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Zhu W, et al. Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice. Emerg Microbes Infect. 2019;8(1):989-999..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Emerg Microbes Infect. 2019;8(1):989-999. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes ...

Bradley KC, et al. Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection. Cell Rep. 2019 Jul 2;28(1):245-256.e4.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Cell Rep. 2019 Jul 2;28(1):245-256.e4 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)307)
Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying mechanisms are unclear. ...

Li X, Gao Y, Ye Z. A Single Amino Acid Substitution at Residue 218 of Hemagglutinin Improves the Growth of Influenza A(H7N9) Candidate Vaccine Viruses. J Virol. 2019 Jul 3. pii: JVI.00570-19.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from J Virol. 2019 Jul 3. pii: JVI.00570-19 (via https://jvi.asm.org/content/early/2019/06/27/JVI.00570-19)
The potential avian influenza pandemic remains a threat to public health, as the avian-originated influenza A(H7N9) virus has caused more than 1560 laboratory-confirmed human infections since 2013, with ...

Choi WS. The National Influenza Surveillance System of Korea. Infect Chemother. 2019 Jun;51(2):98-106.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Infect Chemother. 2019 Jun;51(2):98-106 (via https://www.ncbi.nlm.nih.gov/pubmed/31270989)
Influenza is a very important respiratory infectious disease that causes seasonal epidemics and pandemics. A well-organized surveillance system is necessary to monitor and respond effectively to the epidemiologic ...

Cohen L, et al. A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls. Front Immunol. 2019 Jun 18.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Front Immunol. 2019 Jun 18 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0133)
Cytokines and chemokines are key signaling molecules of the immune system. Recent technological advances enable measurement of multiplexed cytokine profiles in biological samples. These profiles can then ...

Horwood PF, et al. Circulation and characterization of seasonal influenza viruses in Cambodia, 2012~2015. Influenza Other Respir Viruses. 2019 Jun 28..  Abstract  
submitted by kickingbird at Jul, 2, 2019 from Influenza Other Respir Viruses. 2019 Jun 28. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12647)
BACKGROUND: Influenza virus circulation is monitored through the Cambodian influenza-like illness (ILI) sentinel surveillance system and isolates are characterized by the National Influenza Centre (NIC). ...

Boumart Z, et al. Pathogenicity and Full Genome Sequencing of the Avian Influenza H9N2 Moroccan Isolate 2016. Avian Dis. 2018 Nov 16;63(1):24-30.  Abstract  
submitted by kickingbird at Jul, 2, 2019 from Avian Dis. 2018 Nov 16;63(1):24-30 (via https://bioone.org/journals/Avian-Diseases/volume-63/issue-1)
In Morocco in early 2016, a low pathogenic avian influenza virus serotype H9N2 caused large economic losses to the poultry industry, with specific clinical symptoms and high mortality rates on infected ...

Mu?oz-Aguayo J, et al. Environmental Sampling for Influenza A Viruses in Turkey Barns. Avian Dis. 2018 Nov 9;63(1):17-23.  Abstract  
submitted by kickingbird at Jul, 2, 2019 from Avian Dis. 2018 Nov 9;63(1):17-23 (via https://bioone.org/journals/Avian-Diseases/volume-63/issue-1)
We have examined a variety of sampling strategies for detecting pathogens in turkey flocks undergoing infections with low pathogenicity avian influenza virus (LPAIV). We found that viral RNA was widely ...

Guo F, et al. Adaptive Evolution of Human-Isolated H5Nx Avian Influenza A Viruses. Front Microbiol. 2019 Jun 12;10:1328.  Abstract  
submitted by kickingbird at Jul, 2, 2019 from Front Microbiol. 2019 Jun 12;10:1328 (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0132)
Avian influenza A viruses (AIVs) H5N1, first identified in 1996, are highly pathogenic in domestic poultry and continue to occasionally infect humans. In this study, we sought to identify genetic changes ...

Spackman E, et al. Clade 2.3.4.4 H5 North American Highly Pathogenic Avian Influenza Viruses Infect, but Do Not Cause Clinical Signs in, American Black Ducks (Anas rubripes).. Avian Dis. 2019 Jan 18;63(2):366-370.  Abstract  
submitted by kickingbird at Jul, 2, 2019 from Avian Dis. 2019 Jan 18;63(2):366-370 (via https://www.ncbi.nlm.nih.gov/pubmed/31251539)
Highly pathogenic avian influenza virus (HPAIV) from the goose/Guangdong/1996 clade 2.3.4.4 H5 lineage spread from Asia into North America in 2014, most likely by wild bird migrations. Although several ...

Chen X, Li C, Sun HT, Ma J, Qi Y, Qin SY. Prevalence of avian influenza viruses and their associated antibodies in wild birds in China: A systematic review and meta-analysis. Microb Pathog. 2019 Jun 26:103613.  Abstract  
submitted by kickingbird at Jul, 2, 2019 from Microb Pathog. 2019 Jun 26:103613 (via https://www.sciencedirect.com/science/article/pii/S088240101)
Avian influenza viruses (AIVs) in wild birds pose a pandemic threat to humans and to the poultry industry. To assess AIV and AIV antibody prevalence in wild birds in China, a systematic review and meta-analysis ...

He CQ, He M, He HB, Wang HM, Ding NZ. The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses. Transbound Emerg Dis. 2019 Jun 26.  Abstract  
submitted by kickingbird at Jun, 28, 2019 from Transbound Emerg Dis. 2019 Jun 26 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13282)
The 1918 Spanish flu virus has claimed more than 50 million lives. However, the mechanism of its high pathogenicity remains elusive; and the origin of the virus is controversial. The matrix (M) segment ...

Mine J, et al. Phylogeographic evidence for the inter-and intracontinental dissemination of avian influenza viruses via migration flyways. PLoS One. 2019 Jun 26;14(6):e0218506..  Abstract  
submitted by kickingbird at Jun, 28, 2019 from PLoS One. 2019 Jun 26;14(6):e0218506. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Genetically related highly pathogenic avian influenza viruses (HPAIVs) of H5N6 subtype caused outbreaks simultaneously in East Asia and Europe-geographically distinct regions-during winter 2017-2018. This ...

Zhuang Q, et al. Diversity and distribution of type A influenza viruses: an updated panorama analysis based on protein sequences. Virol J. 2019 Jun 26;16(1):85.  Abstract  
submitted by kickingbird at Jun, 28, 2019 from Virol J. 2019 Jun 26;16(1):85 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Type A influenza viruses (IAVs) cause significant infections in humans and multiple species of animals including pigs, horses, birds, dogs and some marine animals. They are of complicated phylogenetic ...

Sanz Fadrique R, et al. Guillain-Barré syndrome and influenza vaccines: current evidence. Rev Esp Quimioter. 2019 Jun 20..  Abstract  
submitted by kickingbird at Jun, 25, 2019 from Rev Esp Quimioter. 2019 Jun 20. (via https://www.ncbi.nlm.nih.gov/pubmed/31232571)
OBJECTIVE: Guillain-Barré Syndrome (GBS) as a consequence of influenza vaccination is a relevant topic, yet to be clarified, which raises concern both amongst health care personnel and the general population. ...

Leach S, et al. Requirement for memory B cell activation in protection from heterologous influenza virus reinfection. Int Immunol. 2019 Jun 20..  Abstract  
submitted by kickingbird at Jun, 25, 2019 from Int Immunol. 2019 Jun 20. (via https://academic.oup.com/intimm/advance-article-abstract/doi)
While two memory compartments, memory B cells and long-lived plasma cells, are thought to contribute to the successful establishment of memory recall responses, the unique roles of each cellular compartment ...

Yuan HT, et al. A rare case of influenza A (H3N2)-associated encephalitis with seizure. Am J Emerg Med. 2019 Jun 16..  Abstract  
submitted by kickingbird at Jun, 25, 2019 from Am J Emerg Med. 2019 Jun 16. (via https://www.ajemjournal.com/article/S0735-6757(19)30406-1/fu)
Influenza-associated acute encephalopathy (IAE) is more prevalent in children than in adults and often results in neurological sequelae or even death. Diagnosis of IAE is difficult as clinical presentation ...

Yan HX, Xu HF, He WJ, Xie Y, Dong GY.. Phylogenetic analysis of HA and NA genes of influenza H1N1 viruses from 1918 to 2017. Acta Virol. 2019;63(2):195-202..  Abstract  
submitted by kickingbird at Jun, 25, 2019 from Acta Virol. 2019;63(2):195-202. (via https://www.ncbi.nlm.nih.gov/pubmed/31230448)
The 1918 "Spanish" pandemic is the earliest known influenza H1N1 virus. Since then H1N1 viruses circulated between humans and animals continuously. With the increased amount of samples of H1N1 viruses ...

Ma MJ, et al. Characterization of antibody and memory T cell response in H7N9 survivors: A cross-sectional analysis. Clin Microbiol Infect. 2019 Jun 20.  Abstract  
submitted by kickingbird at Jun, 25, 2019 from Clin Microbiol Infect. 2019 Jun 20 (via https://www.clinicalmicrobiologyandinfection.com/article/S11)
OBJECTIVES: Despite the importance of immunological memory for protective immunity against viral infection, whether H7N9-specific antibodies and memory T-cell responses remain detectable years after the ...

Adams SE, et al. Effect of influenza H1N1 neuraminidase V116A and I117V mutations on NA activity and sensitivity to NA inhibitors. Antiviral Res. 2019 Jun 19:104539..  Abstract  
submitted by kickingbird at Jun, 24, 2019 from Antiviral Res. 2019 Jun 19:104539. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Neuraminidase inhibitors (NAIs) play a key role in the management of influenza. Given the limited number of FDA-approved anti-influenza drugs, evaluation of potential drug-resistant variants is of high ...

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