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2019-11-23 1:26:26
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Calderon BM, et al. Dysregulation of M segment gene expression contributes to influenza A virus host restriction. PLoS Pathog. 2019 Aug 15;15(8):e1007892.  Abstract  
submitted by kickingbird at Aug, 18, 2019 from PLoS Pathog. 2019 Aug 15;15(8):e1007892 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations. To elucidate the genetic contributions of the M segment to host adaptation, and the ...

Liu YM, et al. Exosome-delivered and Y RNA-derived small RNA suppresses influenza virus replication. J Biomed Sci. 2019 Aug 15;26(1):58.  Abstract  
submitted by kickingbird at Aug, 18, 2019 from J Biomed Sci. 2019 Aug 15;26(1):58 (via https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929)
BACKGROUND: Multiple interplays between viral and host factors are involved in influenza virus replication and pathogenesis. Several small RNAs have recently emerged as important regulators of host response ...

Zheng S, et al. Factors associated with fatality due to avian influenza A(H7N9) infection in China. Clin Infect Dis. 2019 Aug 16.  Abstract  
submitted by kickingbird at Aug, 18, 2019 from Clin Infect Dis. 2019 Aug 16 (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: The high case fatality rate of influenza A H7N9 infected patients has been a major clinical concern.METHODS: To identify the common causes of death due to H7N9 as well as identify risk factors ...

Gou X, Wu X, Shi Y, Zhang K, Huang J. A systematic review and meta-analysis of cross-reactivity of antibodies induced by H7 influenza vaccine. Hum Vaccin Immunother. 2019 Aug 16.  Abstract  
submitted by kickingbird at Aug, 18, 2019 from Hum Vaccin Immunother. 2019 Aug 16 (via https://www.tandfonline.com/doi/abs/10.1080/21645515.2019.16)
Inoculation with vaccine is the major intervention currently used to prevent influenza infections. However, it will be a challenge to produce and implement a new vaccine when a novel highly pathogenic ...

Wan H, et al. The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain. Nat Microbiol. 2019 Aug 12..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Nat Microbiol. 2019 Aug 12. (via https://www.nature.com/articles/s41564-019-0522-6)
A(H3N2) virus predominated recent influenza seasons, which has resulted in the rigorous investigation of haemagglutinin, but whether neuraminidase (NA) has undergone antigenic change and contributed to ...

Eom G, et al. Diagnosis of Tamiflu-Resistant Influenza Virus in Human Nasal Fluid and Saliva using Surface-enhanced Raman Scattering. ACS Sens. 2019 Aug 13..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from ACS Sens. 2019 Aug 13. (via https://pubs.acs.org/doi/10.1021/acssensors.9b00697)
Influenza viruses cause respiratory infection, spread through respiratory secretions and are shed into the nasal secretion and saliva specimens. Therefore, nasal fluid and saliva are effective clinical ...

Ang JC, et al. Comparative Immunogenicity of the 2014-2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children. Vaccines (Basel). 2019 Aug 12;7(3)..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Vaccines (Basel). 2019 Aug 12;7(3). (via https://www.mdpi.com/2076-393X/7/3/87)
Both inactivated influenza vaccines (IIV) and live-attenuated influenza vaccines (LAIV) have been recommended for administration to children. Children are a high-risk group for severe influenza, and a ...

Zhao Y, et al. Airborne transmission may have played a role in the spread of 2015 highly pathogenic avian influenza outbreaks in the United States. Sci Rep. 2019 Aug 13;9(1):11755..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Sci Rep. 2019 Aug 13;9(1):11755. (via https://www.nature.com/articles/s41598-019-47788-z)
The unprecedented 2015 outbreaks of highly pathogenic avian influenza (HPAI) H5N2 in the U.S. devastated its poultry industry and resulted in over $3 billion economic impacts. Today HPAI continues eroding ...

Biuso F, et al. Use of lentiviral pseudotypes as an alternative to reassortant or Triton X-100-treated wild-type Influenza viruses in the neuraminidase inhibition enzyme-linked lectin assay. Influenza Other Respir Viruses. 2019 Sep;13(5):504.  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Influenza Other Respir Viruses. 2019 Sep;13(5):504 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12669)
BACKGROUND: Formulation of neuraminidase (NA) within influenza vaccines is gaining importance in light of recent human studies. The enzyme-linked lectin assay (ELLA) is considered a reliable assay to evaluate ...

Zhao P, et al. Semiaquatic mammals might be intermediate hosts to spread avian influenza viruses from avian to human. Sci Rep. 2019 Aug 12;9(1):11641.  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Sci Rep. 2019 Aug 12;9(1):11641 (via https://www.nature.com/articles/s41598-019-48255-5)
Avian influenza A viruses (AIVs) can occasionally transmit to mammals and lead to the development of human pandemic. A species of mammal is considered as a mixing vessel in the process of host adaptation. ...

Hideshima S, et al. Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles. Sci Rep. 2019 Aug 12;9(1):11616.  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Sci Rep. 2019 Aug 12;9(1):11616 (via https://www.nature.com/articles/s41598-019-48076-6)
Pandemic influenza, triggered by the mutation of a highly pathogenic avian influenza virus (IFV), has caused considerable damage to public health. In order to identify such pandemic IFVs, antibodies that ...

Dumm RE, Heaton NS. The Development and Use of Reporter Influenza B Viruses. Viruses. 2019 Aug 9;11(8)..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Viruses. 2019 Aug 9;11(8). (via https://www.mdpi.com/1999-4915/11/8/736)
Influenza B viruses (IBVs) are major contributors to total human influenza disease, responsible for ~1/3 of all infections. These viruses, however, are relatively less studied than the related influenza ...

De Vlugt C, Sikora D, Rocheleau L, Pelchat M. Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA. Virology. 2019 Aug 2;536:91-100..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Virology. 2019 Aug 2;536:91-100. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Initiation of influenza A virus (IAV) transcription depends on RNA primers derived from host RNAs. During this process, some primers are elongated by a few nucleotides, realigned on the viral RNA templates ...

Lai CC, et al. Evaluation of novel disposable bioreactors on pandemic influenza virus production. PLoS One. 2019 Aug 12;14(8):e0220803..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from PLoS One. 2019 Aug 12;14(8):e0220803. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Since 1997, the highly pathogenic influenza H5N1 virus has spread from Hong Kong. According to the WHO bulletin report, the H5N1 virus is a zoonotic disease threat that has infected more than 850 humans, ...

Xiong J, Zhao P, Yang P, Yan Q, Jiang L. Evolutionary dynamics of the H7N9 avian influenza virus based on large-scale sequence analysis. PLoS One. 2019 Aug 12;14(8):e0220249..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from PLoS One. 2019 Aug 12;14(8):e0220249. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Since 2013, epidemics caused by novel H7N9 avian influenza A viruses (AIVs) have become a considerable public health issue. This study investigated the evolution of these viruses at the population level. ...

Khan S, et al. Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes. J Vis Exp. 2019 Jul 26;(149)..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from J Vis Exp. 2019 Jul 26;(149). (via https://www.jove.com/video/59973/use-an-influenza-antigen-mi)
The influenza virus remains a significant cause of mortality worldwide due to the limited effectiveness of currently available vaccines. A key challenge to the development of universal influenza vaccines ...

Li X, et al. Characterization of avian influenza H5N3 reassortants isolated from migratory waterfowl and domestic ducks in China from 2015 to 2018. Transbound Emerg Dis. 2019 Aug 11..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Transbound Emerg Dis. 2019 Aug 11. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13324)
Wild and domestic aquatic birds are the natural reservoirs of avian influenza viruses (AIVs). All subtypes of AIVs, including 16 hemagglutinin (HA) and nine neuraminidase (NA), have been isolated from ...

Trost JF, et al. A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity. Virology. 2019 Aug 6;536:78-90..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Virology. 2019 Aug 6;536:78-90. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A viruses enter host cells through the endocytic pathway, where acidification triggers conformational changes of the viral hemagglutinin (HA) to drive membrane fusion. During this process, the ...

Gouma S, Weirick M, Hensley SE. Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine. Clin Infect Dis. 2019 Aug 11..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Clin Infect Dis. 2019 Aug 11. (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. ...

Ge Y, et al. The evolution and characterization of influenza A(H7N9) virus under the selective pressure of peramivir. Virology. 2019 Aug 6;536:58-67..  Abstract  
submitted by kickingbird at Aug, 15, 2019 from Virology. 2019 Aug 6;536:58-67. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Human infection with H7N9 virus has provoked global public health concern due to the substantial morbidity and mortality. Neuraminidase inhibitors (NAIs) are used as first-line drugs to treat the infection. ...

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