Farrukee R, Gunalan V, Maurer-Stroh S, Reading PC,. Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution. J Virol. 2022 Jul 14:e0091822. Abstract
submitted by kickingbird at Jul, 24, 2022 from J Virol. 2022 Jul 14:e0091822 (via https://journals.asm.org/doi/10.1128/jvi.00918-22)
Oseltamivir-resistant influenza viruses arise due to amino acid mutations in key residues of the viral neuraminidase (NA). These changes often come at a fitness cost; however, it is known that permissive ... Ge Y, Liu K, Chi Y, Zhu X, Wu T, Zhao K, Qiao Q, W. Exosomal microRNA expression profiles derived from A549 human lung cells in response to influenza A/H1N1pdm09 infection. Virology. 2022 Jul 16;574:9-17. Abstract
submitted by kickingbird at Jul, 24, 2022 from Virology. 2022 Jul 16;574:9-17 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Exosomes participate in intercellular communication by shuttling various small molecules from donor to recipient cells. We aimed to examine the role of exosomes and exosomal miRNAs in influenza virus infection. ... Zhou P, Chen B, Hu X, Xiao X, Liu R, Li S. Domestic poultry are not susceptible to avian-origin H3N2 subtype canine influenza A virus. Vet Microbiol. 2022 Jun 30;272:109501. Abstract
submitted by kickingbird at Jul, 21, 2022 from Vet Microbiol. 2022 Jun 30;272:109501 (via https://www.sciencedirect.com/science/article/pii/S037811352)
At present, avian-origin H3N2 subtype canine influenza virus (H3N2 CIV) is prevalent in East Asian and North American countries. The host tropism of H3N2 CIV to mammals, including mice, guinea pigs, ferrets, ... Tsang TK, Lam KT, Liu Y, Fang VJ, Mu X, Leung NHL,. Investigation of CD4 and CD8 T cell-mediated protection against influenza A virus in a cohort study. BMC Med. 2022 Jul 21;20(1):230. Abstract
submitted by kickingbird at Jul, 21, 2022 from BMC Med. 2022 Jul 21;20(1):230 (via https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291)
Background: The protective effect of T cell-mediated immunity against influenza virus infections in natural settings remains unclear, especially in seasonal epidemics.Methods: To explore the potential ... Cuevas F, Kawabata H, Krammer F, Carre?o JM. An In Vitro Microneutralization Assay for Influenza Virus Serology. Curr Protoc. 2022 Jul;2(7):e465. Abstract
submitted by kickingbird at Jul, 19, 2022 from Curr Protoc. 2022 Jul;2(7):e465 (via https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002)
Influenza is an infectious respiratory disease with significant morbidity and mortality rates among people of all ages. Influenza viruses spread and evolve rapidly in the human population. Different immune ... Wang Z, Zhao Q, Huang M, Duan Y, Li F, Wang T. Dual Detection of Hemagglutinin Proteins of H5N1 and H1N1 Influenza Viruses Based on FRET Combined With DNase I. Front Microbiol. 2022 Jun 30;13:934475. Abstract
submitted by kickingbird at Jul, 19, 2022 from Front Microbiol. 2022 Jun 30;13:934475 (via https://www.frontiersin.org/articles/10.3389/fmicb.2022.9344)
Influenza A viruses (IAV) are classified based on their surface proteins hemagglutinin (HA) and neuraminidase (NA). Both pandemic H1N1 (pH1N1) and highly pathogenic avian influenza (HPAI) H5N1 viruses ... Ye H, Zhang J, Sang Y, Shan N, Qiu W, Zhong W, Li. Divergent Reassortment and Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Virus in Birds of China During 2021. Front Microbiol. 2022 Jun 30;13:913551. Abstract
submitted by kickingbird at Jul, 19, 2022 from Front Microbiol. 2022 Jun 30;13:913551 (via https://www.frontiersin.org/articles/10.3389/fmicb.2022.9135)
Highly pathogenic influenza A(H5N8) viruses had caused several outbreaks among wild bird and poultry populations across the globe, and strikingly, caused human infection, posing serious public health concerns. ... Pulit-Penaloza JA, Belser JA, Brock N, Thakur PB,. Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets. Emerg Infect Dis. 2022 Jul 15;28(9). Abstract
submitted by kickingbird at Jul, 18, 2022 from Emerg Infect Dis. 2022 Jul 15;28(9) (via https://pubmed.ncbi.nlm.nih.gov/35840125/)
Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility ... Liu M, Huang LZX, Smits AA, Büll C, Narimatsu Y, v. Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions. Nat Commun. 2022 Jul 13;13(1):4054. Abstract
submitted by kickingbird at Jul, 16, 2022 from Nat Commun. 2022 Jul 13;13(1):4054 (via https://www.nature.com/articles/s41467-022-31840-0)
Establishment of zoonotic viruses, causing pandemics like the Spanish flu and Covid-19, requires adaptation to human receptors. Pandemic influenza A viruses (IAV) that crossed the avian-human species barrier ... Leow BL, Syamsiah Aini S, Faizul Fikri MY, Muhamma. Molecular characterisation of hemagglutinin and neuraminidase genes of the first highly pathogenic Avian Influenza H5N1 2.3.2.1c virus isolated from Sabah, Malaysia. Trop Biomed. 2022 Jun 1;39(2):160-169. Abstract
submitted by kickingbird at Jul, 16, 2022 from Trop Biomed. 2022 Jun 1;39(2):160-169 (via https://msptm.org/files/Vol39No2/tb-39-2-001-Leow-B-L.pdf)
Highly Pathogenic Avian Influenza (HPAI) is a highly contagious disease in poultry. The outbreaks can lead to flock mortality up to 100% in two to three days. In July 2018, high mortality in a commercial ... ones JC, Zagribelnyy B, Pascua PNQ, Bezrukov DS, B. Influenza A virus polymerase acidic protein E23G/K substitutions weaken key baloxavir drug-binding contacts with minimal impact on replication and transmission. PLoS Pathog. 2022 Jul 13;18(7):e1010698. Abstract
submitted by kickingbird at Jul, 14, 2022 from PLoS Pathog. 2022 Jul 13;18(7):e1010698 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Baloxavir marboxil (BXM) is approved for treating uncomplicated influenza. The active metabolite baloxavir acid (BXA) inhibits cap-dependent endonuclease activity of the influenza virus polymerase acidic ... Caliendo V, Lewis NS, Pohlmann A, Baillie SR, Bany. Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021. Sci Rep. 2022 Jul 11;12(1):11729. Abstract
submitted by kickingbird at Jul, 14, 2022 from Sci Rep. 2022 Jul 11;12(1):11729 (via https://www.nature.com/articles/s41598-022-13447-z)
Highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/1996 lineage (GsGd), which threaten the health of poultry, wildlife and humans, are spreading across Asia, Europe, Africa and ... Xu H, Palpant T, Weinberger C, Shaw DE. Characterizing Receptor Flexibility to Predict Mutations That Lead to Human Adaptation of Influenza Hemagglutinin. J Chem Theory Comput. 2022 Jul 11. Abstract
submitted by kickingbird at Jul, 13, 2022 from J Chem Theory Comput. 2022 Jul 11 (via https://pubs.acs.org/doi/10.1021/acs.jctc.1c01044)
A key step in the emergence of human pandemic influenza strains has been a switch in binding preference of the viral glycoprotein hemagglutinin (HA) from avian to human sialic acid (SA) receptors. The ... Song H, Liu X, Gao X, Li J, Shang Y, Gao W, Li Y,. Transcriptome analysis of pre-immune state induced by interferon gamma inhibiting the replication of H9N2 avian influenza viruses in chicken embryo fibroblasts. Infect Genet Evol. 2022 Jul 7:105332. Abstract
submitted by kickingbird at Jul, 13, 2022 from Infect Genet Evol. 2022 Jul 7:105332 (via https://www.sciencedirect.com/science/article/pii/S156713482)
Interferon (IFN), a critical antiviral cytokine produced by pathogens-induced cells, plays an important role in host innate immune system. In this study, to investigate the inhibition effect of IFN on ... Song Y, Zhu W, Wang Y, Deng L, Ma Y, Dong C, Gonza. Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages. Biomaterials. 2022 Jul 4;287:121664. Abstract
submitted by kickingbird at Jul, 13, 2022 from Biomaterials. 2022 Jul 4;287:121664 (via https://www.sciencedirect.com/science/article/abs/pii/S01429)
The influenza epidemics pose a significant threat to public health. Of them, type B influenza coincided with several severe flu outbreaks. The efficacy of the current seasonal flu vaccine is limited due ... Xu W, Wang Y, Li L, Qu X, Liu Q, Li T, Wu S, Liao. Transmembrane domain of IFITM3 is responsible for its interaction with influenza virus HA 2 subunit. Xu W, Wang Y, Li L, Qu X, Liu Q, Li T, Wu S, Liao. Abstract
submitted by kickingbird at Jul, 11, 2022 from Xu W, Wang Y, Li L, Qu X, Liu Q, Li T, Wu S, Liao (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Interferon-inducible transmembrane protein 3 (IFITM3) inhibits influenza virus infection by blocking viral membrane fusion, but the exact mechanism remains elusive. Here, we investigated the function and ... Baek YG, Lee YN, Park YR, Chung DH, Kwon JH, Si YJ. Evolution, Transmission, and Pathogenicity of High Pathogenicity Avian Influenza Virus A (H5N8) Clade 2.3.4.4, South Korea, 2014-2016. Front Vet Sci. 2022 Jun 21;9:906944. Abstract
submitted by kickingbird at Jul, 9, 2022 from Front Vet Sci. 2022 Jun 21;9:906944 (via https://www.frontiersin.org/articles/10.3389/fvets.2022.9069)
During 2014-2016, clade 2.3.4.4 H5N8 high pathogenicity avian influenza virus (HPAIV) caused the largest known avian influenza epidemic in South Korea. Based on data from earlier H5N8 outbreaks, primitive ... Tanikawa T, Fujii K, Sugie Y, Tsunekuni R, Nakayam. Comparative susceptibility of mallard (Anas platyrhynchos) to infection with high pathogenicity avian influenza virus strains (Gs/Gd lineage) isolated in Japan in 2004-2017. Vet Microbiol. 2022 Jun 28;272:109496. Abstract
submitted by kickingbird at Jul, 9, 2022 from Vet Microbiol. 2022 Jun 28;272:109496 (via https://www.sciencedirect.com/science/article/pii/S037811352)
The Goose/Guangdong-lineage (Gs/Gd) H5 high pathogenicity avian influenza viruses (HPAIVs) spread among poultry and wild birds worldwide; an association has been identified between the migration of wild ... Si L, Shen Q, Li J, Chen L, Shen J, Xiao X, Bai H,. Generation of a live attenuated influenza A vaccine by proteolysis targeting. Nat Biotechnol. 2022 Jul 4. Abstract
submitted by kickingbird at Jul, 7, 2022 from Nat Biotechnol. 2022 Jul 4 (via https://www.nature.com/articles/s41587-022-01381-4)
The usefulness of live attenuated virus vaccines has been limited by suboptimal immunogenicity, safety concerns or cumbersome manufacturing processes and techniques. Here we describe the generation of ... Wang C, Qu R, Zong Y, Qin C, Liu L, Gao X, Sun H,. Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals. PLoS Pathog. 2022 Jul 6;18(7):e1010645.. Abstract
submitted by kickingbird at Jul, 7, 2022 from PLoS Pathog. 2022 Jul 6;18(7):e1010645. (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Avian influenza virus (AIV) can evolve multiple strategies to combat host antiviral defenses and establish efficient infectivity in mammals, including humans. H9N2 AIV and its reassortants (such as H5N6 ... 5584 items, 20/Page, Page[56/280][|<<] [|<] [51] [52] [53] [54] [55] [56] [57] [58] [59] [60] [>|] [>>|] |
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