Lee J, et al. Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations. Cell Host Microbe. 2019 Feb 6.. Abstract
submitted by kickingbird at Feb, 24, 2019 from Cell Host Microbe. 2019 Feb 6. (via https://www.sciencedirect.com/science/article/pii/S193131281)
Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact antibody responses is essential for vaccine development. ...
Wang SH, et al. Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge. Vaccine. 2019 Feb 19.. Abstract
submitted by kickingbird at Feb, 24, 2019 from Vaccine. 2019 Feb 19. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: Highly pathogenic H5N1 influenza viruses remain a pandemic risk to the world population. Although vaccines are the best solution to prevent this threat, a more effective vaccine for H5 strains ...
Awadalla M, et al. Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors. J Immunother Cancer. 2019 Feb 22;7(1):53. Abstract
submitted by kickingbird at Feb, 24, 2019 from J Immunother Cancer. 2019 Feb 22;7(1):53 (via https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0)
BACKGROUND: Influenza vaccination (FV) is recommended for patients with cancer. Recent data suggested that the administration of the FV was associated with an increase in immune-related adverse events ...
Kim JW, et al. An optimized molecular method for detection of influenza A virus using improved generic primers and concentration of the viral genomic RNA and nucleoprotein complex. J Vet Diagn Invest. 2019 Feb 22. Abstract
submitted by kickingbird at Feb, 24, 2019 from J Vet Diagn Invest. 2019 Feb 22 (via https://journals.sagepub.com/doi/abs/10.1177/104063871983076)
For reported primer sets used to detect influenza A viruses (IAVs), we verified the nucleotide identities with 9,103 complete sequences of matrix (M) genes. At best, only 93.2% and 85.3% of the sequences ...
Wang Q, et al. Host cell interactome of PB1 N40 protein of H5N1 influenza A virus in chicken cells. J Proteomics. 2019 Feb 18. Abstract
submitted by kickingbird at Feb, 24, 2019 from J Proteomics. 2019 Feb 18 (via https://www.sciencedirect.com/science/article/pii/S187439191)
H5N1 influenza A virus (IAV) causes seasonal epidemics that represent a worldwide threat to public health. IAV relies on host factors for viral replication. PB1 N40 is translated from the fifth starting ...
Byrd-Leotis L, et al. Influenza binds phosphorylated glycans from human lung. Sci Adv. 2019 Feb 13;5(2):eaav2554. Abstract
submitted by kickingbird at Feb, 24, 2019 from Sci Adv. 2019 Feb 13;5(2):eaav2554 (via http://advances.sciencemag.org/content/5/2/eaav2554)
Influenza A viruses can bind sialic acid-terminating glycan receptors, and species specificity is often correlated with sialic acid linkage with avian strains recognizing α2,3-linked sialylated glycans ...
Nieto A, et al. Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model. Front Immunol. 2019 Feb 6;10:132.. Abstract
submitted by kickingbird at Feb, 24, 2019 from Front Immunol. 2019 Feb 6;10:132. (via https://www.ncbi.nlm.nih.gov/pubmed/30787926)
Characterization of a pandemic 2009 H1N1 influenza virus isolated from a fatal case patient (F-IAV), showed the presence of three different mutations; potential determinants of its high pathogenicity that ...
To EE, et al. Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice. Sci Rep. 2019 Feb 20;9(1):2366. Abstract
submitted by kickingbird at Feb, 24, 2019 from Sci Rep. 2019 Feb 20;9(1):2366 (via https://www.nature.com/articles/s41598-019-38864-5)
Toll-like receptor 7 (TLR7) is a pattern recognition receptor that recognizes viral RNA following endocytosis of the virus and initiates a powerful immune response characterized by Type I IFN production ...
Meineke R, Rimmelzwaan GF, Elbahesh H. Influenza Virus Infections and Cellular Kinases. Viruses. 2019 Feb 20;11(2). Abstract
submitted by kickingbird at Feb, 24, 2019 from Viruses. 2019 Feb 20;11(2) (via https://www.mdpi.com/1999-4915/11/2/171)
Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs may cause pandemic outbreaks ...
Turgeon N, et al. Design and Validation with Influenza A Virus of an Aerosol Transmission Chamber for Ferrets. Int J Environ Res Public Health. 2019 Feb 19;16(4). Abstract
submitted by kickingbird at Feb, 24, 2019 from Int J Environ Res Public Health. 2019 Feb 19;16(4) (via https://www.mdpi.com/1660-4601/16/4/609)
Background: The importance of aerosols in the spread of viruses like influenza is still a subject of debate. Indeed, most viruses can also be transmitted through direct contact and droplets. Therefore, ...
Zhang W, et al. Genetic Evolution and Molecular Selection of the HE Gene of Influenza C Virus. Viruses. 2019 Feb 19;11(2). Abstract
submitted by kickingbird at Feb, 24, 2019 from Viruses. 2019 Feb 19;11(2) (via https://www.mdpi.com/1999-4915/11/2/167)
Influenza C virus (ICV) was first identified in humans and swine, but recently also in cattle, indicating a wider host range and potential threat to both the livestock industry and public health than was ...
Jiao H, et al. MicroRNA expression profiles from HEK293 cells expressing H5N1 avian influenza virus non-structural protein 1. Innate Immun. 2019 Feb;25(2):110-117. Abstract
submitted by kickingbird at Feb, 22, 2019 from Innate Immun. 2019 Feb;25(2):110-117 (via https://journals.sagepub.com/doi/full/10.1177/17534259198263)
H5N1 avian influenza poses a serious threat to the poultry industry and human health. Non-structural protein 1 (NS1) plays an important role in the replication and pathogenesis of avian influenza virus ...
Koutsakos M, et al. Human CD8+ T cell cross-reactivity across influenza A, B and C viruses. Nat Immunol. 2019 Feb 18.. Abstract
submitted by kickingbird at Feb, 21, 2019 from Nat Immunol. 2019 Feb 18. (via https://www.nature.com/articles/s41590-019-0320-6)
Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross-protection against IAV strains, ...
Rüdiger D, Kupke SY, Laske T, Zmora P, Reichl U. Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditions. PLoS Comput Biol. 2019 Feb 19;15(2):e1006819.. Abstract
submitted by kickingbird at Feb, 21, 2019 from PLoS Comput Biol. 2019 Feb 19;15(2):e1006819. (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Influenza A viruses (IAV) are commonly used to infect animal cell cultures for research purposes and vaccine production. Their replication is influenced strongly by the multiplicity of infection (MOI), ...
Ilyushina NA, Dickensheets H, Donnelly RP. A comparison of interferon gene expression induced by influenza A virus infection of human airway epithelial cells from two different donors. Virus Res. 2019 Feb 16. Abstract
submitted by kickingbird at Feb, 21, 2019 from Virus Res. 2019 Feb 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30779949)
Influenza is an acute respiratory disease that can cause local annual epidemics and worldwide pandemics of different morbidity and mortality. Our understanding of host factors that modulate the frequency ...
Ren L, et al. Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia-inducible factor-1α via inhibition of proteasome. Virology. 2019 Feb 11;530:51-58. Abstract
submitted by kickingbird at Feb, 21, 2019 from Virology. 2019 Feb 11;530:51-58 (via https://www.ncbi.nlm.nih.gov/pubmed/30780125)
Virus reprogramming of host cellular function is a critical strategy for viral survival and replication. A better understanding of virus-host interaction may provide new potential avenues for the treatment ...
Roy Chowdhury I, Yeddula SGR, Kim SH. Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys. Viruses. 2019 Feb 16;11(2). Abstract
submitted by kickingbird at Feb, 21, 2019 from Viruses. 2019 Feb 16;11(2) (via https://www.ncbi.nlm.nih.gov/pubmed/30781528)
Low pathogenic avian influenza (LPAI) viruses can silently circulate in poultry and wild aquatic birds and potentially mutate into highly pathogenic avian influenza (HPAI) viruses. In the U.S., recent ...
Zhang T, Zhao H, Wang J, Han GZ. Wild birds do not harbor higher diversity of influenza virus internal genes than poultry. Virology. 2019 Feb 7;530:59-64. Abstract
submitted by kickingbird at Feb, 20, 2019 from Virology. 2019 Feb 7;530:59-64 (via https://www.ncbi.nlm.nih.gov/pubmed/30776509)
Avian influenza A virus (AIV) has threatened global economy and public health. Wild birds have long been thought to serve as the natural reservoir of influenza virus, and thus it is expected that wild ...
Hu Q, Gilley RP, Dube PH. House dust mite exposure attenuates influenza A infection in a mouse model of pulmonary allergic inflammation. Microb Pathog. 2019 Feb 15.. Abstract
submitted by kickingbird at Feb, 20, 2019 from Microb Pathog. 2019 Feb 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30776411)
Environmental allergens elicit complex immune responses in the lungs that can promote the development of asthma or exacerbate preexisting asthma in susceptible individuals. House dust mites are one of ...
Fu Y, et al. Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence. J Infect Dis. 2019 Feb 18.. Abstract
submitted by kickingbird at Feb, 20, 2019 from J Infect Dis. 2019 Feb 18. (via https://www.ncbi.nlm.nih.gov/pubmed/30776304)
We analyzed the virulence of pandemic H1N1 2009 influenza A viruses in vivo and in vitro. Selected viruses isolated in 2009, 2010, 2014, and 2015 were assessed using an aerosol-mediated high-dose infection ...
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