Hussain S, et al. Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses. J Virol. 2018 Oct 31.. Abstract
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31. (via https://www.ncbi.nlm.nih.gov/pubmed/30381488)
The PA-X protein of influenza A virus has roles in host cell shut-off and viral pathogenesis. While most strains are predicted to encode PA-X, strain-dependent variations in activity have been noted. We ...
Houser KV, et al. DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial. PLoS One. 2018 Nov 2;13(11):e0206837. Abstract
submitted by kickingbird at Nov, 3, 2018 from PLoS One. 2018 Nov 2;13(11):e0206837 (via https://www.ncbi.nlm.nih.gov/pubmed/30388160)
BACKGROUND: Children are susceptible to severe influenza infections and facilitate community transmission. One potential strategy to improve vaccine immunogenicity in children against seasonal influenza ...
Zeller MA, et al. ISU FLUture: a veterinary diagnostic laboratory web-based platform to monitor the temporal genetic patterns of Influenza A virus in swine. BMC Bioinformatics. 2018 Nov 1;19(1):397. Abstract
submitted by kickingbird at Nov, 3, 2018 from BMC Bioinformatics. 2018 Nov 1;19(1):397 (via https://www.ncbi.nlm.nih.gov/pubmed/30382842)
BACKGROUND: Influenza A Virus (IAV) causes respiratory disease in swine and is a zoonotic pathogen. Uncontrolled IAV in swine herds not only affects animal health, it also impacts production through increased ...
Liu XX, et al. Effects of air pollutants on occurrences of influenza-like illness and laboratory-confirmed influenza in Hefei, China. Int J Biometeorol. 2018 Oct 31. Abstract
submitted by kickingbird at Nov, 3, 2018 from Int J Biometeorol. 2018 Oct 31 (via https://www.ncbi.nlm.nih.gov/pubmed/30382350)
Accumulating evidence suggests that air pollution is a risk factor for adverse respiratory and cardiovascular health outcomes. However, the different impacts of exposure to air pollutants on influenza ...
Kandeil A, et al. Isolation and characterization of a distinct influenza A virus from Egyptian bats. J Virol. 2018 Oct 31.. Abstract
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31. (via https://www.ncbi.nlm.nih.gov/pubmed/30381492)
Recently, two genetically distinct influenza viruses were detected in bats in Guatemala and Peru. We conducted influenza A surveillance among four bat species in Egypt. Out of 1202 swabs, 105 were positive ...
Saito S, Nakauchi M, Takayama I, Nagata S, et al. Development and evaluation of new real-time RT-PCR assays for identifying the influenza A virus Cluster IV H3N2 variant. Jpn J Infect Dis. 2018 Oct 31. Abstract
submitted by kickingbird at Nov, 3, 2018 from Jpn J Infect Dis. 2018 Oct 31 (via https://www.ncbi.nlm.nih.gov/pubmed/30381693)
From 2005 to July 6, 2018, a total of 435 swine-origin influenza A H3N2 variant virus (H3N2v) human infections were reported in the USA. The largest H3N2v outbreak in the USA occurred in 2011-2012. This ...
Insel M, Natt B, Mosier J, Malo J, Bime C. The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis. Respir Care. 2018 Oct 30. Abstract
submitted by kickingbird at Nov, 3, 2018 from Respir Care. 2018 Oct 30 (via https://www.ncbi.nlm.nih.gov/pubmed/30377246)
BACKGROUND: The 2009 H1N1 influenza epidemic saw a rise in the use of extracorporeal membrane oxygenation (ECMO) as a supportive therapy for refractory ARDS. We sought to determine whether ECMO utilization ...
Murakami S, Horimoto T. Novel type D influenza virus. Uirusu. 2017;67(2):161-170. Abstract
submitted by kickingbird at Oct, 31, 2018 from Uirusu. 2017;67(2):161-170 (via https://www.ncbi.nlm.nih.gov/pubmed/30369540)
Influenza viruses have been known to be types A to C, including human seasonal influenza virus and avian influenza virus. In recent years, the influenza D virus, which possesses different characteristics ...
Wille M, Br?jer C, Lundkvist ?, J?rhult JD. Alternate routes of influenza A virus infection in Mallard (Anas platyrhynchos). Vet Res. 2018 Oct 29;49(1):110. Abstract
submitted by kickingbird at Oct, 31, 2018 from Vet Res. 2018 Oct 29;49(1):110 (via https://www.ncbi.nlm.nih.gov/pubmed/30373662)
The natural reservoir for all influenza A viruses (IAVs) is wild birds, particularly dabbling ducks. During the autumn, viral prevalence can be very high in dabbling ducks (>?30%) in the Northern Hemisphere, ...
Jochems SP, et al. Inflammation induced by influenza virus impairs human innate immune control of pneumococcus. Nat Immunol. 2018 Oct 29. Abstract
submitted by kickingbird at Oct, 31, 2018 from Nat Immunol. 2018 Oct 29 (via https://www.ncbi.nlm.nih.gov/pubmed/30374129)
Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus ...
Beshara R, et al. Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection. PLoS Pathog. 2018 Oct 29;14(10):e1007360.. Abstract
submitted by kickingbird at Oct, 31, 2018 from PLoS Pathog. 2018 Oct 29;14(10):e1007360. (via https://www.ncbi.nlm.nih.gov/pubmed/30372491)
Secondary bacterial infections contribute to the excess morbidity and mortality of influenza A virus (IAV) infection. Disruption of lung integrity and impaired antibacterial immunity during IAV infection ...
Benam KH, Denney L, Ho LP. How the Respiratory Epithelium Senses and Reacts to Influenza Virus. Am J Respir Cell Mol Biol. 2018 Oct 29.. Abstract
submitted by kickingbird at Oct, 31, 2018 from Am J Respir Cell Mol Biol. 2018 Oct 29. (via https://www.ncbi.nlm.nih.gov/pubmed/30372120)
Our lungs are constantly exposed to the environment and potential pathogens. As the interface between host and environment, the respiratory epithelium has evolved sophisticated sensing mechanisms as part ...
Li C, et al. Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production. Front Immunol. 2018 Oct 12;9:2370.. Abstract
submitted by kickingbird at Oct, 31, 2018 from Front Immunol. 2018 Oct 12;9:2370. (via https://www.ncbi.nlm.nih.gov/pubmed/30369932)
Current influenza vaccines have relatively low effectiveness, especially against antigenically drifted strains, the effectiveness is even lower in the elderly and immunosuppressed individuals. We have ...
van der Lubbe JEM, et al. Mini-HA Is Superior to Full Length Hemagglutinin Immunization in Inducing Stem-Specific Antibodies and Protection Against Group 1 Influenza Virus Challenges in Mice. Front Immunol. 2018 Oct 12;9:2350. Abstract
submitted by kickingbird at Oct, 31, 2018 from Front Immunol. 2018 Oct 12;9:2350 (via https://www.frontiersin.org/articles/10.3389/fimmu.2018.0235)
Seasonal influenza vaccines are updated almost annually to match the antigenic drift in influenza hemagglutinin (HA) surface glycoprotein. A new HA stem-based antigen, the so-called "mini-HA," was recently ...
Wei X, Cui J. Why were so few people infected with H7N9 influenza A viruses in China from late 2017 to 2018?. Sci China Life Sci. 2018 Oct 23. Abstract
submitted by kickingbird at Oct, 30, 2018 from Sci China Life Sci. 2018 Oct 23 (via https://link.springer.com/article/10.1007%2Fs11427-018-9406-)
Since the first human infection case with H7N9 avian influenzavirus(AIVs)wasidentifiedinMarch2013,therehas six viral outbreak waves recorded in China as of September 2018. In total, there have been 1,567 ...
Yegani S, Shoushtari AH, Eshratabadi F, Molouki A. Full sequence analysis of hemagglutinin and neuraminidase genes and proteins of highly pathogenic avian influenza H5N1 virus detected in Iran, 2015. Trop Anim Health Prod. 2018 Oct 27.. Abstract
submitted by kickingbird at Oct, 29, 2018 from Trop Anim Health Prod. 2018 Oct 27. (via https://www.ncbi.nlm.nih.gov/pubmed/30368763)
Over the last two decades, the highly pathogenic avian influenza H5N1 virus has gained a lot of attention due to its zoonotic and mutative nature. Iran is among the countries significantly affected by ...
Deka H, Nath D, Uddin A, Chakraborty S. DNA compositional dynamics and codon usage patterns of M1 and M2 matrix protein genes in influenza A virus. Infect Genet Evol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 29, 2018 from Infect Genet Evol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30367980)
Influenza A virus subtype H3N2 has been a serious health issue across the globe with approximately 36 thousand annual casualties in the United States of America only. Co-circulation in avian, swine and ...
Fukuta H, Goto T, Wakami K, Kamiya T, Ohte N. The effect of influenza vaccination on mortality and hospitalization in patients with heart failure: a systematic review and meta-analysis. Heart Fail Rev. 2018 Oct 26.. Abstract
submitted by kickingbird at Oct, 29, 2018 from Heart Fail Rev. 2018 Oct 26. (via https://www.ncbi.nlm.nih.gov/pubmed/30367316)
Influenza infection is associated with increased risk for mortality and hospitalization in heart failure patients. Although there are no published randomized controlled trials examining the effect of influenza ...
Harland KL, et al. Limited Phenotypic and Functional Plasticity of Influenza Virus-Specific Memory CD8+ T Cells during Activation in an Alternative Cytokine Environment. J Immunol. 2018 Oct 26. Abstract
submitted by kickingbird at Oct, 29, 2018 from J Immunol. 2018 Oct 26 (via https://www.ncbi.nlm.nih.gov/pubmed/30366957)
Naive CD8+ T cells show phenotypic, functional, and epigenetic plasticity, enabling differentiation into distinct cellular states. However, whether memory CD8+ T cells demonstrate similar flexibility upon ...
Korenkov D, Isakova-Sivak I, Rudenko L. Basics of CD8 T-cell immune responses after influenza infection and vaccination with inactivated or live attenuated influenza vaccine. Expert Rev Vaccines. 2018 Oct 26. Abstract
submitted by kickingbird at Oct, 29, 2018 from Expert Rev Vaccines. 2018 Oct 26 (via https://www.ncbi.nlm.nih.gov/pubmed/30365908)
Numerous effector reactions are involved in antiviral immunity. The antibody and T-cell-mediated reactions are the best-understood processes of the adaptive immune response against influenza virus. One ...
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