Criado MF, et al. Efficacy of novel recombinant fowlpox vaccine against recent Mexican H7N3 highly pathogenic avian influenza virus. Vaccine. 2019 Mar 15. Abstract
submitted by kickingbird at Mar, 21, 2019 from Vaccine. 2019 Mar 15 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Since 2012, H7N3 highly pathogenic avian influenza (HPAI) has produced negative economic and animal welfare impacts on poultry in central Mexico. In the present study, chickens were vaccinated with two ...
Nannetti G, et al. Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance. Antiviral Res. 2019 Mar 15.. Abstract
submitted by kickingbird at Mar, 21, 2019 from Antiviral Res. 2019 Mar 15. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Influenza viruses are major respiratory pathogens responsible for both seasonal epidemics and occasional pandemics worldwide. The current available treatment options have limited efficacy and thus the ...
Chen Y, Wen Y. Spatiotemporal Distributions and Dynamics of Human Infections with the A H7N9 Avian Influenza Virus. Comput Math Methods Med. 2019 Feb 7;2019:9248246. Abstract
submitted by kickingbird at Mar, 19, 2019 from Comput Math Methods Med. 2019 Feb 7;2019:9248246 (via https://www.hindawi.com/journals/cmmm/2019/9248246/)
In 2013 in mainland China, a novel avian influenza virus H7N9 began to infect humans and had aroused severe fatality in the infected humans, followed by the annual outbreaks. By methods of GIS and kriging ...
Paget C, Trottein F. Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells. Front Immunol. 2019 Mar 1;10:336.. Abstract
submitted by kickingbird at Mar, 19, 2019 from Front Immunol. 2019 Mar 1;10:336. (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0033)
Despite the widespread application of vaccination programs and antiviral drug treatments, influenza viruses are still among the most harmful human pathogens. Indeed, influenza results in significant seasonal ...
Pu Z, Yang J, Shen X, Irwin DM, Shen Y. Human-isolated H7N9 obtained internal genes from duck and human influenza viruses. J Infect. 2019 Mar 14.. Abstract
submitted by kickingbird at Mar, 19, 2019 from J Infect. 2019 Mar 14. (via https://www.journalofinfection.com/article/S0163-4453(19)300)
Recent studies in this journal revealed that some H7N9 viruses reassorted with duck AIVs, and then attained the ability to efficiently infect ducks.1,2 H7N9 AIVs have been endemic in chicken since their ...
Tang W, Li X, Hu CH, Zhu C, Li Z, Wu D, Wang T, He. Isolation of H8N4 avian influenza virus from wild birds in Shanghai, China.. Acta Virol. 2019;63(1):121-125.. Abstract
submitted by kickingbird at Mar, 19, 2019 from Acta Virol. 2019;63(1):121-125. (via https://www.ncbi.nlm.nih.gov/pubmed/30879322)
The H8 subtype viruses are rarely isolated from wild ducks. Shanghai is one of the important wintering or stopover sites on the East Asia-Australia Migration Flyway. An influenza virus, subtype H8N4, was ...
Parvandeh S, et al. Multi-Level Model to Predict Antibody Response to Influenza Vaccine Using Gene Expression Interaction Network Feature Selection. Microorganisms. 2019 Mar 14;7(3).. Abstract
submitted by kickingbird at Mar, 19, 2019 from Microorganisms. 2019 Mar 14;7(3). (via https://www.mdpi.com/2076-2607/7/3/79)
Vaccination is an effective prevention of influenza infection. However, certain individuals develop a lower antibody response after vaccination, which may lead to susceptibility to subsequent infection. ...
Lee CC, et al. An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells. Sci Rep. 2019 Mar 14;9(1):4546. Abstract
submitted by kickingbird at Mar, 19, 2019 from Sci Rep. 2019 Mar 14;9(1):4546 (via https://www.nature.com/articles/s41598-019-40937-4)
Influenza is a contagious acute respiratory disease caused by the influenza virus infection. Hemagglutinin (HA) is an important target in the therapeutic treatment and diagnostic detection of the influenza ...
Kolpe A, et al. Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface. Sci Rep. 2019 Mar 14;9(1):4450.. Abstract
submitted by kickingbird at Mar, 19, 2019 from Sci Rep. 2019 Mar 14;9(1):4450. (via https://www.ncbi.nlm.nih.gov/pubmed/30872764)
Influenza A virions are highly pleomorphic, exhibiting either spherical or filamentous morphology. The influenza A virus strain A/Udorn/72 (H3N2) produces copious amounts of long filaments on the surface ...
Pulit-Penaloza JA, Belser JA, Tumpey TM, Maines TR. Swine-origin H1 influenza viruses isolated from humans exhibit sustained infectivity in an aerosol state. Appl Environ Microbiol. 2019 Mar 15.. Abstract
submitted by kickingbird at Mar, 17, 2019 from Appl Environ Microbiol. 2019 Mar 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30877121)
The relative importance of influenza virus transmission via aerosols is not fully understood, but experimental data suggests that aerosol transmission may represent a critical mode of influenza virus spread ...
Chong CR, et al. Safety of Inactivated Influenza Vaccine in Cancer Patients Receiving Immune Checkpoint Inhibitors (ICI). Clin Infect Dis. 2019 Mar 15.. Abstract
submitted by kickingbird at Mar, 17, 2019 from Clin Infect Dis. 2019 Mar 15. (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: Cancer patients are at a higher risk for developing influenza (flu) related complications. It is unclear if the flu vaccine exacerbates immune events in patients treated with ICIs.METHODS: ...
Takizawa N, et al. Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging. Virology. 2019 Mar 7;531:126-140. Abstract
submitted by kickingbird at Mar, 17, 2019 from Virology. 2019 Mar 7;531:126-140 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The influenza A virus genome consists of eight single-stranded negative-sense RNA segments. The noncoding regions located at the 3'- and 5'- ends of each segment are necessary for genome packaging, and ...
Zhou AC, Batista NV, Watts TH. 4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influ. J Immunol. 2019 Mar 13.. Abstract
submitted by kickingbird at Mar, 16, 2019 from J Immunol. 2019 Mar 13. (via http://www.jimmunol.org/content/early/2019/03/13/jimmunol.18)
The TNFR superfamily member 4-1BB is important in the establishment of tissue-resident memory T cells (Trm) in the lung tissue following influenza infection. Moreover, supraphysiological boosting of 4-1BB ...
Siegers JY, et al. Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System. J Virol. 2019 Mar 13.. Abstract
submitted by kickingbird at Mar, 15, 2019 from J Virol. 2019 Mar 13. (via https://jvi.asm.org/content/early/2019/03/07/JVI.02273-18)
Central nervous system (CNS) disease is one of the most common extra-respiratory tract complication of influenza A virus infections. Remarkably, zoonotic H5N1 virus infections are more frequently associated ...
Alnaji FG, et al. Sequencing framework for the sensitive detection and precise mapping of defective interfering particle-associated deletions across influenza A and B viruses. J Virol. 2019 Mar 13.. Abstract
submitted by kickingbird at Mar, 15, 2019 from J Virol. 2019 Mar 13. (via https://jvi.asm.org/content/early/2019/03/07/JVI.00354-19)
The mechanisms and consequences of defective interfering particle (DIP) formation during influenza virus infection remain poorly understood. The development of next generation sequencing (NGS) technologies ...
Lai JCC, et al. Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding. Emerg Microbes Infect. 2019;8(1):327-338. Abstract
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):327-338 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza virus haemagglutinin (HA) and neuraminidase (NA) are involved in the recognition and modulation of sialic acids on the cell surface as the virus receptor. Although the balance between two proteins ...
Welkers MRA, et al. Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection. Emerg Microbes Infect. 2019;8(1):262-271.. Abstract
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):262-271. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The continuing pandemic threat posed by avian influenza A/H5N1 viruses calls for improved insights into their evolution during human infection. We performed whole genome deep sequencing of respiratory ...
Monamele CG, et al. Evidence of exposure and human seroconversion during an outbreak of avian influenza A(H5N1) among poultry in Cameroon. Emerg Microbes Infect. 2019;8(1):186-196. Abstract
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):186-196 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
From May 2016 to March 2017, 22 poultry outbreaks of avian influenza A(H5N1) were reported in Cameroon, mainly in poultry farms and live bird markets. No human cases were reported. In this study, we sought ...
Pan M, Yang HP, Jian J, et al. Association of meteorological factors with seasonal activity of influenza A subtypes and B lineages in subtropical western China. Epidemiol Infect. 2019 Jan;147:e72. Abstract
submitted by kickingbird at Mar, 15, 2019 from Epidemiol Infect. 2019 Jan;147:e72 (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
The seasonality of individual influenza subtypes/lineages and the association of influenza epidemics with meteorological factors in the tropics/subtropics have not been well understood. The impact of the ...
Amanat F, Meade P, Strohmeier S, Krammer F. Cross-reactive antibodies binding to H4 hemagglutinin protect against a lethal H4N6 influenza virus challenge in the mouse model. Emerg Microbes Infect. 2019;8(1):155-168. Abstract
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):155-168 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
Influenza viruses of the H4 subtype are widespread in wild birds, circulate in domestic poultry, readily infect mammals, and tolerate the insertion of a polybasic cleavage site. In addition, serological ...
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