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2025-12-20 1:27:18
Article

Zhu, Y., Sun, Y., Deng, X., Cao, P., Li, S., Yu, H. Matrix Protein 1 (M1) of Influenza A Virus: Structural and Functional Insights. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at Sep, 10, 2025 from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Enveloped viruses rely on matrix proteins for structural integrity and lifecycle progression. Matrix protein 1 (M1) is the most abundant structural protein of influenza A virus (IAV), playing a multifaceted ...

Ismaila Shittu, Daniel B. Cummings, John T. Groves. Low Levels of Neutralizing Antibodies to Influenza A (H5N1) and D Viruses Among Cattle and Cattle Workers on US Farms, 2024–2025. Influenza and Other Respiratory Viruses.  Abstract  
submitted by kickingbird at Sep, 9, 2025 from Influenza and Other Respiratory Viruses (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70162)
Bovine respiratory disease complex (BRDC) is a major disease problem in cattle production systems. Numerous pathogens have been implicated as causing BRDC, including the recently discovered influenza D ...

Qiao Y, Tang M, Du M, Zhao C, Lv Y, Zhou J, Liu Y,. H5N1 influenza virus-like particles based on BEVS induce robust functional antibodies and immune responses. Virology. 2025 Aug 29;612:110672.  Abstract  
submitted by kickingbird at Sep, 9, 2025 from Virology. 2025 Aug 29;612:110672 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Avian influenza virus infections pose a potential pandemic threat. The currently licensed vaccines have inherent limitations, emphasizing the urgent need for improved influenza vaccines. Here, we developed ...

Chloe Stenkamp-Strahm, etc.,al. [preprint]Dairy Environments with Milk Exposure are Most Likely to Have Detection of Influenza A Virus. https://doi.org/10.1101/2025.09.03.25335023.  Abstract  
submitted by kickingbird at Sep, 9, 2025 from https://doi.org/10.1101/2025.09.03.25335023 (via https://www.medrxiv.org/content/10.1101/2025.09.03.25335023v)
Highly pathogenic avian influenza virus of the H5N1 subtype has been infecting U.S dairy cattle and spreading among dairy farms since March 2024. H5N1 surveillance systems for dairy farms are needed, but ...

Chen P-L, Yang G, Ojha C, Banoth B, Russell CJ. Modification of H1N1 Influenza Luciferase Reporter Viruses Using StopGo Translation and/or Mouse-Adapted Mutations. Viruses. 2025; 17(9):1211.  Abstract  
submitted by kickingbird at Sep, 8, 2025 from Viruses. 2025; 17(9):1211 (via https://www.mdpi.com/1999-4915/17/9/1211)
Reporter viruses are valuable tools for studying infections at the cellular level and in living animals. They also enable rapid, high-throughput antiviral drug screening and serological studies. We previously ...

Asante IA, Asante-Ntim NA, Abankwa AA, Ofori OB, B. Characterization of the first detected Avian Influenza A(H9N2) human case in Ghana. Emerg Microbes Infect. 2025 Sep 3:2556717.  Abstract  
submitted by kickingbird at Sep, 6, 2025 from Emerg Microbes Infect. 2025 Sep 3:2556717 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Avian influenza A(H9N2) has been circulating in poultry across Asia, the Middle East, and Africa, posing human health risks. In Ghana, it has co-circulated among poultry with influenza A (H5N1). This report ...

Xia Y, Yuan J, Liu T, Zhang R, Wu C, Sui N, Li L,. TRPM2 knockdown alleviated H9N2 influenza virus infected ferroptosis in mouse pulmonary microvascular endothelial cells. Vet Microbiol. 2025 Sep 1;310:110703.  Abstract  
submitted by kickingbird at Sep, 6, 2025 from Vet Microbiol. 2025 Sep 1;310:110703 (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
H9N2 influenza virus, a prevalent influenza A virus, causes acute lung injury through mitochondrial damage associated with oxidative stress. Transient receptor potential melastatin 2 (TRPM2) is a Ca2+ ...

Beckmen KB, Burek Huntington KA, Spraker T, Ellis. Pathologic Characterization of Highly Pathogenic H5N1 Avian Influenza Virus Infections in Wild Mammals in Alaska, USA. J Wildl Dis. 2025 Sep 5.  Abstract  
submitted by kickingbird at Sep, 6, 2025 from J Wildl Dis. 2025 Sep 5 (via https://meridian.allenpress.com/jwd/article/doi/10.7589/JWD-)
This report describes highly pathogenic avian influenza virus (HPAI) H5N1 infections in carnivores in Alaska, US between 2022 and 2024, including a black bear (Ursus americanus), a brown bear (Ursus arctos), ...

Tobolowsky FA, Morris E, Castro L, Schaff T, Jacin. Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Child with No Known Exposure - San Francisco, California, December 2024-January 2025. MMWR Morb Mortal Wkly Rep. 2025 Sep 4;74(33):522-5.  Abstract  
submitted by kickingbird at Sep, 5, 2025 from MMWR Morb Mortal Wkly Rep. 2025 Sep 4;74(33):522-5 (via https://www.cdc.gov/mmwr/volumes/74/wr/mm7433a2.htm?s_cid=mm)
In response to a highly pathogenic avian influenza (HPAI) A(H5N1) outbreak in U.S. dairy cows detected in March 2024, with subsequent identification of human cases, the San Francisco Department of Public ...

Jordan T. Ort, etc.,al. [preprint]Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history. https://doi.org/10.1101/2025.09.02.25334929.  Abstract  
submitted by kickingbird at Sep, 5, 2025 from https://doi.org/10.1101/2025.09.02.25334929 (via https://www.medrxiv.org/content/10.1101/2025.09.02.25334929v)
H5N1 highly pathogenic avian influenza viruses have spread globally and pose a risk for a human pandemic. Prior studies suggest that early life exposures to group 1 influenza viruses (H1N1 and H2N2) prime ...

Rute Maria Pinto, etc.,al. [preprint]The cow udder is a potential mixing vessel for influenza A viruses. https://doi.org/10.1101/2025.08.29.673079.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from https://doi.org/10.1101/2025.08.29.673079 (via https://www.biorxiv.org/content/10.1101/2025.08.29.673079v1)
The incursion of high pathogenicity avian influenza A virus (IAV) into US dairy cows is unprecedented in the era of molecular diagnosis and pathogen sequencing. This raises questions over the likelihood ...

Steve Leumi, etc.,al. [preprint]Cardioprotective effects of AMPK activation in H1N1 influenza virus infection. https://doi.org/10.1101/2025.08.28.672931.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from https://doi.org/10.1101/2025.08.28.672931 (via https://www.biorxiv.org/content/10.1101/2025.08.28.672931v1)
Cardiac complications are among the most common and severe extrapulmonary manifestations of influenza virus infection, yet they are rarely recapitulated in mouse models without immunodeficiency. We found ...

Feline F. W. Benavides, etc.,al. [preprint]Influenza A Virus Infection Impairs Neuronal Activity in Human iPSC-Derived NGN2 Neural Co-Cultures. https://doi.org/10.1101/2025.08.26.672266.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from https://doi.org/10.1101/2025.08.26.672266 (via https://www.biorxiv.org/content/10.1101/2025.08.26.672266v1)
Influenza A virus (IAV) infection is associated with a wide variety of neurological complications, of which mild complications like impaired cognitive functioning are most prominent. Even though several ...

PENG Huanwen, PAN Xia, WANG Yun, DING Min, JI Huiq. Epidemiological investigation of two cases infection with avian influenza A(H5N6) virus in Dazhou, Sichuan. China Tropical Medicine, Aug 2025, Vol.25, No.8.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from China Tropical Medicine, Aug 2025, Vol.25, No.8 (via http://www.flu.org.cn/scn/article_detail.asp?articleId=23839)
Objective To analyze clinical and epidemiological characteristics of two cases of H5N6 avian influenza infection in Dazhou City in July 2021, to identify the transmission routes, and assess the risk of ...

XIAO Shan, LI Lingzhi, HUANG Zheng, OU Xinhua, YAO. Molecular tracing and evolutionary characteristics analysis of H9N2 avian influenza virus from two human infections. China Tropical Medicine, Aug 2025, Vol.25, No.8.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from China Tropical Medicine, Aug 2025, Vol.25, No.8 (via http://www.flu.org.cn/scn/article_detail.asp?articleId=23837)
Objective To analyze molecular tracing and evolutionary characteristics of H9N2 avian influenza virus (AIV) strains isolated from two human cases and related environmental samples collected from live poultry ...

Zhang, Q., Cheng, J., Hou, J. et al. Synthetic biology-inspired development of live attenuated influenza vaccines. npj Vaccines 10, 204 (2025).  Abstract  
submitted by kickingbird at Sep, 4, 2025 from npj Vaccines 10, 204 (2025) (via https://link.springer.com/article/10.1038/s41541-025-01255-1)
Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns. Recent advances in rational ...

Corrin, T., K. M. Young, M. Qamar, et al. A Rapid Review Contrasting the Evidence on Avian Influenza A(H5Nx) Clades 2.3.4.4b and 2.3.2.1c in Humans. Zoonoses and Public Health 1-34.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from Zoonoses and Public Health 1-34 (via https://onlinelibrary.wiley.com/doi/10.1111/zph.70006)
Avian influenza viruses (AIV) circulate in wild and domestic bird populations, posing an on-going risk for zoonotic transmission and virus adaptation to mammals and humans. The A(H5Nx) clades 2.3.2.1c ...

Md. Musa Baker, etc.,al. [preprint]Poultry slaughter and carcass disposal practices in Bangladesh: Piloting the use of killing cones to reduce avian influenza transmission. https://doi.org/10.1101/2025.08.30.25334525.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from https://doi.org/10.1101/2025.08.30.25334525 (via https://www.medrxiv.org/content/10.1101/2025.08.30.25334525v)
Mobile poultry vending and slaughtering of sick poultry have been linked to the spread of highly pathogenic avian influenza (HPAI) H5N1 in Bangladesh. However, limited data exist on associated practices ...

Nemoto M, Kawanishi N, Kamei R, Furusho K, Kawauch. Genetic and serological analyses of equine influenza viruses isolated in Kumamoto and Hokkaido, Japan in 2025. Vet Microbiol. 2025 Aug 30;310:110701.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from Vet Microbiol. 2025 Aug 30;310:110701 (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
In April and May 2025, outbreaks of equine influenza occurred for the first time in 17 years in Japan. Equine influenza virus (EIV) of the H3N8 subtype was mainly detected in heavy draft horse populations ...

Wang W, Ma Z, Lou Q, Li T, Huang Z, Yin W, Lou C,. Development Strategies for Influenza Vaccines Utilizing Phage RNA Polymerase and Capping Enzyme NP868R. Chem Bio Eng . 2025 Jun 9;2(8):475-484.  Abstract  
submitted by kickingbird at Sep, 4, 2025 from Chem Bio Eng . 2025 Jun 9;2(8):475-484 (via https://pubs.acs.org/doi/10.1021/cbe.5c00030)
Influenza remains a highly contagious respiratory disease with profound global health and economic implications. Although traditional vaccines, including inactivated influenza vaccines (IIVs), live attenuated ...

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