Liu Y, Wang Y, Liu B, Cong X, Ji Y, Guo X, Gao Y. Phylogenetic analysis and clinical characteristics of the co-occurring mutations in HA and NA genes of influenza A(H1N1)pdm09 viruses during 2015-2017 in Beijing, China. Virol J. 2020 Nov 19;17(1):182.. Abstract
submitted by kickingbird at Nov, 22, 2020 from Virol J. 2020 Nov 19;17(1):182. (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Influenza A(H1N1)pdm09 viruses have undergone rapid evolution, and in recent years the complementary and antagonistic effects of HA and NA have gathered more attentions; however, the effects ...
Melidou A, Pereyaslov D, Hungnes O, Prosenc K, Alm. Virological surveillance of influenza viruses in the WHO European Region in 2019/20 - impact of the COVID-19 pandemic. Euro Surveill. 2020 Nov;25(46). Abstract
submitted by kickingbird at Nov, 22, 2020 from Euro Surveill. 2020 Nov;25(46) (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
The COVID-19 pandemic negatively impacted the 2019/20 WHO European Region influenza surveillance. Compared with previous 4-year averages, antigenic and genetic characterisations decreased by 17% (3,140 ...
Yu J, Li F, Wang D. The first decade of research advances in influenza D virus. J Gen Virol. 2020 Nov 19. Abstract
submitted by kickingbird at Nov, 22, 2020 from J Gen Virol. 2020 Nov 19 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
From its initial isolation in the USA in 2011 to the present, influenza D virus (IDV) has been detected in cattle and swine populations worldwide. IDV has exceptional thermal and acid stability and a broad ...
Nasamran C, Janetanakit T, Chiyawong S, Boonyapisi. Persistence of pdm2009-H1N1 internal genes of swine influenza in pigs, Thailand. Sci Rep. 2020 Nov 16;10(1):19847. Abstract
submitted by kickingbird at Nov, 19, 2020 from Sci Rep. 2020 Nov 16;10(1):19847 (via https://www.nature.com/articles/s41598-020-76771-2)
Swine influenza is one of the important zoonotic diseases of pigs. We conducted a longitudinal survey of swine influenza A viruses (S-IAV) circulating in a pig farm with history of endemic S-IAV infection ...
Chastagner A, Hervé S, Quéguiner S, Hirchaud E, Lu. Genetic and Antigenic Evolution of European Swine Influenza A Viruses of HA-1C (Avian-Like) and HA-1B (Human-Like) Lineages in France from 2000 to 2018. Viruses. 2020 Nov 13;12(11):E1304. Abstract
submitted by kickingbird at Nov, 19, 2020 from Viruses. 2020 Nov 13;12(11):E1304 (via https://www.mdpi.com/1999-4915/12/11/1304)
This study evaluated the genetic and antigenic evolution of swine influenza A viruses (swIAV) of the two main enzootic H1 lineages, i.e., HA-1C (H1av) and -1B (H1hu), circulating in France between 2000 ...
Amal EB, Saadi N, Asma F, Moncef B, Ouafae FF. Characterization and Phylogenetic Analysis of the Hemagglutinin Gene in H9 Influenza Viruses from Chickens in Morocco from 2017 to 2019. Avian Dis. 2020 Sep 1;64(3):310-314. Abstract
submitted by kickingbird at Nov, 19, 2020 from Avian Dis. 2020 Sep 1;64(3):310-314 (via https://bioone.org/journals/avian-diseases/volume-64/issue-3)
Since the early 2000s, the avian influenza virus (AIV) subtype H9N2 has been widely circulating in North African countries, including Libya, Tunisia, and Egypt. For unknown reasons, H9N2 was not detected ...
Abhijeet A Bakre, et al. Molecular epidemiology and glycomics of swine influenza viruses circulating in commercial swine farms in the southeastern and midwest United States. Vet Microbiol . 2020 Oct 31;251:108914. Abstract
submitted by kickingbird at Nov, 16, 2020 from Vet Microbiol . 2020 Oct 31;251:108914 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Tracking the genetic diversity and spread of swine influenza viruses (SIVs) in commercial swine farms is central for control and to reduce the potential emergence of SIV reassortants. We analyzed the diversity ...
Carre?o JM, McDonald JU, Hurst T, Rigsby P, Atkins. Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies. Vaccines (Basel). 2020 Nov 9;8(4):E666. Abstract
submitted by kickingbird at Nov, 16, 2020 from Vaccines (Basel). 2020 Nov 9;8(4):E666 (via https://www.mdpi.com/2076-393X/8/4/666)
The stalk domain of the hemagglutinin has been identified as a target for induction of protective antibody responses due to its high degree of conservation among numerous influenza subtypes and strains. ...
Tian X, Landreth S, Lu Y, Pandey K, Zhou Y. A Replication-Defective Influenza Virus Harboring H5 and H7 Hemagglutinins Provides Protection against H5N1 and H7N9 Infection in Mice. J Virol. 2020 Nov 11:JVI.02154-20. Abstract
submitted by kickingbird at Nov, 13, 2020 from J Virol. 2020 Nov 11:JVI.02154-20 (via https://jvi.asm.org/content/early/2020/11/06/JVI.02154-20)
The recent highly pathogenic avian influenza (HPAI) H5N1 and H7N9 viruses have caused hundreds of human infections with high mortality rates. Although H5N1 and H7N9 viruses have been mainly limited to ...
Bao D, Xue R, Zhang M, Lu C, Ma T, Ren C, Zhang T,. N-linked glycosylation plays an important role in budding of NA protein and virulence of influenza viruses. J Virol. 2020 Nov 11:JVI.02042-20. Abstract
submitted by kickingbird at Nov, 13, 2020 from J Virol. 2020 Nov 11:JVI.02042-20 (via https://jvi.asm.org/content/early/2020/11/06/JVI.02042-20)
Neuraminidase (NA) has multiple functions in the life cycle of influenza virus, especially in the late stage of virus replication. Both of Hemagglutinin (HA) and NA are highly glycosylated proteins. N-linked ...
Speake HA, Pereira G, Regan AK. Risk of adverse maternal and foetal outcomes associated with inactivated influenza vaccination in first trimester of pregnancy. Paediatr Perinat Epidemiol. 2020 Nov 5. Abstract
submitted by kickingbird at Nov, 9, 2020 from Paediatr Perinat Epidemiol. 2020 Nov 5 (via https://onlinelibrary.wiley.com/doi/10.1111/ppe.12715)
Background: In many countries, influenza vaccination is routinely recommended during any stage of pregnancy, yet uptake remains low, particularly in the first trimester. This is thought to be due to maternal ...
Toy R, Keenum MC, Pradhan P, Phang K, Chen P, Chuk. TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccinatio. J Control Release. 2020 Nov 4:S0168-3659(20)30641-. Abstract
submitted by kickingbird at Nov, 9, 2020 from J Control Release. 2020 Nov 4:S0168-3659(20)30641- (via https://www.sciencedirect.com/science/article/abs/pii/S01683)
Although the existing flu vaccines elicit strong antigen-specific antibody responses, they fail to provide effective, long term protection - partly due to the absence of robust cellular memory immunity. ...
Zaraket H, Hurt AC, Clinch B, Barr I, Lee N. Burden of influenza B virus infection and considerations for clinical management. Antiviral Res. 2020 Nov 4:104970. Abstract
submitted by kickingbird at Nov, 9, 2020 from Antiviral Res. 2020 Nov 4:104970 (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
Influenza B viruses cause significant morbidity and mortality, particularly in children, but the awareness of their impact is often less than influenza A viruses partly due to their lack of pandemic potential. ...
Vagima Y, Gur D, Erez N, Achdout H, Aftalion M, Le. Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments. Sci Rep. 2020 Nov 5;10(1):19116. Abstract
submitted by kickingbird at Nov, 8, 2020 from Sci Rep. 2020 Nov 5;10(1):19116 (via https://www.nature.com/articles/s41598-020-75840-w)
Various respiratory viral infections in general and seasonal influenza in particular may increase the susceptibility to bacterial infections. Plague caused by Yersinia pestis endangers large populations ...
Timofeeva TA, Rudneva IA, Sadykova GK, Lomakina NF. Variability of nonpathogenic influenza virus H5N3 under immune pressure. Acta Virol. 2020 Nov 5. Abstract
submitted by kickingbird at Nov, 7, 2020 from Acta Virol. 2020 Nov 5 (via https://pubmed.ncbi.nlm.nih.gov/33151742/)
Mutations arising in influenza viruses that have undergone immune pressure may promote a successful spread of mutants in nature. In order to evaluate the variability of nonpathogenic influenza virus A/duck/Moscow/4182-C/2010(H5N3) ...
Igboh LS, McMorrow M, Tempia S, Emukule GO, Talla. Influenza surveillance capacity improvements in Africa during 2011-2017. Influenza Other Respir Viruses. 2020 Nov 4. Abstract
submitted by kickingbird at Nov, 7, 2020 from Influenza Other Respir Viruses. 2020 Nov 4 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12818)
Background: Influenza surveillance helps time prevention and control interventions especially where complex seasonal patterns exist. We assessed influenza surveillance sustainability in Africa where influenza ...
Kotomina T, Isakova-Sivak I, Kim KH, Park BR, Jung. Generation and Characterization of Universal Live-Attenuated Influenza Vaccine Candidates Containing Multiple M2e Epitopes. Vaccines (Basel). 2020 Nov 3;8(4):E648. Abstract
submitted by kickingbird at Nov, 7, 2020 from Vaccines (Basel). 2020 Nov 3;8(4):E648 (via https://www.mdpi.com/2076-393X/8/4/648)
Influenza viruses constantly evolve, reducing the overall protective effect of routine vaccination campaigns. Many different strategies are being explored to design universal influenza vaccines capable ...
Liu X, Zhang B, Wang Y, Haymour HS, Zhang F, Xu LC. A universal dual mechanism immunotherapy for the treatment of influenza virus infections. Nat Commun. 2020 Nov 5;11(1):5597. Abstract
submitted by kickingbird at Nov, 7, 2020 from Nat Commun. 2020 Nov 5;11(1):5597 (via https://www.nature.com/articles/s41467-020-19386-5)
Seasonal influenza epidemics lead to 3-5 million severe infections and 290,000-650,000 annual global deaths. With deaths from the 1918 influenza pandemic estimated at >50,000,000 and future pandemics anticipated, ...
Thompson AJ, Paulson JC. Adaptation of Influenza Viruses to Human Airway Receptors. Biol Chem. 2020 Nov 3:jbc.REV120.013309. Abstract
submitted by kickingbird at Nov, 5, 2020 from Biol Chem. 2020 Nov 3:jbc.REV120.013309 (via https://www.jbc.org/content/early/2020/11/03/jbc.REV120.0133)
Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global ...
Cox A, Schmierer J, D´Angelo J, Smith A, Lev. A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity. Viruses. 2020 Oct 31;12(11):E1246. Abstract
submitted by kickingbird at Nov, 5, 2020 from Viruses. 2020 Oct 31;12(11):E1246 (via https://www.mdpi.com/1999-4915/12/11/1246)
Current influenza vaccines have modest efficacy. This is especially true for current live attenuated influenza vaccines (LAIV), which have been inferior to the inactivated versions in recent years. Therefore, ...
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