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2025-12-19 23:42:33
Article

Zhu H, Pu S, He P, Luo J, Gao R. Construction and Research Progress of Animal Models and Mouse Adapted Strains of Seasonal Influenza Virus. Vaccines. 2025; 13(10):1077.  Abstract  
submitted by kickingbird at Oct, 22, 2025 from Vaccines. 2025; 13(10):1077 (via https://www.mdpi.com/2076-393X/13/10/1077)
Influenza viruses, featured by high variability, pose a persistent public health threat because of an annual seasonal epidemic in the world and irregular global pandemic, requiring animal models to elucidate ...

Stettler, M., Hoby, S., Wenker, C. et al. RNA replicon vaccination confers long-lasting protection against H5N1 avian influenza in 23 zoo bird species. Nat Commun 16, 9245 (2025).  Abstract  
submitted by kickingbird at Oct, 22, 2025 from Nat Commun 16, 9245 (2025) (via https://link.springer.com/article/10.1038/s41467-025-64301-5)
Highly pathogenic avian influenza (HPAI) H5N1 viruses (clade 2.3.4.4b) cause mass mortality in birds and have infected over 50 mammalian species, including humans. Approved avian vaccines remain limited. ...

Bacsik DJ, Mills MG, Monroe LD, Spring C, Perez-Os. Validation of H5 influenza virus subtyping RT-qPCR assay and low prevalence of H5 detection in 2024-2025 influenza virus season. J Clin Microbiol. 2025 Oct 21:e0041525.  Abstract  
submitted by kickingbird at Oct, 22, 2025 from J Clin Microbiol. 2025 Oct 21:e0041525 (via https://journals.asm.org/doi/10.1128/jcm.00415-25)
A sustained outbreak of H5N1 influenza virus among wild fowl and domestic livestock has caused more than 70 zoonotic infections in humans in North America, including two deaths. The United States Centers ...

Chang N, Wang H, Aisaiti K, Guo J, Wu T, Zhang C,. Complex Reassortment Dynamics of H9N2 Avian Influenza Viruses in Xinjiang, China: Implications for Zoonotic Spillover. Influenza Other Respir Viruses. 2025;19(10):e70170.  Abstract  
submitted by kickingbird at Oct, 21, 2025 from Influenza Other Respir Viruses. 2025;19(10):e70170 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70170)
BackgroundH9N2 avian influenza viruses (AIVs) donate their genes to other subtype AIVs, posing significant threats to poultry industries and public health due to their endemicity and zoonotic potential. ...

Lau, K., Kirkland, P., Byers, D., Pitman, C., Thei. The detection of avian influenza virus in human pathology laboratories in Australia, New Zealand, and South Pacific nations. Medical Journal of Australia.  Abstract  
submitted by kickingbird at Oct, 21, 2025 from Medical Journal of Australia (via https://onlinelibrary.wiley.com/doi/10.5694/mja2.70076)
Australia has been relatively free from highly pathogenic avian influenza A (HPAI) virus outbreaks. HPAI viruses are primarily transmitted by wild birds, but avian influenza viruses have recently entered ...

WPRO. Avian Influenza Weekly Update # 1019: 17 October 2025. WHO.  Abstract  
submitted by kickingbird at Oct, 20, 2025 from WHO (via https://cdn.who.int/media/docs/default-source/2021-dha-docs/)
Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. ...

Lorcan Carnegie, etc.,al. OFFLU Guidelines for High Pathogenicity Avian Influenza Virus Risk Mitigation in Cattle. OFFLU.  Abstract  
submitted by kickingbird at Oct, 19, 2025 from OFFLU (via https://offlu.org/publications/offlu-guidelines-for-high-pat)
High pathogenicity avian influenza viruses (HPAIVs) of the A(H5) Goose/Guangdong (Gs/Gd) lineage1 continue to pose. Previously largely restricted to avian hosts, these viruses have recently been involved ...

PAHO. PAHO: Epidemiological Update Avian Influenza A(H5N1) in the Americas Region, 15 October 2025. PAHO.  Abstract  
submitted by kickingbird at Oct, 19, 2025 from PAHO (via https://www.paho.org/sites/default/files/2025-10/2025-oct-15)
In 2020, the highly pathogenic avian influenza (HPAI) virus subtype H5N1 clade 2.3.4.4b caused an unprecedented number of deaths among wild birds and poultry in numerous countries in Africa, Asia, and ...

Ailam Lim, etc.,al. [preprint]Unexpected Detection of Highly Pathogenic Avian Influenza (HPAI) H5N1 virus in bovine Semen. https://doi.org/10.1101/2025.10.16.682947.  Abstract  
submitted by kickingbird at Oct, 19, 2025 from https://doi.org/10.1101/2025.10.16.682947 (via https://www.biorxiv.org/content/10.1101/2025.10.16.682947v1)
Since March 2024, HPAI H5N1 virus has infected dairy cattle in the U.S., prompting concern about novel transmission routes. During an outbreak in California, HPAI H5N1 RNA was detected in an asymptomatic ...

Molly C Hetherington-Rauth, etc.,al. [preprint]Targeted tiled amplicon based protocol for sequencing the Hemagglutinin (HA) gene segment of seasonal influenza A and influenza B virus from wastewater at high depth of coverage. https://doi.org/10.1101/2025.10.15.25338105.  Abstract  
submitted by kickingbird at Oct, 18, 2025 from https://doi.org/10.1101/2025.10.15.25338105 (via https://www.medrxiv.org/content/10.1101/2025.10.15.25338105v)
Wastewater based epidemiology has emerged as a compelling tool to monitor the spread and evolution of pathogens of public health concern. Next generation sequencing (NGS) of pathogens detected in wastewater ...

Fei-fei Ge, etc.,al. Robust and sustained immunity in beagles following one single nasal administration of H3N2 canine influenza virus-like particle. Vaccine: X.  Abstract  
submitted by kickingbird at Oct, 18, 2025 from Vaccine: X (via https://www.sciencedirect.com/science/article/pii/S259013622)
In this study, we used baculovirus to express hemagglutinin (HA) and neuraminidase (NA) to prepare a novel genotype of H3N2 canine influenza virus particles (VLPs). The effectiveness of the H3N2 VLP vaccine ...

Huibin Lv, etc.,al. Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline. Cell Host & Microbe.  Abstract  
submitted by kickingbird at Oct, 18, 2025 from Cell Host & Microbe (via https://www.sciencedirect.com/science/article/abs/pii/S19313)
The ongoing spread of highly pathogenic avian influenza H5N1 clade 2.3.4.4b virus in animals and its occasional spillover to humans have raised concerns about a potential H5N1 pandemic. Although recent ...

Gregory L Damhorst, Wilbur A Lam. Point-of-care and Home Use Influenza Diagnostics for Advancing Therapeutic and Public Health Strategies. The Journal of Infectious Diseases, Volume 232.  Abstract  
submitted by kickingbird at Oct, 18, 2025 from The Journal of Infectious Diseases, Volume 232 (via https://academic.oup.com/jid/article/232/Supplement_3/S314/8)
Point-of-care (POC) antigen-based diagnostics for influenza that have been granted waived status since the Clinical Laboratory Improvement Amendments of 1988 (CLIA-waived) have been available commercially ...

Madeleine R Heldman, Michael J Boeckh, Michael G I. Influenza Antivirals for Prevention and Treatment in Immunocompromised People. The Journal of Infectious Diseases, Volume 232.  Abstract  
submitted by kickingbird at Oct, 18, 2025 from The Journal of Infectious Diseases, Volume 232 (via https://academic.oup.com/jid/article/232/Supplement_3/S243/8)
Antivirals form a foundation for protecting immunocompromised individuals (ICIs) from influenza complications. Neuraminidase inhibitors have demonstrated benefit for both prophylaxis and treatment in ICIs, ...

Lindsey E Hastings, Edward P Acosta, David W Kimbe. Influenza Antiviral Pharmacokinetic-Pharmacodynamic Relationships in Pregnancy, Infancy, and Early Childhood. The Journal of Infectious Diseases, Volume 232.  Abstract  
submitted by kickingbird at Oct, 18, 2025 from The Journal of Infectious Diseases, Volume 232 (via https://academic.oup.com/jid/article/232/Supplement_3/S286/8)
Owing to its decades of use among patients of all ages and health conditions, oseltamivir has the most widely described pharmacokinetics (PK) and pharmacodynamics (PD) of all the modern influenza antivirals. ...

Jahid MJ, Owsiany MC, Smith LM, Foreman BM, Cao Z,. Serological Evidence of Exposure to Eurasian-Lineage HPAI H5N1 Clade 2.3.4.4b in Wild Mammals in Ohio, USA, 2024-2025. Viruses. 2025; 17(10):1388.  Abstract  
submitted by kickingbird at Oct, 18, 2025 from Viruses. 2025; 17(10):1388 (via https://www.mdpi.com/1999-4915/17/10/1388)
The Goose/Guandong lineage of highly pathogenic avian influenza virus [A/Goose/Guangdong/1/1996(H5N1)] is the progenitor of the currently circulating Eurasian-lineage highly pathogenic avian influenza ...

Puttahonnappa, S.K., Anandakumar, J., Barman, N.N.. Investigating environmental determinants and spatiotemporal dynamics of highly pathogenic avian influenza H5N1 outbreaks in India through machine learning. Sci Rep 15, 36132 (2025).  Abstract  
submitted by kickingbird at Oct, 18, 2025 from Sci Rep 15, 36132 (2025) (via https://link.springer.com/article/10.1038/s41598-025-96765-2)
Avian Influenza (AI), caused by highly pathogenic strains of influenza viruses, poses a significant threat to poultry populations and public health worldwide. This study offers a comprehensive evaluation ...

Gaglani M, Raiyani C, Murthy K, Smith M, da Graca. Absolute and Relative Effectiveness of Cell- and Egg-based Quadrivalent Inactivated Influenza Vaccine Products from 2014-2015 to 2018-2019 seasons, U.S. Flu VE Network. Clin Infect Dis. 2025 Oct 16:ciaf579.  Abstract  
submitted by kickingbird at Oct, 18, 2025 from Clin Infect Dis. 2025 Oct 16:ciaf579 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
Background: Estimates of annual effectiveness of influenza vaccination combine multiple vaccine types. Reports of brand/product-specific vaccine effectiveness (VE) of egg- and cell-culture based quadrivalent ...

Liu Z, Guo J, Zhang C, Ding Y, Sun S, Yao B, Xing. Computational Discovery of Potent Nucleoprotein Inhibitors for Influenza A Virus: Validation Through QM/MM Analysis and Experimental Binding Assays. Molecules. 2025; 30(19):3960.  Abstract  
submitted by kickingbird at Oct, 17, 2025 from Molecules. 2025; 30(19):3960 (via https://www.mdpi.com/1420-3049/30/19/3960)
This study employed an integrated computational approach to discover novel nucleoprotein (NP) inhibitors for influenza A virus (IAV). Beginning with virtual screening of over 10 million compounds using ...

Hepp C, Zhao Q, Robb N, Fodor E, Kapanidis AN. High-throughput single-virion DNA-PAINT reveals structural diversity, cooperativity, and flexibility during selective packaging in influenza. Nucleic Acids Res. 2025 Oct 14;53(19):gkaf1020.  Abstract  
submitted by kickingbird at Oct, 17, 2025 from Nucleic Acids Res. 2025 Oct 14;53(19):gkaf1020 (via https://academic.oup.com/nar/article/53/19/gkaf1020/8285782)
Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in reassortant viruses that contain gene segments from multiple ...

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