Sun J, Brooke CB. Influenza A Virus Superinfection Potential Is Regulated by Viral Genomic Heterogeneity. MBio. 2018 Oct 30;9(5). Abstract
submitted by kickingbird at Nov, 3, 2018 from MBio. 2018 Oct 30;9(5) (via https://www.ncbi.nlm.nih.gov/pubmed/30377278)
Defining the specific factors that govern the evolution and transmission of influenza A virus (IAV) populations is of critical importance for designing more-effective prediction and control strategies. ...
Goldhill DH, et al. Determining the Mutation Bias of Favipiravir in Influenza Using Next-generation Sequencing. J Virol. 2018 Oct 31. Abstract
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31 (via https://www.ncbi.nlm.nih.gov/pubmed/30381482)
avipiravir is a broad-spectrum antiviral drug that may be used to treat influenza. Previous research has identified that favipiravir likely acts as a mutagen but the precise mutation bias that favipiravir ...
Prachanronarong KL, et al. Mutations in influenza A virus neuraminidase and hemagglutinin confer resistance against a broadly neutralizing hemagglutinin stem antibody. J Virol. 2018 Oct 31. Abstract
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31 (via https://www.ncbi.nlm.nih.gov/pubmed/30381484)
Influenza A virus (IAV), a major cause of human morbidity and mortality, continuously evolves in response to selective pressures. Stem-directed, broadly neutralizing antibodies (sBnAbs) targeting influenza ...
Meliopoulos V, et al. Absence of β6 integrin reduces influenza disease severity in highly susceptible obese mice. J Virol. 2018 Oct 31.. Abstract
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31. (via https://www.ncbi.nlm.nih.gov/pubmed/30381485)
Obese individuals are considered a high-risk group for developing severe influenza virus infection. While the exact mechanisms for increased disease severity remain under investigation, obese mouse models ...
Sun W, et al. Antibody responses towards the major antigenic sites of influenza B virus hemagglutinin in mice, ferrets and humans. J Virol. 2018 Oct 31. Abstract
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31 (via https://www.ncbi.nlm.nih.gov/pubmed/30381487)
The influenza B virus hemagglutinin contains four major antigenic sites (the 120 loop, the 150 loop, the 160 loop and the 190 helix) within the head domain. These immunodominant antigenic sites are the ...
Wang SC, Liao HY, Zhang JY, Cheng TR, Wong CH. Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris. Virology. 2018 Oct 26;526:125-137. Abstract
submitted by kickingbird at Nov, 3, 2018 from Virology. 2018 Oct 26;526:125-137 (via https://www.ncbi.nlm.nih.gov/pubmed/30388628)
The development of a universal influenza vaccine has become a major effort to combat the high mutation rate of influenza. To explore the use of the highly conserved stem region of hemagglutinin (HA) as ...
Houser KV, et al. DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial. PLoS One. 2018 Nov 2;13(11):e0206837. Abstract
submitted by kickingbird at Nov, 3, 2018 from PLoS One. 2018 Nov 2;13(11):e0206837 (via https://www.ncbi.nlm.nih.gov/pubmed/30388160)
BACKGROUND: Children are susceptible to severe influenza infections and facilitate community transmission. One potential strategy to improve vaccine immunogenicity in children against seasonal influenza ...
Kandeil A, et al. Isolation and characterization of a distinct influenza A virus from Egyptian bats. J Virol. 2018 Oct 31.. Abstract
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31. (via https://www.ncbi.nlm.nih.gov/pubmed/30381492)
Recently, two genetically distinct influenza viruses were detected in bats in Guatemala and Peru. We conducted influenza A surveillance among four bat species in Egypt. Out of 1202 swabs, 105 were positive ...
Saito S, Nakauchi M, Takayama I, Nagata S, et al. Development and evaluation of new real-time RT-PCR assays for identifying the influenza A virus Cluster IV H3N2 variant. Jpn J Infect Dis. 2018 Oct 31. Abstract
submitted by kickingbird at Nov, 3, 2018 from Jpn J Infect Dis. 2018 Oct 31 (via https://www.ncbi.nlm.nih.gov/pubmed/30381693)
From 2005 to July 6, 2018, a total of 435 swine-origin influenza A H3N2 variant virus (H3N2v) human infections were reported in the USA. The largest H3N2v outbreak in the USA occurred in 2011-2012. This ...
Murakami S, Horimoto T. Novel type D influenza virus. Uirusu. 2017;67(2):161-170. Abstract
submitted by kickingbird at Oct, 31, 2018 from Uirusu. 2017;67(2):161-170 (via https://www.ncbi.nlm.nih.gov/pubmed/30369540)
Influenza viruses have been known to be types A to C, including human seasonal influenza virus and avian influenza virus. In recent years, the influenza D virus, which possesses different characteristics ...
Wille M, Br?jer C, Lundkvist ?, J?rhult JD. Alternate routes of influenza A virus infection in Mallard (Anas platyrhynchos). Vet Res. 2018 Oct 29;49(1):110. Abstract
submitted by kickingbird at Oct, 31, 2018 from Vet Res. 2018 Oct 29;49(1):110 (via https://www.ncbi.nlm.nih.gov/pubmed/30373662)
The natural reservoir for all influenza A viruses (IAVs) is wild birds, particularly dabbling ducks. During the autumn, viral prevalence can be very high in dabbling ducks (>?30%) in the Northern Hemisphere, ...
Jochems SP, et al. Inflammation induced by influenza virus impairs human innate immune control of pneumococcus. Nat Immunol. 2018 Oct 29. Abstract
submitted by kickingbird at Oct, 31, 2018 from Nat Immunol. 2018 Oct 29 (via https://www.ncbi.nlm.nih.gov/pubmed/30374129)
Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus ...
Beshara R, et al. Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection. PLoS Pathog. 2018 Oct 29;14(10):e1007360.. Abstract
submitted by kickingbird at Oct, 31, 2018 from PLoS Pathog. 2018 Oct 29;14(10):e1007360. (via https://www.ncbi.nlm.nih.gov/pubmed/30372491)
Secondary bacterial infections contribute to the excess morbidity and mortality of influenza A virus (IAV) infection. Disruption of lung integrity and impaired antibacterial immunity during IAV infection ...
Benam KH, Denney L, Ho LP. How the Respiratory Epithelium Senses and Reacts to Influenza Virus. Am J Respir Cell Mol Biol. 2018 Oct 29.. Abstract
submitted by kickingbird at Oct, 31, 2018 from Am J Respir Cell Mol Biol. 2018 Oct 29. (via https://www.ncbi.nlm.nih.gov/pubmed/30372120)
Our lungs are constantly exposed to the environment and potential pathogens. As the interface between host and environment, the respiratory epithelium has evolved sophisticated sensing mechanisms as part ...
Li C, et al. Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production. Front Immunol. 2018 Oct 12;9:2370.. Abstract
submitted by kickingbird at Oct, 31, 2018 from Front Immunol. 2018 Oct 12;9:2370. (via https://www.ncbi.nlm.nih.gov/pubmed/30369932)
Current influenza vaccines have relatively low effectiveness, especially against antigenically drifted strains, the effectiveness is even lower in the elderly and immunosuppressed individuals. We have ...
Yegani S, Shoushtari AH, Eshratabadi F, Molouki A. Full sequence analysis of hemagglutinin and neuraminidase genes and proteins of highly pathogenic avian influenza H5N1 virus detected in Iran, 2015. Trop Anim Health Prod. 2018 Oct 27.. Abstract
submitted by kickingbird at Oct, 29, 2018 from Trop Anim Health Prod. 2018 Oct 27. (via https://www.ncbi.nlm.nih.gov/pubmed/30368763)
Over the last two decades, the highly pathogenic avian influenza H5N1 virus has gained a lot of attention due to its zoonotic and mutative nature. Iran is among the countries significantly affected by ...
Deka H, Nath D, Uddin A, Chakraborty S. DNA compositional dynamics and codon usage patterns of M1 and M2 matrix protein genes in influenza A virus. Infect Genet Evol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 29, 2018 from Infect Genet Evol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30367980)
Influenza A virus subtype H3N2 has been a serious health issue across the globe with approximately 36 thousand annual casualties in the United States of America only. Co-circulation in avian, swine and ...
Harland KL, et al. Limited Phenotypic and Functional Plasticity of Influenza Virus-Specific Memory CD8+ T Cells during Activation in an Alternative Cytokine Environment. J Immunol. 2018 Oct 26. Abstract
submitted by kickingbird at Oct, 29, 2018 from J Immunol. 2018 Oct 26 (via https://www.ncbi.nlm.nih.gov/pubmed/30366957)
Naive CD8+ T cells show phenotypic, functional, and epigenetic plasticity, enabling differentiation into distinct cellular states. However, whether memory CD8+ T cells demonstrate similar flexibility upon ...
Korenkov D, Isakova-Sivak I, Rudenko L. Basics of CD8 T-cell immune responses after influenza infection and vaccination with inactivated or live attenuated influenza vaccine. Expert Rev Vaccines. 2018 Oct 26. Abstract
submitted by kickingbird at Oct, 29, 2018 from Expert Rev Vaccines. 2018 Oct 26 (via https://www.ncbi.nlm.nih.gov/pubmed/30365908)
Numerous effector reactions are involved in antiviral immunity. The antibody and T-cell-mediated reactions are the best-understood processes of the adaptive immune response against influenza virus. One ...
Kim TH, Zhou H. Overexpression of Chicken IRF7 Increased Viral Replication and Programmed Cell Death to the Avian Influenza Virus Infection Through TGF-Beta/FoxO Signaling Axis in DF-1. Front Genet. 2018 Sep 25;9:415. Abstract
submitted by kickingbird at Oct, 27, 2018 from Front Genet. 2018 Sep 25;9:415 (via https://www.ncbi.nlm.nih.gov/pubmed/30356848)
During mammalian viral infections, interferon regulatory factor 7 (IRF7) partners with IRF3 to regulate the type I interferon response. In chickens, however, it is still unclear how IRF7 functions in the ...
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