Fujioka Y, et al. A peptide derived from phosphoinositide 3-kinase inhibits endocytosis and influenza virus infection. Cell Struct Funct. 2019 Mar 21.. Abstract
submitted by kickingbird at Mar, 26, 2019 from Cell Struct Funct. 2019 Mar 21. (via https://www.jstage.jst.go.jp/article/csf/advpub/0/advpub_190)
Endocytosis mediates the internalization and ingestion of a variety of endogenous or exogenous substances, including virus particles, under the control of intracellular signaling pathways. We have previously ... Kannan S, Shankar R, Kolandaivel P. Insights into structural and inhibitory mechanisms of low pH-induced conformational change of influenza HA2 protein: a computational approach. J Mol Model. 2019 Mar 23;25(4):99. Abstract
submitted by kickingbird at Mar, 26, 2019 from J Mol Model. 2019 Mar 23;25(4):99 (via https://link.springer.com/article/10.1007%2Fs00894-019-3982-)
Though oseltamivir and zanamivir are the active anti-influenza drugs, the emergence of different strains of influenza A virus with mutations creates drug-resistance to these drugs. Therefore, it is essential ... Lindert K, Leav B, Heijnen E, Barrett J, Nicolay U. MF59-Adjuvanted Seasonal Trivalent Influenza Vaccine: Pooled Analysis of Safety in Older Adults ≥65 Years of Age. Int J Infect Dis. 2019 Mar 20.. Abstract
submitted by kickingbird at Mar, 26, 2019 from Int J Infect Dis. 2019 Mar 20. (via https://www.ijidonline.com/article/S1201-9712(19)30149-3/pdf)
OBJECTIVE: To assess the long-term safety of MF59-adjuvanted trivalent influenza vaccine (aIIV3; Fluad?) in adults ≥65 years of age.METHODS: Data from 36 primary vaccination and 7 re-vaccination Phase ... Akand EH, Downard KM. Mechanisms of Antiviral Resistance in Influenza Neuraminidase Revealed by a Mass Spectrometry Based Phylonumerics Approach. Mol Phylogenet Evol. 2019 Mar 20. Abstract
submitted by kickingbird at Mar, 26, 2019 from Mol Phylogenet Evol. 2019 Mar 20 (via https://www.sciencedirect.com/science/article/pii/S105579031)
A mass based phylonumerics approach is shown to be able to investigate the origins of the emergence of antiviral resistance mutations in influenza neuraminidase through a global view of mutational trends. ... Yamamoto Y, et al. Peptides with the multibasic cleavage site of the hemagglutinin from highly pathogenic influenza viruses act as cell-penetrating via binding to heparan sulfate and neuropilins. Biochem Biophys Res Commun. 2019 Mar 20. Abstract
submitted by kickingbird at Mar, 26, 2019 from Biochem Biophys Res Commun. 2019 Mar 20 (via https://www.sciencedirect.com/science/article/pii/S0006291X1)
Cell-penetrating peptides (CPPs) show promise as an attractive delivery vehicle for therapeutic molecules-including nucleic acids, peptides, proteins, and even particulates-into several cell types. It ... Jiang W, et al. Prevalence of H7N9 subtype avian influenza viruses in poultry in China, 2013-2018. Transbound Emerg Dis. 2019 Mar 23. Abstract
submitted by kickingbird at Mar, 26, 2019 from Transbound Emerg Dis. 2019 Mar 23 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13183)
H7N9 subtype avian influenza viruses (AIV) circulating in China over recent years have had an enormous impact on public health and economy. During the period between November 2016 and April 2017, an increase ... Cherdantseva LA, et al. Death Mechanisms of Pulmonary Alveolocytes in Mice Infected with Influenza Viruses A/H1N1/California/04/2009 and A/H5N1/Goose/Krasnoozerskoye/627/05. Bull Exp Biol Med. 2019 Mar 22. Abstract
submitted by kickingbird at Mar, 26, 2019 from Bull Exp Biol Med. 2019 Mar 22 (via https://link.springer.com/article/10.1007%2Fs10517-019-04408)
In CBA mice infected with influenza viruses A/H1N1/California/04/2009 and A/H5N1/Goose/Krasnoozerskoye/627/05 in a dose of 10 MLD50, the mechanisms of death of pulmonary alveolocytes over 10 postinfection ... Amarelle L, et al. Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 20. Abstract
submitted by kickingbird at Mar, 25, 2019 from Am J Physiol Lung Cell Mol Physiol. 2019 Mar 20 (via https://www.physiology.org/doi/abs/10.1152/ajplung.00173.201)
Cardiac glycosides (CG) are used primarily for cardiac failure and have been reported to have other effects, including inhibition of viral replication. Here we set out to study mechanisms by which CG as ... Puchades C, et al. Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS. Sci Rep. 2019 Mar 18;9(1):4735. Abstract
submitted by kickingbird at Mar, 25, 2019 from Sci Rep. 2019 Mar 18;9(1):4735 (via https://www.nature.com/articles/s41598-019-41179-0)
Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous ... Oishi K, Yamayoshi S, Kawaoka Y. Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity. Front Microbiol. 2019 Mar 6;10:432.. Abstract
submitted by kickingbird at Mar, 25, 2019 from Front Microbiol. 2019 Mar 6;10:432. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0043)
The influenza virus protein PA-X modulates the host immune responses and viral pathogenicity through suppression of host protein expression. The endonuclease active site in the N-terminal region, the basic ... Karunarathna HMTK, et al. Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections. Emerg Microbes Infect. 2019;8(1):404-412.. Abstract
submitted by kickingbird at Mar, 24, 2019 from Emerg Microbes Infect. 2019;8(1):404-412. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Haemagglutination inhibition (HAI) antibody titres are a correlate of protection for influenza virus infection, but several studies have also demonstrated the protective role of anti-neuraminidase (anti-NA) ... El Guerche-Séblain C, et al. Epidemiology and timing of seasonal influenza epidemics in the Asia-Pacific region, 2010-2017: implications for influenza vaccination programs. BMC Public Health. 2019 Mar 21;19(1):331. Abstract
submitted by kickingbird at Mar, 24, 2019 from BMC Public Health. 2019 Mar 21;19(1):331 (via https://bmcpublichealth.biomedcentral.com/articles/10.1186/s)
BACKGROUND: Description of the epidemiology of influenza is needed to inform influenza vaccination policy. Here we examined influenza virus circulation in countries in the Asia-Pacific region and compared ... Kumar P, et al. IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection. Sci Rep. 2019 Mar 21;9(1):4984. Abstract
submitted by kickingbird at Mar, 24, 2019 from Sci Rep. 2019 Mar 21;9(1):4984 (via https://www.nature.com/articles/s41598-019-41478-6)
Influenza virus targets epithelial cells in the upper respiratory tract. Natural Killer (NK) cell-mediated early innate defense responses to influenza infection include the killing of infected epithelial ... Niakan Kalhori SR, Ghazisaeedi M, Azizi R, et al. Studying the influence of mass media and environmental factors on influenza virus transmission in the US Midwest. Public Health. 2019 Mar 19;170:17-22. Abstract
submitted by kickingbird at Mar, 24, 2019 from Public Health. 2019 Mar 19;170:17-22 (via https://www.sciencedirect.com/science/article/pii/S003335061)
OBJECTIVES: Disease burden and high financial cost of seasonal influenza emphasize the importance of studying the epidemics transmission dynamics. Our aim in this article is to extend the Susceptible Exposed ... Zheng H, et al. Evolved avian influenza virus (H7N9) isolated from human cases in a middle Yangtze River city in China, from February to April 2017. Heliyon. 2019 Mar 7;5(3):e01253.. Abstract
submitted by kickingbird at Mar, 24, 2019 from Heliyon. 2019 Mar 7;5(3):e01253. (via https://www.heliyon.com/article/e01253)
Seven cases of avian influenza A H7N9 virus infection were reported from February to April 2017 in Changsha City. Viral genome was acquired by RT-PCR, aligned with other H7N9 viruses using Clustal W, and ... Gandhi-Banga S, et al. Enhanced passive safety surveillance of three marketed influenza vaccines in the UK and the Republic of Ireland during the 2017/18 season. Hum Vaccin Immunother. 2019 Mar 21.. Abstract
submitted by kickingbird at Mar, 23, 2019 from Hum Vaccin Immunother. 2019 Mar 21. (via https://www.ncbi.nlm.nih.gov/pubmed/30897026)
Safety surveillance is required for each season's influenza vaccines to rapidly detect and evaluate potential new safety concerns before the peak period of immunization. Here we report the results of an ... Wang Y, et al. Comparative Outcomes of Adults Hospitalized With Seasonal Influenza A or B Virus Infection: Application of the 7-Category Ordinal Scale. Open Forum Infect Dis. 2019 Feb 15;6(3):ofz053. Abstract
submitted by kickingbird at Mar, 23, 2019 from Open Forum Infect Dis. 2019 Feb 15;6(3):ofz053 (via https://academic.oup.com/ofid/article/6/3/ofz053/5320627)
Background: The objective of this study was to investigate the difference in disease severity between influenza A and B among hospitalized adults using a novel ordinal scale and existing clinical outcome ... Peng C, Hou G, Li J, Cheng S, Wang S, Yi Y,. Isolation and characterization of a novel H7N8 avian influenza virus from domestic ducks in Central China in 2017. Virus Genes. 2019 Mar 20. Abstract
submitted by kickingbird at Mar, 23, 2019 from Virus Genes. 2019 Mar 20 (via https://link.springer.com/article/10.1007%2Fs11262-018-01630)
In 2017, an H7N8 avian influenza virus (AIV) was isolated from a domestic duck from a farm in Central China. Sequences analysis showed that this strain received its genes from H7, H1, H2, H3, H5, and H6 ... Yasuhara A, et al. Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus. Nat Microbiol. 2019 Mar 18.. Abstract
submitted by kickingbird at Mar, 21, 2019 from Nat Microbiol. 2019 Mar 18. (via https://www.nature.com/articles/s41564-019-0401-1)
Influenza viruses possess two surface glycoproteins, haemagglutinin and neuraminidase (NA). Although haemagglutinin plays a major role as a protective antigen, immunity to NA also contributes to protection. ... Hajam IA, Kim J, Lee JH. Intranasally administered polyethylenimine adjuvanted influenza M2 ectodomain induces partial protection against H9N2 influenza A virus infection in chickens. Vet Immunol Immunopathol. 2019 Mar;209:78-83.. Abstract
submitted by kickingbird at Mar, 21, 2019 from Vet Immunol Immunopathol. 2019 Mar;209:78-83. (via https://www.sciencedirect.com/science/article/pii/S016524271)
This study aimed to investigate whether intranasally coadministered four tandem copies of extracellular domains of M2 (M2e) and polyethyleneimine (PEI), a mucosal adjuvant, can protect chickens against ... 7550 items, 20/Page, Page[162/378][|<<] [|<] [161] [162] [163] [164] [165] [166] [167] [168] [169] [170] [>|] [>>|] |
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