Leonenko V, Bobashev G. Analyzing influenza outbreaks in Russia using an age-structured dynamic transmission model. Epidemics. 2019 Jul 22:100358.. Abstract
submitted by kickingbird at Nov, 3, 2019 from Epidemics. 2019 Jul 22:100358. (via https://www.ncbi.nlm.nih.gov/pubmed/31668495)
In this study, we addressed the ability of a minimalistic SEIR model to satisfactorily describe influenza outbreak dynamics in Russian settings. For that purpose, we calibrated an age-specific influenza ...
Kang YM, Cho HK, Kim HM, Lee MH, To TL, Kang HM. Protective efficacy of vaccines of the Korea national antigen bank against the homologous H5Nx clade 18.104.22.168 and clade 22.214.171.124 highly pathogenic avian influenza viruses. Vaccine. 2019 Oct 25. Abstract
submitted by kickingbird at Nov, 3, 2019 from Vaccine. 2019 Oct 25 (via https://www.ncbi.nlm.nih.gov/pubmed/31669062)
The occurrence of severe outbreaks of highly pathogenic avian influenza in Korea led to establishment of a national antigen bank for emergency preparedness. Here, we developed five vaccines for this bank ...
Ivan FX, et al. Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore. Int J Infect Dis. 2019 Oct 25. Abstract
submitted by kickingbird at Nov, 3, 2019 from Int J Infect Dis. 2019 Oct 25 (via https://www.ncbi.nlm.nih.gov/pubmed/31669593)
BACKGROUND: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular ...
Escuyer KL, E Fuschino M, St George K. New York State Emergency Preparedness and Response to Influenza Pandemics 1918-2018. Trop Med Infect Dis. 2019 Oct 30;4(4).. Abstract
submitted by kickingbird at Nov, 3, 2019 from Trop Med Infect Dis. 2019 Oct 30;4(4). (via https://www.mdpi.com/2414-6366/4/4/132)
Emergency health preparedness and response efforts are a necessity in order to safeguard the public against major events, such as influenza pandemics. Since posting warnings of the epidemic influenza in ...
Paget J, et al. Global mortality associated with seasonal influenza epidemics: New burden estimates and predictors from the GLaMOR Project. J Glob Health. 2019 Dec;9(2):020421.. Abstract
submitted by kickingbird at Nov, 3, 2019 from J Glob Health. 2019 Dec;9(2):020421. (via https://www.ncbi.nlm.nih.gov/pubmed/31673337)
Background: Until recently, the World Health Organization (WHO) estimated the annual mortality burden of influenza to be 250?000 to 500?000 all-cause deaths globally; however, a 2017 study indicated a ...
He G, Yang P, Yan Q, Xiong C. Debate on the compositions of influenza B in northern hemisphere seasonal influenza vaccines. Antimicrob Resist Infect Control. 2019 Oct 28;8:16. Abstract
submitted by kickingbird at Nov, 3, 2019 from Antimicrob Resist Infect Control. 2019 Oct 28;8:16 (via https://www.ncbi.nlm.nih.gov/pubmed/31673353)
Background: Annual influenza vaccination is the most effective way to prevent influenza. Influenza vaccines have traditionally included the hemagglutinins (HA) and neuraminidases (NA) from the two A viruses ...
Kwon JH, et al. Domestic ducks play a major role in the maintenance and spread of H5N8 highly pathogenic avian influenza viruses in South Korea. Transbound Emerg Dis. 2019 Nov 1. Abstract
submitted by kickingbird at Nov, 3, 2019 from Transbound Emerg Dis. 2019 Nov 1 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13406)
The H5N8 highly pathogenic avian influenza viruses (HPAIV) belonging to clade 126.96.36.199 spread from Eastern China to Korea in 2014 and caused outbreaks in domestic poultry until 2016. To understand how H5N8 ...
Stadlbauer D, et al. Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Science. 2019 Oct 25;366(6464):499-504.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Science. 2019 Oct 25;366(6464):499-504. (via https://science.sciencemag.org/content/366/6464/499)
Better vaccines against influenza virus are urgently needed to provide broader protection against diverse strains, subtypes, and types. Such efforts are assisted by the identification of novel broadly ...
Wu L, et al. Characterization of H7N9 avian influenza viruses isolated from duck meat products. Transbound Emerg Dis. 2019 Oct 25.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Transbound Emerg Dis. 2019 Oct 25. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13398)
Avian influenza H7N9 viruses have caused five epidemic waves of human infections since the first human cases were reported in 2013. In 2016, the initial low pathogenic avian influenza (LPAI) H7N9 viruses ...
Harada Y, et al. Comparison of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for selective isolation of influenza viruses to be used as vaccine seeds. Influenza Other Respir Viruses. 2019 Oct 25.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Influenza Other Respir Viruses. 2019 Oct 25. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12694)
BACKGROUND: Cell-based influenza vaccines can solve the problem of the frequent occurrence of egg adaptation-associated antigenic changes observed in egg-based vaccines. Seed viruses for cell-based vaccines ...
Matsuzawa Y, et al. Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals. Viruses. 2019 Oct 23;11(11).. Abstract
submitted by kickingbird at Oct, 29, 2019 from Viruses. 2019 Oct 23;11(11). (via https://www.mdpi.com/1999-4915/11/11/978)
Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal ...
Belser JA, et al. A guide for the use of the ferret model for influenza virus infection. Am J Pathol. 2019 Oct 22.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Am J Pathol. 2019 Oct 22. (via https://www.ncbi.nlm.nih.gov/pubmed/31654637)
As influenza viruses continue to jump species barriers to cause human infection, assessments of disease severity and viral replication kinetics in vivo provide crucial information for public health professionals. ...
Lee S, et al. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. Sci Immunol. 2019 Oct 25;4(40).. Abstract
submitted by kickingbird at Oct, 29, 2019 from Sci Immunol. 2019 Oct 25;4(40). (via https://immunology.sciencemag.org/content/4/40/eaau4643)
The respiratory epithelium is exposed to the environment and initiates inflammatory responses to exclude pathogens. Influenza A virus (IAV) infection triggers inflammatory responses in the respiratory ...
Toots M, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019 Oct 23;11(515).. Abstract
submitted by kickingbird at Oct, 27, 2019 from Sci Transl Med. 2019 Oct 23;11(515). (via https://stm.sciencemag.org/content/11/515/eaax5866)
Influenza viruses constitute a major health threat and economic burden globally, frequently exacerbated by preexisting or rapidly emerging resistance to antiviral therapeutics. To address the unmet need ...
Liu L, Zhang Y, Cui P, Wang C, Zeng X, Deng G. Development of a duplex TaqMan real-time RT-PCR assay for simultaneous detection of newly emerged H5N6 influenza viruses. Virol J. 2019 Oct 22;16(1):119. Abstract
submitted by kickingbird at Oct, 27, 2019 from Virol J. 2019 Oct 22;16(1):119 (via https://www.ncbi.nlm.nih.gov/pubmed/31640801)
BACKGROUND: In 2017-2018, a new highly pathogenic H5N6 avian influenza virus (AIV) variant appeared in poultry and wild birds in Asian and European countries and caused multiple outbreaks. These variant ...
Strohmeier S, Amanat F, Krammer F. Cross-Reactive Antibodies Binding to the Influenza Virus Subtype H11 Hemagglutinin. Pathogens. 2019 Oct 21;8(4).. Abstract
submitted by kickingbird at Oct, 27, 2019 from Pathogens. 2019 Oct 21;8(4). (via https://www.mdpi.com/2076-0817/8/4/199)
H11 subtype influenza viruses were isolated from a wide range of bird species and one strain also was isolated from swine. In an effort to generate reagents for a chimeric H11/1 hemagglutinin-based universal ...
Li X1,2, Chan KKY, Xu B, Lu M, Xu B. Spatial, Temporal and Genetic Dynamics Characteristics of Influenza B Viruses in China, 1973~2018. Virol Sin. 2019 Oct 21. Abstract
submitted by kickingbird at Oct, 27, 2019 from Virol Sin. 2019 Oct 21 (via https://www.ncbi.nlm.nih.gov/pubmed/31637629)
Annual influenza B virus epidemics and outbreaks cause severe influenza diseases in humans and pose a threat to public health. China is an important epidemic area of influenza B viruses. However, the spatial, ...
Kariithi HM, et al. Genetic characterization and pathogenesis of the first H9N2 low pathogenic avian influenza viruses isolated from chickens in Kenyan live bird markets. Infect Genet Evol. 2019 Oct 18:104074. Abstract
submitted by kickingbird at Oct, 23, 2019 from Infect Genet Evol. 2019 Oct 18:104074 (via https://www.sciencedirect.com/science/article/pii/S156713481)
Poultry production plays an important role in the economy and livelihoods of rural households in Kenya. As part of a surveillance program, avian influenza virus (AIV)-specific real-time RT-PCR (RRT-PCR) ...
Hao X, et al. The PB2 and M genes are critical for the superiority of genotype S H9N2 virus to genotype H in optimizing viral fitness of H5Nx and H7N9 avian influenza viruses in mice. Transbound Emerg Dis. 2019 Oct 21.. Abstract
submitted by kickingbird at Oct, 23, 2019 from Transbound Emerg Dis. 2019 Oct 21. (via https://www.ncbi.nlm.nih.gov/pubmed/31631569)
Genotype S H9N2 avian influenza virus, which has been predominant in China since 2010, and contributed its entire internal gene cassette to the genesis of novel reassortant influenza viruses, including ...
de Vries E, Du W, Guo H, de Haan CAM. Influenza A Virus Hemagglutinin-Neuraminidase-Receptor Balance: Preserving Virus Motility. Trends Microbiol. 2019 Oct 16.. Abstract
submitted by kickingbird at Oct, 22, 2019 from Trends Microbiol. 2019 Oct 16. (via https://www.ncbi.nlm.nih.gov/pubmed/31629602)
Influenza A viruses (IAVs) occasionally cross the species barrier and adapt to novel host species. This requires readjustment of the functional balance of the sialic acid receptor-binding hemagglutinin ...
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