Wang, Y., Wang, H., Zhang, Y. et al. Single-dose suraxavir marboxil for acute uncomplicated influenza in adults and adolescents: a multicenter, randomized, double-blind, placebo-controlled phase 3 trial. Nat Med (2025). Abstract
submitted by kickingbird at Jan, 9, 2025 from Nat Med (2025) (via https://www.nature.com/articles/s41591-024-03419-3)
Suraxavir marboxil (GP681) is an antiviral drug inhibiting the polymerase acidic protein (PA) of RNA polymerase, of influenza. It has shown therapeutic activity against influenza A and B virus infections ... Vidhi Dholakia, etc.,al. [preprint]Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals. https://doi.org/10.1101/2025.01.06.631435. Abstract
submitted by kickingbird at Jan, 9, 2025 from https://doi.org/10.1101/2025.01.06.631435 (via https://www.biorxiv.org/content/10.1101/2025.01.06.631435v1)
In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds ... Manlin He, etc.,al. The H5N6 Virus Containing Internal Genes From H9N2 Exhibits Enhanced Pathogenicity and Transmissibility. Transboundary and Emerging Diseases. Abstract
submitted by kickingbird at Jan, 8, 2025 from Transboundary and Emerging Diseases (via https://onlinelibrary.wiley.com/doi/10.1155/tbed/6252849)
The H5N6 avian influenza virus (AIV) is constantly undergoing recombination and evolution with other subtypes of AIV, resulting in various types of recombinant H5N6 viruses. However, the risk to human ... Arvia R, Rocca A, Casciato B, Stincarelli MA, Gian. High-resolution melting analysis for detection of nucleotide mutation markers in the polymerase-acidic (PA) gene of influenza virus that are associated with baloxavir marboxil resistance. Arch Virol. 2025 Jan 6;170(2):29. Abstract
submitted by kickingbird at Jan, 8, 2025 from Arch Virol. 2025 Jan 6;170(2):29 (via https://link.springer.com/article/10.1007/s00705-024-06214-0)
The I38T substitution in the influenza virus polymerase-acidic (PA) subunit is a resistance marker of concern for treatment with the antiviral baloxavir marboxil (BXM). Thus, monitoring PA/I38T mutations ... Tremlett, C. J., Cleasby, I. R., Bolton, M., & Wil. Declines in UK breeding populations of seabird species of conservation concern following the outbreak of high pathogenicity avian influenza (HPAI) in 2021–2022. Bird Study, 1–18. Abstract
submitted by kickingbird at Jan, 6, 2025 from Bird Study, 1–18 (via https://www.tandfonline.com/doi/full/10.1080/00063657.2024.2)
CapsuleUK breeding populations of Great Skua Stercorarius skua, Northern Gannet Morus bassanus, Sandwich Tern Thalasseus sandvicensis and Common Tern Sterna hirundo decreased substantially between the ... Przymencki, M., Beuch, S., Indykiewicz, P., Litwin. Mortality among scarce breeding gulls and terns during a highly pathogenic avian influenza (HPAI) H5N1 virus outbreak in Poland during 2023. Bird Study, 1–10. Abstract
submitted by kickingbird at Jan, 6, 2025 from Bird Study, 1–10 (via https://www.tandfonline.com/doi/full/10.1080/00063657.2024.2)
CapsuleDuring spring and summer 2023, the highly pathogenic avian influenza (HPAI) H5N1 virus caused mass mortality among colony-breeding gulls and terns in Poland.AimsTo document the national impact of ... Altan, E., Avelin, V., Aaltonen, K., Korhonen, E.,. Highly Pathogenic Avian Influenza (HPAI) H5N1 virus in Finland in 2021-2023 – Genetic diversity of the viruses and infection kinetics in human dendritic cells. Emerging Microbes & Infections. Abstract
submitted by kickingbird at Jan, 6, 2025 from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Highly pathogenic avian influenza (HPAI) H5N1 is known for its virulence and zoonotic potential, infecting birds and mammals, thus raising public health concerns. Since 2021 its spread among birds has ... Yuncong Yin, etc.,al. Random forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus. Virologica Sinica. Abstract
submitted by kickingbird at Jan, 6, 2025 from Virologica Sinica (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
A switch from avian-type α-2,3 to human-type α-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus. Some H9N2 viruses exhibit a preference for binding to ... Abigail P Paulos, etc.,al. [preprint]Detection of Hemagglutinin H5 influenza A virus RNA and model of potential inputs in an urban California sewershed. https://doi.org/10.1101/2024.12.31.24319823. Abstract
submitted by kickingbird at Jan, 5, 2025 from https://doi.org/10.1101/2024.12.31.24319823 (via https://www.medrxiv.org/content/10.1101/2024.12.31.24319823v)
In 2024, the highly pathogenic avian influenza A H5N1 caused outbreaks in wild birds, poultry, cows, and other mammals in the United States with 61 human cases also reported by the CDC. Detection of influenza ... Zhao Y, Han L, Sang H, Yang P, Hou Y, Xiao Y. Two genotypes of H3N2 swine influenza viruses identified in pigs from Shandong Province, China. Front Cell Infect Microbiol. 2024 Dec 16;14:151702. Abstract
submitted by kickingbird at Jan, 3, 2025 from Front Cell Infect Microbiol. 2024 Dec 16;14:151702 (via https://www.frontiersin.org/journals/cellular-and-infection-)
Swine influenza virus (SIV) is a highly contagious pathogen that poses significant economic challenges to the swine industry and carries zoonotic potential, underscoring the need for vigilant surveillance. ... Maria Ogrzewalska, etc.,al. [preprint]High Pathogenicity Avian Influenza Virus (HPAIV) H5N1 clade 2.3.4.4b recovered from a kelp gull (Larus dominicanus) in the South Shetland Islands, Antarctica. https://doi.org/10.1101/2024.12.29.630510. Abstract
submitted by kickingbird at Jan, 1, 2025 from https://doi.org/10.1101/2024.12.29.630510 (via https://www.biorxiv.org/content/10.1101/2024.12.29.630510v1)
Whole-genome analysis of the earliest-detected High Pathogenicity Avian Influenza Virus (HPAIV) H5N1 clade 2.3.4.4b detected in Hannah Point, Antarctica (January 2024) reveals close relatedness to strains ... Jasmina M. Luczo, Erica Spackman. Molecular Evolution of the H5 and H7 Highly Pathogenic Avian Influenza Virus Haemagglutinin Cleavage Site Motif. Reviews in Medical Virology Volume 35, Issue 1. Abstract
submitted by kickingbird at Jan, 1, 2025 from Reviews in Medical Virology Volume 35, Issue 1 (via https://onlinelibrary.wiley.com/doi/10.1002/rmv.70012)
Avian influenza viruses are ubiquitous in the Anatinae subfamily of aquatic birds and occasionally spill over to poultry. Infection with low pathogenicity avian influenza viruses generally leads to subclinical ... Kevin S. Kuchinski, etc.,al. Detection of a Reassortant Swine- and Human-Origin H3N2 Influenza A Virus in Farmed Mink in British Columbia, Canada. Zoonoses and Public Health. Abstract
submitted by kickingbird at Jan, 1, 2025 from Zoonoses and Public Health (via https://onlinelibrary.wiley.com/doi/10.1111/zph.13205)
IntroductionIn December 2021, influenza A viruses (IAV) were detected in a population of farmed mink in British Columbia, Canada. Circulation of IAVs in farmed mink populations has raised public health ... Lin-Lei Chen, etc.,al. [preprint]Risk assessment of 2024 cattle H5N1 using age-stratified serosurveillance data. https://doi.org/10.1101/2024.12.23.24319580. Abstract
submitted by kickingbird at Jan, 1, 2025 from https://doi.org/10.1101/2024.12.23.24319580 (via https://www.medrxiv.org/content/10.1101/2024.12.23.24319580v)
The highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b has caused a human outbreak in North America since March 2024. Here, we conducted a serosurveillance study to determine the risk of A(H5N1) ... Resende PC, Junqueira DM, Tochetto C, Ogrzewalska. Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023. Nat Commun. 2024 Dec 30;15(1):10748. Abstract
submitted by kickingbird at Jan, 1, 2025 from Nat Commun. 2024 Dec 30;15(1):10748 (via https://www.nature.com/articles/s41467-024-53815-z)
Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild ... Sun L, Guo X, Yu M, Wang XF, Ren H, Wang X. Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction. Nat Commun. 2024 Dec 30;15(1):10805. Abstract
submitted by kickingbird at Jan, 1, 2025 from Nat Commun. 2024 Dec 30;15(1):10805 (via https://www.nature.com/articles/s41467-024-55034-y)
Human ANP32A/B (huANP32A/B) poorly support the polymerase activity of avian influenza viruses (AIVs), thereby limiting interspecies transmission of AIVs from birds to humans. The SUMO-interacting motif ... Good, M.R., Fernández-Quintero, M.L., Ji, W. et al. A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth. Nat Commun 15, 10768 (2024). Abstract
submitted by kickingbird at Dec, 31, 2024 from Nat Commun 15, 10768 (2024) (via https://www.nature.com/articles/s41467-024-54934-3)
Clade 2.3.4.4b H5N1 is causing an unprecedented outbreak in dairy cows in the United States. To understand if recent H5N1 viruses are changing their receptor use, we screened recombinant hemagglutinin ... Daniel Higgins, etc.,al. [preprint]Introducing a framework for within-host dynamics and mutations modelling of H5N1 influenza infection in humans. https://doi.org/10.1101/2024.09.01.24312235. Abstract
submitted by kickingbird at Dec, 30, 2024 from https://doi.org/10.1101/2024.09.01.24312235 (via https://www.medrxiv.org/content/10.1101/2024.09.01.24312235v)
Avian influenza A(H5N1) poses a public health risk due to its pandemic potential should the virus mutate to become human-to-human transmissible. To date, reported influenza A(H5N1) human cases have typically ... Chen X, Kong M, Ma C, Zhang M, Hu Z, Gu M, Wang X,. The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens. Virulence. 2025 Dec;16(1):2445238. Abstract
submitted by kickingbird at Dec, 30, 2024 from Virulence. 2025 Dec;16(1):2445238 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2024.2)
Several viruses, including influenza A virus (IAV), encode viral factors to hijack cellular RNA biogenesis processes to direct the degradation of host mRNAs, termed "host shutoff." Host shutoff enables ... Jaemoo Kim, etc.,al. A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity. Virologica Sinica. Abstract
submitted by kickingbird at Dec, 30, 2024 from Virologica Sinica (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Influenza, a highly contagious respiratory infectious disease caused by an influenza virus, is a threat to public health worldwide. Avian influenza viruses (AIVs) have the potential to cause the next pandemic ... 6502 items, 20/Page, Page[43/326][|<<] [|<] [41] [42] [43] [44] [45] [46] [47] [48] [49] [50] [>|] [>>|] |
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