Zhang X, Li Y, Jin S, Wang T, Sun W, Zhang Y, Li F. H9N2 influenza virus spillover into wild birds from poultry in China bind to human-type receptors and transmit in mammals via respiratory droplets. Transbound Emerg Dis. 2021 Feb 10. Abstract
submitted by kickingbird at Feb, 11, 2021 from Transbound Emerg Dis. 2021 Feb 10 (via https://pubmed.ncbi.nlm.nih.gov/33566453/)
H9N2 influenza virus has been reported worldwide for several decades, and it has evolved into multiple genotypes among domestic poultry. However, the study involving ecology and evolution of low pathogenic ...
De Conto F, Conversano F, Razin SV, Belletti S, Ar. Host-cell dependent role of phosphorylated keratin 8 during influenza A/NWS/33 virus (H1N1) infection in mammalian cells. Virus Res. 2021 Feb 5:198333. Abstract
submitted by kickingbird at Feb, 10, 2021 from Virus Res. 2021 Feb 5:198333 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
In this study, we investigated the involvement of keratin 8 during human influenza A/NWS/33 virus (H1N1) infection in semi-permissive rhesus monkey-kidney (LLC-MK2) and permissive human type II alveolar ...
Li H, Huang L, Yu Y, Ren X, Li B, Zhang J, Liao M,. Generation of recombinant influenza virus bearing strep tagged PB2 and effective identification of interactional host factors. Vet Microbiol. 2021 Jan 13;254:108985. Abstract
submitted by kickingbird at Feb, 10, 2021 from Vet Microbiol. 2021 Jan 13;254:108985 (via https://www.sciencedirect.com/science/article/pii/S037811352)
The genome of influenza A virus is negative-sense and segmented RNA, which is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRp) during the virus life cycle. The viral RdRp is ...
Crossley BM, Rejmanek D, Baroch J, Stanton JB, You. Nanopore sequencing as a rapid tool for identification and pathotyping of avian influenza A viruses. J Vet Diagn Invest. 2021 Feb 6:1040638720984114. Abstract
submitted by kickingbird at Feb, 10, 2021 from J Vet Diagn Invest. 2021 Feb 6:1040638720984114 (via https://journals.sagepub.com/doi/10.1177/1040638720984114)
We report whole-genome sequencing of influenza A virus (IAV) with 100% diagnostic sensitivity and results available in 500× coverage from each of 16 reference virus isolates evaluated. Subgenomic viral ...
Orr-Burks N, Murray J, Todd KV, Bakre A, Tripp RA. GPCR and ion channel genes used by influenza virus for replication. J Virol. 2021 Feb 3:JVI.02410-20. Abstract
submitted by kickingbird at Feb, 5, 2021 from J Virol. 2021 Feb 3:JVI.02410-20 (via https://pubmed.ncbi.nlm.nih.gov/33536179/)
Influenza virus causes epidemics and sporadic pandemics resulting in morbidity, mortality and economic losses. Influenza viruses require host genes to replicate. RNA interference (RNAi) screens can identify ...
Mezhenskaya D, Isakova-Sivak I, Kotomina T, Matyus. A Strategy to Elicit M2e-Specific Antibodies Using a Recombinant H7N9 Live Attenuated Influenza Vaccine Expressing Multiple M2e Tandem Repeats. Biomedicines. 2021 Feb 1;9(2):133. Abstract
submitted by kickingbird at Feb, 5, 2021 from Biomedicines. 2021 Feb 1;9(2):133 (via https://www.mdpi.com/2227-9059/9/2/133)
Influenza viruses remain a serious public health problem. Vaccination is the most effective way to prevent the disease; however, seasonal influenza vaccines demonstrate low or no effectiveness against ...
Youk S, Cho AY, Lee DH, Jeong S, Kim Y, Lee S, Kim. Detection of newly introduced Y280-lineage H9N2 avian influenza viruses in live bird markets in Korea. Transbound Emerg Dis . 2021 Feb 1. Abstract
submitted by kickingbird at Feb, 2, 2021 from Transbound Emerg Dis . 2021 Feb 1 (via https://pubmed.ncbi.nlm.nih.gov/33523603/)
We report the first detection of Y280-lineage H9N2 avian influenza viruses in live bird markets in Korea during July 2020. The viruses were isolated from domestic ducks and chickens traded in three markets ...
Liu Y, Fu C, Ye S, Liang Y, Qi Z, Yao C, Wang Z, W. The inactivated vaccine of reassortant H3N2 canine influenza virus based on internal gene cassette from PR8 is safe and effective. Vet Microbiol. 2021 Jan 27;254:108997. Abstract
submitted by kickingbird at Feb, 2, 2021 from Vet Microbiol. 2021 Jan 27;254:108997 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Canine influenza (CI) is a contagious respiratory disease in dogs, which poses a threat to canine health. A safe, high-yield vaccine seed virus is critical for CI vaccine development. We developed a PR8-based ...
Mohd-Kipli F, Claridge JK, Habjani? J, Jiang A, Sc. Conformational triggers associated with influenza matrix protein 1 polymerization. J Biol Chem. 2021 Jan 28:100316. Abstract
submitted by kickingbird at Feb, 1, 2021 from J Biol Chem. 2021 Jan 28:100316 (via https://www.jbc.org/article/S0021-9258(21)00086-7/fulltext)
A central role for the influenza matrix protein 1 (M1) is to form a polymeric coat on the inner leaflet of the host membrane that ultimately provides shape and stability to the virion. M1 polymerizes upon ...
Shi N, Zhang S, Guo Y, Yu X, Zhao W, Zhang M, Guan. CircRNA_0050463 promotes influenza A virus replication by sponging miR-33b-5p to regulate EEF1A1. Vet Microbiol. 2021 Jan 19;254:108995. Abstract
submitted by kickingbird at Feb, 1, 2021 from Vet Microbiol. 2021 Jan 19;254:108995 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Circular RNAs (circRNAs), a new class of widely expressed endogenous regulatory RNAs, are characterized by a covalently closed loop structure without a 5' cap or 3' tail. Increasing numbers of studies ...
Tang W, Li X, Tang L, Wang T, He G. Characterization of the low-pathogenic H7N7 avian influenza virus in Shanghai, China. Poult Sci. 2021 Feb;100(2):565-574. Abstract
submitted by kickingbird at Feb, 1, 2021 from Poult Sci. 2021 Feb;100(2):565-574 (via https://www.sciencedirect.com/science/article/pii/S003257912)
H7N7 avian influenza virus (AIV) can divided into low-pathogenic AIV and high-pathogenic AIV groups. It has been shown to infect humans and animals. Its prevalence state in wild birds in China remains ...
Wang G, Liu D, Hu J, Gu M, Wang X, He D, Zhang L,. Mutations during the adaptation of H7N9 avian influenza virus to mice lungs enhance human-like sialic acid binding activity and virulence in mice. Vet Microbiol. 2021 Jan 20;254:109000. Abstract
submitted by kickingbird at Feb, 1, 2021 from Vet Microbiol. 2021 Jan 20;254:109000 (via https://www.sciencedirect.com/science/article/pii/S037811352)
The first avian H7N9 influenza outbreak in spring of 2013 emerged in an unprecedented transmission from infected poultry to humans in the Yangtze delta area, eastern China, posing a dual challenge to public ...
Wu Y, Bissinger T, Genzel Y, Liu X, Reichl U, Tan. High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells. Appl Microbiol Biotechnol. 2021 Jan 30. Abstract
submitted by kickingbird at Jan, 31, 2021 from Appl Microbiol Biotechnol. 2021 Jan 30 (via https://link.springer.com/article/10.1007/s00253-020-11050-8)
Similar to the recent COVID-19 pandemic, influenza A virus poses a constant threat to the global community. For the treatment of flu disease, both antivirals and vaccines are available with vaccines the ...
Li X, Zhang L, Liu Y, Ma L, Zhang N, Xia C. Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope. J Biol Chem. 2020 Apr 17;295(16):5292-5306. Abstract
submitted by kickingbird at Jan, 30, 2021 from J Biol Chem. 2020 Apr 17;295(16):5292-5306 (via https://www.jbc.org/article/S0021-9258(17)48550-4/fulltext)
Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes ...
Levene RE, Shrestha SD, Gaglia MM. The influenza A virus host shutoff factor PA-X is rapidly turned over in a strain-specific manner. J Virol. 2021 Jan 27:JVI.02312-20.. Abstract
submitted by kickingbird at Jan, 29, 2021 from J Virol. 2021 Jan 27:JVI.02312-20. (via https://jvi.asm.org/content/early/2021/01/25/JVI.02312-20)
The influenza A endoribonuclease PA-X regulates virulence and transmission of the virus by reducing host gene expression and thus regulating immune responses to influenza A virus. Despite this key function ...
McBride DS, Lauterbach SE, Li YT, Smith GJD, Killi. Genomic Evidence for Sequestration of Influenza A Virus Lineages in Sea Duck Host Species. Viruses. 2021 Jan 24;13(2):172. Abstract
submitted by kickingbird at Jan, 28, 2021 from Viruses. 2021 Jan 24;13(2):172 (via https://www.mdpi.com/1999-4915/13/2/172)
Wild birds are considered the natural reservoir of influenza A viruses (IAVs) making them critical for IAV surveillance efforts. While sea ducks have played a role in novel IAV emergence events that threatened ...
Lei GL, Wang LP, Dong SH, Sun F, Cheng JX, Yang XL. A recombinant influenza virus with a CTLA4-specific scFv inhibits tumor growth in a mouse model. Cell Biol Int. 2021 Jan 26. Abstract
submitted by kickingbird at Jan, 28, 2021 from Cell Biol Int. 2021 Jan 26 (via https://onlinelibrary.wiley.com/doi/10.1002/cbin.11559)
Oncolytic viruses (OV) have shown excellent safety and efficacy in preclinical and clinical studies. Influenza A virus (IAV) is considered a promising oncolytic virus. In this report, we generated a recombinant ...
Li Z, Zhao Y, Li Y, Chen X. Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity. Vaccines (Basel). 2021 Jan 21;9(2):75. Abstract
submitted by kickingbird at Jan, 27, 2021 from Vaccines (Basel). 2021 Jan 21;9(2):75 (via https://www.mdpi.com/2076-393X/9/2/75)
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies ...
Luczo JM, Ronzulli SL, Tompkins SM. Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30. Viruses. 2021 Jan 21;13(2):156. Abstract
submitted by kickingbird at Jan, 27, 2021 from Viruses. 2021 Jan 21;13(2):156 (via https://www.mdpi.com/1999-4915/13/2/156)
Natural killer (NK) cells are part of the innate immunity repertoire, and function in the recognition and destruction of tumorigenic and pathogen-infected cells. Engagement of NK cell activating receptors ...
Borchering RK, Gunning CE, Gokhale DV, Weedop KB,. Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e20123. Abstract
submitted by kickingbird at Jan, 27, 2021 from Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e20123 (via https://www.pnas.org/content/118/5/e2012327118)
The 2019/2020 influenza season in the United States began earlier than any season since the 2009 H1N1 pandemic, with an increase in influenza-like illnesses observed as early as August. Also noteworthy ...
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