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Elhakim M, et al. Epidemiology of severe cases of influenza and other acute respiratory infections in the Eastern Mediterranean Region, July 2016 to June 2018. J Infect Public Health. 2019 Jul 4.  Abstract  
submitted by kickingbird at Jul, 12, 2019 from J Infect Public Health. 2019 Jul 4 (via https://www.ncbi.nlm.nih.gov/pubmed/31281105)
BACKGROUND: Influenza surveillance systems in the Eastern Mediterranean Region have been strengthened in the past few years and 16 of the 19 countries in the Region with functional influenza surveillance ...

Mei K, et al. Different Pathogenicity and Transmissibility of Goose-Origin H5N6 Avian Influenza Viruses in Chickens. Viruses. 2019 Jul 4;11(7)..  Abstract  
submitted by kickingbird at Jul, 10, 2019 from Viruses. 2019 Jul 4;11(7). (via https://www.mdpi.com/1999-4915/11/7/612)
Highly pathogenic avian influenza H5N6 viruses have been circulating in poultry in Asia since 2013 and producing serious diseases in chickens. Here, we analyzed the genetic properties of 10 H5N6 subtypes ...

Ding P, et al. A Universal Influenza Nanovaccine for "Mixing Vessel" Hosts Confers Potential Ability to Block Cross-Species Transmission. Adv Healthc Mater. 2019 Jul 3:e1900456..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Adv Healthc Mater. 2019 Jul 3:e1900456. (via https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.2019004)
Influenza A virus (IAV), a deadly zoonotic pathogen, poses a tremendous threat and burden to global health systems. Pigs act as "mixing vessel" hosts to support and generate new pandemic viruses. Preventing ...

Basch CH, Fera J, Garcia P. Readability of influenza information online: Implications for consumer health. Am J Infect Control. 2019 Jun 25.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Am J Infect Control. 2019 Jun 25 (via https://www.ajicjournal.org/article/S0196-6553(19)30461-4/fu)
BACKGROUND: Influenza (flu) is pervasive and burdensome. The purpose of this study was to determine the readability levels of online articles related to flu.METHODS: Using the search term "influenza," ...

To J, Torres J. Viroporins in the Influenza Virus. Cells. 2019 Jun 29;8(7)..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Cells. 2019 Jun 29;8(7). (via https://www.mdpi.com/2073-4409/8/7/654)
Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable pandemics. Four influenza virus types have been identified to date: A, B, C, and D, where only A-C are known to infect ...

Zhang K, et al. Structural basis for influenza virus NS1 protein block of mRNA nuclear export. Nat Microbiol. 2019 Jul 1..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Nat Microbiol. 2019 Jul 1. (via https://www.nature.com/articles/s41564-019-0482-x)
Influenza viruses antagonize key immune defence mechanisms via the virulence factor non-structural protein 1 (NS1). A key mechanism of virulence by NS1 is blocking nuclear export of host messenger RNAs, ...

Wang GL, Gray GC, Chen JM, Ma MJ. Will China´s H7N9 Control Strategy Continue to Be Effective?. Open Forum Infect Dis. 2019 May 31;6(6):ofz258.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Open Forum Infect Dis. 2019 May 31;6(6):ofz258 (via https://academic.oup.com/ofid/article/6/6/ofz258/5509882)
Since the first outbreak of avian influenza A(H7N9) virus in China in early 2013, several interventions to control the transmission of H7N9 virus from poultry to humans have been implemented. Temporarily ...

Watkins LC, Liang R, Swanson JMJ, DeGrado WF, Voth. Proton Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel. J Am Chem Soc. 2019 Jul 2..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from J Am Chem Soc. 2019 Jul 2. (via https://pubs.acs.org/doi/10.1021/jacs.9b05136)
The influenza A M2 protein is an acid-activated proton channel responsible for the acidification of the inside of the virus, a critical step in the viral life cycle. This channel has four central histidine ...

Zhou L, Li Q, Uyeki TM.. Estimated Incubation Period and Serial Interval for Human-to-Human Influenza A(H7N9) Virus Transmission. Emerg Infect Dis. 2019 Oct 17;25(10)..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Emerg Infect Dis. 2019 Oct 17;25(10). (via https://wwwnc.cdc.gov/eid/article/25/10/19-0117_article)
We estimated the incubation period and serial interval for human-to-human-transmitted avian influenza A(H7N9) virus infection using case-patient clusters from epidemics in China during 2013-2017. The median ...

Gomaa MR, et al. Development of an effective contemporary trivalent avian influenza vaccine against circulating H5N1, H5N8, and H9N2 in Egypt. Poult Sci. 2019 Jul 2..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Poult Sci. 2019 Jul 2. (via https://academic.oup.com/ps/advance-article-abstract/doi/10.)
Low pathogenicity avian influenza (LPAI) H9N2, highly pathogenic avian influenza (HPAI) H5N1, and H5N8 circulate in Egyptian poultry and cause veterinary and public health burdens. In response, AIV vaccines ...

Arai Y, et al. PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals. PLoS Pathog. 2019 Jul 2;15(7):e1007919..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from PLoS Pathog. 2019 Jul 2;15(7):e1007919. (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Avian influenza virus H9N2 has been endemic in birds in the Middle East, in particular in Egypt with multiple cases of human infections since 1998. Despite concerns about the pandemic threat posed by H9N2, ...

Tang J, et al. Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts. Virol J. 2019 Jul 2;16(1):87.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Virol J. 2019 Jul 2;16(1):87 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Human infection with avian influenza H7N9 virus was first reported in 2013. Since the fifth epidemic, a highly pathogenic avian influenza (HPAI) H7N9 virus has emerged and caused 33 human infections. ...

Coronel J, et al. Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systems. Vaccine. 2019 Jun 29. pii: S0264-410X(19)30764-9..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Vaccine. 2019 Jun 29. pii: S0264-410X(19)30764-9. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Driven by the concept of plug-and-play cell culture-based viral vaccine production using disposable bioreactors, we evaluated an orbital shaken bioreactor (OSB) for human influenza A virus production at ...

Saraiya N, Singh S, Corpuz M. Fatal influenza myocarditis with incessant ventricular tachycardia. BMJ Case Rep. 2019 Jul 1;12(7)..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from BMJ Case Rep. 2019 Jul 1;12(7). (via https://casereports.bmj.com/content/12/7/e228201)
Influenza myocarditis is an underappreciated and severe complication of influenza infection, estimated to be present in about 10% of all influenza cases. We present a case of a woman who precipitously ...

Zhu W, et al. Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice. Emerg Microbes Infect. 2019;8(1):989-999..  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Emerg Microbes Infect. 2019;8(1):989-999. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes ...

Bradley KC, et al. Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection. Cell Rep. 2019 Jul 2;28(1):245-256.e4.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Cell Rep. 2019 Jul 2;28(1):245-256.e4 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)307)
Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying mechanisms are unclear. ...

Li X, Gao Y, Ye Z. A Single Amino Acid Substitution at Residue 218 of Hemagglutinin Improves the Growth of Influenza A(H7N9) Candidate Vaccine Viruses. J Virol. 2019 Jul 3. pii: JVI.00570-19.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from J Virol. 2019 Jul 3. pii: JVI.00570-19 (via https://jvi.asm.org/content/early/2019/06/27/JVI.00570-19)
The potential avian influenza pandemic remains a threat to public health, as the avian-originated influenza A(H7N9) virus has caused more than 1560 laboratory-confirmed human infections since 2013, with ...

Choi WS. The National Influenza Surveillance System of Korea. Infect Chemother. 2019 Jun;51(2):98-106.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Infect Chemother. 2019 Jun;51(2):98-106 (via https://www.ncbi.nlm.nih.gov/pubmed/31270989)
Influenza is a very important respiratory infectious disease that causes seasonal epidemics and pandemics. A well-organized surveillance system is necessary to monitor and respond effectively to the epidemiologic ...

Cohen L, et al. A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls. Front Immunol. 2019 Jun 18.  Abstract  
submitted by kickingbird at Jul, 7, 2019 from Front Immunol. 2019 Jun 18 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0133)
Cytokines and chemokines are key signaling molecules of the immune system. Recent technological advances enable measurement of multiplexed cytokine profiles in biological samples. These profiles can then ...

Horwood PF, et al. Circulation and characterization of seasonal influenza viruses in Cambodia, 2012~2015. Influenza Other Respir Viruses. 2019 Jun 28..  Abstract  
submitted by kickingbird at Jul, 2, 2019 from Influenza Other Respir Viruses. 2019 Jun 28. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12647)
BACKGROUND: Influenza virus circulation is monitored through the Cambodian influenza-like illness (ILI) sentinel surveillance system and isolates are characterized by the National Influenza Centre (NIC). ...

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