Kiseleva I, Isakova-Sivak I, Stukova M, et al. A Phase 1 Randomized Placebo-Controlled Study to Assess the Safety, Immunogenicity and Genetic Stability of a New Potential Pandemic H7N9 Live Attenuated Influenza Vaccine in Healthy Adults. Vaccines (Basel). 2020;8(2):E296.. Abstract
submitted by kickingbird at Jun, 16, 2020 from Vaccines (Basel). 2020;8(2):E296. (via https://pubmed.ncbi.nlm.nih.gov/32532097/)
This study describes a double-blind randomized placebo-controlled phase I clinical trial in healthy adults of a new potential pandemic H7N9 live attenuated influenza vaccine (LAIV) based on the human influenza ...
Mosad SM, El-Gohary FA, Ali HS, El-Sharkawy H, Elm. Pathological and Molecular Characterization of H5 Avian Influenza Virus in Poultry Flocks From Egypt Over a Ten-Year Period (2009-2019). Animals (Basel). 2020;10(6):E1010. Abstract
submitted by kickingbird at Jun, 13, 2020 from Animals (Basel). 2020;10(6):E1010 (via https://pubmed.ncbi.nlm.nih.gov/32527004)
Avian influenza virus (AIV) remains one of the enzootic zoonotic diseases that challenges the poultry industry in Egypt. In the present study, a total of 500 tissue samples were collected from 100 chicken ...
Yang H, Carney PJ, Chang JC, Stevens J. Molecular Characterization and Three-Dimensional Structures of Avian H8, H11, H14, H15 and Swine H4 Influenza Virus Hemagglutinins. Heliyon. 2020;6(6):e04068.. Abstract
submitted by kickingbird at Jun, 13, 2020 from Heliyon. 2020;6(6):e04068. (via https://pubmed.ncbi.nlm.nih.gov/32529072)
Of the eighteen hemagglutinin (HA) subtypes (H1-H18) that have been identified in bats and aquatic birds, many HA subtypes have been structurally characterized. However, several subtypes (H8, H11 and H12) ...
Zhang T, Fan K, Zhang X, et al. Diversity of Avian Influenza A(H5N6) Viruses in Wild Birds in Southern China. J Gen Virol. 2020;10.1099/jgv.0.001449. Abstract
submitted by kickingbird at Jun, 11, 2020 from J Gen Virol. 2020;10.1099/jgv.0.001449 (via https://pubmed.ncbi.nlm.nih.gov/32519938)
The predominance of H5N6 in ducks and continuous human cases have heightened its potential threat to public health in China. Therefore, the detection of emerging variants of H5N6 avian influenza viruses ...
Leong NKC, Chu DKW, Chu JTS, et al. A Six-Plex Droplet Digital RT-PCR Assay for Seasonal Influenza Virus Typing, Subtyping, and Lineage Determination. Influenza Other Respir Viruses. 2020;10.1111/irv.1. Abstract
submitted by kickingbird at Jun, 11, 2020 from Influenza Other Respir Viruses. 2020;10.1111/irv.1 (via https://pubmed.ncbi.nlm.nih.gov/32519796)
Background: There are two influenza A subtypes (H1 and H3) and two influenza B lineages (Victoria and Yamagata) that currently co-circulate in humans. In this study, we report the development of a six-plex ...
Abd Raman HS, Tan S, August JT, Khan AM. Dynamics of Influenza A (H5N1) Virus Protein Sequence Diversity. PeerJ. 2020;7:e7954. Abstract
submitted by kickingbird at Jun, 11, 2020 from PeerJ. 2020;7:e7954 (via https://pubmed.ncbi.nlm.nih.gov/32518710)
Background: Influenza A (H5N1) virus is a global concern with potential as a pandemic threat. High sequence variability of influenza A viruses is a major challenge for effective vaccine design. A continuing ...
Li Y, Edwards J, Huang B, et al. Risk of Zoonotic Transmission of Swine Influenza at the Human-Pig Interface in Guangdong Province, China. Zoonoses Public Health. 2020;10.1111/zph.12723. Abstract
submitted by kickingbird at Jun, 9, 2020 from Zoonoses Public Health. 2020;10.1111/zph.12723
A cross-sectional survey was conducted from 2015 to 2018 to assess the risk of zoonotic influenza to humans at the human-pig interface in Guangdong Province, south China. One hundred and fifty-three pig ...
Zhou BX, Li J, Liang XL, et al. β-Sitosterol Ameliorates Influenza A Virus-Induced Proinflammatory Response and Acute Lung Injury in Mice by Disrupting the Cross-Talk Between RIG-I and IFN/STAT Signaling. Acta Pharmacol Sin. 2020;10.1038/s41401-020-0403-9. Abstract
submitted by kickingbird at Jun, 8, 2020 from Acta Pharmacol Sin. 2020;10.1038/s41401-020-0403-9 (via https://pubmed.ncbi.nlm.nih.gov/32504068)
β-Sitosterol (24-ethyl-5-cholestene-3-ol) is a common phytosterol Chinese medical plants that has been shown to possess antioxidant and anti-inflammatory activity. In this study we investigated the effects ...
Morales KF, Menning L, Lambach P. The Faces of Influenza Vaccine Recommendation: A Literature Review of the Determinants and Barriers to Health Providers´ Recommendation of Influenza Vaccine in Pregnancy. Vaccine. 2020;S0264-410X(20)30513-2.. Abstract
submitted by kickingbird at Jun, 5, 2020 from Vaccine. 2020;S0264-410X(20)30513-2. (via https://pubmed.ncbi.nlm.nih.gov/32499068)
Introduction: WHO recommends influenza vaccination for pregnant women and health providers (HPs), yet global uptake for both is persistently low. Research suggests that HPs greatly influence uptake of ...
Loeb N, Andrew MK, Loeb M, et al. Frailty Is Associated With Increased Hemagglutination-Inhibition Titers in a 4-Year Randomized Trial Comparing Standard- And High-Dose Influenza Vaccination. Open Forum Infect Dis. 2020;7(5):ofaa148.. Abstract
submitted by kickingbird at Jun, 5, 2020 from Open Forum Infect Dis. 2020;7(5):ofaa148. (via https://pubmed.ncbi.nlm.nih.gov/32500087)
Background: Although high-dose (HD) vaccines have been reported to stimulate higher antibody responses compared with standard-dose (SD) influenza vaccines, there have been limited studies on the impact ...
Shin DL, Yang W, Peng JY, et al. Avian Influenza A Virus Infects Swine Airway Epithelial Cells Without Prior Adaptation. Viruses. 2020;12(6):E589. Published 2020 May 28. Abstract
submitted by kickingbird at Jun, 3, 2020 from Viruses. 2020;12(6):E589. Published 2020 May 28 (via https://pubmed.ncbi.nlm.nih.gov/32481674)
Pigs play an important role in the interspecies transmission of influenza A viruses (IAV). The porcine airway epithelium contains binding sites for both swine/human IAV (α2,6-linked sialic acids) and avian ...
Pawestri HA, Nugraha AA, Han AX, et al. Genetic and Antigenic Characterization of Influenza A/H5N1 Viruses Isolated From Patients in Indonesia, 2008-2015. Virus Genes. 2020;10.1007/s11262-020-01765-1. Abstract
submitted by kickingbird at Jun, 3, 2020 from Virus Genes. 2020;10.1007/s11262-020-01765-1 (via https://pubmed.ncbi.nlm.nih.gov/32483655)
Since the initial detection in 2003, Indonesia has reported 200 human cases of highly pathogenic avian influenza H5N1 (HPAI H5N1), associated with an exceptionally high case fatality rate (84%) compared ...
Jallow MM, Fall A, Barry MA, et al. Genetic Characterization of the First Detected Human Case of Low Pathogenic Avian Influenza A/H9N2 in sub-Saharan Africa, Senegal. Emerg Microbes Infect. 2020;9(1):1092‐1095. Abstract
submitted by kickingbird at Jun, 2, 2020 from Emerg Microbes Infect. 2020;9(1):1092‐1095 (via https://pubmed.ncbi.nlm.nih.gov/32471335)
The H9N2 influenza virus has become one of the dominant subtypes of influenza virus circulating in poultry, wild birds, and can occasionally cross the mammalian species barrier. Here, we report the first ...
Germeraad EA, Elbers ARW, de Bruijn ND, et al. Detection of Low Pathogenic Avian Influenza Virus Subtype H10N7 in Poultry and Environmental Water Samples During a Clinical Outbreak in Commercial Free-Range Layers, Netherlands 2017. Front Vet Sci. 2020;7:237. Published 2020 May 5. Abstract
submitted by kickingbird at Jun, 2, 2020 from Front Vet Sci. 2020;7:237. Published 2020 May 5 (via https://pubmed.ncbi.nlm.nih.gov/32478107)
Wild birds are the natural reservoir of the avian influenza virus (AIV) and may transmit AIV to poultry via direct contact or indirectly through the environment. In the Netherlands, a clinically suspected ...
Belser JA, Sun X, Brock N, et al. Mammalian Pathogenicity and Transmissibility of Low Pathogenic Avian Influenza H7N1 and H7N3 Viruses Isolated From North America in 2018. Emerg Microbes Infect. 2020;9(1):1037‐1045. Abstract
submitted by kickingbird at May, 27, 2020 from Emerg Microbes Infect. 2020;9(1):1037‐1045 (via https://pubmed.ncbi.nlm.nih.gov/32449503)
ABSTRACTLow pathogenic avian influenza (LPAI) H7 subtype viruses are infrequently, but persistently, associated with outbreaks in poultry in North America. These LPAI outbreaks provide opportunities for ...
Li YH, Hu CY, Cheng LF, et al. Highly Pathogenic H7N9 Avian Influenza Virus Infection Associated With Up-Regulation of PD-1/PD-Ls Pathway-Related Molecules. Int Immunopharmacol. 2020;85:106558. Abstract
submitted by kickingbird at May, 27, 2020 from Int Immunopharmacol. 2020;85:106558 (via https://pubmed.ncbi.nlm.nih.gov/32450532)
To investigate the main transcriptional and biological changes of human host during low and highly pathogenic avian H7N9 influenza virus infection and to analyze the possible causes of escalated virulence ...
Li L, Dai H, Nguyen AP, Hai R, Gu W. Influenza A Virus Utilizes Non-Canonical Cap-Snatching to Diversify Its mRNA/ncRNA. RNA. 2020;rna.073866.119.. Abstract
submitted by kickingbird at May, 25, 2020 from RNA. 2020;rna.073866.119. (via https://pubmed.ncbi.nlm.nih.gov/32444459)
Influenza A virus (IAV) utilizes cap-snatching to obtain host capped small RNAs for priming viral mRNA synthesis, generating capped hybrid mRNAs for translation. Previous studies have been focusing on ...
Chen Y, Cheng J, Xu Z, Hu W, Lu J. Live Poultry Market Closure and Avian Influenza A (H7N9) Infection in Cities of China, 2013-2017: An Ecological Study. BMC Infect Dis. 2020;20(1):369. Abstract
submitted by kickingbird at May, 25, 2020 from BMC Infect Dis. 2020;20(1):369 (via https://pubmed.ncbi.nlm.nih.gov/32448137)
Background: Previous studies have proven that the closure of live poultry markets (LPMs) was an effective intervention to reduce human risk of avian influenza A (H7N9) infection, but evidence is limited ...
Fukuyama S, Iwatsuki-Horimoto K, Kiso M, et al. Pathogenesis of Influenza A(H7N9) Virus in Aged Non-Human Primates. J Infect Dis. 2020;jiaa267. Abstract
submitted by kickingbird at May, 23, 2020 from J Infect Dis. 2020;jiaa267 (via https://pubmed.ncbi.nlm.nih.gov/32433769)
The avian influenza A(H7N9) virus has caused high mortality in humans, especially in the elderly; however, little is known about the mechanistic basis for this. In this study, we employed non-human primates ...
Sch?n J, Ran W, Gorka M, Schwemmle M, Beer M, Hoff. A Modified Live Bat Influenza A Virus-Based Vaccine Prototype Provides Full Protection Against HPAIV H5N1. NPJ Vaccines. 2020;5:40. Abstract
submitted by kickingbird at May, 23, 2020 from NPJ Vaccines. 2020;5:40 (via https://pubmed.ncbi.nlm.nih.gov/32435514)
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5 are a major threat for poultry holdings worldwide, here especially the zoonotic Asian H5N1 viruses. These HPAIVs have caused more than 500 ...
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