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2024-3-29 12:35:55
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Mena J, etc.,al. Re-emergence of H3N8 Equine Influenza A virus in Chile, 2018. Transbound Emerg Dis. 2018 Jul 28.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Transbound Emerg Dis. 2018 Jul 28 (via https://www.ncbi.nlm.nih.gov/pubmed/30054993)
A new outbreak of equine Influenza A virus (IAV) was reported in Chile in January 2018, six years after its last report in 2012. Equine IAV was detected by rtRT-PCR, followed by virus isolation and full ...

Machado A, etc.,al. Factors associated to repeated influenza vaccination in the Portuguese adults with chronic conditions. Vaccine. 2018 Jul 24. pii: S0264-410X(18)31010-7..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Vaccine. 2018 Jul 24. pii: S0264-410X(18)31010-7. (via https://www.ncbi.nlm.nih.gov/pubmed/30054159)
Annual influenza vaccination is recommended to people with chronic conditions. This study aimed to estimate the proportion of chronically ill adults vaccinated against influenza in consecutive seasons ...

Dal Negro RW, Turco P, Povero M. Cost of influenza and influenza-like syndromes (I-LSs) in Italy: Results of a cross-sectional telephone survey on a representative sample of general population. Respir Med. 2018 Aug;141:144-149.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Respir Med. 2018 Aug;141:144-149 (via https://www.ncbi.nlm.nih.gov/pubmed/30053960)
OBJECTIVES: Influenza and Influenza-like syndromes (I-LSs) are very common events in general practice, and their relevance is frequently underestimated. Aim of the study was to assess the economic impact ...

Tapia R, García V, Mena J, Bucarey S, Medina. Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model. Vet Res. 2018 Jul 27;49(1):73..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Vet Res. 2018 Jul 27;49(1):73. (via https://www.ncbi.nlm.nih.gov/pubmed/30053826)
Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, ...

Diefenbacher M, Sun J, Brooke CB. The parts are greater than the whole: the role of semi-infectious particles in influenza A virus biology. Curr Opin Virol. 2018 Jul 24;33:42-46.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Curr Opin Virol. 2018 Jul 24;33:42-46 (via https://www.ncbi.nlm.nih.gov/pubmed/30053722)
The influenza A virus (IAV) genome is incorporated into newly produced virions through a tightly orchestrated process that is one of the best studied examples of genome packaging by a segmented virus. ...

Guo Z, Wilson JR, York IA, Stevens J. Biosensor-based epitope mapping of antibodies targeting the hemagglutinin and neuraminidase of influenza A virus. J Immunol Methods. 2018 Jul 24. pii: S0022-1759(17.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from J Immunol Methods. 2018 Jul 24. pii: S0022-1759(17 (via https://www.ncbi.nlm.nih.gov/pubmed/30053389)
Characterization of the epitopes on antigen recognized by monoclonal antibodies (mAb) is useful for the development of therapeutic antibodies, diagnostic tools, and vaccines. Epitope mapping also provides ...

Cocoros NM, etc.,al. Outpatient influenza antivirals in a distributed data network for influenza surveillance. Influenza Other Respir Viruses. 2018 Jul 27.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Influenza Other Respir Viruses. 2018 Jul 27 (via https://www.ncbi.nlm.nih.gov/pubmed/30053342)
Electronic data collected from routine healthcare can be used for public health surveillance. To examine the Sentinel System, a distributed data network of health plans, as a source for influenza surveillance, ...

Yogaratnam J, etc.,al. Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study. J Infect Dis. 2018 Jul 26..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from J Infect Dis. 2018 Jul 26. (via https://www.ncbi.nlm.nih.gov/pubmed/30053042)
Background: AL-794 is an orally active prodrug of ALS-033719, which selectively inhibits the endonuclease domain of influenza virus A and B polymerase.Methods: In a phase 1, double-blinded, randomized, ...

Machablishvili A, etc.,al. Overview of three influenza seasons in Georgia, 2014-2017. PLoS One. 2018 Jul 27;13(7):e0201207.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from PLoS One. 2018 Jul 27;13(7):e0201207 (via https://www.ncbi.nlm.nih.gov/pubmed/30052663)
BACKGROUND: Influenza epidemiological and virologic data from Georgia are limited. We aimed to present Influenza Like Illness (ILI) and Severe Acute Respiratory Infection (SARI) surveillance data and characterize ...

Szymański K, etc.,al. Infections with Influenza A/H3N2/ Subtype in Poland in the 2016/2017 Epidemic Season. Adv Exp Med Biol. 2018 Jul 27..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Adv Exp Med Biol. 2018 Jul 27. (via https://www.ncbi.nlm.nih.gov/pubmed/30051316)
The 2016/2017 epidemic season was characterized by a lower number of diagnostically tested samples of the nasal and throat swabs and bronchoalveolar lavage fluid, compared with the preceding season. The ...

Jasmina M. Luczo, etc.,al. Evolution of high pathogenicity of H5 avian influenza virus: haemagglutinin cleavage site selection of reverse-genetics mutants during passage in chickens. Scientific Reports volume 8, Article number: 1151.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Scientific Reports volume 8, Article number: 1151 (via https://www.nature.com/articles/s41598-018-29944-z)
Low pathogenicity avian influenza viruses (LPAIVs) are generally asymptomatic in their natural avian hosts. LPAIVs can evolve into highly pathogenic forms, which can affect avian and human populations ...

Kumar A, etc.,al. MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2. J Virol. 2018 Jul 25.  Abstract  
submitted by kickingbird at Jul, 29, 2018 from J Virol. 2018 Jul 25 (via https://www.ncbi.nlm.nih.gov/pubmed/30045983)
MicroRNAs (miRNAs) are small non-coding RNAs that are crucial post-transcriptional regulator for host mRNAs. Recent studies indicate that miRNAs may modulate host response during RNA viruses infection. ...

Nachbagauer R, Krammer F, Albrecht RA. A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study. Vaccines (Basel). 2018 Jul 25;6(3)..  Abstract  
submitted by kickingbird at Jul, 29, 2018 from Vaccines (Basel). 2018 Jul 25;6(3). (via https://www.ncbi.nlm.nih.gov/pubmed/30044403)
Influenza viruses cause severe diseases and mortality in humans on an annual basis. The current influenza virus vaccines can confer protection when they are well-matched with the circulating strains. However, ...

Patel U, etc.,al. Susceptibility of influenza viruses to hypothiocyanite and hypoiodite produced by lactoperoxidase in a cell-free system. PLoS One. 2018 Jul 25;13(7):e0199167..  Abstract  
submitted by kickingbird at Jul, 29, 2018 from PLoS One. 2018 Jul 25;13(7):e0199167. (via https://www.ncbi.nlm.nih.gov/pubmed/30044776)
Lactoperoxidase (LPO) is an enzyme found in several exocrine secretions including the airway surface liquid producing antimicrobial substances from mainly halide and pseudohalide substrates. Although the ...

Oishi K, Yamayoshi S, Kozuka-Hata H, Oyama M. N-Terminal Acetylation by NatB Is Required for the Shutoff Activity of Influenza A Virus PA-X. Cell Rep. 2018 Jul 24;24(4):851-860.  Abstract  
submitted by kickingbird at Jul, 29, 2018 from Cell Rep. 2018 Jul 24;24(4):851-860 (via https://www.ncbi.nlm.nih.gov/pubmed/30044982)
N-terminal acetylation is a major posttranslational modification in eukaryotes catalyzed by N-terminal acetyltransferases (NATs), NatA through NatF. Although N-terminal acetylation modulates diverse protein ...

Yip TF, Selim ASM, Lian I, Lee SM.. Advancements in Host-Based Interventions for Influenza Treatment. Front Immunol. 2018 Jul 10;9:1547..  Abstract  
submitted by kickingbird at Jul, 29, 2018 from Front Immunol. 2018 Jul 10;9:1547. (via https://www.ncbi.nlm.nih.gov/pubmed/30042762)
Influenza is a major acute respiratory infection that causes mortality and morbidity worldwide. Two classes of conventional antivirals, M2 ion channel blockers and neuraminidase inhibitors, are mainstays ...

Smith AP, Moquin DJ, Bernhauerova V, Smith AM.. Influenza Virus Infection Model With Density Dependence Supports Biphasic Viral Decay. Front Microbiol. 2018 Jul 10;9:1554..  Abstract  
submitted by kickingbird at Jul, 29, 2018 from Front Microbiol. 2018 Jul 10;9:1554. (via https://www.ncbi.nlm.nih.gov/pubmed/30042759)
Mathematical models that describe infection kinetics help elucidate the time scales, effectiveness, and mechanisms underlying viral growth and infection resolution. For influenza A virus (IAV) infections, ...

Chan MC, etc.,al. First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome. J Formos Med Assoc. 2018 Jul 3..  Abstract  
submitted by kickingbird at Jul, 29, 2018 from J Formos Med Assoc. 2018 Jul 3. (via https://www.ncbi.nlm.nih.gov/pubmed/30041997)
BACKGROUNDS: Severe influenza infection causes substantial morbidity and mortality worldwide and remains an important threat to global health. This study addressed factors related to treatment outcomes ...

Ho A, Mallewa J, etc.,al. Epidemiology of Severe Acute Respiratory Illness and Risk Factors for Influenza Infection and Clinical Severity among Adults in Malawi, 2011-2013. Am J Trop Med Hyg. 2018 Jul 23.  Abstract  
submitted by kickingbird at Jul, 29, 2018 from Am J Trop Med Hyg. 2018 Jul 23 (via https://www.ncbi.nlm.nih.gov/pubmed/30039785)
Data on the epidemiology of severe acute respiratory illness (SARI) in adults from low-income, high human immunodeficiency virus (HIV) prevalence African settings are scarce. We conducted adult SARI surveillance ...

Kühnl A, etc.,al. Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus. MBio. 2018 Jul 24;9(4). pii: e01345-18..  Abstract  
submitted by kickingbird at Jul, 29, 2018 from MBio. 2018 Jul 24;9(4). pii: e01345-18. (via https://www.ncbi.nlm.nih.gov/pubmed/30042202)
To transfer the viral genome into the host cell cytoplasm, internalized influenza A virus (IAV) particles depend on the fusion of the IAV envelope with host endosomal membranes. The antiviral host interferon ...

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