MAAMARY J, Pica N, Belicha-Villanueva A, Chou YY,. Attenuated influenza virus construct with enhanced hemagglutinin protein expression. J Virol. 2012. Abstract
submitted by kickingbird at Mar, 14, 2012 from J Virol. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22398291)
Influenza A viruses encoding an altered viral NS1 protein have emerged as promising live attenuated vaccine platforms. A carboxy-terminal truncation in the NS1 protein compromises its interferon antagonism ... Belser JA, Gustin KM, Maines TR, Pantin-Jackwood M. Influenza Virus Respiratory Infection and Transmission Following Ocular Inoculation in Ferrets. PLoS Pathog 8(3): e1002569. doi:10.1371/journal.p. Abstract
submitted by kickingbird at Mar, 3, 2012 from PLoS Pathog 8(3): e1002569. doi:10.1371/journal.p (via http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2F)
While influenza viruses are a common respiratory pathogen, sporadic reports of conjunctivitis following human infection demonstrates the ability of this virus to cause disease outside of the respiratory ... S. Tong,etc.,al. A distinct lineage of influenza A virus from bats. PNAS February 27, 2012. Abstract
submitted by kickingbird at Feb, 29, 2012 from PNAS February 27, 2012 (via http://www.pnas.org/content/early/2012/02/17/1116200109.abst)
Influenza A virus reservoirs in animals have provided novel genetic elements leading to the emergence of global pandemics in humans. Most influenza A viruses circulate in waterfowl, but those that infect ... MACDONALD LA, Aggarwal S, Bussey KA, Desmet EA, et. Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies. Virology. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Virology. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22325937)
The influenza polymerase complex composed of PA, PB1 and PB2, plays a key role in viral replication and pathogenicity. Newly synthesized components must be translocated to the nucleus, where replication ... J Gen Virol. 2012. An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo. SHELTON H, Smith M, Hartgroves LC, Stilwell P, et. Abstract
submitted by kickingbird at Feb, 19, 2012 from SHELTON H, Smith M, Hartgroves LC, Stilwell P, et (via http://www.ncbi.nlm.nih.gov/pubmed/22323532)
Influenza viruses readily mutate by accumulating point mutations and also by reassortment in which they acquire whole gene segments from another virus in a co-infected host. The NS1 gene is a major virulence ... FERRARIS O, Escuret V, Bouscambert M, Casalegno JS. H1N1 influenza A virus neuraminidase modulates infectivity in mice. Antiviral Res. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22321413)
In the 2years since the onset of the H1N1 2009 pandemic virus (H1N1pdm09), sporadic cases of oseltamivir-resistant viruses have been reported. We investigated the impact of oseltamivir-resistant neuraminidase ... NGUYEN HT, Trujillo AA, Sheu TG, Levine M, et al.. Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States. Antiviral Res. 2012. Abstract
submitted by kickingbird at Feb, 19, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22330888)
During the 2009 influenza pandemic, the Centers for Disease Control and Prevention provided antiviral susceptibility testing for patients infected with suspected drug-resistant viruses. Specimens from ... VEITS J, Weber S, Stech O, Breithaupt A, et al.. Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype. Proc Natl Acad Sci U S A. 2012. Abstract
submitted by kickingbird at Feb, 16, 2012 from Proc Natl Acad Sci U S A. 2012 (via http://www.pnas.org/content/109/7/2579.long)
High-pathogenic avian influenza viruses (HPAIVs) evolve from low-pathogenic precursors specifying the HA serotypes H5 or H7 by acquisition of a polybasic HA cleavage site. As the reason for this serotype ... WANG M, Tscherne DM, McCullough C, Caffrey M, et a. Residue Y161 of influenza hemagglutinin is involved in viral recognition of sialylated complexes from different hosts. J Virol. 2012 Feb 1. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Virol. 2012 Feb 1 (via http://www.ncbi.nlm.nih.gov/pubmed/22301136)
Influenza A virus glycoprotein hemagglutinin (HA) binds to host cell surface sialic acid (SA)-terminated sugars in glycoproteins to initiate viral entry. It is thought that avian influenza viruses preferentially ... MEUNIER I, von Messling V. PB1-F2 Modulates Early Host Responses but Does not Affect the Pathogenesis of H1N1 Seasonal Influenza Virus. J Virol. 2012 Feb 8.. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Virol. 2012 Feb 8. (via http://www.ncbi.nlm.nih.gov/pubmed/22318139)
In the context of infections with highly pathogenic influenza A viruses the PB1-F2 protein contributes to virulence and enhances lung inflammation. In contrast, its role in the pathogenesis of seasonal ... VAN STRY M, Oguin T, Cheloufi S, Vogel P, et al.. Enhanced Susceptibility to Influenza A Virus of Ago1/3 Double Null Mice. J Virol. 2012 Feb 8.. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Virol. 2012 Feb 8. (via http://www.ncbi.nlm.nih.gov/pubmed/22318144)
RNAi is a critical component of many cellular anti-viral responses in plants, invertebrates, and mammals. However, its in vivo role in host protection from the negative sense RNA virus Influenza Type A ... PICA N, Chou YY, Bouvier NM, Palese P, et al.. Transmission of Influenza B viruses in the Guinea Pig. J Virol. 2012 Feb 1. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Virol. 2012 Feb 1 (via http://www.ncbi.nlm.nih.gov/pubmed/22301149)
Epidemic influenza is typically caused by infection of viruses of the A and B type and can result in substantial morbidity and mortality during a given season. Here we demonstrate that influenza B viruses ... MENEGHESSO S, Vanderlinden E, Stevaert A, McGuigan. Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus. Antiviral Res. 2012. Abstract
submitted by kickingbird at Feb, 16, 2012 from Antiviral Res. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22306172)
Uridine-based nucleoside analogues have often been found to have relatively poor antiviral activity. Enzymatic assays, evaluating inhibition of influenza virus RNA polymerase, revealed that some uridine ... FAN K, Jia Y, Wang S, Li H, et al. Role of Itk signaling in the interaction between influenza A virus and T cells. J Gen Virol. 2012. Abstract
submitted by kickingbird at Feb, 16, 2012 from J Gen Virol. 2012 (via http://www.ncbi.nlm.nih.gov/pubmed/22302878)
Although T cell-mediated immune response to influenza virus has been extensively studied, little information is available on direct interaction between influenza virus and T cells that pertains to severe ... McCullers JA, Hayden FG. Fatal Influenza B Infections: Time to Reexamine Influenza Research Priorities. J Infect Dis 2012 Jan 30. Abstract
submitted by kickingbird at Feb, 2, 2012 from J Infect Dis 2012 Jan 30 (via http://jid.oxfordjournals.org/content/early/2012/01/28/infdi)
Influenza A viruses (IAVs) are zoonotic pathogens that sometimes establish long-term lineages in humans and other mammalian hosts. New introductions of influenza genes or whole viruses from animal reservoirs ... Paddock CD, Liu L, Denison AM, et al. Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection. J Infect Dis 2012 Jan 30. Abstract
submitted by kickingbird at Feb, 2, 2012 from J Infect Dis 2012 Jan 30 (via http://jid.oxfordjournals.org/content/early/2012/01/28/infdi)
Background.?Influenza B virus infection causes rates of hospitalization and influenza-associated pneumonia similar to seasonal influenza A virus infection and accounts for a substantial percentage of all ... Yuan Fang, David Banner, Alyson A. Kelvin, Stephen. Seasonal H1N1 Influenza Virus Infection Induces Cross-Protective Pandemic H1N1 Virus Immunity through a CD8-Independent, B Cell-Dependent Mechanism. J. Virol. February 2012 86:2229-2238. Abstract
submitted by kickingbird at Feb, 2, 2012 from J. Virol. February 2012 86:2229-2238 (via http://jvi.asm.org/content/86/4/2229.abstract)
During the 2009 H1N1 influenza virus pandemic (pdmH1N1) outbreak, it was found that most individuals lacked antibodies against the new pdmH1N1 virus, and only the elderly showed anti-hemagglutinin (anti-HA) ... Li Lin, Yang Li, Hyun-Mi Pyo, Xinya Lu, Sathya N.. Identification of RNA Helicase A as a Cellular Factor That Interacts with Influenza A Virus NS1 Protein and Its Role in the Virus Life Cycle. J. Virol. February 2012 86:1942-1954. Abstract
submitted by kickingbird at Feb, 2, 2012 from J. Virol. February 2012 86:1942-1954 (via http://jvi.asm.org/content/86/4/1942.abstract)
Influenza A virus NS1 protein has multiple functions in the infected cell during the virus life cycle. Identification of novel cellular factors that interact with NS1 and understanding their functions ... Xiaohui Fan, Huachen Zhu, Boping Zhou, David K. Sm. Emergence and Dissemination of a Swine H3N2 Reassortant Influenza Virus with 2009 Pandemic H1N1 Genes in Pigs in China. J. Virol. February 2012 86:2375-2378;. Abstract
submitted by kickingbird at Feb, 2, 2012 from J. Virol. February 2012 86:2375-2378; (via http://jvi.asm.org/content/86/4/2375.abstract)
The 2009 pandemic influenza virus (pdm/09) has been frequently introduced to pigs and has reassorted with other swine viruses. Recently, H3N2 reassortants with pdm/09-like internal genes were isolated ... Skowronski DM, De Serres G, Janjua NZ, Gardy JL, G. Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November. Euro Surveill. 2012;17(4):pii=20066. Full Text
submitted by kickingbird at Jan, 28, 2012 from Euro Surveill. 2012;17(4):pii=20066 (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
In pre- and post-immunisation sera from children (17–120 months-old) and adults (20–59 years-old) immunised with 2010/11 trivalent inactivated influenza vaccine, we assessed age-related patterns of sero-susceptibility ... 8128 items, 20/Page, Page[311/407][|<<] [|<] [311] [312] [313] [314] [315] [316] [317] [318] [319] [320] [>|] [>>|] |
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