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2019-9-17 17:22:45
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Xiao Y, et al. Deep sequencing of 2009 influenza A/H1N1 virus isolated from volunteer human challenge study participants and natural infections. Virology. 2019 Jun 13;534:96-107..  Abstract  
submitted by kickingbird at Jun, 23, 2019 from Virology. 2019 Jun 13;534:96-107. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Nasal wash samples from 15 human volunteers challenged with GMP manufactured influenza A/California/04/2009(H1N1) and from 5 naturally infected influenza patients of the 2009 pandemic were deep sequenced ...

Nichols JE, Niles JA, Fleming EH, Roberts NJ. The role of cell surface expression of influenza virus neuraminidase in induction of human lymphocyte apoptosis. Virology. 2019 Jun 10;534:80-86..  Abstract  
submitted by kickingbird at Jun, 21, 2019 from Virology. 2019 Jun 10;534:80-86. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The immunopathological mechanisms as well as the role played by influenza A virus infection of human leukocytes and induction of apoptosis have not been fully elucidated. We confirm here that the percentage ...

Liu JH, Chang CC, Chen CW, Wong LT, Chu YW. Conservation Region Finding for Influenza A Viruses by Machine Learning methods of N-linked Glycosylation Sites and B-cell Epitopes. Math Biosci. 2019 Jun 17:108217.  Abstract  
submitted by kickingbird at Jun, 21, 2019 from Math Biosci. 2019 Jun 17:108217 (via https://www.sciencedirect.com/science/article/abs/pii/S00255)
Influenza type A, a serious infectious disease of the human respiratory tract, poses an enormous threat to human health worldwide. It leads to high mortality rates in poultry, pigs, and humans. The primary ...

Li X, Xu B, Shaman J. Pathobiological features favouring the intercontinental dissemination of highly pathogenic avian influenza virus. R Soc Open Sci. 2019 May 8;6(5):190276.  Abstract  
submitted by kickingbird at Jun, 21, 2019 from R Soc Open Sci. 2019 May 8;6(5):190276 (via https://royalsocietypublishing.org/doi/10.1098/rsos.190276)
Avian influenza viruses (AIVs) are a continued threat to global health and economy. Unlike other highly pathogenic AIVs, novel H5N8 disseminated very quickly from Korea to other areas in Asia, Europe and ...

Spencer S, Thompson MG, Flannery B, Fry A. Comparison of Respiratory Specimen Collection Methods for Detection of Influenza Virus Infection by RT-PCR: A Literature Review. J Clin Microbiol. 2019 Jun 19..  Abstract  
submitted by kickingbird at Jun, 21, 2019 from J Clin Microbiol. 2019 Jun 19. (via https://jcm.asm.org/content/early/2019/06/17/JCM.00027-19)
Detection of influenza virus in respiratory specimens from ill individuals is the most commonly used method to identify influenza virus infection. A number of respiratory specimen types may be used, including ...

Staller E, et al. ANP32 proteins are essential for influenza virus replication in human cells. J Virol. 2019 Jun 19..  Abstract  
submitted by kickingbird at Jun, 21, 2019 from J Virol. 2019 Jun 19. (via https://jvi.asm.org/content/early/2019/06/13/JVI.00217-19)
ANP32 proteins have been implicated in supporting influenza virus replication, but most of the work to date has focused on the ability of avian Anp32 proteins to overcome restriction of avian influenza ...

Lim HK, et al. Severe influenza pneumonitis in children with inherited TLR3 deficiency. J Exp Med. 2019 Jun 19..  Abstract  
submitted by kickingbird at Jun, 21, 2019 from J Exp Med. 2019 Jun 19. (via http://jem.rupress.org/content/early/2019/06/18/jem.20181621)
Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and underlie severe influenza pneumonitis. We report three unrelated children with influenza A virus (IAV) infection manifesting ...

Peng Q, et al. Structural insight into RNA synthesis by influenza D polymerase. Nat Microbiol. 2019 Jun 17.  Abstract  
submitted by kickingbird at Jun, 19, 2019 from Nat Microbiol. 2019 Jun 17 (via https://www.nature.com/articles/s41564-019-0487-5)
The influenza virus polymerase uses capped RNA primers to initiate transcription, and a combination of terminal and internal de novo initiations for the two-step replication process by binding the conserved ...

Libin Liang, et al. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. mBio.  Abstract  
submitted by kickingbird at Jun, 19, 2019 from mBio (via https://mbio.asm.org/content/10/3/e01162-19)
Avian influenza viruses (AIVs) must acquire mammalian-adaptive mutations before they can efficiently replicate in and transmit among humans. The PB2 E627K mutation is known to play a prominent role in ...

Gao L, et al. Integration analysis of a miRNA-mRNA expression in A549 cells infected with a novel H3N2 swine influenza virus and the 2009 H1N1 pandemic influenza virus. Infect Genet Evol. 2019 Jun 14:103922.  Abstract  
submitted by kickingbird at Jun, 18, 2019 from Infect Genet Evol. 2019 Jun 14:103922 (via https://www.ncbi.nlm.nih.gov/pubmed/31207403)
Swine are reservoirs for anthropogenic/zoonotic influenza viruses, and the prevalence and repeated introduction of the 2009 H1N1 pandemic influenza virus (pdm/09) into pigs raises the possibility of generating ...

Andreychuk DB, et al. Armored Exogenous Internal Control for Real-Time PCR Diagnosis of Avian Influenza. Avian Pathol. 2019 Jun 17:1-15..  Abstract  
submitted by kickingbird at Jun, 18, 2019 from Avian Pathol. 2019 Jun 17:1-15. (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2019.16)
An exogenous "armored" PCR internal control (IC) short RNA was analyzed in conjunction with real-time RT-PCR method for diagnosis of avian influenza. The resistance to nucleases and increase the physical ...

Wu H, Yang F, Xiao Y, Liu F, Yao H, Wu N. Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice. Infect Genet Evol. 2019 Jun 11:103918.  Abstract  
submitted by kickingbird at Jun, 16, 2019 from Infect Genet Evol. 2019 Jun 11:103918 (via https://www.sciencedirect.com/science/article/pii/S156713481)
The H6N1 subtype avian influenza virus (AIV) is a zoonotic infectious disease pathogen, which poses a threat to human health. In order to study the possible substitution of H6N1 AIV for mammals, an avian-origin ...

Yang L, et al. Emergence of waterfowl-originated gene cassettes in HPAI H7N9 viruses caused severe human infection in Fujian, China. Influenza Other Respir Viruses. 2019 Jun 11.  Abstract  
submitted by kickingbird at Jun, 14, 2019 from Influenza Other Respir Viruses. 2019 Jun 11 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12657)
BACKGROUND: Highly pathogenic avian influenza (HPAI) A(H7N9) virus emerged and caused human infections during the 2016-2017 epidemic wave of influenza A(H7N9) viruses in China. We report a human infection ...

Thomaston JL, Wu Y, Polizzi N, Liu L, et al. X-ray crystal structure of the influenza A M2 proton channel S31N mutant in two conformational states: an open and shut case. J Am Chem Soc. 2019 Jun 11..  Abstract  
submitted by kickingbird at Jun, 14, 2019 from J Am Chem Soc. 2019 Jun 11. (via https://pubs.acs.org/doi/10.1021/jacs.9b02196)
The amantadine-resistant S31N mutant of the influenza A M2 proton channel has become prevalent in currently circulating viruses. Here we have solved an X-ray crystal structure of M2(22-46) S31N that contains ...

Qiang X, Kou Z. Scoring amino acid mutation to predict pandemic risk of avian influenza virus. BMC Bioinformatics. 2019 Jun 10.  Abstract  
submitted by kickingbird at Jun, 13, 2019 from BMC Bioinformatics. 2019 Jun 10 (via https://bmcbioinformatics.biomedcentral.com/articles/10.1186)
BACKGROUND: Avian influenza virus can directly cross species barriers and infect humans with high fatality. As antigen novelty for human host, the public health is being challenged seriously. The pandemic ...

Du W, et al. The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLoS Pathog. 2019 Jun 10;15(6):e1007860.  Abstract  
submitted by kickingbird at Jun, 13, 2019 from PLoS Pathog. 2019 Jun 10;15(6):e1007860 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus (IAV) neuraminidase (NA) receptor-destroying activity and hemagglutinin (HA) receptor-binding affinity need to be balanced with the host receptor repertoire for optimal viral fitness. ...

Eladl AH, Alzayat AA, Ali HS, Fahmy HA, Ellakany H. Comparative molecular characterization, pathogenicity and seroprevalence of avian influenza virus H9N2 in commercial and backyard poultry flocks. Comp Immunol Microbiol Infect Dis. 2019 Jun;64:81-.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Comp Immunol Microbiol Infect Dis. 2019 Jun;64:81- (via https://www.sciencedirect.com/science/article/pii/S014795711)
This study was conducted to perform the comparative molecular characterization of avian influenza virus (AIV) H9N2, pathogenicity and seroprevalence in commercial and backyard poultry flocks. Fifty commercial ...

Musharrafieh R, et al. The L46P mutant confers a novel allosteric mechanism of resistance towards the influenza A virus M2 S31N proton channel blockers. Mol Pharmacol. 2019 Jun 7.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Mol Pharmacol. 2019 Jun 7 (via http://molpharm.aspetjournals.org/content/early/2019/06/07/m)
The FDA-approved influenza A antiviral amantadine inhibits the wild-type (WT) AM2 channel but not the S31N mutant predominantly found in circulating strains. In this study, serial viral passages were applied ...

Jia R, et al. Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase. Eur J Med Chem. 2019 May 30;178:64-80.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Eur J Med Chem. 2019 May 30;178:64-80 (via https://www.sciencedirect.com/science/article/pii/S022352341)
Encouraged by our earlier discovery of neuraminidase inhibitors targeting 150-cavity or 430-cavity, herein, to yield more potent inhibitors, we designed, synthesized, and biologically evaluated a series ...

Artarini A, et al. Regulation of influenza a virus mRNA splicing by CLK1. Antiviral Res. 2019 Jun 6.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Antiviral Res. 2019 Jun 6 (via https://www.sciencedirect.com/science/article/pii/S016635421)
Influenza A virus carries eight negative single-stranded RNAs and uses spliced mRNAs to increase the number of proteins produced from them. Several genome-wide screens for essential host factors for influenza ...

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