Sougat Misra, etc.,al. [preprint]Enhanced Diversifying Selection on Polymerase Genes in H5N1 Clade 2.3.4.4b: A Key Driver of Altered Species Tropism and Host Range Expansion. https://doi.org/10.1101/2024.08.19.606826. Abstract
submitted by kickingbird at Aug, 21, 2024 from https://doi.org/10.1101/2024.08.19.606826 (via https://www.biorxiv.org/content/10.1101/2024.08.19.606826v1)
Highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses have shown unprecedented host range and pathogenicity, including infections in cattle, previously not susceptible to H5N1.We investigated whether ... Thomas Tipih, etc.,al. [preprint]Recent Bovine HPAI H5N1 Isolate is Highly Virulent for Mice, Rapidly Causing Acute Pulmonary and Neurologic Disease. https://doi.org/10.1101/2024.08.19.608652. Abstract
submitted by kickingbird at Aug, 21, 2024 from https://doi.org/10.1101/2024.08.19.608652 (via https://www.biorxiv.org/content/10.1101/2024.08.19.608652v1)
The highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses, responsible for the current outbreak in dairy cows in the United States, pose a significant animal and public health threat. ... Ke Zhai, etc.,al. Global antigenic landscape and vaccine recommendation strategy for low pathogenic avian influenza A (H9N2) viruses. Journal of Infection Vol. 89 Issue 2. Abstract
submitted by kickingbird at Aug, 20, 2024 from Journal of Infection Vol. 89 Issue 2 (via https://www.journalofinfection.com/article/S0163-4453(24)001)
The sustained circulation of H9N2 avian influenza viruses (AIVs) poses a significant threat for contributing to a new pandemic. Given the temporal and spatial uncertainty in the antigenicity of H9N2 AIVs, ... Alexander Helmut Rotsch, etc.,al. [preprint]Mechanism of Co-Transcriptional Cap-Snatching by Influenza Polymerase. https://doi.org/10.1101/2024.08.11.607481. Abstract
submitted by kickingbird at Aug, 20, 2024 from https://doi.org/10.1101/2024.08.11.607481 (via https://www.biorxiv.org/content/10.1101/2024.08.11.607481v1)
Influenza virus mRNA is stable and competent for nuclear export and translation because it receives a 5′ cap(1) structure in a process called cap-snatching1. During cap-snatching, the viral RNA-dependent ... Yu H, Sun Y, Zhang J, Zhang W, Liu W, Liu P, Liu K. Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination. Cell Mol Life Sci. 2024 Aug 19;81(1):355. Abstract
submitted by kickingbird at Aug, 20, 2024 from Cell Mol Life Sci. 2024 Aug 19;81(1):355 (via https://link.springer.com/article/10.1007/s00018-024-05392-z)
Caspase-8, an aspartate-specific cysteine protease that primarily functions as an initiator caspase to induce apoptosis, can downregulate innate immunity in part by cleaving RIPK1 and IRF3. However, patients ... Spackman E, Anderson N, Walker S, Suarez DL, Jones. Inactivation of highly pathogenic avian influenza virus with high temperature short time continuous flow pasteurization and virus detection in bulk milk tanks. J Food Prot. 2024 Aug 16:100349. Abstract
submitted by kickingbird at Aug, 20, 2024 from J Food Prot. 2024 Aug 16:100349 (via https://pubmed.ncbi.nlm.nih.gov/39154916/)
Infections of dairy cattle with clade 2.3.4.4b H5N1 highly pathogenic avian influenza virus (HPAIV) were reported in March 2024 in the U.S. and viable virus was detected at high levels in raw milk from ... Zhang, Y., Cui, P., Shi, J. et al. A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes. npj Vaccines 9, 152 (2024). Abstract
submitted by kickingbird at Aug, 20, 2024 from npj Vaccines 9, 152 (2024) (via https://www.nature.com/articles/s41541-024-00947-4)
The global spread of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses threatens poultry and public health. The continuous circulation of these viruses has led to their considerable genetic ... Arragain, B., Krischuns, T., Pelosse, M. et al. Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun 15, 6910 (2024). Abstract
submitted by kickingbird at Aug, 20, 2024 from Nat Commun 15, 6910 (2024) (via https://www.nature.com/articles/s41467-024-51007-3)
Replication of influenza viral RNA depends on at least two viral polymerases, a parental replicase and an encapsidase, and cellular factor ANP32. ANP32 comprises an LRR domain and a long C-terminal low ... Qitao Jia and others. MetaFluAD: meta-learning for predicting antigenic distances among influenza viruses. Briefings in Bioinformatics, Volume 25, Issue 5. Abstract
submitted by kickingbird at Aug, 20, 2024 from Briefings in Bioinformatics, Volume 25, Issue 5 (via https://academic.oup.com/bib/article/25/5/bbae395/7731492)
Influenza viruses rapidly evolve to evade previously acquired human immunity. Maintaining vaccine efficacy necessitates continuous monitoring of antigenic differences among strains. Traditional serological ... Liu L, Li Z, Liu J, Li X, Zhou J, Xiao N, Yang L,. Effects of different HA and NA gene combinations on the growth characteristics of the H3N8 influenza candidate vaccine virus. Vaccine X. 2024 Jul 18;19:100531. Abstract
submitted by kickingbird at Aug, 20, 2024 from Vaccine X. 2024 Jul 18;19:100531 (via https://www.sciencedirect.com/science/article/pii/S259013622)
Since 2022, three human cases of a novel H3N8 avian influenza virus infection have been reported in three provinces in China. Specific vaccines are important means of preparing for the potential influenza ... Colby T Ford, etc.,al. [preprint]Large-Scale Computational Modeling of H5 Influenza Variants Against HA1-Neutralizing Antibodies. https://doi.org/10.1101/2024.07.14.603367. Abstract
submitted by kickingbird at Aug, 20, 2024 from https://doi.org/10.1101/2024.07.14.603367 (via https://www.biorxiv.org/content/10.1101/2024.07.14.603367v3)
In June 2024, the United States Department of Agriculture released a report that showed over 300 samples from 2022-2024 of highly pathogenic avian influenza have been detected in mammals. To date, the ... Shohaimi SA, Leow BL, Mohd Yusop FF, Sidik MR, Bar. Sequence analysis and molecular characterization of low pathogenic avian influenza H9N2 virus isolated from chickens in Sabah. Trop Biomed. 2024 Jun 1;41(2):183-189. Abstract
submitted by kickingbird at Aug, 19, 2024 from Trop Biomed. 2024 Jun 1;41(2):183-189 (via https://msptm.org/files/Vol41No2/tb-41-2-008-Shohaimi-S-A.pd)
Low pathogenic avian influenza (LPAI) subtype H9N2 is a causative agent that has raised increasing concern about its impact on poultry and potential public health threats. Even though H9N2 is endemic in ... Gao P, Wu F, Liu J, Li R, Jiang X, Pan W, Zhao F,. Development of a dual-component biosensor for rapid and sensitive detection of influenza H7 and H5 subtypes. Talanta. 2024 Aug 13;280:126704. Abstract
submitted by kickingbird at Aug, 18, 2024 from Talanta. 2024 Aug 13;280:126704 (via https://www.sciencedirect.com/science/article/abs/pii/S00399)
The outbreak of highly pathogenic influenza virus subtypes, such as H7 and H5, presents a significant global health challenge, necessitating the development of rapid and sensitive diagnostic methods. In ... Owuor DC, de Laurent ZR, Oketch JW, Murunga N, Oti. Phylogeography and reassortment patterns of human influenza A viruses in sub-Saharan Africa. Sci Rep. 2024 Aug 16;14(1):18987. Abstract
submitted by kickingbird at Aug, 18, 2024 from Sci Rep. 2024 Aug 16;14(1):18987 (via https://www.nature.com/articles/s41598-024-70023-3)
The role of sub-Saharan Africa in the global spread of influenza viruses remains unclear due to insufficient spatiotemporal sequence data. Here, we analyzed 222 codon-complete sequences of influenza A ... Landazabal-Castillo S, Suarez-Agüero D, Alva-Alvar. Highly pathogenic avian influenza A virus subtype H5N1 (clade 2.3.4.4b) isolated from a natural protected area in Peru. Microbiol Resour Announc. 2024 Aug 16:e0041724. Abstract
submitted by kickingbird at Aug, 17, 2024 from Microbiol Resour Announc. 2024 Aug 16:e0041724 (via https://journals.asm.org/doi/10.1128/mra.00417-24)
The panzootic caused by H5N1 avian influenza viruses is a high concern for wild birds' conservation and the study of spillover events into mammals. The near coding-complete genome of H5N1 clade 2.3.3.4b ... Du L, Hou YN, Fu DD, Li J, Ao J, Ma AX, Wan QQ, Wa. Revealing Different Pathways for Influenza A Virus To Reach Microtubules after Endocytosis by Quantum Dot-Based Single-Virus Tracking. ACS Nano. 2024 Aug 14. Abstract
submitted by kickingbird at Aug, 15, 2024 from ACS Nano. 2024 Aug 14 (via https://pubs.acs.org/doi/10.1021/acsnano.4c05261)
Actin- and microtubule (MT)-based transport systems are essential for intracellular transport. During influenza A virus (IAV) infection, MTs provide long tracks for virus trafficking toward the nucleus. ... Russell SL, Andrew CL, Yang KC, Coombe M, McGregor. Descriptive epidemiology and phylogenetic analysis of highly pathogenic avian influenza H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada, September 2022 to June 2023. Emerg Microbes Infect. 2024 Aug 15:2392667. Abstract
submitted by kickingbird at Aug, 15, 2024 from Emerg Microbes Infect. 2024 Aug 15:2392667 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Surveillance data from wildlife and poultry was used to describe the spread of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada from September ... Yu J, Shang C, Deng X, Jia J, Shang X, Wang Z, Zhe. Time-resolved scRNA-seq reveals transcription dynamics of polarized macrophages with influenza A virus infection and antigen presentation to T cells. Emerg Microbes Infect. 2024 Aug 12:2387450. Abstract
submitted by kickingbird at Aug, 15, 2024 from Emerg Microbes Infect. 2024 Aug 12:2387450 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Throughout history, the influenza A virus has caused numerous devastating global pandemics. Macrophages, as pivotal innate immune cells, exhibit a wide range of immune functions characterized by distinct ... Chi X, Huang G, Wang L, Zhang X, Liu J, Yin Z, Guo. A small protein encoded by PCBP1-AS1 is identified as a key regulator of influenza virus replication via enhancing autophagy. PLoS Pathog. 2024 Aug 13;20(8):e1012461. Abstract
submitted by kickingbird at Aug, 15, 2024 from PLoS Pathog. 2024 Aug 13;20(8):e1012461 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Many annotated long noncoding RNAs (lncRNAs) contain small open reading frames (sORFs), some of which have been demonstrated to encode small proteins or micropeptides with fundamental biological importance. ... Zhang Y, Li L, Xin X, Chang L, Luo H, Qiao W, Xia. Effects of H9N2 avian influenza virus infection on metabolite content and gene expression in chick DF1 cells. Poult Sci. 2024 Jul 30;103(10):104125. Abstract
submitted by kickingbird at Aug, 15, 2024 from Poult Sci. 2024 Jul 30;103(10):104125 (via https://www.sciencedirect.com/science/article/pii/S003257912)
After viral infection, the virus relies on the host cell's complex metabolic and biosynthetic machinery for replication. However, the impact of avian influenza virus (AIV) on metabolites and gene expression ... 8125 items, 20/Page, Page[16/407][|<<] [|<] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [>|] [>>|] |
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