Youk SS, Leyson CM, Seibert BA, Jadhao S, Perez DR. Mutations in PB1, NP, HA, and NA Contribute to Increased Virus Fitness of H5N2 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4 in Chickens. J Virol. 2020 Dec 2:JVI.01675-20. Abstract
submitted by kickingbird at Feb, 22, 2021 from J Virol. 2020 Dec 2:JVI.01675-20 (via https://jvi.asm.org/content/95/5/e01675-20)
The H5N8 highly pathogenic avian influenza (HPAI) clade 2.3.4.4 virus spread to North America by wild birds and reassorted to generate the H5N2 HPAI virus that caused the poultry outbreak in the United ... Sánchez-González R, Ramis A, Nofrarías M, Wali N,. Infectivity and pathobiology of H7N1 and H5N8 high pathogenicity avian influenza viruses for pigeons ( Columba livia var. domestica). Avian Pathol. 2021 Feb;50(1):98-106. Abstract
submitted by kickingbird at Feb, 22, 2021 from Avian Pathol. 2021 Feb;50(1):98-106 (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2020.18)
Avian influenza (AI) is one of the most important viral diseases in poultry, wildlife and humans. Available data indicate that pigeons play a minimum role in the epidemiology of AI. However, a degree of ... Pronier C, Gacouin A, Lagathu G, Le Tulzo Y, Tadié. Respiratory Influenza viral load as a marker of poor prognosis in patients with severe symptoms. J Clin Virol. 2021 Feb 12;136:104761. Abstract
submitted by kickingbird at Feb, 22, 2021 from J Clin Virol. 2021 Feb 12;136:104761 (via https://www.sciencedirect.com/science/article/abs/pii/S13866)
Background: The link between influenza virus (IV) viral load (VL) in respiratory samples and disease severity is not clearly established. This study was designed to assess IV-VL in respiratory samples ... Park BR, Kim KH, Kotomina T, Kim MC, Kwon YM, Jeev. Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin. Sci Rep. 2021 Feb 18;11(1):4151. Abstract
submitted by kickingbird at Feb, 20, 2021 from Sci Rep. 2021 Feb 18;11(1):4151 (via https://pubmed.ncbi.nlm.nih.gov/33603072/)
Hemagglutinin (HA)-based current vaccines provide suboptimum cross protection. Influenza A virus contains an ion channel protein M2 conserved extracellular domain (M2e), a target for developing universal ... Liu L, Li Z, Zhou J, Lu J, Li X, Liu J, Xiao N, Wa. The effect of single amino acid substitution at position 220 in the hemagglutinin glycoprotein on avian influenza H7N9 candidate vaccine virus. Virus Genes. 2021 Feb 19. Abstract
submitted by kickingbird at Feb, 20, 2021 from Virus Genes. 2021 Feb 19 (via https://link.springer.com/article/10.1007/s11262-021-01827-y)
Influenza vaccines represent the most effective preventive strategy to control influenza virus infections; however, adaptive mutations frequently occur in the hemagglutinin (HA) glycoprotein during the ... Li X, Gu M, Zheng Q, Gao R, Liu X. Packaging signal of influenza A virus. Virol J. 2021 Feb 17;18(1):36. Abstract
submitted by kickingbird at Feb, 19, 2021 from Virol J. 2021 Feb 17;18(1):36 (via https://pubmed.ncbi.nlm.nih.gov/33596956/)
Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated ... Yang F, Xiao Y, Liu F, Yao H, Wu N, Wu H. Isolation and characterization of two novel reassortant H5N6 avian influenza viruses from waterfowl in eastern China. Arch Virol. 2021 Feb 17. Abstract
submitted by kickingbird at Feb, 19, 2021 from Arch Virol. 2021 Feb 17 (via https://pubmed.ncbi.nlm.nih.gov/33598814/)
Waterfowl are considered to be the natural hosts of avian influenza virus. In 2017, two reassortant highly pathogenic H5N6 avian influenza viruses of clade 2.3.4.4, subclade II, were identified in wild ... Le Sage V, Jones JE, Kormuth KA, Fitzsimmons WJ, N. Pre-existing heterosubtypic immunity provides a barrier to airborne transmission of influenza viruses. PLoS Pathog. 2021 Feb 18;17(2):e1009273. Abstract
submitted by kickingbird at Feb, 19, 2021 from PLoS Pathog. 2021 Feb 18;17(2):e1009273 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Human-to-human transmission of influenza viruses is a serious public health threat, yet the precise role of immunity from previous infections on the susceptibility to airborne infection is still unknown. ... Kaku N, Hashiguchi K, Akamatsu N, Wakigawa F, Mats. Evaluation of a novel rapid TRC assay for the detection of influenza using nasopharyngeal swabs and gargle samples. Eur J Clin Microbiol Infect Dis. 2021 Feb 16. Abstract
submitted by kickingbird at Feb, 17, 2021 from Eur J Clin Microbiol Infect Dis. 2021 Feb 16 (via https://pubmed.ncbi.nlm.nih.gov/33594599/)
We evaluated a novel transcription-reverse transcription concerted reaction (TRC) assay that can detect influenza A and B within 15 min using nasopharyngeal swab and gargle samples obtained from patients ... Li APY, Cohen CA, Leung NHL, Fang VJ, Gangappa S,. Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults. NPJ Vaccines. 2021 Feb 16;6(1):25. Abstract
submitted by kickingbird at Feb, 17, 2021 from NPJ Vaccines. 2021 Feb 16;6(1):25 (via https://pubmed.ncbi.nlm.nih.gov/33594050/)
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled ... Roubidoux EK, Carre?o JM, McMahon M, Jiang K, van. Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model. mBio. 2021 Feb 16;12(1):e03617-20. Abstract
submitted by kickingbird at Feb, 17, 2021 from mBio. 2021 Feb 16;12(1):e03617-20 (via https://mbio.asm.org/content/12/1/e03617-20)
Current seasonal influenza virus vaccines target regions of the hemagglutinin (HA) head domain that undergo constant antigenic change, forcing the painstaking annual reformulation of vaccines. The development ... Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K,. Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018. Abstract
submitted by kickingbird at Feb, 17, 2021 from Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018 (via https://www.pnas.org/content/118/8/e2018102118)
In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/2015 influenza virus vaccination (Fluarix) to study the ... Wang B, Su Q, Luo J, Li M, Wu Q, Chang H, Du J, Hu. Differences in Highly Pathogenic H5N6 Avian Influenza Viral Pathogenicity and Inflammatory Response in Chickens and Ducks. Front Microbiol. 2021 Jan 29;12:593202. Abstract
submitted by kickingbird at Feb, 16, 2021 from Front Microbiol. 2021 Jan 29;12:593202 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.5932)
Infection with H5N6 highly pathogenic avian influenza virus caused high mortality in chickens, while ducks often appear to be asymptomatic. But, some recent H5Nx subtype viruses could cause high mortality ... Huang J, Wu S, Wu W, Liang Y, Zhuang H, Ye Z, Qu X. The Biological Characteristics of Novel H5N6 Highly Pathogenic Avian Influenza Virus and Its Pathogenesis in Ducks. Front Microbiol. 2021 Jan 26;12:628545. Abstract
submitted by kickingbird at Feb, 16, 2021 from Front Microbiol. 2021 Jan 26;12:628545 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.6285)
Clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses (HPAIVs) have caused outbreaks in poultry in the world. Some of these viruses acquired internal genes from other subtype avian influenza viruses ... Gierak A, ?mietanka K, de Vos CJ. Quantitative risk assessment of the introduction of low pathogenic avian influenza H5 and H7 strains into Poland via legal import of live poultry. Prev Vet Med. 2021 Jan 28;189:105289. Abstract
submitted by kickingbird at Feb, 16, 2021 from Prev Vet Med. 2021 Jan 28;189:105289 (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
Low pathogenic avian influenza (LPAI) caused by H5 and H7 viruses is considered a threatening disease for poultry production due to the possibility of prolonged undetected virus circulation in a poultry ... Hulme KD, Karawita AC, Pegg C, Bunte MJ, Bielefeld. A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants. Elife. 2021 Feb 16;10:e61803. Abstract
submitted by kickingbird at Feb, 16, 2021 from Elife. 2021 Feb 16;10:e61803 (via https://pubmed.ncbi.nlm.nih.gov/33588989/)
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals ... Tsuneki-Tokunaga A, Kanai K, Itagaki A, Tsuchie H,. Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic. Arch Virol. 2021 Feb 12. Abstract
submitted by kickingbird at Feb, 14, 2021 from Arch Virol. 2021 Feb 12 (via https://link.springer.com/article/10.1007/s00705-021-04976-5)
AbstractThe correlation of viral growth capability (n = 156) with the viral load in nasopharyngeal swabs (n = 76) was assessed. Epidemic influenza A/H1N1, A/H3N2, and B viruses showed a wide range of growth ... Hidekazu Osada, Chon I, Phyu WW, Wagatsuma K, Naga. Development of cycling probe based real-time PCR methodology for influenza A viruses possessing the PA/I38T amino acid substitution associated with reduced baloxavir susceptibility. Antiviral Res. 2021 Feb 9:105036. Abstract
submitted by kickingbird at Feb, 14, 2021 from Antiviral Res. 2021 Feb 9:105036 (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
Baloxavir marboxil has been used for influenza treatment since March 2018 in Japan. After baloxavir treatment, the most frequently detected substitution is Ile38Thr in polymerase acidic protein (PA/I38T), ... Ashraf U, Benoit-Pilven C, Navratil V, Ligneau C,. Influenza virus infection induces widespread alterations of host cell splicing. NAR Genom Bioinform. 2020 Nov 21;2(4):lqaa095. Abstract
submitted by kickingbird at Feb, 13, 2021 from NAR Genom Bioinform. 2020 Nov 21;2(4):lqaa095 (via https://academic.oup.com/nargab/article/2/4/lqaa095/5998301)
Influenza A viruses (IAVs) use diverse mechanisms to interfere with cellular gene expression. Although many RNA-seq studies have documented IAV-induced changes in host mRNA abundance, few were designed ... Zeng Y, Xu S, Wei Y, Zhang X, Wang Q, Jia Y, Wang. The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation. PLoS Pathog. 2021 Feb 12;17(2):e1009300. Abstract
submitted by kickingbird at Feb, 13, 2021 from PLoS Pathog. 2021 Feb 12;17(2):e1009300 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated. In this study, we identified ... 5328 items, 20/Page, Page[72/267][|<<] [|<] [71] [72] [73] [74] [75] [76] [77] [78] [79] [80] [>|] [>>|] |
Related Pages:
Browse by Category
Learn about the flu news, articles, events and more
Subscribe to the weekly F.I.C newsletter!
|
- 
