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2026-2-12 9:34:46
Article

Shanshan Guan, etc.,al. Optimization of the Monoclonal Antibody 3E1 through W32I Mutation Enhances Antiviral Efficacy against Influenza Virus Subtypes H1N1 and H3N2. Antiviral Research.  Abstract  
submitted by kickingbird at Aug, 17, 2025 from Antiviral Research (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
The influenza virus has caused a global pandemic with significant morbidity and mortality, underscoring the need to optimize antibodies for improved antiviral efficacy. The monoclonal antibody 3E1 effectively ...

Lorin Adams, etc.,al. Improved Resolution of Influenza Vaccination Responses With High-Throughput Live Virus Microneutralisation. Influenza and Other Respiratory Viruses.  Abstract  
submitted by kickingbird at Aug, 16, 2025 from Influenza and Other Respiratory Viruses (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70140)
BackgroundInfluenza remains a significant threat to human and animal health. Assessing serological protection against influenza has relied upon haemagglutinin inhibition (HAI) assays, which are used to ...

Hu, S., & Cui, J.. Cattle H5N1 Outbreak in US Driven by Cow’s ´Cross-Nursing´ Behavior: Elucidating a Novel Transmission Mechanism. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at Aug, 16, 2025 from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The emergence of highly pathogenic avian influenza A(H5N1) in US dairy cattle represents an unprecedented zoonotic event with critical pandemic implications. As of June 2025, over 1,070 dairy farms across ...

ZHENG Mengjia, etc.,al. Investigation and Analysis of a Reported Highly Pathogenic Avian Influenza Outbreak. China Poultry Science, Vol.47 No.8 2025.  Abstract  
submitted by kickingbird at Aug, 16, 2025 from China Poultry Science, Vol.47 No.8 2025 (via http://www.flu.org.cn/scn/article-23700.html)
On February 10, 2025, the Shandong Animal Disease Prevention and Control Center received a report of a suspected highly pathogenic avian influenza (HPAI) outbreak at a poultry farm. To verify the authenticity ...

Eduard Puente-Massaguer, etc.,al. [preprint]A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoprotein. https://doi.org/10.1101/2025.08.14.670375.  Abstract  
submitted by kickingbird at Aug, 16, 2025 from https://doi.org/10.1101/2025.08.14.670375 (via https://www.biorxiv.org/content/10.1101/2025.08.14.670375v1)
The continuous evolution and widespread dissemination of highly pathogenic avian influenza (HPAI) H5N1 viruses, particularly clade 2.3.4.4b, pose critical challenges to global pandemic preparedness. In ...

Johanna Hol Fosse, etc.,al. [preprint]Detection of antibodies specific to H5 avian influenza virus in a sheep in Norway, June 2024, eleven months after an outbreak of highly pathogenic avian influenza in a nearby seabird colony. https://doi.org/10.1101/2025.08.14.670265.  Abstract  
submitted by kickingbird at Aug, 16, 2025 from https://doi.org/10.1101/2025.08.14.670265 (via https://www.biorxiv.org/content/10.1101/2025.08.14.670265v1)
A 2023 outbreak of highly pathogenic avian influenza in seabirds in Norway caused substantial environmental contamination of grazing areas frequented by local sheep. Eleven months later, 220 sheep were ...

Persad G, Dellgren JL, Emanuel EJ. Avoiding four fallacies in the fair allocation of influenza countermeasures. BMJ Glob Health. 2025 Aug 12;10(8):e018391.  Abstract  
submitted by kickingbird at Aug, 15, 2025 from BMJ Glob Health. 2025 Aug 12;10(8):e018391 (via https://gh.bmj.com/content/10/8/e018391)
Since first detected in 1996, the highly pathogenic H5N1 ‘bird influenza’ has been perennially widespread in wild birds and poultry worldwide. Outbreaks among cattle in the USA and recent infections in ...

Cárdenas Parra AK, Barón Vera JP, Calixto-Botía IF. A Broad Wildlife Survey of Influenza A Virus in the Orinoco Flooded Savannas from Colombia: New Reports and Perspectives. Animals (Basel). 2025 Jul 26;15(15):2201.  Abstract  
submitted by kickingbird at Aug, 15, 2025 from Animals (Basel). 2025 Jul 26;15(15):2201 (via https://www.mdpi.com/2076-2615/15/15/2201)
Influenza A virus (IAV) poses a significant threat to animal and public health due to its wide host range and potential for interspecies transmission. This study aimed to conduct a comprehensive survey ...

Albert Perlas Puente, etc.,al. [preprint]From feather to fur: gull and mink H5N1 clade 2.3.4.4b HPAIV in their original hosts and their spillover and spillback potential. https://doi.org/10.21203/rs.3.rs-7357485/v1.  Abstract  
submitted by kickingbird at Aug, 15, 2025 from https://doi.org/10.21203/rs.3.rs-7357485/v1 (via https://www.researchsquare.com/article/rs-7357485/v1)
The ongoing panzootic of H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus (HPAIV) increasingly involves non-traditional hosts such as seabirds and mammals. To assess their role in viral-host ...

Xu Y, Anirudhan V, Gaisina IN, Du H, Alqarni S, Mo. Mechanistic insights into the small-molecule inhibition of influenza A virus entry. Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e250.  Abstract  
submitted by kickingbird at Aug, 14, 2025 from Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e250 (via https://www.pnas.org/doi/10.1073/pnas.2503899122)
Influenza A virus (IAV) is a zoonotic pathogen responsible for seasonal and pandemic flu. The extensive genetic and antigenic diversity within and between IAV phylogenetic groups presents major challenges ...

Mo J, Ferreri LM, Geiger G, Perez DR, Rajao DS. Passage of human-origin influenza A virus in swine tracheal epithelial cells selects for adaptive mutations in the hemagglutinin gene. PLoS One. 2025 Aug 13;20(8):e0327096.  Abstract  
submitted by kickingbird at Aug, 14, 2025 from PLoS One. 2025 Aug 13;20(8):e0327096 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Frequent spillover of influenza A viruses from humans to swine contributes to the increasing diversity of influenza viruses circulating in pigs. Although these events are common, little is known about ...

Cho, Andrew Y., Kim, Tae-Hyeon, Lee, Heesu, Lee, S. Evolution and Spread of Y280-Lineage H9N2 Low Pathogenicity Avian Influenza Viruses in Korea, 2020–2023. Transboundary and Emerging Diseases, 2025, 8009335.  Abstract  
submitted by kickingbird at Aug, 14, 2025 from Transboundary and Emerging Diseases, 2025, 8009335 (via https://onlinelibrary.wiley.com/doi/10.1155/tbed/8009335)
In 2020, Y280-lineage H9N2 low pathogenic avian influenza was detected in South Korea for the first time. Active surveillance from live bird markets (LBMs) and farms revealed the continuous circulation ...

León, F., Le Bohec, C., Pizarro, E.J. et al. Tracking HPAIV H5 through a geographic survey of Antarctic seabird populations. Sci Rep 15, 29499 (2025).  Abstract  
submitted by kickingbird at Aug, 14, 2025 from Sci Rep 15, 29499 (2025) (via https://link.springer.com/article/10.1038/s41598-025-14651-3)
An extensive survey for the detection of Highly Pathogenic Avian Influenza virus (HPAIV) H5 in seabird species is reported here. It was conducted between December 2023 and January 2024, in thirteen breeding ...

Markin A, Macken CA, Baker AL, Anderson TK. Revealing Reassortment in Influenza A Viruses with TreeSort. Mol Biol Evol. 2025 Jul 30;42(8):msaf133.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from Mol Biol Evol. 2025 Jul 30;42(8):msaf133 (via https://academic.oup.com/mbe/article/doi/10.1093/molbev/msaf)
Reassortment among influenza A viruses (IAV) facilitates evolution and has been associated with interspecies transmission and pandemics. We introduce a novel tool called TreeSort that accurately identifies ...

Cecilia Di Genova, etc.,al. [preprint]Pigeons exhibit low susceptibility and poor transmission capacity for H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus. https://doi.org/10.1101/2025.05.02.651910.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from https://doi.org/10.1101/2025.05.02.651910 (via https://www.biorxiv.org/content/10.1101/2025.05.02.651910v2)
The ongoing panzootic of H5N1 high pathogenicity avian influenza virus (HPAIV) has caused the deaths of over half a billion wild birds and poultry, and has led to spillover events in both wild and domestic ...

Sharp CP, Thompson BH, Hoque AF, Diebold O, Tesla. Understanding off-target growth defects introduced to influenza A virus by synonymous recoding. RNA. 2025 Aug 12:rna.080675.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from RNA. 2025 Aug 12:rna.080675 (via https://rnajournal.cshlp.org/content/early/2025/08/12/rna.08)
CpG dinucleotides are under-represented in the genomes of most RNA viruses. Synonymously increasing CpG content of a range of RNA virus genomes reliably causes replication defects due to the recognition ...

Gao X, Chen S, Zhong Z, Li J, Chen J, Li B, Lin K,. Global association between air pollution and risk of influenza-related outcomes: a systematic review and meta-analysis. Int J Environ Health Res. 2025 Aug 12:1-16.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from Int J Environ Health Res. 2025 Aug 12:1-16 (via https://www.tandfonline.com/doi/full/10.1080/09603123.2025.2)
Despite extensive research, air pollution-influenza associations remain inconsistent. This evidence synthesis aggregated evidence from 28 studies to quantify air pollution-influenza associations, employing ...

Park ES, Gayashan MK, Kim KH. Thermogenesis dynamics and influenza A virus: unveiling the intriguing interplay. Crit Rev Microbiol. 2025 Aug 12:1-22.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from Crit Rev Microbiol. 2025 Aug 12:1-22 (via https://www.tandfonline.com/doi/full/10.1080/1040841X.2025.2)
Maintaining body temperature is critical, with brown adipose tissue (BAT) and uncoupling protein 1 (UCP1) activation playing pivotal roles in heat generation and metabolism. Modulating thermoregulation ...

Mena-Vasquez J, Marco-Fuertes A, Culhane M, Torrem. Emerging threats of HPAI H5N1 clade 2.3.4.4b in swine: knowledge gaps and the imperative for a One Health approach. Front. Vet. Sci. 12:1648878.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from Front. Vet. Sci. 12:1648878 (via https://www.frontiersin.org/journals/veterinary-science/arti)
Highly pathogenic avian influenza (HPAI) H5N1 represents a significant threat to wildlife, livestock, and public health. The recent detection of HPAI H5N1 clade 2.3.4.4b genotypes B3.13 and D1.1 in dairy ...

Kelvin AA, Baker PH, Ghosh S, Schultz-Cherry S, La. Influenza infection of the mammary gland. J Virol 0:e01940-24.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from J Virol 0:e01940-24 (via https://journals.asm.org/doi/10.1128/jvi.01940-24)
The mammary gland is an essential organ for milk production, providing essential immune and nutritional support to offspring and supplying dairy products for human consumption. In both humans and animals, ...

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