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2025-12-19 2:50:52
Article

Mostafa A, Barre RS, Allué-Guardia A, Escobedo RA,. Replication Kinetics, Pathogenicity and Virus-induced Cellular Responses of Cattle-origin Influenza A(H5N1) isolates from Texas, United States. Emerg Microbes Infect. 2024 Dec 27:2447614.  Abstract  
submitted by kickingbird at Dec, 28, 2024 from Emerg Microbes Infect. 2024 Dec 27:2447614 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
The host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States (US). Shortly after, human H5N1 infection was reported in a dairy worker in Texas ...

He L, Zhang Y, Si K, Yu C, Shang K, Yu Z, Wei Y, D. Evidence of an emerging triple-reassortant H3N3 avian influenza virus in China. BMC Genomics. 2024 Dec 26;25(1):1249.  Abstract  
submitted by kickingbird at Dec, 27, 2024 from BMC Genomics. 2024 Dec 26;25(1):1249 (via https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286)
The H3 subtype of avian influenza virus (AIV) stands out as one of the most prevalent subtypes, posing a significant threat to public health. In this study, a novel triple-reassortant H3N3 AIV designated ...

Ando H, Murakami M, Kitajima M, Reynolds KA. Wastewater-based estimation of temporal variation in shedding amount of influenza A virus and clinically identified cases using the PRESENS model. Environ Int. 2024 Dec 19;195:109218.  Abstract  
submitted by kickingbird at Dec, 25, 2024 from Environ Int. 2024 Dec 19;195:109218 (via https://www.sciencedirect.com/science/article/pii/S016041202)
Wastewater-based estimation of infectious disease prevalence in real-time assists public health authorities in developing effective responses to current outbreaks. However, wastewater-based estimation ...

Xuyong Li, etc.,al. Novel H16N3 avian influenza viruses isolated from migratory gulls in China in 2023. Front. Microbiol. Volume 15 - 2024.  Abstract  
submitted by kickingbird at Dec, 25, 2024 from Front. Microbiol. Volume 15 - 2024 (via https://www.frontiersin.org/journals/microbiology/articles/1)
As a rare subtype of avian influenza virus, H16 viruses are predominant in gulls but rarely found in domestic birds. The low prevalence of H16 viruses has limited our understanding of their epidemiology ...

Fumiya Kozawa, etc.,al. [preprint]The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection. https://doi.org/10.1101/2024.12.20.629723.  Abstract  
submitted by kickingbird at Dec, 24, 2024 from https://doi.org/10.1101/2024.12.20.629723 (via https://www.biorxiv.org/content/10.1101/2024.12.20.629723v1)
Influenza A viruses (IAVs) initially infect a few host cells, and the infection subsequently spreads to neighboring cells. However, the molecular mechanisms underlying this expansion remain unclear. Here, ...

Sidney J, Kim A-R, de Vries RD, Peters B, Meade PS. Targets of influenza human T-cell response are mostly conserved in H5N1. mBio. 2024 Dec 26:e0347924.  Abstract  
submitted by kickingbird at Dec, 24, 2024 from mBio. 2024 Dec 26:e0347924 (via https://journals.asm.org/doi/10.1128/mbio.03479-24)
Frequent recent spillovers of subtype H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI) virus into poultry and mammals, especially dairy cattle, including several human cases, increased concerns ...

Niedringhaus KD, Chan TC, McDowell A, Maxwell L, S. Surveillance of Highly Pathogenic Avian Influenza Virus in Wild Canids from Pennsylvania, USA. Animals. 2024; 14(24):3700.  Abstract  
submitted by kickingbird at Dec, 23, 2024 from Animals. 2024; 14(24):3700 (via https://www.mdpi.com/2076-2615/14/24/3700)
The avian influenza virus is a global pathogen with significant health and economic implications. While primarily a pathogen of wild and domestic birds, recent outbreaks of the H5N1 highly pathogenic avian ...

Ishraq Rahman, etc.,al. Recurring incursions and dissemination of novel Eurasian-origin H5Nx avian influenza viruses in Atlantic Canada. Virus Evolution, veae111.  Abstract  
submitted by kickingbird at Dec, 22, 2024 from Virus Evolution, veae111 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
Wild birds are important hosts of influenza A viruses (IAVs) and play an important role in their ecology. The emergence of the A/goose/Guangdong/1/1996 H5N1 (Gs/GD) lineage marked a shift in IAV ecology, ...

Lambodhar Damodaran, Anna Jaeger, Louise H Moncla. [preprint]Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America. https://doi.org/10.1101/2024.12.16.628739.  Abstract  
submitted by kickingbird at Dec, 22, 2024 from https://doi.org/10.1101/2024.12.16.628739 (via https://www.biorxiv.org/content/10.1101/2024.12.16.628739v1)
Since late 2021, a panzootic of highly pathogenic H5N1 avian influenza virus has driven significant morbidity and mortality in wild birds, domestic poultry, and mammals. In North America, infections in ...

Chen W, Lu S, Xiong H, Xiang Z, Wang Y, Hu J, Pan. Gene flow and its sporadic spillover: H10 and N5 avian influenza viruses from wild birds and the H10N5 human cases in China. Virol Sin. 2024 Dec 18:S1995-820X(24)00198-6.  Abstract  
submitted by kickingbird at Dec, 22, 2024 from Virol Sin. 2024 Dec 18:S1995-820X(24)00198-6 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
On 30 January 2024, China announced the first human case of H10N5 influenza infection. Prior to this, human cases of H10N7 and H10N8 had been reported. It is now appropriate to re-examine the evolution ...

Yan Zhou, etc.,al. [preprint]Highly pathogenic avian influenza virus H5N1 infection in dairy cows confers protective immunity against reinfection. https://doi.org/10.21203/rs.3.rs-5613077/v1.  Abstract  
submitted by kickingbird at Dec, 21, 2024 from https://doi.org/10.21203/rs.3.rs-5613077/v1 (via https://www.researchsquare.com/article/rs-5613077/v1)
An unprecedented spillover of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b to dairy cows in March 2024 has affected over 700 US dairy herds in addition to spillback to commercial poultry ...

Zhao L, Tian M, Hu X, Fan M, Hou C, Ping J. PB2 627V and HA 217 sites synergistically affect the lethality of H9N2 in mice. Virol Sin. 2024 Dec 17:S1995-820X(24)00199-8.  Abstract  
submitted by kickingbird at Dec, 21, 2024 from Virol Sin. 2024 Dec 17:S1995-820X(24)00199-8 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
The H9N2 subtype avian influenza virus (AIV) continues to propagate and undergo evolution within China, thereby posing a significant threat to the poultry industry. This study encompassed the collection ...

Zhao B, Sun Z, Wang S, Shi Z, Jiang Y, Wang X, Den. Structural basis of different neutralization capabilities of monoclonal antibodies against H7N9 virus. J Virol. 2024 Dec 20:e0140024.  Abstract  
submitted by kickingbird at Dec, 21, 2024 from J Virol. 2024 Dec 20:e0140024 (via https://journals.asm.org/doi/10.1128/jvi.01400-24)
Neutralizing antibodies (nAbs) are important for the treatment of emerging viral diseases and for effective vaccine development. In this study, we generated and evaluated three nAbs (1H9, 2D7, and C4H4) ...

Nishiura H, Kumagai A, Mine J, Takadate Y, Sakuma. Phylogenetic and Pathogenic Analysis of H5N1 and H5N6 High Pathogenicity Avian Influenza Virus Isolated from Poultry Farms (Layer and Broiler Chickens) in Japan in the 2023/2024 Season. Viruses 16, no. 12: 1956.  Abstract  
submitted by kickingbird at Dec, 21, 2024 from Viruses 16, no. 12: 1956 (via https://www.mdpi.com/1999-4915/16/12/1956)
During the 2023–2024 winter, 11 high pathogenicity avian influenza (HPAI) outbreaks caused by clade 2.3.4.4b H5N1 and H5N6 HPAI viruses were confirmed in Japanese domestic poultry among 10 prefectures ...

Komami M, Komu JG, Ishiguro Y, Sasaki M, Matsuda S. Detection of antibodies against H5 subtype highly pathogenic avian influenza viruses in multiple raccoons in Tokachi District, Hokkaido, Japan, from 2022 to 2023. Virus Res. 2024 Dec 15:199515.  Abstract  
submitted by kickingbird at Dec, 18, 2024 from Virus Res. 2024 Dec 15:199515 (via https://pubmed.ncbi.nlm.nih.gov/39689812/)
In recent years, infection cases of H5 subtype highly pathogenic avian influenza viruses (HPAIVs) in wild mammals have increased globally. To obtain recent epidemiological information regarding influenza ...

Li M, Wu Y, Li H, Song W, Chen Z, Peng Y, Yang B,. Mutagenesis studies suggest a mechanism for influenza polymerase stalling during polyadenylation. Nucleic Acids Res. 2024 Dec 16:gkae1225.  Abstract  
submitted by kickingbird at Dec, 17, 2024 from Nucleic Acids Res. 2024 Dec 16:gkae1225 (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
Influenza polymerase (FluPol) carries out both viral transcription and replication using the same viral genome segment as a template to yield distinct end products. However, it remains largely unclear ...

Wang X, Yu H, Ma Y, Zhang P, Wang X, Liang J, Zhan. The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health. mBio. 2024 Dec 16:e0236324.  Abstract  
submitted by kickingbird at Dec, 17, 2024 from mBio. 2024 Dec 16:e0236324 (via https://journals.asm.org/doi/10.1128/mbio.02363-24)
Following two human infections with the H10N3 avian influenza virus (AIV) in 2021 and 2022, a third case was discovered in Yunnan, China, in 2024, raising concerns about the potential for future pandemics. ...

Andrew J. Lail, etc.,al. [preprint]Pasteurized retail dairy enables genomic surveillance of H5N1 avian influenza virus in United States cattle. https://doi.org/10.1101/2024.12.12.24318872.  Abstract  
submitted by kickingbird at Dec, 16, 2024 from https://doi.org/10.1101/2024.12.12.24318872 (via https://www.medrxiv.org/content/10.1101/2024.12.12.24318872v)
Highly pathogenic avian influenza (HPAI) viruses with H5 hemagglutinin (HA) genes (clade 2.3.4.4b) are causing an ongoing panzootic in wild birds. Circulation of these viruses is associated with spillover ...

Jack Ward, etc.,al. [preprint]Estimates of epidemiological parameters for H5N1 influenza in humans: a rapid review. https://doi.org/10.1101/2024.12.11.24318702.  Abstract  
submitted by kickingbird at Dec, 16, 2024 from https://doi.org/10.1101/2024.12.11.24318702 (via https://www.medrxiv.org/content/10.1101/2024.12.11.24318702v)
Background The ongoing H5N1 panzootic in mammals has amplified zoonotic pathways to facilitate human infection. Characterising key epidemiological parameters for H5N1 is critical should this become widespread.Aim ...

Pia Ryt-Hansen, etc.,al. [preprint]Rapid Surge of Reassortant A(H1N1) Influenza Viruses in Danish Swine and their Zoonotic Potential. https://doi.org/10.1101/2024.12.11.627926.  Abstract  
submitted by kickingbird at Dec, 16, 2024 from https://doi.org/10.1101/2024.12.11.627926 (via https://www.biorxiv.org/content/10.1101/2024.12.11.627926v1)
In 2018, a single detection of a novel reassortant swine influenza A virus (swIAV) was made in Denmark. The hemagglutinin (HA) of the virus was from the H1N1 pandemic 2009 (H1N1pdm09) lineage and the neuraminidase ...

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