Balraam KVV, Sidhu A, Srinivas V. Interesting post-mortem findings in a H1N1 influenza-positive pneumonia patient. Autops Case Rep. 2019 Apr 5;9(2):e2018079. Abstract
submitted by kickingbird at May, 16, 2019 from Autops Case Rep. 2019 Apr 5;9(2):e2018079 (via http://www.autopsyandcasereports.org/article/doi/10.4322/acr)
Reports of histopathological findings in a patient infected with H1N1 influenza virus are limited in the literature, although many deaths have occurred because of this viral infection. In an otherwise ...
Lui WY, et al. SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection. Emerg Microbes Infect. 2019;8(1):662-674. Abstract
submitted by kickingbird at May, 16, 2019 from Emerg Microbes Infect. 2019;8(1):662-674 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza defective interfering (DI) particles are replication-incompetent viruses carrying large internal deletion in the genome. The loss of essential genetic information causes abortive viral replication, ...
Gahan J, et al. Whole Genome Sequencing of the First H3N8 Equine Influenza Virus Identified in Malaysia. Pathogens. 2019 May 10;8(2).. Abstract
submitted by kickingbird at May, 16, 2019 from Pathogens. 2019 May 10;8(2). (via https://www.mdpi.com/2076-0817/8/2/62)
In August 2015, Malaysia experienced an outbreak of acute respiratory disease in racehorses. Clinical signs observed were consistent with equine influenza (EI) infection. The index cases were horses recently ...
Feldman RA, et al. mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials. Vaccine. 2019 May 9.. Abstract
submitted by kickingbird at May, 15, 2019 from Vaccine. 2019 May 9. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: We evaluated safety and immunogenicity of the first mRNA vaccines against potentially pandemic avian H10N8 and H7N9 influenza viruses.METHODS: Two randomized, placebo-controlled, double-blind, ...
Qin C, et al. Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection. Biomed Res Int. 2019 Apr 7;2019:2121357. Abstract
submitted by kickingbird at May, 15, 2019 from Biomed Res Int. 2019 Apr 7;2019:2121357 (via https://www.hindawi.com/journals/bmri/2019/2121357/)
Background: cIAP2 is involved in necroptosis as a key upstream regulation factor. We aimed to investigate the role of cIAP2 in ARDS/ALI induced by H7N9 virus through regulating the RIPK1/3 necroptosis ...
Xu G, et al. Mutations in PB2 and HA enhanced pathogenicity of H4N6 avian influenza virus in mice. J Gen Virol. 2019 May 13. Abstract
submitted by kickingbird at May, 15, 2019 from J Gen Virol. 2019 May 13 (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
The H4 subtype avian influenza virus (AIV) continues to circulate in both wild birds and poultry, and occasionally infects mammals (e.g. pigs). H4-specific antibodies have also been detected in poultry ...
Luo W, et al. The codon usage bias of avian influenza A viruses. J Infect. 2019 May 7. pii: S0163-4453(19)30131-8.. Abstract
submitted by kickingbird at May, 12, 2019 from J Infect. 2019 May 7. pii: S0163-4453(19)30131-8. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
A recent study in this journal revealed that avian influenza A viruses (AIVs) H5Nx (N1, N6 and N8) showed pathogenicity,1 and accordingly had different adaptation to the codon usage pattern of its hosts.2 ...
Nguyen ATV, et al. Peptide Aptamer of Complementarity-determining Region to Detect Avian Influenza Virus. J Biomed Nanotechnol. 2019 Jun 1;15(6):1185-1200. Abstract
submitted by kickingbird at May, 12, 2019 from J Biomed Nanotechnol. 2019 Jun 1;15(6):1185-1200 (via https://www.ingentaconnect.com/content/asp/jbn/2019/00000015)
Despite significant progress in the development of diagnostic methods for influenza, avian influenza (AI) infection continues to represent a substantial threat to human health. Among the subtypes of AI, ...
Ashraf U, et al. Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy. PNAS 2019 May 10. Abstract
submitted by kickingbird at May, 12, 2019 from PNAS 2019 May 10 (via https://www.pnas.org/content/early/2019/05/09/1901214116)
New therapeutic strategies targeting influenza are actively sought due to limitations in current drugs available. Host-directed therapy is an emerging concept to target host functions involved in pathogen ...
Rigby RE, Wise HM, Smith N, Digard P, Rehwinkel J. PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection. Sci Rep. 2019 May 10;9(1):7216.. Abstract
submitted by kickingbird at May, 12, 2019 from Sci Rep. 2019 May 10;9(1):7216. (via https://www.nature.com/articles/s41598-019-43632-6)
The sensing of viral nucleic acids by the innate immune system activates a potent antiviral response in the infected cell, a key component of which is the expression of genes encoding type I interferons ...
Russell AB, et al. Single-cell virus sequencing of influenza infections that trigger innate immunity. J Virol. 2019 May 8. Abstract
submitted by kickingbird at May, 12, 2019 from J Virol. 2019 May 8 (via https://www.ncbi.nlm.nih.gov/pubmed/31068418)
Influenza-infected cells vary widely in their expression of viral genes, and only occasionally activate innate immunity. Here we develop a new method to assess how the genetic variation in viral populations ...
Muscatello DJ, Leong RNF, Turner RM, Newall A. Rapid mapping of the spatial and temporal intensity of influenza. Eur J Clin Microbiol Infect Dis. 2019 May 8. Abstract
submitted by kickingbird at May, 12, 2019 from Eur J Clin Microbiol Infect Dis. 2019 May 8 (via https://www.ncbi.nlm.nih.gov/pubmed/31069558)
Surveillance of influenza epidemics is a priority for risk assessment and pandemic preparedness, yet representation of their spatiotemporal intensity remains limited. Using the epidemic of influenza type ...
Mine J, et al. Genetics and pathogenicity of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and a chicken in Japan during winter 2017~2018. Virology. 2019 May 2;533:1-11.. Abstract
submitted by kickingbird at May, 12, 2019 from Virology. 2019 May 2;533:1-11. (via https://www.ncbi.nlm.nih.gov/pubmed/31071540)
An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017~2018. Time-measured ...
Zhang Q, et al. Contaminated feed-borne Bacillus cereus aggravates respiratory distress post avian influenza virus H9N2 infection by inducing pneumonia. Sci Rep. 2019 May 10;9(1):7231. Abstract
submitted by kickingbird at May, 12, 2019 from Sci Rep. 2019 May 10;9(1):7231 (via https://www.nature.com/articles/s41598-019-43660-2)
Avian influenza virus subtype H9N2 is identified in chickens with respiratory disease while Bacillus cereus (B. cereus) has been frequently isolated from chicken feed in China. However, the roles of co-infection ...
Fallah Mehrabadi MH, et al. Serological Survey of Avian Influenza (H9N2) in Commercial Ostrich Farms in Iran, 2015. Arch Razi Inst. 2018 Dec;73(4):325-330.. Abstract
submitted by kickingbird at May, 12, 2019 from Arch Razi Inst. 2018 Dec;73(4):325-330. (via http://archrazi.areeo.ac.ir/article_117279.html)
The aim of this study was to determine the seroprevalence of avian influenzaH9N2 subtype in the industrial ostrich farms and its geographical distribution. This cross-sectional study was conducted from ...
Scheibner D, et al. Virulence of three European highly pathogenic H7N1 and H7N7 avian influenza viruses in Pekin and Muscovy ducks. BMC Vet Res. 2019 May 10;15(1):142.. Abstract
submitted by kickingbird at May, 12, 2019 from BMC Vet Res. 2019 May 10;15(1):142. (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
BACKGROUND: There is paucity of data on the virulence of highly pathogenic (HP) avian influenza viruses (AIV) H7 in ducks compared to HPAIV H5. Here, the virulence of HPAIV H7N1 (designated H7N1-FPV34 ...
Han Y, et al. Determinants of Parental Intentions to Vaccinate Kindergarten Children Against Seasonal Influenza in Xiamen, China. J Prim Prev. 2019 May 10. Abstract
submitted by kickingbird at May, 12, 2019 from J Prim Prev. 2019 May 10 (via https://link.springer.com/article/10.1007%2Fs10935-019-00550)
Seasonal influenza epidemics occur almost every year, and children under 6 years of age constitute one of the most susceptible groups. While free vaccinations are offered to preschool children in some ...
Bonomo ME, Kim RY, Deem MW. Modular epitope binding predicts influenza quasispecies dominance and vaccine effectiveness: Application to 2018/19 season. Vaccine. 2019 May 3. pii: S0264-410X(19)30417-7.. Abstract
submitted by kickingbird at May, 10, 2019 from Vaccine. 2019 May 3. pii: S0264-410X(19)30417-7. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
The modular binding sites on the influenza A(H3N2) hemagglutinin protein are under significant pressure to acquire mutations in order to evade human antibody recognition. Analysis of these hemagglutinin ...
Bao J, et al. Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus. J Immunol Res. 2019 Apr 2;2019:1418251. Abstract
submitted by kickingbird at May, 10, 2019 from J Immunol Res. 2019 Apr 2;2019:1418251 (via https://www.hindawi.com/journals/jir/2019/1418251/)
The outbreak of avian influenza A (H7N9) virus infection, with a high mortality rate, has caused concern worldwide. Although interleukin-17- (IL-17-) secreting CD4+ T (Th17) and CD8+ T (Tc17) cells have ...
Harcourt SE, et al. Developing influenza and respiratory syncytial virus activity thresholds for syndromic surveillance in England. Epidemiol Infect. 2019 Jan;147:e163. Abstract
submitted by kickingbird at May, 10, 2019 from Epidemiol Infect. 2019 Jan;147:e163 (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
Influenza and respiratory syncytial virus (RSV) are common causes of respiratory tract infections and place a burden on health services each winter. Systems to describe the timing and intensity of such ...
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