Matsuda K, et al. Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine. Sci Immunol. 2019 Apr 19;4(34).. Abstract
submitted by kickingbird at Apr, 21, 2019 from Sci Immunol. 2019 Apr 19;4(34). (via https://immunology.sciencemag.org/content/4/34/eaau2710)
Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and influenza. Here, we report the dynamics of ...
Ma J, et al. Virus survival and fitness when multiple genotypes and subtypes of influenza A viruses exist and circulate in swine. Virology. 2019 Apr 9;532:30-38. Abstract
submitted by kickingbird at Apr, 21, 2019 from Virology. 2019 Apr 9;532:30-38 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
We performed swine influenza virus (SIV) surveillance in Midwest USA and isolated 100 SIVs including endemic and reassortant H1 and H3 viruses with 2009 pandemic H1N1 genes. To determine virus evolution ...
Koshimichi H, Ishibashi T, Wajima T. Population Pharmacokinetics of Baloxavir Marboxil in Japanese Pediatric Influenza Patients. J Pharm Sci. 2019 Apr 15.. Abstract
submitted by kickingbird at Apr, 19, 2019 from J Pharm Sci. 2019 Apr 15. (via https://jpharmsci.org/article/S0022-3549(19)30236-9/pdf)
Baloxavir marboxil is a prodrug of baloxavir acid, an inhibitor of cap-dependent endonuclease, and suppresses the replication of influenza virus. The aim of this study is to investigate its pharmacokinetic ...
Yamagata Y, et al. Generation of a purely clonal defective interfering influenza virus. Microbiol Immunol. 2019 Apr 18.. Abstract
submitted by kickingbird at Apr, 19, 2019 from Microbiol Immunol. 2019 Apr 18. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/1348-0421.12)
A defective interfering (DI) influenza virus carries a large deletion in a viral gene segment and shows potential for antiviral therapy by interfering with the replication of infectious virus. However, ...
Guan M, et al. Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets. J Virol. 2019 Apr 17. pii: JVI.00282-19.. Abstract
submitted by kickingbird at Apr, 19, 2019 from J Virol. 2019 Apr 17. pii: JVI.00282-19. (via https://jvi.asm.org/content/early/2019/04/12/JVI.00282-19)
Subtype H10 influenza A viruses (IAVs) have been recovered from domestic poultry and various aquatic bird species, and sporadic transmission of these IAVs from avian species to mammals (i.e., human, seal, ...
Gaucherand L, et al. The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression. Cell Rep. 2019 Apr 16;27(3):776-792.e7. Abstract
submitted by kickingbird at Apr, 19, 2019 from Cell Rep. 2019 Apr 16;27(3):776-792.e7 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)303)
Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and host proteins required for viral replication are typically spared in this process, but the mechanisms of target ...
Zhang H, et al. Fundamental contribution and host range determination of ANP32A and ANP32B in influenza A virus polymerase activity. J Virol. 2019 Apr 17. Abstract
submitted by kickingbird at Apr, 19, 2019 from J Virol. 2019 Apr 17 (via https://jvi.asm.org/content/early/2019/04/12/JVI.00174-19)
The polymerase of the influenza virus is part of the key machinery necessary for viral replication. However, the avian influenza virus polymerase is restricted in mammalian cells. The cellular protein ...
Gong YN, et al. Population dynamics at neuraminidase position 151 of influenza A (H1N1)pdm09 virus in clinical specimens. J Gen Virol. 2019 Apr 17.. Abstract
submitted by kickingbird at Apr, 19, 2019 from J Gen Virol. 2019 Apr 17. (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
Influenza A virus mutates rapidly, allowing it to escape natural and vaccine-induced immunity. Neuraminidase (NA) is a surface protein capable of cleaving the glycosidic linkages of neuraminic acids to ...
Roy S, et al. Whole-genome Sequencing Provides Data for Stratifying Infection Prevention and Control Management of Nosocomial Influenza A. Clin Infect Dis. 2019 Apr 17.. Abstract
submitted by kickingbird at Apr, 19, 2019 from Clin Infect Dis. 2019 Apr 17. (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
BACKGROUND: Influenza A virus causes annual epidemics in humans and is associated with significant morbidity and mortality. Haemagglutinin (HA) and neuraminidase (NA) gene sequencing have traditionally ...
Okuda M, et al. Subclade 2.2.1-Specific Human Monoclonal Antibodies That Recognize an Epitope in Antigenic Site A of Influenza A(H5) Virus HA Detected between 2015 and 2018. Viruses. 2019 Apr 2;11(4).. Abstract
submitted by kickingbird at Apr, 17, 2019 from Viruses. 2019 Apr 2;11(4). (via https://www.mdpi.com/1999-4915/11/4/321)
Highly pathogenic avian H5 influenza viruses persist among poultry and wild birds throughout the world. They sometimes cause interspecies transmission between avian and mammalian hosts. H5 viruses possessing ...
Wellington D, et al. IFITM3: How genetics influence influenza infection demographically. Biomed J. 2019 Feb;42(1):19-26.. Abstract
submitted by kickingbird at Apr, 17, 2019 from Biomed J. 2019 Feb;42(1):19-26. (via https://www.sciencedirect.com/science/article/pii/S231941701)
The role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role ...
Biondo C, Lentini G, Beninati C, Teti G. The dual role of innate immunity during influenza. Biomed J. 2019 Feb;42(1):8-18.. Abstract
submitted by kickingbird at Apr, 17, 2019 from Biomed J. 2019 Feb;42(1):8-18. (via https://www.sciencedirect.com/science/article/pii/S231941701)
One of the distinguishing features of the 1918 pandemic is the occurrence of massive, potentially detrimental, activation of the innate immune system in critically ill patients. Whether this reflects an ...
Park ES, et al. Co-degradation of interferon signaling factor DDX3 by PB1-F2 as a basis for high virulence of 1918 pandemic influenza. EMBO J. 2019 Apr 12. Abstract
submitted by kickingbird at Apr, 15, 2019 from EMBO J. 2019 Apr 12 (via http://emboj.embopress.org/content/early/2019/04/12/embj.201)
The multifunctional influenza virus protein PB1-F2 plays several roles in deregulation of host innate immune responses and is a known immunopathology enhancer of the 1918 influenza pandemic. Here, we show ...
Yang J, et al. Ducks induce rapid and robust antibody responses than chickens at early time after intravenous infection with H9N2 avian influenza virus. Virol J. 2019 Apr 11;16(1):46.. Abstract
submitted by kickingbird at Apr, 14, 2019 from Virol J. 2019 Apr 11;16(1):46. (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Compared with chickens, ducks are normally resistant to avian influenza virus without clinical signs while they habor almost all subtypes of influenza A viruses. To date, however the mechanism ...
Tao P, Ning Z, Hao X, Lin X, Zheng Q, Li S. Comparative Analysis of Whole-Transcriptome RNA Expression in MDCK Cells Infected With the H3N2 and H5N1 Canine Influenza Viruses. Front Cell Infect Microbiol. 2019 Mar 26;9:76. Abstract
submitted by kickingbird at Apr, 12, 2019 from Front Cell Infect Microbiol. 2019 Mar 26;9:76 (via https://www.frontiersin.org/articles/10.3389/fcimb.2019.0007)
This study aimed to detect changes in the complete transcriptome of MDCK cells after infection with the H5N1 and H3N2 canine influenza viruses using high-throughput sequencing, search for differentially ...
Bergervoet SA, et al. Genetic analysis identifies potential transmission of low pathogenic avian influenza viruses between poultry farms. Transbound Emerg Dis. 2019 Apr 9.. Abstract
submitted by kickingbird at Apr, 11, 2019 from Transbound Emerg Dis. 2019 Apr 9. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13199)
Poultry can become infected with low pathogenic avian influenza (LPAI) viruses via (in)direct contact with infected wild birds, or by transmission of the virus between farms. This study combines routinely ...
Xie C, et al. Detection of influenza and other respiratory viruses in air sampled from a university campus: a longitudinal study. Clin Infect Dis. 2019 Apr 9.. Abstract
submitted by kickingbird at Apr, 11, 2019 from Clin Infect Dis. 2019 Apr 9. (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: Respiratory virus-laden particles are commonly detected in the exhaled breath of symptomatic patients or in air sampled from healthcare settings. However, the temporal relationship of detecting ...
Sugishita Y, Sugawara T, Ohkusa Y. Association of influenza outbreak in each nursery school and community in a ward in Tokyo, Japan. J Infect Chemother. 2019 Apr 6.. Abstract
submitted by kickingbird at Apr, 11, 2019 from J Infect Chemother. 2019 Apr 6. (via https://www.ncbi.nlm.nih.gov/pubmed/30962116)
In nursery schools, influenza outbreaks have occurred every year. However, influenza characteristics of its diffusion among nursery schools, within each nursery school, and among classes of different ages ...
Ladman BS, et al. Protection Afforded By Avian Influenza Vaccination Programs Consisting Of A Novel RNA Particle And An Inactivated Avian Influenza Vaccine Against A Highly Pathogenic Avian Influenza Virus Challenge In. Avian Pathol. 2019 Apr 9:1-34. Abstract
submitted by kickingbird at Apr, 11, 2019 from Avian Pathol. 2019 Apr 9:1-34 (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2019.16)
The efficacies of an oil adjuvanted-inactivated reverse genetics derived H5 avian influenza virus (AIV) vaccine and an alphavirus replicon RNA particle (RP) AIV vaccine were evaluated in commercial leghorn ...
Carnaccini S, et al. Age-dependent pathogenesis of clade 22.214.171.124A H5N2 HPAIV in experimentally infected Broad Breasted White turkeys. Vet Microbiol. 2019 Apr;231:183-190. Abstract
submitted by kickingbird at Apr, 9, 2019 from Vet Microbiol. 2019 Apr;231:183-190 (via https://www.sciencedirect.com/science/article/pii/S037811351)
Highly pathogenic avian influenza (HPAI) is a viral disease with devastating consequences to the poultry industry as it results in high morbidity, mortality and international trade restrictions. In the ...
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