Masaki Imai, etc.,al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 2012 doi:10.1038/nature10831. Full Text
submitted by kickingbird at May, 3, 2012 from Nature 2012 doi:10.1038/nature10831 (via http://www.nature.com/nature/journal/vaop/ncurrent/full/natu)
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known host-range determinant ... NIH. Statement on NSABB´s March 30, 2012 Recommendations to NIH on H5N1 Research. NIH. Abstract
submitted by kickingbird at May, 3, 2012 from NIH (via http://www.nih.gov/about/director/04142012_NSABB.htm)
April 14, 2012
On March 29-30, 2012, the National Science Advisory Board for Biosecurity (NSABB) was convened to examine two revised manuscripts regarding the transmissibility of the H5N1 avian flu virus ... Hongjie Yu, Simon Cauchemez, Christl A. Donnelly. Transmission Dynamics, Border Entry Screening, and School Holidays during the 2009 Influenza A (H1N1) Pandemic, China. Apr 18 Emerg Infect Dis. Abstract
submitted by kickingbird at Apr, 22, 2012 from Apr 18 Emerg Infect Dis (via http://wwwnc.cdc.gov/eid/article/18/5/11-0356_article.htm)
Pandemic influenza A (H1N1) 2009 virus spread rapidly around the world in 2009. We used multiple data sources from surveillance systems and specific investigations to characterize the transmission patterns ... Xiang Huo, Rongqiang Zu, Xian Qi, Yuanfang Qin, Li. Seroprevalence of avian influenza A (H5N1) virus among poultry workers in Jiangsu Province, China: an observational study. BMC Infectious Diseases 2012, 12:93. Abstract
submitted by kickingbird at Apr, 22, 2012 from BMC Infectious Diseases 2012, 12:93 (via http://www.biomedcentral.com/1471-2334/12/93/abstract)
Background
Since 2003 to 06 Jan 2012, the number of laboratory confirmed human cases of infection with avian influenza in China was 41 and 27 were fatal. However, the official estimate of the H5N1 case-fatality ... NORONHA JM, Liu M, Squires RB, Pickett BE, et al. Influenza Sequence Feature Variant Type (Flu-SFVT) analysis: evidence for a role of NS1 in influenza host range restriction. J Virol. 2012 Mar 7.. Abstract
submitted by kickingbird at Mar, 14, 2012 from J Virol. 2012 Mar 7. (via http://www.ncbi.nlm.nih.gov/pubmed/22398283)
Genetic drift of influenza virus genomic sequences occurs through the combined effects of sequence alterations introduced by a low fidelity polymerase and the varying selective pressures experienced as ... MAAMARY J, Pica N, Belicha-Villanueva A, Chou YY,. Attenuated influenza virus construct with enhanced hemagglutinin protein expression. J Virol. 2012. Abstract
submitted by kickingbird at Mar, 14, 2012 from J Virol. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22398291)
Influenza A viruses encoding an altered viral NS1 protein have emerged as promising live attenuated vaccine platforms. A carboxy-terminal truncation in the NS1 protein compromises its interferon antagonism ... Belser JA, Gustin KM, Maines TR, Pantin-Jackwood M. Influenza Virus Respiratory Infection and Transmission Following Ocular Inoculation in Ferrets. PLoS Pathog 8(3): e1002569. doi:10.1371/journal.p. Abstract
submitted by kickingbird at Mar, 3, 2012 from PLoS Pathog 8(3): e1002569. doi:10.1371/journal.p (via http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2F)
While influenza viruses are a common respiratory pathogen, sporadic reports of conjunctivitis following human infection demonstrates the ability of this virus to cause disease outside of the respiratory ... S. Tong,etc.,al. A distinct lineage of influenza A virus from bats. PNAS February 27, 2012. Abstract
submitted by kickingbird at Feb, 29, 2012 from PNAS February 27, 2012 (via http://www.pnas.org/content/early/2012/02/17/1116200109.abst)
Influenza A virus reservoirs in animals have provided novel genetic elements leading to the emergence of global pandemics in humans. Most influenza A viruses circulate in waterfowl, but those that infect ... MACDONALD LA, Aggarwal S, Bussey KA, Desmet EA, et. Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies. Virology. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Virology. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22325937)
The influenza polymerase complex composed of PA, PB1 and PB2, plays a key role in viral replication and pathogenicity. Newly synthesized components must be translocated to the nucleus, where replication ... J Gen Virol. 2012. An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo. SHELTON H, Smith M, Hartgroves LC, Stilwell P, et. Abstract
submitted by kickingbird at Feb, 19, 2012 from SHELTON H, Smith M, Hartgroves LC, Stilwell P, et (via http://www.ncbi.nlm.nih.gov/pubmed/22323532)
Influenza viruses readily mutate by accumulating point mutations and also by reassortment in which they acquire whole gene segments from another virus in a co-infected host. The NS1 gene is a major virulence ... FERRARIS O, Escuret V, Bouscambert M, Casalegno JS. H1N1 influenza A virus neuraminidase modulates infectivity in mice. Antiviral Res. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22321413)
In the 2years since the onset of the H1N1 2009 pandemic virus (H1N1pdm09), sporadic cases of oseltamivir-resistant viruses have been reported. We investigated the impact of oseltamivir-resistant neuraminidase ... NGUYEN HT, Trujillo AA, Sheu TG, Levine M, et al.. Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States. Antiviral Res. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22330888)
During the 2009 influenza pandemic, the Centers for Disease Control and Prevention provided antiviral susceptibility testing for patients infected with suspected drug-resistant viruses. Specimens from ... VEITS J, Weber S, Stech O, Breithaupt A, et al.. Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype. Proc Natl Acad Sci U S A. 2012. Abstract
submitted by kickingbird at Feb, 16, 2012 from Proc Natl Acad Sci U S A. 2012 (via http://www.pnas.org/content/109/7/2579.long)
High-pathogenic avian influenza viruses (HPAIVs) evolve from low-pathogenic precursors specifying the HA serotypes H5 or H7 by acquisition of a polybasic HA cleavage site. As the reason for this serotype ... WANG M, Tscherne DM, McCullough C, Caffrey M, et a. Residue Y161 of influenza hemagglutinin is involved in viral recognition of sialylated complexes from different hosts. J Virol. 2012 Feb 1. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Virol. 2012 Feb 1 (via http://www.ncbi.nlm.nih.gov/pubmed/22301136)
Influenza A virus glycoprotein hemagglutinin (HA) binds to host cell surface sialic acid (SA)-terminated sugars in glycoproteins to initiate viral entry. It is thought that avian influenza viruses preferentially ... MEUNIER I, von Messling V. PB1-F2 Modulates Early Host Responses but Does not Affect the Pathogenesis of H1N1 Seasonal Influenza Virus. J Virol. 2012 Feb 8.. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Virol. 2012 Feb 8. (via http://www.ncbi.nlm.nih.gov/pubmed/22318139)
In the context of infections with highly pathogenic influenza A viruses the PB1-F2 protein contributes to virulence and enhances lung inflammation. In contrast, its role in the pathogenesis of seasonal ... VAN STRY M, Oguin T, Cheloufi S, Vogel P, et al.. Enhanced Susceptibility to Influenza A Virus of Ago1/3 Double Null Mice. J Virol. 2012 Feb 8.. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Virol. 2012 Feb 8. (via http://www.ncbi.nlm.nih.gov/pubmed/22318144)
RNAi is a critical component of many cellular anti-viral responses in plants, invertebrates, and mammals. However, its in vivo role in host protection from the negative sense RNA virus Influenza Type A ... PICA N, Chou YY, Bouvier NM, Palese P, et al.. Transmission of Influenza B viruses in the Guinea Pig. J Virol. 2012 Feb 1. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Virol. 2012 Feb 1 (via http://www.ncbi.nlm.nih.gov/pubmed/22301149)
Epidemic influenza is typically caused by infection of viruses of the A and B type and can result in substantial morbidity and mortality during a given season. Here we demonstrate that influenza B viruses ... MENEGHESSO S, Vanderlinden E, Stevaert A, McGuigan. Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus. Antiviral Res. 2012. Abstract
submitted by kickingbird at Feb, 16, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22306172)
Uridine-based nucleoside analogues have often been found to have relatively poor antiviral activity. Enzymatic assays, evaluating inhibition of influenza virus RNA polymerase, revealed that some uridine ... FAN K, Jia Y, Wang S, Li H, et al. Role of Itk signaling in the interaction between influenza A virus and T cells. J Gen Virol. 2012. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Gen Virol. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22302878)
Although T cell-mediated immune response to influenza virus has been extensively studied, little information is available on direct interaction between influenza virus and T cells that pertains to severe ... McCullers JA, Hayden FG. Fatal Influenza B Infections: Time to Reexamine Influenza Research Priorities. J Infect Dis 2012 Jan 30. Abstract
submitted by kickingbird at Feb, 2, 2012 from J Infect Dis 2012 Jan 30 (via http://jid.oxfordjournals.org/content/early/2012/01/28/infdi)
Influenza A viruses (IAVs) are zoonotic pathogens that sometimes establish long-term lineages in humans and other mammalian hosts. New introductions of influenza genes or whole viruses from animal reservoirs ... 7503 items, 20/Page, Page[277/376][|<<] [|<] [271] [272] [273] [274] [275] [276] [277] [278] [279] [280] [>|] [>>|] |
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