chromatogr B Analyt Technol Biomed Life Sci. 201. Abstract
submitted by kickingbird at Apr, 24, 2019 from J Chromatogr B Analyt Technol Biomed Life Sci. 201 (via https://www.sciencedirect.com/science/article/pii/S157002321)
Options for hydrophobic-interaction chromatography (HIC) for purification of cell culture-derived influenza A and B virus have been assessed using a 96-well plate format using a semi-high-throughput approach. ...
Zhang Y, et al. MORC3 Is a Target of the Influenza A Viral Protein NS1. Structure. 2019 Mar 29. pii: S0969-2126(19)30093-0. Abstract
submitted by kickingbird at Apr, 24, 2019 from Structure. 2019 Mar 29. pii: S0969-2126(19)30093-0 (via https://www.cell.com/structure/fulltext/S0969-2126(19)30093-)
Microrchidia 3 (MORC3), a human ATPase linked to several autoimmune disorders, has been characterized both as a negative and positive regulator of influenza A virus. Here, we report that the CW domain ...
Zhang CQ, et al. Health Beliefs of Wearing Facemasks for Influenza A/H1N1 Prevention: A Qualitative Investigation of Hong Kong Older Adults. Asia Pac J Public Health. 2019 Apr 21:101053951984. Abstract
submitted by kickingbird at Apr, 24, 2019 from Asia Pac J Public Health. 2019 Apr 21:101053951984 (via https://journals.sagepub.com/doi/10.1177/1010539519844082)
Although vaccination is the first-line strategy controlling and preventing influenza A/H1N1 for older adults, personal protective measures, such as wearing facemasks, are also important preventive behaviors ...
Henry B. Canadian Pandemic Influenza Preparedness: Communications strategy. Can Commun Dis Rep. 2018 May 3;44(5):106-109. Abstract
submitted by kickingbird at Apr, 24, 2019 from Can Commun Dis Rep. 2018 May 3;44(5):106-109 (via https://www.ncbi.nlm.nih.gov/pubmed/31007620)
When faced with uncertainty and unpredictability, early and transparent communication during a pandemic is critical to build trust and to ensure the credibility of public health advice. The responsibility ...
Han L, et al. Structural Insights for Anti-Influenza Vaccine Design. Comput Struct Biotechnol J. 2019 Mar 23;17:475-483. Abstract
submitted by kickingbird at Apr, 24, 2019 from Comput Struct Biotechnol J. 2019 Mar 23;17:475-483 (via https://www.sciencedirect.com/science/article/pii/S200103701)
Influenza A virus are a persistent and significant threat to human health, and current vaccines do not provide sufficient protection due to antigenic drift, which allows influenza viruses to easily escape ...
Ranaweera A, Ratnayake PU, Ekanayaka EAP, et al. Hydrogen-deuterium exchange supports independent membrane-interfacial fusion peptide and transmembrane domains in subunit 2 of influenza virus hemagglutinin protein, a structured and aqueous-protected. Biochemistry. 2019 Apr 22. Abstract
submitted by kickingbird at Apr, 24, 2019 from Biochemistry. 2019 Apr 22 (via https://pubs.acs.org.ccindex.cn/doi/10.1021/acs.biochem.8b01)
The influenza virus hemagglutinin (HA) protein has HA1 and HA2 subunits, which form an initial complex. HA1's bind host cell sialic acids which triggers endocytosis, HA1/HA2 separation, and HA2-mediated ...
Klingen TR, et al. Structures and functions linked to genome-wide adaptation of human influenza A virus. Sci Rep. 2019 Apr 18;9(1):6267. Abstract
submitted by kickingbird at Apr, 21, 2019 from Sci Rep. 2019 Apr 18;9(1):6267 (via https://www.nature.com/articles/s41598-019-42614-y)
Human influenza A viruses elicit short-term respiratory infections with considerable mortality and morbidity. While H3N2 viruses circulate for more than 50 years, the recent introduction of pH1N1 viruses ...
Chan LLY, et al. Risk assessment of the tropism & pathogenesis of the highly pathogenic avian influenza A/H7N9 virus using ex vivo & in vitro cultures of human respiratory tract. J Infect Dis. 2019 Apr 18. pii: jiz165. Abstract
submitted by kickingbird at Apr, 21, 2019 from J Infect Dis. 2019 Apr 18. pii: jiz165 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Highly pathogenic avian influenza (HPAI)-H7N9 virus arising from low pathogenic avian influenza (LPAI)-H7N9 virus with polybasic amino acid substitutions in the haemagglutinin was detected in 2017. We ...
Shan X, Lai S, Liao H, Li Z, Lan Y, Yang W. The epidemic potential of avian influenza A (H7N9) virus in humans in mainland China: A two-stage risk analysis. PLoS One. 2019 Apr 19;14(4):e0215857. Abstract
submitted by kickingbird at Apr, 21, 2019 from PLoS One. 2019 Apr 19;14(4):e0215857 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
BACKGROUND: From 2013 to 2017, more than one thousand avian influenza A (H7N9) confirmed cases with hundreds of deaths were reported in mainland China. To identify priorities for epidemic prevention and ...
Di H, et al. Comparison of nucleic acid extraction methods for next-generation sequencing of avian influenza A virus from ferret respiratory samples. J Virol Methods. 2019 Apr 17. Abstract
submitted by kickingbird at Apr, 21, 2019 from J Virol Methods. 2019 Apr 17 (via https://www.sciencedirect.com/science/article/pii/S016609341)
Influenza A virus is a negative-sense RNA virus with a segmented genome consisting of eight RNA segments. Avian influenza A virus (AIV) primarily infects avian hosts and sporadically infects mammals, which ...
Matsuda K, et al. Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine. Sci Immunol. 2019 Apr 19;4(34).. Abstract
submitted by kickingbird at Apr, 21, 2019 from Sci Immunol. 2019 Apr 19;4(34). (via https://immunology.sciencemag.org/content/4/34/eaau2710)
Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and influenza. Here, we report the dynamics of ...
Ma J, et al. Virus survival and fitness when multiple genotypes and subtypes of influenza A viruses exist and circulate in swine. Virology. 2019 Apr 9;532:30-38. Abstract
submitted by kickingbird at Apr, 21, 2019 from Virology. 2019 Apr 9;532:30-38 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
We performed swine influenza virus (SIV) surveillance in Midwest USA and isolated 100 SIVs including endemic and reassortant H1 and H3 viruses with 2009 pandemic H1N1 genes. To determine virus evolution ...
Koshimichi H, Ishibashi T, Wajima T. Population Pharmacokinetics of Baloxavir Marboxil in Japanese Pediatric Influenza Patients. J Pharm Sci. 2019 Apr 15.. Abstract
submitted by kickingbird at Apr, 19, 2019 from J Pharm Sci. 2019 Apr 15. (via https://jpharmsci.org/article/S0022-3549(19)30236-9/pdf)
Baloxavir marboxil is a prodrug of baloxavir acid, an inhibitor of cap-dependent endonuclease, and suppresses the replication of influenza virus. The aim of this study is to investigate its pharmacokinetic ...
Yamagata Y, et al. Generation of a purely clonal defective interfering influenza virus. Microbiol Immunol. 2019 Apr 18.. Abstract
submitted by kickingbird at Apr, 19, 2019 from Microbiol Immunol. 2019 Apr 18. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/1348-0421.12)
A defective interfering (DI) influenza virus carries a large deletion in a viral gene segment and shows potential for antiviral therapy by interfering with the replication of infectious virus. However, ...
Albaker A, Soder C, Top KA. Acute encephalopathy associated with influenza infection: Case report and review of the literature. Paediatr Child Health. 2019 May;24(2):122-124. Abstract
submitted by kickingbird at Apr, 19, 2019 from Paediatr Child Health. 2019 May;24(2):122-124 (via https://academic.oup.com/pch/article-abstract/24/2/122/50466)
Influenza has been associated with neurological complications. We describe the case of a toddler who presented with symptoms and signs of acute encephalopathy and hydrocephalus. Neuroimaging demonstrated ...
Guan M, et al. Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets. J Virol. 2019 Apr 17. pii: JVI.00282-19.. Abstract
submitted by kickingbird at Apr, 19, 2019 from J Virol. 2019 Apr 17. pii: JVI.00282-19. (via https://jvi.asm.org/content/early/2019/04/12/JVI.00282-19)
Subtype H10 influenza A viruses (IAVs) have been recovered from domestic poultry and various aquatic bird species, and sporadic transmission of these IAVs from avian species to mammals (i.e., human, seal, ...
Gaucherand L, et al. The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression. Cell Rep. 2019 Apr 16;27(3):776-792.e7. Abstract
submitted by kickingbird at Apr, 19, 2019 from Cell Rep. 2019 Apr 16;27(3):776-792.e7 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)303)
Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and host proteins required for viral replication are typically spared in this process, but the mechanisms of target ...
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