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Patil G, Zhao M, Song K, Hao W, et al. TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection. J Virol 2018 Jun 13.  Abstract  
submitted by kickingbird at Jun, 18, 2018 from J Virol 2018 Jun 13 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29899090/)
Influenza A virus (IAV) is a highly transmissible respiratory pathogen and a major cause of morbidity and mortality around the world. Nucleoprotein (NP) is an abundant IAV protein essential for multiple ...

Nachbagauer R, Shore D, Yang H, Johnson SK, et al. Broadly-reactive human monoclonal antibodies elicited following pandemic H1N1 influenza virus exposure protect mice from highly pathogenic H5N1 challenge. J Virol 2018 Jun 13.  Abstract  
submitted by kickingbird at Jun, 18, 2018 from J Virol 2018 Jun 13 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29899095/)
Broadly cross-reactive antibodies that recognize conserved epitopes within the influenza virus hemagglutinin (HA) stalk domain are of particular interest for their potential use as therapeutic and prophylactic ...

Segaloff HE, etc al. Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014-2015 and 2015-2016. Epidemiol Infect. 2018 Jun 8:1-9.  Abstract  
submitted by kickingbird at Jun, 18, 2018 from Epidemiol Infect. 2018 Jun 8:1-9 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29880077/)
Our objective was to identify predictors of severe acute respiratory infection in hospitalised patients and understand the impact of vaccination and neuraminidase inhibitor administration on severe influenza. ...

Ko EJ, Lee Y, Lee YT, Kim YJ, et al. MPL and CpG combination adjuvants promote homologous and heterosubtypic cross protection of inactivated split influenza virus vaccine. Antiviral Res 2018 Jun 6..  Abstract  
submitted by kickingbird at Jun, 18, 2018 from Antiviral Res 2018 Jun 6. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29885376/)
Annual vaccination is not effective in conferring cross-protection against antigenically different influenza viruses. Therefore, it is of high priority to improve the cross protective efficacy of influenza ...

Pan W, etc.,al. Patient-derived avian influenza A (H5N6) virus is highly pathogenic in mice but can be effectively treated by anti-influenza polyclonal antibodies. Emerg Microbes Infect. 2018 Jun 13;7(1):107.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from Emerg Microbes Infect. 2018 Jun 13;7(1):107 (via https://www.ncbi.nlm.nih.gov/pubmed/29899428)
Highly pathogenic avian influenza A (H5N6) virus has been circulating in poultry since 2013 and causes sporadic infections and fatalities in humans. Due to the re-occurrence and continuous evolution of ...

Wessels U, etc.,al. A dual motif in the hemagglutinin of H5N1 Goose/Guangdong-like HPAIV is conserved from their early evolution and increases both membrane fusion pH and virulence. J Virol. 2018 Jun 13.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from J Virol. 2018 Jun 13 (via https://www.ncbi.nlm.nih.gov/pubmed/29899102)
Zoonotic highly pathogenic avian influenza viruses (HPAIV) have raised serious public health concerns of a novel pandemic. These strains emerge from low-pathogenic precursors by acquisition of a polybasic ...

Cai H, Liu M, Russell CJ. Directed evolution of an influenza reporter virus to restore replication and virulence and enhance non-invasive bioluminescence imaging in mice. J Virol. 2018 Jun 13.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from J Virol. 2018 Jun 13 (via https://www.ncbi.nlm.nih.gov/pubmed/29899096)
Reporter viruses provide a powerful tool to study infection, yet incorporating a non-essential gene often results in virus attenuation and genetic instability. Here, we used directed evolution of a luciferase-expressing ...

Fulton BO, Sun W, Heaton NS, Palese P. The influenza B virus hemagglutinin head domain is less tolerant to transposon mutagenesis than that of the influenza A virus. J Virol. 2018 Jun 13.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from J Virol. 2018 Jun 13 (via https://www.ncbi.nlm.nih.gov/pubmed/29899093)
Influenza A and B viruses can continuously evade humoral immune responses by developing mutations in the globular head of the hemagglutinin (HA) that prevent antibody binding. However, the influenza B ...

Tong XC, etc.,al. Human infection of novel avian influenza A(H7N4) virus. J Infect. 2018 Jun 10.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from J Infect. 2018 Jun 10 (via https://www.ncbi.nlm.nih.gov/pubmed/29898409)
Multiple reassortant strains of novel, highly pathogenic avian influenza A have recently emerged and spread over the world. Here we report on a 68-year-old woman in Jiangsu, China, with influenza A(H7N4) ...

Engelhardt OG, etc.,al. Comparison of single radial immunodiffusion, SDS-PAGE and HPLC potency assays for inactivated influenza vaccines shows differences in ability to predict immunogenicity of haemagglutinin antigen. Vaccine. 2018 Jun 9. pii: S0264-410X(18)30742-4.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from Vaccine. 2018 Jun 9. pii: S0264-410X(18)30742-4 (via https://www.ncbi.nlm.nih.gov/pubmed/29895503)
The current gold-standard potency test for inactivated influenza vaccines is the single radial immunodiffusion (SRD) assay. A number of alternative potency tests for inactivated influenza vaccines have ...

Malbari K, etc.,al. In search of effective H1N1 neuraminidase inhibitor by molecular docking, antiviral evaluation and membrane interaction studies using NMR. Acta Virol. 2018;62(2):179-190.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from Acta Virol. 2018;62(2):179-190 (via https://www.ncbi.nlm.nih.gov/pubmed/29895159)
Considering the need for discovery of new antiviral drugs, in view to combat the issue of resistance particularly to anti-influenza drugs, a series of 2'-amino, 3'-amino and 2', 4'-dihydroxy chalcone derivatives ...

Chen X, Qi Y, Wang H, Wang Y, Wang H, Ni H. Prevalence of Multiple Subtypes of Avian Influenza Virus Antibodies in Egg Yolks of Mallard ( Anas platyrhynchos) and White-winged Terns ( Chlidonias leucopterus) in the Northeastern Republic of China. J Wildl Dis. 2018 Jun 12.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from J Wildl Dis. 2018 Jun 12 (via https://www.ncbi.nlm.nih.gov/pubmed/29894211)
Wild birds are natural hosts of avian influenza viruses (AIV) and can transmit viruses to poultry and other species. To monitor the prevalence of AIV antibodies, 211 eggs from wild Mallards ( Anas platyrhynchos) ...

Zhou J, etc.,al. Differentiated human airway organoids to assess infectivity of emerging influenza virus. Proc Natl Acad Sci U S A. 2018 Jun 11..  Abstract  
submitted by kickingbird at Jun, 17, 2018 from Proc Natl Acad Sci U S A. 2018 Jun 11. (via https://www.ncbi.nlm.nih.gov/pubmed/29891677)
Novel reassortant avian influenza H7N9 virus and pandemic 2009 H1N1 (H1N1pdm) virus cause human infections, while avian H7N2 and swine H1N1 virus mainly infect birds and pigs, respectively. There is no ...

Chen LW,etc.,al. Influenza-associated neurological complications during 2014-2017 in Taiwan. Brain Dev. 2018 Jun 8..  Abstract  
submitted by kickingbird at Jun, 17, 2018 from Brain Dev. 2018 Jun 8. (via https://www.ncbi.nlm.nih.gov/pubmed/29891404)
INTRODUCTION: Seasonal influenza-associated neurological complications had high mortality and morbidity rates in recent studies. We reported influenza-associated encephalitis/encephalopathy in children ...

Hassan MM, Hoque MA, Ujvari B, Klaassen M. Live bird markets in Bangladesh as a potentially important source for Avian Influenza Virus transmission. Prev Vet Med. 2018 Aug 1;156:22-27.  Abstract  
submitted by kickingbird at Jun, 17, 2018 from Prev Vet Med. 2018 Aug 1;156:22-27 (via https://www.ncbi.nlm.nih.gov/pubmed/29891142)
Live bird markets (LBM) are important for trading poultry in many developing countries where they are being considered hotspots of Avian Influenza Virus (AIV) prevalence and contamination. An active surveillance ...

Davinder Singh, Depeng Jiang, etc.,al. The effect of timing of oseltamivir chemoprophylaxis in controlling influenza A H3N2 outbreaks in long-term care facilities in Manitoba, Canada, 2014-2015: a retrospective cohort study. Infection Control & Hospital Epidemiology 2018, 1–.  Abstract  
submitted by kickingbird at Jun, 14, 2018 from Infection Control & Hospital Epidemiology 2018, 1– (via https://www.cambridge.org/core/journals/infection-control-an)
ObjectiveThis study examined the effect of the timing of administration of oseltamivir chemoprophylaxis for the control of influenza A H3N2 outbreaks among residents in long-term care facilities (LTCFs) ...

Zhou P, etc.,al. PB2 E627K or D701N substitution does not change the virulence of canine influenza virus H3N2 in mice and dogs. Vet Microbiol. 2018 Jul;220:67-72..  Abstract  
submitted by kickingbird at Jun, 13, 2018 from Vet Microbiol. 2018 Jul;220:67-72. (via https://www.ncbi.nlm.nih.gov/pubmed/29885803)
Recently, canine influenza virus H3N2 (CIV H3N2) has circulated continuously in the dog populations of Asia and the United States (US). As humans have close contact with pet dogs, the circulation of CIV ...

Caini S, etc.,al. Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries, 1999-2014. BMC Infect Dis. 2018 Jun 8;18(1):269.  Abstract  
submitted by kickingbird at Jun, 13, 2018 from BMC Infect Dis. 2018 Jun 8;18(1):269 (via https://www.ncbi.nlm.nih.gov/pubmed/29884140)
BACKGROUND: Influenza disease burden varies by age and this has important public health implications. We compared the proportional distribution of different influenza virus types within age strata using ...

Seekings AH, etc.,al. Direct evidence of H7N7 avian influenza virus mutation from low to high virulence on a single poultry premises during an outbreak in free range chickens in the UK, 2008. Infect Genet Evol. 2018 Jun 5. pii: S1567-1348(18).  Abstract  
submitted by kickingbird at Jun, 13, 2018 from Infect Genet Evol. 2018 Jun 5. pii: S1567-1348(18) (via https://www.ncbi.nlm.nih.gov/pubmed/29883773)
H5 and H7 subtypes of low pathogenicity avian influenza viruses (LPAIVs) have the potential to evolve into highly pathogenic avian influenza viruses (HPAIVs), causing high mortality in galliforme poultry ...

Sologuren I, etc.,al. Lethal Influenza in Two Related Adults with Inherited GATA2 Deficiency. J Clin Immunol. 2018 Jun 7.  Abstract  
submitted by kickingbird at Jun, 13, 2018 from J Clin Immunol. 2018 Jun 7 (via https://www.ncbi.nlm.nih.gov/pubmed/29882021)
The pathogenesis of life-threatening influenza A virus (IAV) disease remains elusive, as infection is benign in most individuals. We studied two relatives who died from influenza. We Sanger sequenced GATA2 ...

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