Wang J, Zeng Y, Xu S, Yang J, et al. A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity. J Virol 2018 Mar 21. Abstract
submitted by kickingbird at Mar, 26, 2018 from J Virol 2018 Mar 21 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29563291/)
Nonstructural protein 1 (NS1) of influenza A virus regulates innate immune responses via various mechanisms. We previously showed that a naturally occurring deletion (the EALQR motif) in the NS1 effector ... Aljurayyan A, Puksuriwong S, Ahmed M, Sharma R, et. Activation and induction of antigen-specific T follicular helper cells (TFH) play a critical role in LAIV-induced human mucosal anti-influenza antibody response. J Virol 2018 Mar 21. Abstract
submitted by kickingbird at Mar, 26, 2018 from J Virol 2018 Mar 21 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29563292/)
There is increasing interest recently in developing intranasal vaccines against respiratory tract infections. Antibody response is critical in vaccine-induced protection and TFH is considered important ... Watanabe Y, Arai Y, Kawashita N, Ibrahim MS, et al. Characterization of H5N1 influenza virus quasispecies with adaptive hemagglutinin mutations from single-virus infections of human airway cells. J Virol 2018 Mar 21. Abstract
submitted by kickingbird at Mar, 26, 2018 from J Virol 2018 Mar 21 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29563293/)
Transmission of avian influenza (AI) viruses to mammals involves phylogenetic bottlenecks that select small numbers of variants for transmission to new host species. However, little is known about the ... Quan C, Shi W, Yang Y, Yang Y, et al. New threats of H7N9 influenza virus: the spread and evolution of highly and low pathogenic variants with high genomic diversity in Wave Five. J Virol 2018 Mar 21. Abstract
submitted by kickingbird at Mar, 26, 2018 from J Virol 2018 Mar 21 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29563296/)
H7N9 virus has caused five infection waves since it emerged in 2013. The highest number of human cases was seen in Wave Five; however, the underlying reasons have not been thoroughly elucidated. In this ... Jung KI, Pyo CW, Choi SY. Influenza A virus-induced autophagy contributes to enhancement of virus infectivity by SOD1 downregulation in alveolar epithelial cells. Biochem Biophys Res Commun 2018 Mar 16. Abstract
submitted by kickingbird at Mar, 26, 2018 from Biochem Biophys Res Commun 2018 Mar 16 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29548827/)
Infection with influenza A virus (IAV) A/WSN/1933 (H1N1) causes oxidative stress and severe lung injury. We have demonstrated that the generation of reactive oxygen species (ROS) during IAV infection is ... Cao X, Liu X, Zheng S, Xu L, et al.. Isolation and characterization of an avian-origin H3N8 canine influenza virus from a dog in eastern China. Arch Virol 2018 Mar 20. Abstract
submitted by kickingbird at Mar, 26, 2018 from Arch Virol 2018 Mar 20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29556821/)
Previous studies have shown that dogs are susceptible to influenza A viruses, and the close contact between dogs and humans poses a threat to public health. In 2015, a novel H3N8 influenza virus was isolated ... S. Yamayoshi, etc.,al. Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans. EID Vol 24, No. 4. Abstract
submitted by kickingbird at Mar, 22, 2018 from EID Vol 24, No. 4 (via https://wwwnc.cdc.gov/eid/article/24/4/17-1509_article)
To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2–482R, polymerase basic 2–588V, ... Brianne J. Lindsay, etc.,al. Morphological characterization of a plant-made virus-like particle vaccine bearing influenza virus hemagglutinins by electron microscopy. Vaccine 14 March 2018. Abstract
submitted by kickingbird at Mar, 22, 2018 from Vaccine 14 March 2018 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Plant-made virus-like particle (VLP) vaccines that display wild-type influenza hemagglutinin (HA) are rapidly advancing through clinical trials. Produced by transient transfection of Nicotiana benthamiana, ... Kathleen A. Stellrecht. Incidence of matrix genes mutations affecting PCR tests among influenza H3N2 clades circulating during the 2014/15 season. Diagnostic Microbiology&Infectious Diseases. Abstract
submitted by kickingbird at Mar, 22, 2018 from Diagnostic Microbiology&Infectious Diseases (via http://www.dmidjournal.com/article/S0732-8893(18)30054-3/ful)
Influenza circulating during the 2014/15 season was associated with significant drift and the emergence of new H3N2 subgroups. It was also known that mutations were accumulating in the WHO-recommended ... Kwang Il Jung, etc.,al. Influenza A virus-induced autophagy contributes to enhancement of virus infectivity by SOD1 downregulation in alveolar epithelial cells. Biochemical and Biophysical Research Communication. Abstract
submitted by kickingbird at Mar, 22, 2018 from Biochemical and Biophysical Research Communication (via https://www.sciencedirect.com/science/article/pii/S0006291X1)
Infection with influenza A virus (IAV) A/WSN/1933 (H1N1) causes oxidative stress and severe lung injury. We have demonstrated that the generation of reactive oxygen species (ROS) during IAV infection is ... Ishiguro N. et al. Clinical effectiveness of four neuraminidase inhibitors(oseltamivir, zanamivir, laninamivir,and peramivir) for children with influenza A and B in the 2014-2015 to 2016-2017 influenza seasons in Japan. J Infect Chemother. 2018 Feb 24. Abstract
submitted by kickingbird at Mar, 20, 2018 from J Infect Chemother. 2018 Feb 24 (via https://www.ncbi.nlm.nih.gov/pubmed/29487035)
The clinical effectiveness of four neuraminidase inhibitors (NAIs) (oseltamivir, zanamivir, laninamivir, and peramivir) for children aged 0 months to 18 years with influenza A and B were investigated in ... Lee IW, etc.,al. Comparison of the virulence and transmissibility of canine H3N2 influenza viruses and characterization of their canine adaptation factors. Emerg Microbes Infect. 2018 Mar 7;7(1):17. Abstract
submitted by kickingbird at Mar, 12, 2018 from Emerg Microbes Infect. 2018 Mar 7;7(1):17 (via https://www.ncbi.nlm.nih.gov/pubmed/29511200)
Recent canine influenza outbreaks have raised concerns about the generation of pathogenic variants that may pose a threat to public health. Here, we examine avian-like H3N2 canine influenza viruses (CIVs) ... Jin H, etc.,al. Evolution of H9N2 avian influenza virus in embryonated chicken eggs with or without homologous vaccine antibodies. BMC Vet Res. 2018 Mar 6;14(1):71.. Abstract
submitted by kickingbird at Mar, 12, 2018 from BMC Vet Res. 2018 Mar 6;14(1):71. (via https://www.ncbi.nlm.nih.gov/pubmed/29510698)
BACKGROUND: Vaccines constitute a unique selective pressure, different from natural selection, drives the evolution of influenza virus. In this study, A/Chicken/Shanghai/F/1998 (H9N2) was continually passaged ... Czako R, Vogel L, Sutton T, Matsuoka Y, et al. H5N2 vaccine viruses on Russian and US live attenuated influenza virus backbones demonstrate similar infectivity, immunogenicity and protection in ferrets. Vaccine 2018 Mar 1.. Abstract
submitted by kickingbird at Mar, 12, 2018 from Vaccine 2018 Mar 1. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29503113/)
The continued detection of zoonotic influenza infections, most notably due to the avian influenza A H5N1 and H7N9 subtypes, underscores the need for pandemic preparedness. Decades of experience with live ... Erbelding EJ, Post D, Stemmy E, Roberts PC, et al. A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases. J Infect Dis 2018 Feb 28. Abstract
submitted by kickingbird at Mar, 12, 2018 from J Infect Dis 2018 Feb 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29506129/)
A priority for the National Institute of Allergy and Infectious Diseases (NIAID) is development of an influenza vaccine providing durable protection against multiple influenza strains, including those ... Tinoco R, Carrette F, Henriquez ML, Fujita Y, et a. Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells. J Immunol 2018 Feb 28. Abstract
submitted by kickingbird at Mar, 12, 2018 from J Immunol 2018 Feb 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29491007/)
T cells mediating influenza viral control are instructed in lymphoid and nonlymphoid tissues to differentiate into memory T cells that confer protective immunity. The mechanisms by which influenza virus-specific ... Kwon JJ, Choi WS, Jeong JH, Kim EH, et al. An I436N substitution confers resistance of influenza A(H1N1)pdm09 viruses to multiple neuraminidase inhibitors without affecting viral fitness. J Gen Virol 2018;99:292-302. Abstract
submitted by kickingbird at Mar, 12, 2018 from J Gen Virol 2018;99:292-302 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29493493/)
The resistance of influenza viruses to neuraminidase (NA) inhibitors (NAIs; i.e. oseltamivir, zanamivir, peramivir and laninamivir) can be associated with several NA substitutions, with differing effects ... Takizawa N, Kimura T, Watanabe T, Shibasaki M, et. Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis. Arch Virol 2018 Mar 1. Abstract
submitted by kickingbird at Mar, 12, 2018 from Arch Virol 2018 Mar 1 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29497849/)
Influenza virus infection is a major threat to global health. Although vaccines and anti-influenza virus drugs are available, annual influenza virus epidemics result in severe illness, and an influenza ... Musharrafieh R, Ma C, Wang J. Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers. Antiviral Res 2018 Mar 5.. Abstract
submitted by kickingbird at Mar, 12, 2018 from Antiviral Res 2018 Mar 5. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29518414/)
The majority of human influenza A viruses currently in circulation carry the amantadine-resistant AM2-S31N channel mutation. We previously discovered a series of AM2-S31N inhibitors with potent antiviral ... Shirin Hosseini, Esther Wilk, Kristin Michaelsen-P. Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function. Journal of Neuroscience 27 February 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from Journal of Neuroscience 27 February 2018 (via http://www.jneurosci.org/content/early/2018/02/28/JNEUROSCI.)
Acute influenza infection has been reported to be associated with neurological symptoms. However, the long-term consequences for the CNS of an infection with neurotropic but also with non-neurotropic influenza ... 8181 items, 20/Page, Page[250/410][|<<] [|<] [241] [242] [243] [244] [245] [246] [247] [248] [249] [250] [>|] [>>|] |
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