Li J, Chen Y, Wang X, Yu H. Influenza-associated disease burden in mainland China: a systematic review and meta-analysis. Sci Rep. 2021 Feb 3;11(1):2886. Abstract
submitted by kickingbird at Feb, 5, 2021 from Sci Rep. 2021 Feb 3;11(1):2886 (via https://www.nature.com/articles/s41598-021-82161-z)
Influenza causes substantial morbidity and mortality. Many original studies have been carried out to estimate disease burden of influenza in mainland China, while the full disease burden has not yet been ...
Mezhenskaya D, Isakova-Sivak I, Kotomina T, Matyus. A Strategy to Elicit M2e-Specific Antibodies Using a Recombinant H7N9 Live Attenuated Influenza Vaccine Expressing Multiple M2e Tandem Repeats. Biomedicines. 2021 Feb 1;9(2):133. Abstract
submitted by kickingbird at Feb, 5, 2021 from Biomedicines. 2021 Feb 1;9(2):133 (via https://www.mdpi.com/2227-9059/9/2/133)
Influenza viruses remain a serious public health problem. Vaccination is the most effective way to prevent the disease; however, seasonal influenza vaccines demonstrate low or no effectiveness against ...
Youk S, Cho AY, Lee DH, Jeong S, Kim Y, Lee S, Kim. Detection of newly introduced Y280-lineage H9N2 avian influenza viruses in live bird markets in Korea. Transbound Emerg Dis . 2021 Feb 1. Abstract
submitted by kickingbird at Feb, 2, 2021 from Transbound Emerg Dis . 2021 Feb 1 (via https://pubmed.ncbi.nlm.nih.gov/33523603/)
We report the first detection of Y280-lineage H9N2 avian influenza viruses in live bird markets in Korea during July 2020. The viruses were isolated from domestic ducks and chickens traded in three markets ...
Liu Y, Fu C, Ye S, Liang Y, Qi Z, Yao C, Wang Z, W. The inactivated vaccine of reassortant H3N2 canine influenza virus based on internal gene cassette from PR8 is safe and effective. Vet Microbiol. 2021 Jan 27;254:108997. Abstract
submitted by kickingbird at Feb, 2, 2021 from Vet Microbiol. 2021 Jan 27;254:108997 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Canine influenza (CI) is a contagious respiratory disease in dogs, which poses a threat to canine health. A safe, high-yield vaccine seed virus is critical for CI vaccine development. We developed a PR8-based ...
Sharma S, Kumari V, Kumbhar BV, Mukherjee A, Pande. Immunoinformatics approach for a novel multi-epitope subunit vaccine design against various subtypes of Influenza A virus. Immunobiology. 2021 Jan 21;226(2):152053. Abstract
submitted by kickingbird at Feb, 1, 2021 from Immunobiology. 2021 Jan 21;226(2):152053 (via https://www.sciencedirect.com/science/article/abs/pii/S01712)
Vaccination is the best strategy for the control and prevention of contagious diseases caused by Influenza A viruses. Extraordinary genetic variability and continual evolvability are responsible for the ...
Mohd-Kipli F, Claridge JK, Habjani? J, Jiang A, Sc. Conformational triggers associated with influenza matrix protein 1 polymerization. J Biol Chem. 2021 Jan 28:100316. Abstract
submitted by kickingbird at Feb, 1, 2021 from J Biol Chem. 2021 Jan 28:100316 (via https://www.jbc.org/article/S0021-9258(21)00086-7/fulltext)
A central role for the influenza matrix protein 1 (M1) is to form a polymeric coat on the inner leaflet of the host membrane that ultimately provides shape and stability to the virion. M1 polymerizes upon ...
Shi N, Zhang S, Guo Y, Yu X, Zhao W, Zhang M, Guan. CircRNA_0050463 promotes influenza A virus replication by sponging miR-33b-5p to regulate EEF1A1. Vet Microbiol. 2021 Jan 19;254:108995. Abstract
submitted by kickingbird at Feb, 1, 2021 from Vet Microbiol. 2021 Jan 19;254:108995 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Circular RNAs (circRNAs), a new class of widely expressed endogenous regulatory RNAs, are characterized by a covalently closed loop structure without a 5' cap or 3' tail. Increasing numbers of studies ...
Tang W, Li X, Tang L, Wang T, He G. Characterization of the low-pathogenic H7N7 avian influenza virus in Shanghai, China. Poult Sci. 2021 Feb;100(2):565-574. Abstract
submitted by kickingbird at Feb, 1, 2021 from Poult Sci. 2021 Feb;100(2):565-574 (via https://www.sciencedirect.com/science/article/pii/S003257912)
H7N7 avian influenza virus (AIV) can divided into low-pathogenic AIV and high-pathogenic AIV groups. It has been shown to infect humans and animals. Its prevalence state in wild birds in China remains ...
Wang G, Liu D, Hu J, Gu M, Wang X, He D, Zhang L,. Mutations during the adaptation of H7N9 avian influenza virus to mice lungs enhance human-like sialic acid binding activity and virulence in mice. Vet Microbiol. 2021 Jan 20;254:109000. Abstract
submitted by kickingbird at Feb, 1, 2021 from Vet Microbiol. 2021 Jan 20;254:109000 (via https://www.sciencedirect.com/science/article/pii/S037811352)
The first avian H7N9 influenza outbreak in spring of 2013 emerged in an unprecedented transmission from infected poultry to humans in the Yangtze delta area, eastern China, posing a dual challenge to public ...
Kang M, Tan X, Ye M, Liao Y, Song T, Tang S. Moving Epidemic Method applied on influenza surveillance in Guangdong, China. Int J Infect Dis. 2021 Jan 27:S1201-9712(21)00069-. Abstract
submitted by kickingbird at Feb, 1, 2021 from Int J Infect Dis. 2021 Jan 27:S1201-9712(21)00069- (via https://www.ijidonline.com/article/S1201-9712(21)00069-2/pdf)
Objectives: The moving epidemic method (MEM) has been implemented well for assessing seasonal influenza epidemics in temperate regions. We used the MEM to establish epidemic threshold for influenza in ...
Wu Y, Bissinger T, Genzel Y, Liu X, Reichl U, Tan. High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells. Appl Microbiol Biotechnol. 2021 Jan 30. Abstract
submitted by kickingbird at Jan, 31, 2021 from Appl Microbiol Biotechnol. 2021 Jan 30 (via https://link.springer.com/article/10.1007/s00253-020-11050-8)
Similar to the recent COVID-19 pandemic, influenza A virus poses a constant threat to the global community. For the treatment of flu disease, both antivirals and vaccines are available with vaccines the ...
Li X, Zhang L, Liu Y, Ma L, Zhang N, Xia C. Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope. J Biol Chem. 2020 Apr 17;295(16):5292-5306. Abstract
submitted by kickingbird at Jan, 30, 2021 from J Biol Chem. 2020 Apr 17;295(16):5292-5306 (via https://www.jbc.org/article/S0021-9258(17)48550-4/fulltext)
Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes ...
Levene RE, Shrestha SD, Gaglia MM. The influenza A virus host shutoff factor PA-X is rapidly turned over in a strain-specific manner. J Virol. 2021 Jan 27:JVI.02312-20.. Abstract
submitted by kickingbird at Jan, 29, 2021 from J Virol. 2021 Jan 27:JVI.02312-20. (via https://jvi.asm.org/content/early/2021/01/25/JVI.02312-20)
The influenza A endoribonuclease PA-X regulates virulence and transmission of the virus by reducing host gene expression and thus regulating immune responses to influenza A virus. Despite this key function ...
McBride DS, Lauterbach SE, Li YT, Smith GJD, Killi. Genomic Evidence for Sequestration of Influenza A Virus Lineages in Sea Duck Host Species. Viruses. 2021 Jan 24;13(2):172. Abstract
submitted by kickingbird at Jan, 28, 2021 from Viruses. 2021 Jan 24;13(2):172 (via https://www.mdpi.com/1999-4915/13/2/172)
Wild birds are considered the natural reservoir of influenza A viruses (IAVs) making them critical for IAV surveillance efforts. While sea ducks have played a role in novel IAV emergence events that threatened ...
Yang X, Zhao H, Li Z, Zhu A, Ren M, Geng M, Li Y,. Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-Analysis. Vaccines (Basel). 2021 Jan 23;9(2):79. Abstract
submitted by kickingbird at Jan, 28, 2021 from Vaccines (Basel). 2021 Jan 23;9(2):79 (via https://www.mdpi.com/2076-393X/9/2/79)
Influenza endangers human health but can be prevented in part by vaccination. Assessing influenza vaccine effectiveness (VE) provides scientific evidence for developing influenza vaccination policy. We ...
Krishnarajah G, Divino V, Postma MJ, Pelton SI, An. Clinical and Economic Outcomes Associated with Cell-Based Quadrivalent Influenza Vaccine vs. Standard-Dose Egg-Based Quadrivalent Influenza Vaccines during the 2018-19 Influenza Season in the United S. Vaccines (Basel). 2021 Jan 23;9(2):80. Abstract
submitted by kickingbird at Jan, 28, 2021 from Vaccines (Basel). 2021 Jan 23;9(2):80 (via https://www.mdpi.com/2076-393X/9/2/80)
Non-egg-based influenza vaccines eliminate the potential for egg-adapted mutations and potentially increase vaccine effectiveness. This retrospective study compared hospitalizations/emergency room (ER) ...
Li P, Hayat K, Jiang M, Pu Z, Yao X, Zou Y, Lamboj. Impact of video-led educational intervention on the uptake of influenza vaccine among adults aged 60 years and above in China: a study protocol for a randomized controlled trial. BMC Public Health. 2021 Jan 27;21(1):222. Abstract
submitted by kickingbird at Jan, 28, 2021 from BMC Public Health. 2021 Jan 27;21(1):222 (via https://bmcpublichealth.biomedcentral.com/articles/10.1186/s)
Background: Influenza is a global health threat to older adults, and the influenza vaccine is the most effective approach to prevent influenza infection. However, influenza vaccination coverage among Chinese ...
Duarte MB, Gregianini TS, Martins LG, Veiga ABG. Epidemiology of Influenza B infection in the State of Rio Grande do Sul, Brazil, from 2003 to 2019. J Med Virol. 2021 Jan 26. Abstract
submitted by kickingbird at Jan, 28, 2021 from J Med Virol. 2021 Jan 26 (via https://onlinelibrary.wiley.com/doi/10.1002/jmv.26822)
Introduction: Influenza B virus (IBV) causes respiratory tract infections with mild, moderate or life-threatening symptoms. This study describes the epidemiology of IBV infection in Rio Grande do Sul (RS), ...
Lei GL, Wang LP, Dong SH, Sun F, Cheng JX, Yang XL. A recombinant influenza virus with a CTLA4-specific scFv inhibits tumor growth in a mouse model. Cell Biol Int. 2021 Jan 26. Abstract
submitted by kickingbird at Jan, 28, 2021 from Cell Biol Int. 2021 Jan 26 (via https://onlinelibrary.wiley.com/doi/10.1002/cbin.11559)
Oncolytic viruses (OV) have shown excellent safety and efficacy in preclinical and clinical studies. Influenza A virus (IAV) is considered a promising oncolytic virus. In this report, we generated a recombinant ...
Li Z, Zhao Y, Li Y, Chen X. Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity. Vaccines (Basel). 2021 Jan 21;9(2):75. Abstract
submitted by kickingbird at Jan, 27, 2021 from Vaccines (Basel). 2021 Jan 21;9(2):75 (via https://www.mdpi.com/2076-393X/9/2/75)
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies ...
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