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2022-6-25 9:01:14
Article

Mine J, Tsunekuni R, Tanikawa T, Uchida Y, Dubovit. Genetics of Japanese H5N8 high pathogenicity avian influenza viruses isolated in winter 2020-2021 and their genetic relationship with avian influenza viruses in Siberia. Transbound Emerg Dis. 2022 Apr 21.  Abstract  
submitted by kickingbird at Apr, 22, 2022 from Transbound Emerg Dis. 2022 Apr 21 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14559)
In winter 2020-2021, Japan experienced multiple serious outbreaks of H5N8 high pathogenicity avian influenza (HPAI)-52 outbreaks at poultry farms and 58 cases in wild birds or the environment-that occurred ...

Zeng Q, Wang J, Zhang X, Chen L, Zhou L, Kuang F,. Successful combinatorial therapy of sirolimus and neuraminidase inhibitors in a patient with highly pathogenic avian influenza A (H5N6) virus: a case report. Ann Transl Med. 2022 Mar;10(5):265..  Abstract  
submitted by kickingbird at Apr, 12, 2022 from Ann Transl Med. 2022 Mar;10(5):265. (via https://atm.amegroups.com/article/view/91012/html)
Background: Highly pathogenic avian influenza A (H5N6) virus poses a continuous threat to human health since 2014. Although neuraminidase inhibitors (NAIs) are prescribed in most patients infected with ...

Bao D, Lu C, Ma T, Xu G, Mao Y, Xin L, Niu S, Wu Z. Hydrophobic Residues at the Intracellular Domain of the M2 Protein Play an Important Role in Budding and Membrane Integrity of Influenza Virus. J Virol. 2022 Apr 11:e0037322.  Abstract  
submitted by kickingbird at Apr, 12, 2022 from J Virol. 2022 Apr 11:e0037322 (via https://journals.asm.org/doi/10.1128/jvi.00373-22)
M2 protein of influenza virus plays an important role in virus budding, including membrane scission and vRNP packaging. Three hydrophobic amino acids (91F, 92V, and 94I) at the intracellular domain of ...

Kwon J, Youk S, Lee DH. Role of wild birds in the spread of clade 2.3.4.4e H5N6 highly pathogenic avian influenza virus into South Korea and Japan. Infect Genet Evol. 2022 Apr 5:105281.  Abstract  
submitted by kickingbird at Apr, 10, 2022 from Infect Genet Evol. 2022 Apr 5:105281 (via https://www.sciencedirect.com/science/article/pii/S156713482)
H5Nx highly pathogenic avian influenza viruses (HPAIVs) have caused transboundary epizootics in poultry and wild birds. In 2016, the H5N6 subtype of clade 2.3.4.4e HPAIVs caused multiple outbreaks in Asia, ...

Ge J, Lin X, Guo J, Liu L, Li Z, Lan Y, Liu L, Guo. The Antibody Response Against Neuraminidase in Human Influenza A (H3N2) Virus Infections During 2018/2019 Flu Season: Focusing on the Epitopes of 329- N-Glycosylation and E344 in N2. Front Microbiol. 2022 Mar 21;13:845088.  Abstract  
submitted by kickingbird at Apr, 9, 2022 from Front Microbiol. 2022 Mar 21;13:845088 (via https://www.frontiersin.org/articles/10.3389/fmicb.2022.8450)
Seasonal influenza A (H3N2) virus has been a concern since its first introduction in humans in 1968. Accumulating antigenic changes in viral hemagglutinin (HA), particularly recent cocirculations of multiple ...

Wang Y, Wang M, Zhang H, Zhao C, Zhang Y, He G, De. Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020. Microbiol Spectr. 2022 Apr 7:e0080722.  Abstract  
submitted by kickingbird at Apr, 9, 2022 from Microbiol Spectr. 2022 Apr 7:e0080722 (via https://journals.asm.org/doi/10.1128/spectrum.00807-22)
H10Nx influenza viruses have caused increasing public concern due to their occasional infection of humans. However, the genesis and biological characteristics of H10 viruses in migratory wild birds are ...

Gu W, Shi J, Cui P, Yan C, Zhang Y, Wang C, Zhang. Novel H5N6 reassortants bearing the clade 2.3.4.4b HA gene of H5N8 virus have been detected in poultry and caused multiple human infections in China. Emerg Microbes Infect. 2022 Apr 5:1-27.  Abstract  
submitted by kickingbird at Apr, 6, 2022 from Emerg Microbes Infect. 2022 Apr 5:1-27 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2)
The globally circulating H5N8 avian influenza viruses bearing the clade 2.3.4.4b hemagglutinin (HA) gene are responsible for the loss of more than 33 million domestic poultry since January 2020. Moreover, ...

Xiong W, Tsang TK, Perera RAPM, Leung NHL, Fang VJ. Biphasic waning of hemagglutination inhibition antibody titers after influenza vaccination in children. J Infect Dis. 2022 Apr 5:jiac117.  Abstract  
submitted by kickingbird at Apr, 6, 2022 from J Infect Dis. 2022 Apr 5:jiac117 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
We explored the potential for a biphasic pattern in waning of antibody titers after influenza vaccination. We collected blood samples in a randomized controlled trial of influenza vaccination in children, ...

Ou J, Zheng F, Cheng J, Ye SS, Ye C, Jia K, Lu G,. Isolation and Genetic Characterization of Emerging H3N2 Canine Influenza Virus in Guangdong Province, Southern China, 2018-2021. Front Vet Sci. 2022 Mar 11;9:810855.  Abstract  
submitted by kickingbird at Apr, 5, 2022 from Front Vet Sci. 2022 Mar 11;9:810855 (via https://www.frontiersin.org/articles/10.3389/fvets.2022.8108)
H3N2 canine influenza virus (CIV) emerged in dogs in China or Korea around 2005 and was first reported in 2008. In 2015, H3N2 CIV was detected in the United States and caused a huge outbreak. To date, ...

Soda K, Tomioka Y, Hidaka C, Matsushita M, Usui T,. Susceptibility of common family Anatidae bird species to clade 2.3.4.4e H5N6 high pathogenicity avian influenza virus: an experimental infection study. BMC Vet Res. 2022 Apr 2;18(1):127.  Abstract  
submitted by kickingbird at Apr, 5, 2022 from BMC Vet Res. 2022 Apr 2;18(1):127 (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
Background: There were large outbreaks of high pathogenicity avian influenza (HPAI) caused by clade 2.3.4.4e H5N6 viruses in the winter of 2016-2017 in Japan, which caused large numbers of deaths among ...

Sun H, Wu G, Zhang J, Wang Y, Qiu Y, Man H, Zhang. Characterization of an intracellular humanized single-chain antibody to matrix protein (M1) of H5N1 virus. PLoS One. 2022 Mar 31;17(3):e0266220.  Abstract  
submitted by kickingbird at Apr, 5, 2022 from PLoS One. 2022 Mar 31;17(3):e0266220 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
We developed a human intracellular antibody based on the M1 protein from avian influenza virus H5N1 (A/meerkat/Shanghai/SH-1/2012) and then characterized the properties of this antibody. The M1 protein ...

Morel J, Sedano L, Lejal N, Da Costa B, Batsché E,. The Influenza Virus RNA-Polymerase and the Host RNA-Polymerase II: RPB4 Is Targeted by a PB2 Domain That Is Involved in Viral Transcription. Viruses. 2022 Mar 3;14(3):518.  Abstract  
submitted by kickingbird at Mar, 29, 2022 from Viruses. 2022 Mar 3;14(3):518 (via https://www.mdpi.com/1999-4915/14/3/518)
Influenza virus transcription is catalyzed by the viral RNA-polymerase (FluPol) through a cap-snatching activity. The snatching of the cap of cellular mRNA by FluPol is preceded by its binding to the flexible ...

Javorsky A, Humbert PO, Kvansakul M. Structural Basis of the Avian Influenza NS1 Protein Interactions with the Cell Polarity Regulator Scribble. Viruses. 2022 Mar 11;14(3):583.  Abstract  
submitted by kickingbird at Mar, 29, 2022 from Viruses. 2022 Mar 11;14(3):583 (via https://www.mdpi.com/1999-4915/14/3/583)
Scribble is a highly conserved regulator of cell polarity, a process that enables the generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in concert with Disc-large ...

Abbas ME, Chengzhang Z, Fathalla A, Xiao Y. End-to-end antigenic variant generation for H1N1 influenza HA protein using sequence to sequence models. PLoS One. 2022 Mar 28;17(3):e0266198.  Abstract  
submitted by kickingbird at Mar, 29, 2022 from PLoS One. 2022 Mar 28;17(3):e0266198 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
The growing risk of new variants of the influenza A virus is the most significant to public health. The risk imposed from new variants may have been lethal, as witnessed in the year 2009. Even though the ...

Wang H, Zang Y, Zhao Y, Hao D, Kang Y, Zhang J, Zh. Sequence Matching between Hemagglutinin and Neuraminidase through Sequence Analysis Using Machine Learning. Viruses. 2022 Feb 25;14(3):469.  Abstract  
submitted by kickingbird at Mar, 27, 2022 from Viruses. 2022 Feb 25;14(3):469 (via https://www.mdpi.com/1999-4915/14/3/469)
To date, many experiments have revealed that the functional balance between hemagglutinin (HA) and neuraminidase (NA) plays a crucial role in viral mobility, production, and transmission. However, whether ...

Kandeil A, Moatasim Y, El Taweel A, El Sayes M, Ru. Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017-2021. Microorganisms. 2022 Mar 9;10(3):595..  Abstract  
submitted by kickingbird at Mar, 27, 2022 from Microorganisms. 2022 Mar 9;10(3):595. (via https://www.mdpi.com/2076-2607/10/3/595)
In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance ...

Verma AK, Kumar M, Murugkar HV, Nagarajan S, Tosh. Experimental Infection and In-Contact Transmission of H9N2 Avian Influenza Virus in Crows. Pathogens. 2022 Feb 28;11(3):304.  Abstract  
submitted by kickingbird at Mar, 27, 2022 from Pathogens. 2022 Feb 28;11(3):304
This study aimed to investigate the potential of H9N2 avian influenza virus to cause disease and intra-species transmission in house crows (Corvus splendens). A group of six crows were intranasally inoculated ...

Kaler L, Iverson E, Bader S, Song D, Scull MA, Dun. Influenza A virus diffusion through mucus gel networks. Commun Biol. 2022 Mar 22;5(1):249.  Abstract  
submitted by kickingbird at Mar, 24, 2022 from Commun Biol. 2022 Mar 22;5(1):249 (via https://www.nature.com/articles/s42003-022-03204-3)
Mucus in the lung plays an essential role as a barrier to infection by viral pathogens such as influenza A virus (IAV). Previous work determined mucin-associated sialic acid acts as a decoy receptor for ...

Yu J, Li H, Jia J, Huang Z, Liu S, Zheng Y, Mu S,. Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells. Emerg Microbes Infect. 2022 Mar 23:1-35.  Abstract  
submitted by kickingbird at Mar, 24, 2022 from Emerg Microbes Infect. 2022 Mar 23:1-35 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2)
Influenza A virus still represents a noticeable epidemic risk to international public health at present, despite the extensive use of vaccines and anti-viral drugs. In the fight against pathogens, the ...

Gu J, Yan Y, Zeng Z, Wang W, Gao R, Hu J, Hu S, Wa. Characterization of two chicken origin highly pathogenic H7N9 viruses isolated in northern China. Vet Microbiol. 2022 Mar 8;268:109394.  Abstract  
submitted by kickingbird at Mar, 24, 2022 from Vet Microbiol. 2022 Mar 8;268:109394 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Since the national vaccination program was implemented with the H5/H7 bivalent vaccine in poultry in September 2017, the prevalence of H7N9 avian influenza viruses (AIVs) has been controlled effectively ...

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