Zhao L, Xia H, Huang J, Zheng Y, Liu C, Su J, Ping. Features of Nuclear Export Signals of NS2 Protein of Influenza D Virus. Viruses. 2020 Sep 29;12(10):E1100. Abstract
submitted by kickingbird at Oct, 3, 2020 from Viruses. 2020 Sep 29;12(10):E1100 (via https://www.mdpi.com/1999-4915/12/10/1100)
Emerging influenza D viruses (IDVs), the newest member in the genus Orthomyxovirus family, which can infect and transmit in multiple mammalian species as its relatives the influenza A viruses (IAVs). Additional ...
Madsen A, Dai YN, McMahon M, Schmitz AJ, Turner JS. Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective. Immunity. 2020 Sep 22:S1074-7613(20)30372-1. Abstract
submitted by kickingbird at Sep, 28, 2020 from Immunity. 2020 Sep 22:S1074-7613(20)30372-1 (via https://www.cell.com/immunity/fulltext/S1074-7613(20)30372-1)
nfluenza B virus (IBV) infections can cause severe disease in children and the elderly. Commonly used antivirals have lower clinical effectiveness against IBV compared to influenza A viruses (IAV). Neuraminidase ...
Mooij P, Mortier D, Stammes M, Fagrouch Z, Verscho. Aerosolized pH1N1 influenza infection induces less systemic and local immune activation in the lung than combined intrabronchial, nasal and oral exposure in cynomolgus macaques. J Gen Virol. 2020 Sep 25. Abstract
submitted by kickingbird at Sep, 28, 2020 from J Gen Virol. 2020 Sep 25 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Non-human primates form an important animal model for the evaluation of immunogenicity and efficacy of novel 'universal' vaccine candidates against influenza virus. However, in most studies a combination ...
Feldstein LR, Self WH, Ferdinands JM, Randolph AG,. Incorporating real-time influenza detection into the test-negative design for estimating influenza vaccine effectiveness: The real-time test-negative design (rtTND). Clin Infect Dis. 2020 Sep 25:ciaa1453.. Abstract
submitted by kickingbird at Sep, 26, 2020 from Clin Infect Dis. 2020 Sep 25:ciaa1453. (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
With rapid and accurate molecular influenza testing now widely available in clinical settings, influenza vaccine effectiveness (VE) studies can prospectively select participants for enrollment based on ...
Frank K, Paust S. Dynamic Natural Killer Cell and T Cell Responses to Influenza Infection. Front Cell Infect Microbiol. 2020 Aug 18;10:425. Abstract
submitted by kickingbird at Sep, 26, 2020 from Front Cell Infect Microbiol. 2020 Aug 18;10:425 (via https://www.frontiersin.org/articles/10.3389/fcimb.2020.0042)
Influenza viruses have perplexed scientists for over a hundred years. Yearly vaccines limit their spread, but they do not prevent all infections. Therapeutic treatments for those experiencing severe infection ...
Mostafa A, Mahmoud SH, Shehata M, Müller C, Kandei. PA from a Recent H9N2 (G1-Like) Avian Influenza a Virus (AIV) Strain Carrying Lysine 367 Confers Altered Replication Efficiency and Pathogenicity to Contemporaneous H5N1 in Mammalian Systems. Viruses. 2020 Sep 20;12(9):E1046. Abstract
submitted by kickingbird at Sep, 24, 2020 from Viruses. 2020 Sep 20;12(9):E1046 (via https://pubmed.ncbi.nlm.nih.gov/32962203/)
Egypt is a hotspot for H5- and H9-subtype avian influenza A virus (AIV) infections and co-infections in poultry by both subtypes have been frequently reported. However, natural genetic reassortment of ...
Declercq M, Biquand E, Karim M, Pietrosemoli N, Ja. Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription. Nucleic Acids Res. 2020 Sep 22:gkaa771. Abstract
submitted by kickingbird at Sep, 24, 2020 from Nucleic Acids Res. 2020 Sep 22:gkaa771 (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
Cellular exonucleases involved in the processes that regulate RNA stability and quality control have been shown to restrict or to promote the multiplication cycle of numerous RNA viruses. Influenza A viruses ...
Li K, McCaw JM, Cao P. Modelling within-host macrophage dynamics in influenza virus infection. J Theor Biol. 2020 Sep 20:110492. Abstract
submitted by kickingbird at Sep, 24, 2020 from J Theor Biol. 2020 Sep 20:110492 (via https://www.sciencedirect.com/science/article/abs/pii/S00225)
Human respiratory disease associated with influenza virus infection is of significant public health concern. Macrophages, as part of the front line of host innate cellular defence, have been shown to play ...
Zhu Y, Wang R, Yu L, et al. Human TRA2A determines influenza A virus host adaptation by regulating viral mRNA splicing. Sci Adv. 2020;6(25):eaaz5764. Abstract
submitted by kickingbird at Sep, 19, 2020 from Sci Adv. 2020;6(25):eaaz5764 (via https://advances.sciencemag.org/content/6/25/eaaz5764)
Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host ...
Caliendo V, Leijten L, Begeman L, et al. Enterotropism of highly pathogenic avian influenza virus H5N8 from the 2016/2017 epidemic in some wild bird species. Vet Res. 2020;51(1):117. Abstract
submitted by kickingbird at Sep, 17, 2020 from Vet Res. 2020;51(1):117 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
In 2016/2017, H5N8 highly pathogenic avian influenza (HPAI) virus of the Goose/Guangdong lineage spread from Asia to Europe, causing the biggest and most widespread HPAI epidemic on record in wild and ...
Liu WJ, Wu Y, Bi Y, et al.. Emerging HxNy Influenza A Viruses. Cold Spring Harb Perspect Med. 2020;a038406. Abstract
submitted by kickingbird at Sep, 17, 2020 from Cold Spring Harb Perspect Med. 2020;a038406 (via http://perspectivesinmedicine.cshlp.org/content/early/2020/0)
The continuous emergence and reemergence of diverse subtypes of influenza A viruses, which are known as "HxNy" and are mediated through the reassortment of viral genomes, account for seasonal epidemics, ...
Xia J, Kuang Y, Liang J, Jones M, Swain SL. Influenza Vaccine-Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production. J Immunol. 2020;ji2000597. Abstract
submitted by kickingbird at Sep, 17, 2020 from J Immunol. 2020;ji2000597 (via https://www.jimmunol.org/content/early/2020/09/12/jimmunol.2)
Previously, we discovered that influenza-generated CD4 effectors must recognize cognate Ag at a defined effector checkpoint to become memory cells. Ag recognition was also required for efficient protection ...
Boussier J, Munier S, Achouri E, et al. RNA-seq accuracy and reproducibility for the mapping and quantification of influenza defective viral genomes. RNA. 2020;rna.077529.120. Abstract
submitted by kickingbird at Sep, 17, 2020 from RNA. 2020;rna.077529.120 (via https://rnajournal.cshlp.org/content/early/2020/09/14/rna.07)
Like most RNA viruses, influenza viruses generate defective viral genomes (DVGs) with large internal deletions during replication. There is accumulating evidence supporting a biological relevance of such ...
Watkins LC, DeGrado WF, Voth GA. Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. J Am Chem Soc. 2020;10.1021/jacs.0c06419.. Abstract
submitted by kickingbird at Sep, 17, 2020 from J Am Chem Soc. 2020;10.1021/jacs.0c06419. (via https://pubs.acs.org/doi/10.1021/jacs.0c06419)
Prevalent resistance to inhibitors that target the influenza A M2 proton channel has necessitated a continued drug design effort, supported by a sustained study of the mechanism of channel function and ...
Steiner F, Pavlovic J. Subcellular localization of MxB determines its antiviral potential against influenza A virus. J Virol. 2020;JVI.00125-20. Abstract
submitted by kickingbird at Sep, 14, 2020 from J Virol. 2020;JVI.00125-20 (via https://jvi.asm.org/content/early/2020/09/03/JVI.00125-20)
Mx proteins are interferon (IFN) type I (α/β) and type III (λ) induced effector proteins with intrinsic antiviral activity. Mammalian Mx proteins show different subcellular localizations and distinct yet ...
Peukes J, Xiong X, Erlendsson S, et al. The native structure of the assembled matrix protein 1 of influenza A virus. Nature. 2020;10.1038/s41586-020-2696-8. Abstract
submitted by kickingbird at Sep, 11, 2020 from Nature. 2020;10.1038/s41586-020-2696-8 (via https://www.nature.com/articles/s41586-020-2696-8)
Influenza A virus causes millions of severe cases of disease during annual epidemics. The most abundant protein in influenza virions is matrix protein 1 (M1), which mediates virus assembly by forming an ...
Song J, Sun H, Sun H, et al. Swine microRNAs ssc-miR-221-3p and ssc-miR-222 restrict the cross-species infection of avian influenza virus. J Virol. 2020;JVI.01700-20. Abstract
submitted by kickingbird at Sep, 11, 2020 from J Virol. 2020;JVI.01700-20 (via https://jvi.asm.org/content/early/2020/09/08/JVI.01700-20)
Avian influenza virus (AIV) can cross species barriers to infect humans and other mammals. However, these species-cross transmissions are most often dead-end infection due to host restriction. Current ...
El-Shesheny R, Franks J, Turner J, et al. Continued Evolution of H5Nx Avian Influenza Viruses in Bangladeshi Live Poultry Markets: Pathogenic Potential in Poultry and Mammalian Models. J Virol. 2020;JVI.01141-20. Abstract
submitted by kickingbird at Sep, 11, 2020 from J Virol. 2020;JVI.01141-20 (via https://jvi.asm.org/content/early/2020/09/03/JVI.01141-20)
The genesis of novel influenza viruses through reassortment poses a continuing risk to public health. This is of particular concern in Bangladesh, where highly pathogenic avian influenza viruses of the ...
Kirkpatrick E, Henry C, McMahon M, et al. Characterization of novel cross-reactive influenza B virus hemagglutinin head specific antibodies that lack hemagglutinin inhibition activity. J Virol. 2020;JVI.01185-20. Abstract
submitted by kickingbird at Sep, 11, 2020 from J Virol. 2020;JVI.01185-20 (via https://jvi.asm.org/content/early/2020/09/03/JVI.01185-20)
Humoral immune responses to influenza virus vaccines in elderly individuals are poorly adapted towards new antigenically drifted influenza virus strains. Instead, older individuals respond in an original ...
Dawson AR, Wilson GM, Freiberger EC, Mondal A, Coo. Phosphorylation controls RNA binding and transcription by the influenza virus polymerase. PLoS Pathog. 2020;16(9):e1008841. Abstract
submitted by kickingbird at Sep, 7, 2020 from PLoS Pathog. 2020;16(9):e1008841 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The influenza virus polymerase transcribes and replicates the viral genome. The proper timing and balance of polymerase activity is important for successful replication. Genome replication is controlled ...
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