Chae W, et al. Hemagglutinin Quantitative ELISA-based Potency Assay for Trivalent Seasonal Influenza Vaccine Using Group-Specific Universal Monoclonal Antibodies. Sci Rep. 2019 Dec 23;9(1):19675.. Abstract
submitted by kickingbird at Dec, 27, 2019 from Sci Rep. 2019 Dec 23;9(1):19675. (via https://www.nature.com/articles/s41598-019-56169-5)
The assurance of vaccine potency is important for the timely release and distribution of influenza vaccines. As an alternative to Single Radial Immunodiffusion (SRID), we report a new quantitative enzyme-linked ... Ivan FX, Kwoh CK. Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice. BMC Genomics. 2019 Dec 24. Abstract
submitted by kickingbird at Dec, 27, 2019 from BMC Genomics. 2019 Dec 24 (via https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286)
BACKGROUND: Influenza A virus (IAV) poses threats to human health and life. Many individual studies have been carried out in mice to uncover the viral factors responsible for the virulence of IAV infections. ... Lina L, et al. Adaptive amino acid substitutions enable transmission of an H9N2 avian influenza virus in guinea pigs. Sci Rep. 2019 Dec 24;9(1):19734. Abstract
submitted by kickingbird at Dec, 27, 2019 from Sci Rep. 2019 Dec 24;9(1):19734 (via https://www.nature.com/articles/s41598-019-56122-6)
H9N2 is the most prevalent low pathogenic avian influenza virus (LPAIV) in domestic poultry in the world. Two distinct H9N2 poultry lineages, G1-like (A/quail/Hong Kong/G1/97) and Y280-like (A/Duck/Hong ... Galli C, et al. In-depth phylogenetic analysis of the hemagglutinin gene of influenza A(H3N2) viruses circulating during the 2016-2017 season revealed egg-adaptive mutations of vaccine strains. Expert Rev Vaccines. 2019 Dec 25.. Abstract
submitted by kickingbird at Dec, 27, 2019 from Expert Rev Vaccines. 2019 Dec 25. (via https://www.tandfonline.com/doi/abs/10.1080/14760584.2020.17)
Objectives: The authors conducted an in-depth phylogenetic analysis of the hemagglutinin (HA) gene of A(H3N2) identified during the 2016-2017 season to compare the circulating strains with both the egg-derived ... Zost SJ, et al. Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans. Cell Rep. 2019 Dec 24;29(13):4460-4470.e8.. Abstract
submitted by kickingbird at Dec, 27, 2019 from Cell Rep. 2019 Dec 24;29(13):4460-4470.e8. (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)315)
Antibodies targeting the receptor binding site (RBS) of the influenza virus hemagglutinin (HA) protein are usually not broadly reactive because their footprints are typically large and extend to nearby ... Lin X, Yu S, Ren P, Sun X, Jin M. Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4. Cell Microbiol. 2019 Dec 26:e13150.. Abstract
submitted by kickingbird at Dec, 27, 2019 from Cell Microbiol. 2019 Dec 26:e13150. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13150)
Influenza A virus (IAV) has evolved multiple mechanisms to compromise type I interferon (IFN) responses. The antiviral function of IFN is mainly exerted by activating the JAK/STAT signalling and subsequently ... Honce R, et al. Influenza in High-Risk Hosts-Lessons Learned from Animal Models. Cold Spring Harb Perspect Med. 2019 Dec 23.. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Factoring significantly into the global burden of influenza disease are high-risk populations that suffer the bulk of infections. Classically, the very young, very old, and pregnant women have been identified ... Ciminski K, Schwemmle M. Bat-Borne Influenza A Viruses: An Awakening. Cold Spring Harb Perspect Med. 2019 Dec 23.. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Influenza A viruses (IAVs) originating from aquatic waterfowl recurrently cross interspecies barriers, which is greatly facilitated by utilizing cell surface-exposed monosaccharide sialic acids located ... Fodor E, Te Velthuis AJW. Structure and Function of the Influenza Virus Transcription and Replication Machinery. Cold Spring Harb Perspect Med. 2019 Dec 23.. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Transcription and replication of the influenza virus RNA genome is catalyzed by the viral heterotrimeric RNA-dependent RNA polymerase in the context of viral ribonucleoprotein (vRNP) complexes. Atomic ... Belser JA, Pulit-Penaloza JA, Maines TR. Ferreting Out Influenza Virus Pathogenicity and Transmissibility: Past and Future Risk Assessments in the Ferret Model. Cold Spring Harb Perspect Med. 2019 Dec 23.. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
As influenza A viruses continue to jump species barriers, data generated in the ferret model to assess influenza virus pathogenicity, transmissibility, and tropism of these novel strains continues to inform ... Carnaccini S, Perez DR. H9 Influenza Viruses: An Emerging Challenge. Cold Spring Harb Perspect Med. 2019 Dec 23. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23 (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Influenza A viruses (IAVs) of the H9 subtype are enzootic in Asia, the Middle East, and parts of North and Central Africa, where they cause significant economic losses to the poultry industry. Of note, ... Ludwig S, Hrincius ER, Boergeling Y. The Two Sides of the Same Coin-Influenza Virus and Intracellular Signal Transduction. Cold Spring Harb Perspect Med. 2019 Dec 23. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23 (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Cells respond to extracellular agents by activation of intracellular signaling pathways. Viruses can be regarded as such agents, leading to a firework of signaling inside the cell, primarily induced by ... Wu NC, Wilson IA. Influenza Hemagglutinin Structures and Antibody Recognition. Cold Spring Harb Perspect Med. 2019 Dec 23. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23 (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Hemagglutinin (HA) is most abundant glycoprotein on the influenza virus surface. Influenza HA promotes viral entry by engaging the receptor and mediating virus-host membrane fusion. At the same time, HA ... Wille M, Holmes EC. The Ecology and Evolution of Influenza Viruses. Cold Spring Harb Perspect Med. 2019 Dec 23. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23 (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
The patterns and processes of influenza virus evolution are of fundamental importance, underpinning such traits as the propensity to emerge in new host species and the ability to rapidly generate antigenic ... Wasik BR, Voorhees IEH, Parrish CR. Canine and Feline Influenza. Cold Spring Harb Perspect Med. 2019 Dec 23.. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Influenza virus infections of carnivores-primarily in dogs and in large and small cats-have been repeatedly observed to be caused by a number of direct spillovers of avian viruses or in infections by human ... Johnson KEE, Ghedin E. Quantifying between-Host Transmission in Influenza Virus Infections. Cold Spring Harb Perspect Med. 2019 Dec 23.. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
The error-prone replication and life cycle of influenza virus generate a diverse set of genetic variants. Transmission between hosts strictly limits both the number of virus particles and the genetic diversity ... Schaack GA, Mehle A. Experimental Approaches to Identify Host Factors Important for Influenza Virus. Cold Spring Harb Perspect Med. 2019 Dec 23.. Full Text
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
An ever-expanding toolkit of experimental methods provides the means to discover and characterize host factors important for influenza virus. Here, we describe common methods for investigating genetic ... Gadalla MR, Abrami L, van der Goot FG, Veit M. Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20. Biochem J. 2019 Dec 24. Abstract
submitted by kickingbird at Dec, 26, 2019 from Biochem J. 2019 Dec 24 (via https://portlandpress.com/biochemj/article/doi/10.1042/BCJ20)
Hemagglutinin (HA), a glycoprotein of Influenza A viruses and its proton-channel M2 are site-specifically modified with fatty acids. Whereas two cysteines in the short cytoplasmic tail of HA contain only ... Zhang Y, Wang X, Li Y, Ma J. Spatiotemporal Analysis of Influenza in China, 2005-2018. Sci Rep. 2019 Dec 23;9(1):19650.. Abstract
submitted by kickingbird at Dec, 26, 2019 from Sci Rep. 2019 Dec 23;9(1):19650. (via https://www.nature.com/articles/s41598-019-56104-8)
Influenza is a major cause of morbidity and mortality worldwide, as well as in China. Knowledge of the spatial and temporal characteristics of influenza is important in evaluating and developing disease ... He J, et al. Sporadic occurrence of H9N2 avian influenza infections in human in Anhui province, eastern China: A notable problem. Microb Pathog. 2019 Dec 18:103940. Abstract
submitted by kickingbird at Dec, 23, 2019 from Microb Pathog. 2019 Dec 18:103940 (via https://www.sciencedirect.com/science/article/abs/pii/S08824)
H9N2 viruses can cause great economic losses to the domestic poultry industry when co-infected with other influenza viruses or pathogens. . To better understand the molecular characteristics of H9N2 avian ... 8128 items, 20/Page, Page[161/407][|<<] [|<] [161] [162] [163] [164] [165] [166] [167] [168] [169] [170] [>|] [>>|] |
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