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2025-12-18 4:22:30
Article

Neumann G, Eisfeld AJ, Kawaoka Y. 0. Viral factors underlying the pandemic potential of influenza viruses. Microbiol Mol Biol Rev 0:e00066-24.  Abstract  
submitted by kickingbird at May, 11, 2025 from Microbiol Mol Biol Rev 0:e00066-24 (via https://journals.asm.org/doi/10.1128/mmbr.00066-24)
Over the past 25 years, there has been an increasing number of mammalian (including human) infections caused by avian influenza A viruses that resulted in mild to severe illnesses. These viruses typically ...

Xie Z, Yang J, Jiao W, Li X, Iqbal M, Liao M, Dai. Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges. J Virol 0:e00424-25.  Abstract  
submitted by kickingbird at May, 11, 2025 from J Virol 0:e00424-25 (via https://journals.asm.org/doi/10.1128/jvi.00424-25)
Since 2020, the clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 viruses have caused unprecedented outbreaks in wild birds and domestic poultry globally, resulting in significant ecological ...

Rawson, T., Morgenstern, C., Knock, E.S. et al. A mathematical model of H5N1 influenza transmission in US dairy cattle. Nat Commun 16, 4308 (2025).  Abstract  
submitted by kickingbird at May, 11, 2025 from Nat Commun 16, 4308 (2025) (via https://www.nature.com/articles/s41467-025-59554-z)
2024 saw a novel outbreak of H5N1 avian influenza in US dairy cattle. Limited surveillance data has made determining the true scale of the epidemic difficult. We present a stochastic metapopulation transmission ...

Moraes DCA, Cezar GA, Magalh?es ES, Nicolino RR, R. Macroepidemiological trends of Influenza A virus detection through reverse transcription real-time polymerase chain reaction (RT-rtPCR) in porcine samples in the United States over the last 20 years. Front Vet Sci. 2025 Apr 24;12:1572237.  Abstract  
submitted by kickingbird at May, 11, 2025 from Front Vet Sci. 2025 Apr 24;12:1572237 (via https://www.frontiersin.org/journals/veterinary-science/arti)
Influenza A virus (IAV) in swine is a major respiratory pathogen with global significance. This study aimed to characterize the macroepidemiological patterns of IAV detection using reverse transcription ...

Michael A Zeller, Rong Zhang, Yvonne C F Su, Ki. Forecasting Influenza A Pandemic lineage dominance in the United States using relative reproduction rates. Virus Evolution, veaf032.  Abstract  
submitted by kickingbird at May, 8, 2025 from Virus Evolution, veaf032 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
The 2009 H1N1pandemic (pdm09) lineage is a major component of H1 influenza A virus (IAV) that causes seasonal outbreaks annually. Since its introduction in the 2009-10 season, this lineage has evolved ...

Kristen K Coleman, Ian G Bemis. Avian Influenza Virus Infections in Felines: A Systematic Review of Two Decades of Literature. Open Forum Infectious Diseases, ofaf261.  Abstract  
submitted by kickingbird at May, 8, 2025 from Open Forum Infectious Diseases, ofaf261 (via https://academic.oup.com/ofid/advance-article/doi/10.1093/of)
As an avian influenza virus (AIV) panzootic is underway, the threat of a human pandemic is emerging. Infections among mammalian species in frequent contact with humans should be closely monitored. One ...

Lee SH, Kwon JH, Youk S, Lee SW, Lee DH, Song CS. Epidemiology and pathobiology of H5Nx highly pathogenic avian influenza in South Korea (2003-2024): a comprehensive review. Vet Q. 2025 Dec;45(1):23-38.  Abstract  
submitted by kickingbird at May, 8, 2025 from Vet Q. 2025 Dec;45(1):23-38 (via https://www.tandfonline.com/doi/full/10.1080/01652176.2025.2)
Since their emergence in Guangdong, China, in 1996, Gs/GD H5 highly pathogenic avian influenza viruses (HPAIVs) have diversified into multiple clades, spreading globally through wild bird migrations and ...

Johnston, D. T., Atkinson, P. W., Leech, E. I., Bu. Using ring (band) recovery data to examine the impact of high pathogenicity avian influenza (HPAI) on wild bird populations. Bird Study, 1–12.  Abstract  
submitted by kickingbird at May, 6, 2025 from Bird Study, 1–12 (via https://www.tandfonline.com/doi/full/10.1080/00063657.2025.2)
CapsuleAnalyses of ring recovery data can relatively rapidly detect excessive mortality in wild bird populations, including that arising from outbreaks of high pathogenicity avian influenza (HPAI).AimsWild ...

Wang J, Xiong Y, Li B, Yang J, Xiao D, Fu X, Long. A 14-year influenza reinfection surveillance in Chongqing, China: A retrospective analysis. Hum Vaccin Immunother. 2025 Dec;21(1):2497576.  Abstract  
submitted by kickingbird at May, 6, 2025 from Hum Vaccin Immunother. 2025 Dec;21(1):2497576 (via https://www.tandfonline.com/doi/full/10.1080/21645515.2025.2)
Influenza poses a significant medical burden and has the potential to cause global pandemics. To better understand the epidemiological characteristics of influenza reinfections and identify factors associated ...

Zhang X, Yang Y, Han X, Wei D, Niu B, Huang Q, Li. Unique Phenomenon of H5 Highly Pathogenic Avian Influenza Virus in China: Co-circulation of Clade 2.3.4.4b H5N1 and H5N6 results in diversity of H5 Virus. Emerg Microbes Infect. 2025 May 6:2502005.  Abstract  
submitted by kickingbird at May, 6, 2025 from Emerg Microbes Infect. 2025 May 6:2502005 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Recently, Clade 2.3.4.4b H5N1 virus has been widely prevalent globally. Although no outbreaks of Avian Influenza have occurred in poultry in China recently, Clade 2.3.4.4b H5 virus can still be isolated ...

Song, JH., Son, SE., Kim, HW. et al. Intranasally administered whole virion inactivated vaccine against clade 2.3.4.4b H5N1 influenza virus with optimized antigen and increased cross-protection. Virol J 22, 131 (2025).  Abstract  
submitted by kickingbird at May, 6, 2025 from Virol J 22, 131 (2025) (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
The global spread, frequent antigenic changes, and pandemic potential of clade 2.3.4.4b highly pathogenic avian influenza H5N1 underscore the urgent need for robust cross-protective vaccines. Here, we ...

Yasuhisa Fujita, Marwa Akao, Daiki Tatematsu, etc.. [preprint]Modeling viral shedding and symptom outcomes in oseltamivir-treated experimental influenza infection. https://doi.org/10.1101/2025.05.02.651873.  Abstract  
submitted by kickingbird at May, 6, 2025 from https://doi.org/10.1101/2025.05.02.651873 (via https://www.biorxiv.org/content/10.1101/2025.05.02.651873v1)
Influenza remains a global public health concern, and although the antiviral drug oseltamivir is widely used to treat infections, questions regarding its actual antiviral efficacy and clinical benefits ...

Van Borm S, Ahrens AK, Bachofen C, Banyard AC, Arn. Genesis and Spread of Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Genotype EA-2023-DG Reassortant, Western Europe. Emerg Infect Dis. 2025 Jun.  Abstract  
submitted by kickingbird at May, 6, 2025 from Emerg Infect Dis. 2025 Jun (via https://wwwnc.cdc.gov/eid/article/31/6/24-1870_article)
In Europe, highly pathogenic avian influenza (HPAI) virus circulates in avian wildlife, undergoing frequent reassortment, sporadic introductions in domestic birds, and spillover to mammals. An H5N1 clade ...

Cecilia Di Genova, etc.,al. [preprint]Pigeons exhibit low susceptibility and poor transmission capacity for H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus. https://doi.org/10.1101/2025.05.02.651910.  Abstract  
submitted by kickingbird at May, 4, 2025 from https://doi.org/10.1101/2025.05.02.651910 (via https://www.biorxiv.org/content/10.1101/2025.05.02.651910v1)
The ongoing panzootic of H5N1 high pathogenicity avian influenza virus (HPAIV) has caused the deaths of over half a billion wild birds and poultry, and has led to spillover events in both wild and domestic ...

Emi Takashita, etc.,al. Impact of the Polymerase Acidic Protein E199K Substitution in Influenza A Viruses on Baloxavir Susceptibility. Antiviral Research 2025.  Abstract  
submitted by kickingbird at May, 4, 2025 from Antiviral Research 2025 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Baloxavir marboxil, a cap-dependent endonuclease inhibitor, was approved in Japan in 2018 for the treatment and prophylaxis of influenza. Its active form, baloxavir acid, binds to the polymerase acidic ...

Clément Fage, etc.,al. Influenza A(H1N1)pdm09 Virus Resistance to Baloxavir, Oseltamivir and Sialic Acid Mimetics in Single and Dual therapies: Insights from Human Airway Epithelia and Murine Models. Antiviral Research 2025.  Abstract  
submitted by kickingbird at May, 4, 2025 from Antiviral Research 2025 (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
Influenza viruses pose a significant threat due to annual epidemics and pandemic potential. Resistance to current antivirals underscores the need for new drugs and strategies to prevent its emergence. ...

Heinz Feldmann, etc.,al. [preprint]Bovine Derived Clade 2.3.4.4b HPAI H5N1 Virus Causes Mild Disease and Limited Transmission in Pigs. https://doi.org/10.21203/rs.3.rs-6567595/v1.  Abstract  
submitted by kickingbird at May, 3, 2025 from https://doi.org/10.21203/rs.3.rs-6567595/v1 (via https://www.researchsquare.com/article/rs-6567595/v1)
Highly pathogenic avian influenza virus (HPAIV) H5N1 clade 2.3.4.4b emerged in dairy cows in the United States in early 2024. Since then, this clade simultaneously circulates in wild birds, cattle and ...

Carine K. Souza, etc.,al. [preprint]H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves. https://doi.org/10.1101/2025.05.01.651548.  Abstract  
submitted by kickingbird at May, 3, 2025 from https://doi.org/10.1101/2025.05.01.651548 (via https://www.biorxiv.org/content/10.1101/2025.05.01.651548v2)
Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 is circulating widely in lactating cows in the United States. Due to the critical need for intervention strategies for this outbreak, we evaluated ...

Benjamin C Mollett, etc.,al. [preprint]Diverse Genomic Landscape of Swine Influenza A Virus in England (2014 ~ 2021). https://doi.org/10.1101/2025.04.28.650978.  Abstract  
submitted by kickingbird at May, 2, 2025 from https://doi.org/10.1101/2025.04.28.650978 (via https://www.biorxiv.org/content/10.1101/2025.04.28.650978v1)
Surveillance of influenza A viruses in pigs (SwIAV) is critical for identification of novel genetic groups that pose a risk to pig health and might have zoonotic potential. SwIAVs circulating in pigs in ...

Er JC. Improving Influenza Nomenclature Based on Transmission Dynamics. Viruses. 2025; 17(5):633.  Abstract  
submitted by kickingbird at May, 1, 2025 from Viruses. 2025; 17(5):633 (via https://www.mdpi.com/1999-4915/17/5/633)
Influenza A viruses (IAVs) evolve rapidly, exhibit zoonotic potential, and frequently adapt to new hosts, often establishing long-term reservoirs. Despite advancements in genetic sequencing and phylogenetic ...

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