Lee LY, Zhou J, Koszalka P, Frise R, Farrukee R, B. Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model. PLoS Pathog. 2021 May 6;17(5):e1009527. Abstract
submitted by kickingbird at May, 7, 2021 from PLoS Pathog. 2021 May 6;17(5):e1009527
Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses with reduced susceptibility to baloxavir ... Zhang N, Ma Y, Tian Y, Zhou Y, Tang Y, Hu S. Downregulation of microRNA?221 facilitates H1N1 influenza A virus replication through suppression of type?IFN response by targeting the SOCS1/NF?κB pathway. Mol Med Rep. 2021 Jul;24(1):497. Abstract
submitted by kickingbird at May, 7, 2021 from Mol Med Rep. 2021 Jul;24(1):497 (via https://www.spandidos-publications.com/10.3892/mmr.2021.1213)
Accumulating data has indicated that host microRNAs (miRNAs/miRs) play essential roles in innate immune responses to viral infection; however, the roles and the underlying mechanisms of miRNAs in influenza ... Golabi M, Flodrops M, Grasland B, Vinayaka AC, Quy. Development of Reverse Transcription Loop-Mediated Isothermal Amplification Assay for Rapid and On-Site Detection of Avian Influenza Virus. Front Cell Infect Microbiol. 2021 Apr 19;11:652048. Abstract
submitted by kickingbird at May, 7, 2021 from Front Cell Infect Microbiol. 2021 Apr 19;11:652048 (via https://www.frontiersin.org/articles/10.3389/fcimb.2021.6520)
Avian influenza virus (AIV) outbreaks occur frequently worldwide, causing a potential public health risk and great economic losses to poultry industries. Considering the high mutation rate and frequent ... Guinat C, Tago D, Corre T, Selinger C, Djidjou-Dem. Optimizing the early detection of low pathogenic avian influenza H7N9 virus in live bird markets. J R Soc Interface. 2021 May;18(178):20210074. Abstract
submitted by kickingbird at May, 6, 2021 from J R Soc Interface. 2021 May;18(178):20210074 (via https://royalsocietypublishing.org/doi/10.1098/rsif.2021.007)
In Southeast Asia, surveillance at live bird markets (LBMs) has been identified as crucial for detecting avian influenza viruses (AIV) and reducing the risk of human infections. However, the design of ... Nemoto M, Ohta M, Yamanaka T, Kambayashi Y, Bannai. Antigenic differences between equine influenza virus vaccine strains and Florida sublineage clade 1 strains isolated in Europe in 2019. Vet J. 2021 Jun;272:105674. Abstract
submitted by kickingbird at May, 6, 2021 from Vet J. 2021 Jun;272:105674 (via https://www.sciencedirect.com/science/article/abs/pii/S10900)
From late 2018 to 2019, equine influenza virus (EIV) strains of Florida sublineage clade 1 (Fc1), which had until then been circulating mainly in the United States, suddenly spread across Europe causing ... Svyatchenko SV, Goncharova NI, Marchenko VY, Kolos. An influenza A(H5N8) virus isolated during an outbreak at a poultry farm in Russia in 2017 has an N294S substitution in the neuraminidase and shows reduced susceptibility to oseltamivir. Antiviral Res. 2021 Apr 29:105079. Abstract
submitted by kickingbird at May, 6, 2021 from Antiviral Res. 2021 Apr 29:105079 (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
This study aimed to assess the antiviral susceptibility of influenza A(H5N8) viruses isolated in Russia in 2014-2018. Genetic analysis of 57 Russian isolates with full genome sequences did not find any ... Nogales A, Schotsaert M, Rathnasinghe R, DeDiego M. Replication-Competent ΔNS1 Influenza A Viruses Expressing Reporter Genes. Viruses. 2021 Apr 17;13(4):698. Abstract
submitted by kickingbird at May, 3, 2021 from Viruses. 2021 Apr 17;13(4):698 (via https://www.mdpi.com/1999-4915/13/4/698)
The influenza A virus (IAV) is able to infect multiple mammalian and avian species, and in humans IAV is responsible for annual seasonal epidemics and occasional pandemics of respiratory disease with significant ... Gulyaeva M, De Marco MA, Kovalenko G, Bortz E, Mur. Biological Properties and Genetic Characterization of Novel Low Pathogenic H7N3 Avian Influenza Viruses Isolated from Mallard Ducks in the Caspian Region, Dagestan, Russia. Microorganisms. 2021 Apr 17;9(4):864. Abstract
submitted by kickingbird at May, 3, 2021 from Microorganisms. 2021 Apr 17;9(4):864 (via https://www.mdpi.com/2076-2607/9/4/864)
Avian influenza viruses (AIVs) are maintained in wild bird reservoirs, particularly in mallard ducks and other waterfowl. Novel evolutionary lineages of AIV that arise through genetic drift or reassortment ... Strohmeier S, Carre?o JM, Brito RN, Krammer F. Introduction of Cysteines in the Stalk Domain of Recombinant Influenza Virus N1 Neuraminidase Enhances Protein Stability and Immunogenicity in Mice. Vaccines (Basel). 2021 Apr 19;9(4):404. Abstract
submitted by kickingbird at May, 3, 2021 from Vaccines (Basel). 2021 Apr 19;9(4):404 (via https://www.mdpi.com/2076-393X/9/4/404)
Influenza virus surface glycoproteins represent the main targets of the immune system during infection and vaccination. Current influenza virus vaccines rely mostly on the hemagglutinin, requiring a close ... Kongsomros S, Manopwisedjaroen S, Chaopreecha J, W. Rapid and Efficient Cell-to-Cell Transmission of Avian Influenza H5N1 Virus in MDCK Cells Is Achieved by Trogocytosis. Pathogens. 2021 Apr 16;10(4):483. Abstract
submitted by kickingbird at May, 3, 2021 from Pathogens. 2021 Apr 16;10(4):483 (via https://www.mdpi.com/2076-0817/10/4/483)
Viruses have developed direct cell-to-cell transfer strategies to enter target cells without being released to escape host immune responses and antiviral treatments. These strategies are more rapid and ... Russell CJ. Hemagglutinin Stability and Its Impact on Influenza A Virus Infectivity, Pathogenicity, and Transmissibility in Avians, Mice, Swine, Seals, Ferrets, and Humans. Viruses. 2021 Apr 24;13(5):746. Abstract
submitted by kickingbird at May, 3, 2021 from Viruses. 2021 Apr 24;13(5):746 (via https://www.mdpi.com/1999-4915/13/5/746)
Genetically diverse influenza A viruses (IAVs) circulate in wild aquatic birds. From this reservoir, IAVs sporadically cause outbreaks, epidemics, and pandemics in wild and domestic avians, wild land and ... Kwon JH, Criado MF, Killmaster L, Ali MZ, Giasuddi. Efficacy of two vaccines against recent emergent antigenic variants of clade 2.3.2.1a highly pathogenic avian influenza viruses in Bangladesh. Vaccine. 2021 Apr 25:S0264-410X(21)00459-X.. Abstract
submitted by kickingbird at Apr, 30, 2021 from Vaccine. 2021 Apr 25:S0264-410X(21)00459-X. (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
H5N1 highly pathogenic avian influenza viruses (HPAIVs) have caused outbreaks in poultry in Bangladesh since 2007. While clade 2.2.2 and 2.3.4.2 HPAIVs have not been detected since 2012, clade 2.3.2.1a ... Danilenko AV, Kolosova NP, Shvalov AN, Ilyicheva T. Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018-2019. PLoS One. 2021 Apr 29;16(4):e0251019. Abstract
submitted by kickingbird at Apr, 30, 2021 from PLoS One. 2021 Apr 29;16(4):e0251019 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Outbreaks of influenza, which is a contagious respiratory disease, occur throughout the world annually, affecting millions of people with many fatal cases. The D222G/N mutations in the hemagglutinin (HA) ... Yin X, Deng G, Zeng X, Cui P, Hou Y, Liu Y, Fang J. Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China. PLoS Pathog. 2021 Apr 27;17(4):e1009561. Abstract
submitted by kickingbird at Apr, 28, 2021 from PLoS Pathog. 2021 Apr 27;17(4):e1009561 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The H7N9 avian influenza virus (AIV) that emerged in China have caused five waves of human infection. Further human cases have been successfully prevented since September 2017 through the use of an H7N9 ... Xie X, Pang M, Liang S, Lin Y, Zhao Y, Qiu D, Liu. Cellular microRNAs influence replication of H3N2 canine influenza virus in infected cells. Vet Microbiol. 2021 Apr 20;257:109083. Abstract
submitted by kickingbird at Apr, 26, 2021 from Vet Microbiol. 2021 Apr 20;257:109083 (via https://www.sciencedirect.com/science/article/pii/S037811352)
MicroRNAs (miRNAs) are known to play important regulatory roles in host-virus interactions. Avian-origin H3N2 canine influenza virus (CIV) has emerged as the most prevalent subtype among dogs in Asia since ... Jimenez-Bluhm P, Sepulveda A, Baumberger C, Di Pil. Evidence of influenza infection in dogs and cats in central Chile. Prev Vet Med. 2021 Apr 16;191:105349. Abstract
submitted by kickingbird at Apr, 25, 2021 from Prev Vet Med. 2021 Apr 16;191:105349 (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
As companion animals, dogs and cats live in close contact with humans, generating the possibility of interspecies pathogen transmission events. Equine origin H3N8 and avian origin H5N1 influenza virus ... Sch?n J, Breithaupt A, H?per D, King J, Pohlmann A. Neuraminidase-associated plasminogen recruitment enables systemic spread of natural avian Influenza viruses H3N1. PLoS Pathog. 2021 Apr 23;17(4):e1009490. Abstract
submitted by kickingbird at Apr, 24, 2021 from PLoS Pathog. 2021 Apr 23;17(4):e1009490 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Repeated outbreaks due to H3N1 low pathogenicity avian influenza viruses (LPAIV) in Belgium were associated with unusually high mortality in chicken in 2019. Those events caused considerable economic losses ... Adel A, Mosaad Z, Shalaby AG, Selim K, Samy M, Abd. Molecular evolution of the hemagglutinin gene and epidemiological insight into low-pathogenic avian influenza H9N2 viruses in Egypt. Res Vet Sci. 2021 Apr 14;136:540-549. Abstract
submitted by kickingbird at Apr, 24, 2021 from Res Vet Sci. 2021 Apr 14;136:540-549 (via https://www.sciencedirect.com/science/article/abs/pii/S00345)
Despite the low pathogenicity of the H9N2 avian influenza viruses, they can induce severe economic losses in various poultry sectors in conjunction with other factors. In Egypt, low-pathogenic avian influenza ... Kubota-Koketsu R, Yunoki M, Okuno Y, Ikuta K. Virus Neutralization by Human Intravenous Immunoglobulin Against Influenza Virus Subtypes A/H5 and A/H7. Biologics. 2021 Apr 13;15:87-94. Abstract
submitted by kickingbird at Apr, 22, 2021 from Biologics. 2021 Apr 13;15:87-94 (via https://www.dovepress.com/virus-neutralization-by-human-intr)
Purpose: Highly pathogenic avian influenza viruses are a threat to human health. Although donor populations have not experienced pandemic, they have been immunized by natural infections and/or vaccinations ... Gao J, Wan H, Li X, Rakic Martinez M, Klenow L, Ga. Balancing the influenza neuraminidase and hemagglutinin responses by exchanging the vaccine virus backbone. PLoS Pathog. 2021 Apr 19;17(4):e1009171. Abstract
submitted by kickingbird at Apr, 20, 2021 from PLoS Pathog. 2021 Apr 19;17(4):e1009171 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Virions are a common antigen source for many viral vaccines. One limitation to using virions is that the antigen abundance is determined by the content of each protein in the virus. This caveat especially ... 5584 items, 20/Page, Page[79/280][|<<] [|<] [71] [72] [73] [74] [75] [76] [77] [78] [79] [80] [>|] [>>|] |
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