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2024-7-17 15:29:05
Article

Hamele CE, Russell AB, Heaton NS. In Vivo Profiling of Individual Multiciliated Cells during Acute Influenza A Virus Infection. J Virol. 2022 Jul 6:e0050522.  Abstract  
submitted by kickingbird at Jul, 24, 2022 from J Virol. 2022 Jul 6:e0050522 (via https://journals.asm.org/doi/10.1128/jvi.00505-22)
Influenza virus infections are thought to be initiated in a small number of cells; however, the heterogeneity across the cellular responses of the epithelial cells during establishment of disease is incompletely ...

Farrukee R, Gunalan V, Maurer-Stroh S, Reading PC,. Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution. J Virol. 2022 Jul 14:e0091822.  Abstract  
submitted by kickingbird at Jul, 24, 2022 from J Virol. 2022 Jul 14:e0091822 (via https://journals.asm.org/doi/10.1128/jvi.00918-22)
Oseltamivir-resistant influenza viruses arise due to amino acid mutations in key residues of the viral neuraminidase (NA). These changes often come at a fitness cost; however, it is known that permissive ...

Ge Y, Liu K, Chi Y, Zhu X, Wu T, Zhao K, Qiao Q, W. Exosomal microRNA expression profiles derived from A549 human lung cells in response to influenza A/H1N1pdm09 infection. Virology. 2022 Jul 16;574:9-17.  Abstract  
submitted by kickingbird at Jul, 24, 2022 from Virology. 2022 Jul 16;574:9-17 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Exosomes participate in intercellular communication by shuttling various small molecules from donor to recipient cells. We aimed to examine the role of exosomes and exosomal miRNAs in influenza virus infection. ...

Proa?os NJ, Reyes LF, Bastidas A, Martín-Loeches I. Prior influenza vaccine is not a risk factor for bacterial coinfection in patients admitted to the ICU due to severe influenza. Med Intensiva (Engl Ed). 2022 Aug;46(8):436-445.  Abstract  
submitted by kickingbird at Jul, 24, 2022 from Med Intensiva (Engl Ed). 2022 Aug;46(8):436-445 (via https://www.sciencedirect.com/science/article/abs/pii/S21735)
Objective: To determine whether the prior usage of the flu vaccine is a risk factor for bacterial co-infection in patients with severe influenza.Design: This was a retrospective observational cohort study ...

Zhou P, Chen B, Hu X, Xiao X, Liu R, Li S. Domestic poultry are not susceptible to avian-origin H3N2 subtype canine influenza A virus. Vet Microbiol. 2022 Jun 30;272:109501.  Abstract  
submitted by kickingbird at Jul, 21, 2022 from Vet Microbiol. 2022 Jun 30;272:109501 (via https://www.sciencedirect.com/science/article/pii/S037811352)
At present, avian-origin H3N2 subtype canine influenza virus (H3N2 CIV) is prevalent in East Asian and North American countries. The host tropism of H3N2 CIV to mammals, including mice, guinea pigs, ferrets, ...

Tsang TK, Lam KT, Liu Y, Fang VJ, Mu X, Leung NHL,. Investigation of CD4 and CD8 T cell-mediated protection against influenza A virus in a cohort study. BMC Med. 2022 Jul 21;20(1):230.  Abstract  
submitted by kickingbird at Jul, 21, 2022 from BMC Med. 2022 Jul 21;20(1):230 (via https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291)
Background: The protective effect of T cell-mediated immunity against influenza virus infections in natural settings remains unclear, especially in seasonal epidemics.Methods: To explore the potential ...

Cuevas F, Kawabata H, Krammer F, Carre?o JM. An In Vitro Microneutralization Assay for Influenza Virus Serology. Curr Protoc. 2022 Jul;2(7):e465.  Abstract  
submitted by kickingbird at Jul, 19, 2022 from Curr Protoc. 2022 Jul;2(7):e465 (via https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002)
Influenza is an infectious respiratory disease with significant morbidity and mortality rates among people of all ages. Influenza viruses spread and evolve rapidly in the human population. Different immune ...

Wang Z, Zhao Q, Huang M, Duan Y, Li F, Wang T. Dual Detection of Hemagglutinin Proteins of H5N1 and H1N1 Influenza Viruses Based on FRET Combined With DNase I. Front Microbiol. 2022 Jun 30;13:934475.  Abstract  
submitted by kickingbird at Jul, 19, 2022 from Front Microbiol. 2022 Jun 30;13:934475 (via https://www.frontiersin.org/articles/10.3389/fmicb.2022.9344)
Influenza A viruses (IAV) are classified based on their surface proteins hemagglutinin (HA) and neuraminidase (NA). Both pandemic H1N1 (pH1N1) and highly pathogenic avian influenza (HPAI) H5N1 viruses ...

Ye H, Zhang J, Sang Y, Shan N, Qiu W, Zhong W, Li. Divergent Reassortment and Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Virus in Birds of China During 2021. Front Microbiol. 2022 Jun 30;13:913551.  Abstract  
submitted by kickingbird at Jul, 19, 2022 from Front Microbiol. 2022 Jun 30;13:913551 (via https://www.frontiersin.org/articles/10.3389/fmicb.2022.9135)
Highly pathogenic influenza A(H5N8) viruses had caused several outbreaks among wild bird and poultry populations across the globe, and strikingly, caused human infection, posing serious public health concerns. ...

Quirós-González V, Maderuelo-Fernández Já, Haro-Pé. Influenza complications: Reporting cardiac events through a hospital surveillance system. Rev Clin Esp (Barc). 2022 Jul 14:S2254-8874(22)000.  Abstract  
submitted by kickingbird at Jul, 18, 2022 from Rev Clin Esp (Barc). 2022 Jul 14:S2254-8874(22)000 (via https://www.sciencedirect.com/science/article/abs/pii/S22548)
Background and aims: The aim of this study was to determine the complications of influenza in all adults hospitalized with this disease and, specifically, to analyze the characteristics of post-infection ...

Price O, Birrell FA, Mifsud EJ, Sullivan SG. Epidemiology of repeat influenza infection in Queensland, Australia, 2005-2017. Epidemiol Infect. 2022 Jul 18:1-19..  Abstract  
submitted by kickingbird at Jul, 18, 2022 from Epidemiol Infect. 2022 Jul 18:1-19. (via https://pubmed.ncbi.nlm.nih.gov/35843721/)
Natural infection with influenza virus is believed to generate cross-protective immunity across both types and subtypes. However, less is known about the persistence of this immunity and thus the susceptibility ...

Shin Y, Kim J, Seok JH, Park H, Cha HR, Ko SH, Lee. Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants. Sci Rep. 2022 Jul 16;12(1):12189.  Abstract  
submitted by kickingbird at Jul, 18, 2022 from Sci Rep. 2022 Jul 16;12(1):12189 (via https://www.nature.com/articles/s41598-022-16365-2)
Due to the continuously mutating nature of the H3N2 virus, two aspects were considered when preparing the H3N2 microneedle vaccines: (1) rapid preparation and (2) cross-protection against multiple antigenic ...

Pulit-Penaloza JA, Belser JA, Brock N, Thakur PB,. Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets. Emerg Infect Dis. 2022 Jul 15;28(9).  Abstract  
submitted by kickingbird at Jul, 18, 2022 from Emerg Infect Dis. 2022 Jul 15;28(9) (via https://pubmed.ncbi.nlm.nih.gov/35840125/)
Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility ...

Liu M, Huang LZX, Smits AA, Büll C, Narimatsu Y, v. Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions. Nat Commun. 2022 Jul 13;13(1):4054.  Abstract  
submitted by kickingbird at Jul, 16, 2022 from Nat Commun. 2022 Jul 13;13(1):4054 (via https://www.nature.com/articles/s41467-022-31840-0)
Establishment of zoonotic viruses, causing pandemics like the Spanish flu and Covid-19, requires adaptation to human receptors. Pandemic influenza A viruses (IAV) that crossed the avian-human species barrier ...

Leow BL, Syamsiah Aini S, Faizul Fikri MY, Muhamma. Molecular characterisation of hemagglutinin and neuraminidase genes of the first highly pathogenic Avian Influenza H5N1 2.3.2.1c virus isolated from Sabah, Malaysia. Trop Biomed. 2022 Jun 1;39(2):160-169.  Abstract  
submitted by kickingbird at Jul, 16, 2022 from Trop Biomed. 2022 Jun 1;39(2):160-169 (via https://msptm.org/files/Vol39No2/tb-39-2-001-Leow-B-L.pdf)
Highly Pathogenic Avian Influenza (HPAI) is a highly contagious disease in poultry. The outbreaks can lead to flock mortality up to 100% in two to three days. In July 2018, high mortality in a commercial ...

J?rgensen RL, Lerche CJ, Pedersen MS, Kirkby N, Bo. Emergence of circulating influenza A H3N2 viruses with genetic drift in the matrix gene: Be alert of false negative test results. APMIS. 2022 Jul 14.  Abstract  
submitted by kickingbird at Jul, 16, 2022 from APMIS. 2022 Jul 14 (via https://onlinelibrary.wiley.com/doi/10.1111/apm.13262)
In March 2022, we observed samples with a negative fluorescent signal (60.5%, n=43) for the influenza A matrix gene, and a stronger positive signal for subtype A(H3N2). Forty-three samples were positive ...

Gao J, Li X, Klenow L, Malik T, Wan H, Ye Z, Danie. Antigenic comparison of the neuraminidases from recent influenza A vaccine viruses and 2019-2020 circulating strains. NPJ Vaccines. 2022 Jul 14;7(1):79.  Abstract  
submitted by kickingbird at Jul, 16, 2022 from NPJ Vaccines. 2022 Jul 14;7(1):79 (via https://www.nature.com/articles/s41541-022-00500-1)
Although viral-based influenza vaccines contain neuraminidase (NA or N) antigens from the recommended seasonal strains, NA is not extensively evaluated like hemagglutinin (H) during the strain selection ...

Inaida S, Matsuno S, Okumura J. Longitudinal surveillance of influenza in Japan, 2006-2016. Sci Rep. 2022 Jul 14;12(1):12026.  Abstract  
submitted by kickingbird at Jul, 16, 2022 from Sci Rep. 2022 Jul 14;12(1):12026 (via https://www.nature.com/articles/s41598-022-15867-3)
We analysed 2006-2016 national influenza surveillance data in Japan with regards to age-, sex-, and predominant virus-related epidemic patterns and the prevalence of serum influenza virus antibodies. We ...

ones JC, Zagribelnyy B, Pascua PNQ, Bezrukov DS, B. Influenza A virus polymerase acidic protein E23G/K substitutions weaken key baloxavir drug-binding contacts with minimal impact on replication and transmission. PLoS Pathog. 2022 Jul 13;18(7):e1010698.  Abstract  
submitted by kickingbird at Jul, 14, 2022 from PLoS Pathog. 2022 Jul 13;18(7):e1010698 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Baloxavir marboxil (BXM) is approved for treating uncomplicated influenza. The active metabolite baloxavir acid (BXA) inhibits cap-dependent endonuclease activity of the influenza virus polymerase acidic ...

Caliendo V, Lewis NS, Pohlmann A, Baillie SR, Bany. Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021. Sci Rep. 2022 Jul 11;12(1):11729.  Abstract  
submitted by kickingbird at Jul, 14, 2022 from Sci Rep. 2022 Jul 11;12(1):11729 (via https://www.nature.com/articles/s41598-022-13447-z)
Highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/1996 lineage (GsGd), which threaten the health of poultry, wildlife and humans, are spreading across Asia, Europe, Africa and ...

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