Carre?o JM, McDonald JU, Hurst T, Rigsby P, Atkins. Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies. Vaccines (Basel). 2020 Nov 9;8(4):E666. Abstract
submitted by kickingbird at Nov, 16, 2020 from Vaccines (Basel). 2020 Nov 9;8(4):E666 (via https://www.mdpi.com/2076-393X/8/4/666)
The stalk domain of the hemagglutinin has been identified as a target for induction of protective antibody responses due to its high degree of conservation among numerous influenza subtypes and strains. ...
Tian X, Landreth S, Lu Y, Pandey K, Zhou Y. A Replication-Defective Influenza Virus Harboring H5 and H7 Hemagglutinins Provides Protection against H5N1 and H7N9 Infection in Mice. J Virol. 2020 Nov 11:JVI.02154-20. Abstract
submitted by kickingbird at Nov, 13, 2020 from J Virol. 2020 Nov 11:JVI.02154-20 (via https://jvi.asm.org/content/early/2020/11/06/JVI.02154-20)
The recent highly pathogenic avian influenza (HPAI) H5N1 and H7N9 viruses have caused hundreds of human infections with high mortality rates. Although H5N1 and H7N9 viruses have been mainly limited to ...
Bao D, Xue R, Zhang M, Lu C, Ma T, Ren C, Zhang T,. N-linked glycosylation plays an important role in budding of NA protein and virulence of influenza viruses. J Virol. 2020 Nov 11:JVI.02042-20. Abstract
submitted by kickingbird at Nov, 13, 2020 from J Virol. 2020 Nov 11:JVI.02042-20 (via https://jvi.asm.org/content/early/2020/11/06/JVI.02042-20)
Neuraminidase (NA) has multiple functions in the life cycle of influenza virus, especially in the late stage of virus replication. Both of Hemagglutinin (HA) and NA are highly glycosylated proteins. N-linked ...
Vagima Y, Gur D, Erez N, Achdout H, Aftalion M, Le. Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments. Sci Rep. 2020 Nov 5;10(1):19116. Abstract
submitted by kickingbird at Nov, 8, 2020 from Sci Rep. 2020 Nov 5;10(1):19116 (via https://www.nature.com/articles/s41598-020-75840-w)
Various respiratory viral infections in general and seasonal influenza in particular may increase the susceptibility to bacterial infections. Plague caused by Yersinia pestis endangers large populations ...
Timofeeva TA, Rudneva IA, Sadykova GK, Lomakina NF. Variability of nonpathogenic influenza virus H5N3 under immune pressure. Acta Virol. 2020 Nov 5. Abstract
submitted by kickingbird at Nov, 7, 2020 from Acta Virol. 2020 Nov 5 (via https://pubmed.ncbi.nlm.nih.gov/33151742/)
Mutations arising in influenza viruses that have undergone immune pressure may promote a successful spread of mutants in nature. In order to evaluate the variability of nonpathogenic influenza virus A/duck/Moscow/4182-C/2010(H5N3) ...
Liu X, Zhang B, Wang Y, Haymour HS, Zhang F, Xu LC. A universal dual mechanism immunotherapy for the treatment of influenza virus infections. Nat Commun. 2020 Nov 5;11(1):5597. Abstract
submitted by kickingbird at Nov, 7, 2020 from Nat Commun. 2020 Nov 5;11(1):5597 (via https://www.nature.com/articles/s41467-020-19386-5)
Seasonal influenza epidemics lead to 3-5 million severe infections and 290,000-650,000 annual global deaths. With deaths from the 1918 influenza pandemic estimated at >50,000,000 and future pandemics anticipated, ...
Thompson AJ, Paulson JC. Adaptation of Influenza Viruses to Human Airway Receptors. Biol Chem. 2020 Nov 3:jbc.REV120.013309. Abstract
submitted by kickingbird at Nov, 5, 2020 from Biol Chem. 2020 Nov 3:jbc.REV120.013309 (via https://www.jbc.org/content/early/2020/11/03/jbc.REV120.0133)
Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global ...
Cox A, Schmierer J, D´Angelo J, Smith A, Lev. A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity. Viruses. 2020 Oct 31;12(11):E1246. Abstract
submitted by kickingbird at Nov, 5, 2020 from Viruses. 2020 Oct 31;12(11):E1246 (via https://www.mdpi.com/1999-4915/12/11/1246)
Current influenza vaccines have modest efficacy. This is especially true for current live attenuated influenza vaccines (LAIV), which have been inferior to the inactivated versions in recent years. Therefore, ...
Liu B, Wang Y, Liu Y, Chen Y, Liu Y, Cong X, Ji Y,. Molecular evolution and characterization of hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 viruses isolated in Beijing, China, during the 2017-2018 and 2018-2019 influenza seasons. Arch Virol. 2020 Nov 3. Abstract
submitted by kickingbird at Nov, 5, 2020 from Arch Virol. 2020 Nov 3 (via https://link.springer.com/article/10.1007/s00705-020-04869-z)
We investigated and analysed the molecular evolution of hemagglutinin (HA) and neuraminidase (NA) of influenza A(H1N1)pdm09 virus during the 2017-2018 and 2018-2019 influenza seasons in Beijing, China. ...
Escalera-Zamudio, M., Golden, M., Gutiérrez, B. et. Parallel evolution in the emergence of highly pathogenic avian influenza A viruses. Nat Commun 11, 5511 (2020). Abstract
submitted by kickingbird at Nov, 5, 2020 from Nat Commun 11, 5511 (2020) (via https://www.nature.com/articles/s41467-020-19364-x)
Parallel molecular evolution and adaptation are important phenomena commonly observed in viruses. Here, we exploit parallel molecular evolution to understand virulence evolution in avian influenza viruses ...
Wang X, Lin L, Yu Y, Yan Y, Ojha NK, Zhou J. The N-terminal residual arginine 19 of influenza A virus NS1 protein is required for its nuclear localization and RNA binding. Vet Microbiol. 2020 Oct 14;251:108895. Abstract
submitted by kickingbird at Nov, 2, 2020 from Vet Microbiol. 2020 Oct 14;251:108895 (via https://www.sciencedirect.com/science/article/pii/S037811352)
RNA binding ability and cellular distribution are important for nonstructural protein 1 (NS1) of influenza A virus to act as a viral regulatory factor to control virus life cycle. In this study, we identified ...
Huang SW, Wang SF. The Effects of Genetic Variation on H7N9 Avian Influenza Virus Pathogenicity. Viruses. 2020 Oct 28;12(11):E1220. Abstract
submitted by kickingbird at Nov, 2, 2020 from Viruses. 2020 Oct 28;12(11):E1220 (via https://www.mdpi.com/1999-4915/12/11/1220)
Since the H7N9 avian influenza virus emerged in China in 2013, there have been five seasonal waves which have shown human infections and caused high fatality rates in infected patients. A multibasic amino ...
Elsobky Y, El Afandi G, Abdalla E, Byomi A, Reddy. Possible ramifications of climate variability on HPAI-H5N1 outbreak occurrence: Case study from the Menoufia, Egypt. PLoS One. 2020 Oct 29;15(10):e0240442. Abstract
submitted by kickingbird at Oct, 31, 2020 from PLoS One. 2020 Oct 29;15(10):e0240442 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Long endemicity of the Highly Pathogenic Avian Influenza (HPAI) H5N1 subtype in Egypt poses a lot of threats to public health. Contrary to what is previously known, outbreaks have been circulated continuously ...
Wang W, Chen X, Wang Y, Lai S, Yang J, Cowling BJ,. Serological evidence of human infection with avian influenza A(H7N9) virus: a systematic review and meta-analysis. J Infect Dis. 2020 Oct 29:jiaa679. Abstract
submitted by kickingbird at Oct, 31, 2020 from J Infect Dis. 2020 Oct 29:jiaa679 (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Background: The extent of human infections with avian influenza A(H7N9) virus, including mild and asymptomatic infections, is uncertain.Methods: We performed a systematic review and meta-analysis of serosurveys ...
Chen S, Miao X, Huangfu D, Zhao X, Zhang M, Qin T,. H5N1 Avian Influenza Virus without 80-84 Amino Acid Deletion at the NS1 Protein Hijacks the Innate Immune System of Dendritic Cells for an Enhanced Mammalian Pathogenicity. Transbound Emerg Dis. 2020 Oct 30. doi: 10.1111/tb. Abstract
submitted by kickingbird at Oct, 31, 2020 from Transbound Emerg Dis. 2020 Oct 30. doi: 10.1111/tb (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.13904)
NS gene is generally considered to be related to the virulence of highly pathogenic avian influenza virus (AIVs). In recent years, the strains with 5 amino acids added to the 80-84 positions of the NS1 ...
Kamiya Y, Fujisawa T, Katsumata M, Yasui H, Suzuki. Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium. Respir Res. 2020 Oct 27;21(1):282. Abstract
submitted by kickingbird at Oct, 29, 2020 from Respir Res. 2020 Oct 27;21(1):282 (via https://respiratory-research.biomedcentral.com/articles/10.1)
Background: Viral respiratory tract infections, such as influenza A virus (IAV), are common and life-threatening illnesses worldwide. The mechanisms by which viruses are removed from the respiratory tract ...
Bamunuarachchi G, Yang X, Huang C, Liang Y, Guo Y,. MicroRNA-206 Inhibits Influenza A Virus Replication by Targeting Tankyrase 2. Cell Microbiol. 2020 Oct 25:e13281. Abstract
submitted by kickingbird at Oct, 28, 2020 from Cell Microbiol. 2020 Oct 25:e13281 (via https://onlinelibrary.wiley.com/doi/10.1111/cmi.13281)
Due to the frequent mutations, influenza A virus (IAV) becomes resistant to anti-viral drugs targeting influenza viral proteins. There are increasing interests in anti-viral agents that target host cellular ...
Sharma A, Batra J, Stuchlik O, Reed MS, Pohl J, Ch. Influenza A Virus Nucleoprotein Activates the JNK Stress-Signaling Pathway for Viral Replication by Sequestering Host Filamin A Protein. Front Microbiol. 2020 Sep 25;11:581867. Abstract
submitted by kickingbird at Oct, 28, 2020 from Front Microbiol. 2020 Sep 25;11:581867 (via https://www.frontiersin.org/articles/10.3389/fmicb.2020.5818)
Influenza A virus (IAV) poses a major threat to global public health and is known to employ various strategies to usurp the host machinery for survival. Due to its fast-evolving nature, IAVs tend to escape ...
Burke DF, Mantell RG, Pitt CE, Wales DJ. Energy Landscape for the Membrane Fusion Pathway in Influenza A Hemagglutinin From Discrete Path Samplin. Front Chem. 2020 Sep 25;8:575195. Abstract
submitted by kickingbird at Oct, 28, 2020 from Front Chem. 2020 Sep 25;8:575195 (via https://www.frontiersin.org/articles/10.3389/fchem.2020.5751)
The conformational change associated with membrane fusion for Influenza A Hemagglutinin is investigated with a model based upon pre- and post-fusion structures of the HA2 component. We employ computational ...
Poulson R, Carter D, Beville S, Niles L, Dey A, Mi. Influenza A Viruses in Ruddy Turnstones ( Arenaria interpres); Connecting Wintering and Migratory Sites with an Ecological Hotspot at Delaware Bay. Viruses. 2020 Oct 22;12(11):E1205. Abstract
submitted by kickingbird at Oct, 28, 2020 from Viruses. 2020 Oct 22;12(11):E1205 (via https://www.mdpi.com/1999-4915/12/11/1205)
Each May for over three decades, avian influenza A viruses (IAVs) have been isolated from shorebirds and gulls (order Charadriiformes) at Delaware Bay (DE Bay), USA, which is a critical stopover site for ...
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