Gouma S, Furey C, Santos JJS, Parkhouse K, Weirick. Nucleoside-Modified mRNA-Based Influenza Vaccines Circumvent Problems Associated with H3N2 Vaccine Strain Egg Adaptation. J Virol. 2022 Dec 19:e0172322. Abstract
submitted by kickingbird at Dec, 21, 2022 from J Virol. 2022 Dec 19:e0172322 (via https://journals.asm.org/doi/10.1128/jvi.01723-22)
Most human influenza vaccine antigens are produced in fertilized chicken eggs. Recent H3N2 egg-based vaccine antigens have limited effectiveness, partially due to egg-adaptive substitutions that alter ... Chiba S, Hatta M, Pattinson D, Yasuhara A, Neumann. Ferret model to mimic the sequential exposure of humans to historical H3N2 influenza viruses. Vaccine. 2022 Dec 12:S0264-410X(22)01518-3. Abstract
submitted by kickingbird at Dec, 17, 2022 from Vaccine. 2022 Dec 12:S0264-410X(22)01518-3 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Mutations accumulate in influenza A virus proteins, especially in the main epitopes on the virus surface glycoprotein hemagglutinin (HA). For influenza A(H3N2) viruses, in particular, the antigenicity ... Noisumdaeng P, Phadungsombat J, Weerated S, Wiriya. Genetic evolution of hemagglutinin and neuraminidase genes of H5N1 highly pathogenic avian influenza viruses in Thailand. PeerJ. 2022 Nov 30;10:e14419. Abstract
submitted by kickingbird at Dec, 17, 2022 from PeerJ. 2022 Nov 30;10:e14419 (via https://peerj.com/articles/14419/)
Background: Ongoing outbreaks of H5N1 highly pathogenic avian influenza (HPAI) viruses and the emergence of the genetic-related hemagglutinin (HA) gene of reassortant H5Nx viruses currently circulating ... Zhang B, Huang W, Pei S, Zeng J, Shen W, Wang D, W. Mechanisms for the circulation of influenza A(H3N2) in China: A spatiotemporal modelling study. PLoS Pathog. 2022 Dec 16;18(12):e1011046.. Abstract
submitted by kickingbird at Dec, 17, 2022 from PLoS Pathog. 2022 Dec 16;18(12):e1011046. (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Circulation of seasonal influenza is the product of complex interplay among multiple drivers, yet characterizing the underlying mechanism remains challenging. Leveraging the diverse seasonality of A(H3N2) ... Marcenac P, McCarron M, Davis W, Igboh LS, Mott JA. Leveraging International Influenza Surveillance Systems and Programs during the COVID-19 Pandemic. Emerg Infect Dis. 2022;28(13):26-33. Abstract
submitted by kickingbird at Dec, 12, 2022 from Emerg Infect Dis. 2022;28(13):26-33 (via https://wwwnc.cdc.gov/eid/article/28/13/21-2248_article)
A network of global respiratory disease surveillance systems and partnerships has been built over decades as a direct response to the persistent threat of seasonal, zoonotic, and pandemic influenza. These ... Chen Y, Wang F, Yin L, Jiang H, Lu X, Bi Y, Zhang. Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun. 2022 Dec 9;13(1):7603. Abstract
submitted by kickingbird at Dec, 11, 2022 from Nat Commun. 2022 Dec 9;13(1):7603 (via https://www.nature.com/articles/s41467-022-35236-y)
Influenza infection continues are a persistent threat to public health. The identification and characterization of human broadly neutralizing antibodies can facilitate the development of antibody drugs ... He J, Hou S, Xiong C, Hu L, Gong L, Yu J, Zhou X,. Avian influenza A virus H7N9 in China, a role reversal from reassortment receptor to the donator. J Med Virol. 2022 Dec 9. Abstract
submitted by kickingbird at Dec, 11, 2022 from J Med Virol. 2022 Dec 9 (via https://onlinelibrary.wiley.com/doi/10.1002/jmv.28392)
Reassortment can introduce one or more gene segments of influenza A viruses (IAVs) into another, resulting in novel subtypes. Since 2013, a new outbreak of human highly pathogenic avian influenza has emerged ... Kandeil A, Kayed A, Moatasim Y, Aboulhoda BE, El T. Molecular identification and virological characteristics of highly pathogenic avian influenza A/H5N5 virus in wild birds in Egypt. Microb Pathog. 2022 Dec 2:105928. Abstract
submitted by kickingbird at Dec, 8, 2022 from Microb Pathog. 2022 Dec 2:105928 (via https://www.sciencedirect.com/science/article/abs/pii/S08824)
Multiple incursions of different subtypes of highly pathogenic avian influenza (HPAI) A/H5NX viruses have caused widely considerable outbreaks in poultry and hundreds of human infections. Extensive reassortment ... Ren W, Pei S, Jiang W, Zhao M, Jiang L, Liu H, Yi. A replication-deficient H9N2 influenza virus carrying H5 hemagglutinin conferred protection against H9N2 and H5N1 influenza viruses in mice. Front Microbiol. 2022 Nov 15;13:1042916. Abstract
submitted by kickingbird at Dec, 4, 2022 from Front Microbiol. 2022 Nov 15;13:1042916 (via https://www.frontiersin.org/articles/10.3389/fmicb.2022.1042)
H5N1 and H9N2 influenza viruses have been reported to cause human infections and are believed to have pandemic potential. The vaccine is an effective tool to prevent influenza virus infection. However, ... Yang B, García-Carreras B, Lessler J, Read JM, Zhu. Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modelling study. Elife. 2022 Dec 2;11:e81457. Abstract
submitted by kickingbird at Dec, 4, 2022 from Elife. 2022 Dec 2;11:e81457 (via https://elifesciences.org/articles/81457)
Background: Over a life-course, human adaptive immunity to antigenically mutable pathogens exhibits competitive and facilitative interactions. We hypothesize that such interactions may lead to cyclic dynamics ... Zhu H, Li X, Chen H, Qian P. Genetic characterization and pathogenicity of a Eurasian avian-like H1N1 swine influenza reassortant virus. Virol J. 2022 Dec 2;19(1):205. Abstract
submitted by kickingbird at Dec, 4, 2022 from Virol J. 2022 Dec 2;19(1):205 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Swine influenza viruses (SIV), considered the "mixing vessels" of influenza viruses, posed a significant threat to global health systems and are dangerous pathogens. Eurasian avian-like H1N1(EA-H1N1) ... Ran W, Sch?n J, Ciminski K, Kraft J, Kessler S, Eu. Generation of an Attenuated Chimeric Bat Influenza A Virus Live-Vaccine Prototype. Microbiol Spectr. 2022 Nov 29:e0142422. Abstract
submitted by kickingbird at Nov, 30, 2022 from Microbiol Spectr. 2022 Nov 29:e0142422 (via https://journals.asm.org/doi/10.1128/spectrum.01424-22)
Recurring epizootic influenza A virus (IAV) infections in domestic livestock such as swine and poultry are associated with a substantial economic burden and pose a constant threat to human health. Therefore, ... Zhang C, Cui H, Zhang C, Zhao K, Kong Y, Chen L, D. Pathogenicity and Transmissibility of Clade 2.3.4.4h H5N6 Avian Influenza Viruses in Mammals. Animals (Basel). 2022 Nov 9;12(22):3079. Abstract
submitted by kickingbird at Nov, 28, 2022 from Animals (Basel). 2022 Nov 9;12(22):3079 (via https://www.mdpi.com/2076-2615/12/22/3079)
Avian influenza viruses (AIVs) have the potential for cross-species transmission and pandemics. In recent years, clade 2.3.4.4 H5N6 AIVs are prevalent in domestic poultry, posing a threat to the domestic ... Mashaal D, Mahmoud SH, Müller C, Abo Shama NM, Kam. Differential Impact of Specific Amino Acid Residues on the Characteristics of Avian Influenza Viruses in Mammalian Systems. Pathogens. 2022 Nov 19;11(11):1385. Abstract
submitted by kickingbird at Nov, 25, 2022 from Pathogens. 2022 Nov 19;11(11):1385 (via https://www.mdpi.com/2076-0817/11/11/1385)
Avian influenza virus (AIV) H9N2 was declared to be endemic in birds of the Middle East, in particular in Egypt, with multiple cases of human infections. Despite concerns about the pandemic threat posed ... Marchenko V, Mukhametdinova D, Amosova I, Lioznov. Influenza A(H1N1)pdm09 Virus Alters Expression of Endothelial Factors in Pulmonary Vascular Endothelium in Rats. Viruses. 2022 Nov 14;14(11):2518. Abstract
submitted by kickingbird at Nov, 25, 2022 from Viruses. 2022 Nov 14;14(11):2518 (via https://www.mdpi.com/1999-4915/14/11/2518)
Influenza virus infection may cause endothelial activation and dysfunction. However, it is still not known to what extent the influenza virus can dysregulate the expression of various endothelial proteins. ... Wang Y, Li X, Xu Q, Niu X, Zhang S, Qu X, Chu H, C. Characterization of Neutralizing Monoclonal Antibodies and Identification of a Novel Conserved C-Terminal Linear Epitope on the Hemagglutinin Protein of the H9N2 Avian Influenza Virus. Viruses. 2022 Nov 15;14(11):2530. Abstract
submitted by kickingbird at Nov, 25, 2022 from Viruses. 2022 Nov 15;14(11):2530 (via https://www.mdpi.com/1999-4915/14/11/2530)
The H9N2 avian influenza virus (AIV) remains a serious threat to the global poultry industry and public health. The hemagglutinin (HA) protein is an essential protective antigen of AIVs and a major target ... Liu T, Huang Y, Xie S, Xu L, Chen J, Qi W, Liao M,. A Characterization and an Evolutionary and a Pathogenicity Analysis of Reassortment H3N2 Avian Influenza Virus in South China in 2019-2020. Viruses. 2022 Nov 21;14(11):2574. Abstract
submitted by kickingbird at Nov, 25, 2022 from Viruses. 2022 Nov 21;14(11):2574 (via https://www.mdpi.com/1999-4915/14/11/2574)
Seasonal H3N2 influenza virus has always been a potential threat to public health. The reassortment of the human and avian H3N2 influenza viruses has resulted in major influenza outbreaks, which have seriously ... Niqueux é, Flodrops M, Allée C, Lebras MO, Pierre. Evaluation of three hemagglutinin-based vaccines for the experimental control of a panzootic clade 2.3.4.4b A(H5N8) high pathogenicity avian influenza virus in mule ducks. Vaccine. 2022 Nov 18:S0264-410X(22)01398-6. Abstract
submitted by kickingbird at Nov, 22, 2022 from Vaccine. 2022 Nov 18:S0264-410X(22)01398-6 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
In France during winter 2016-2017, 487 outbreaks of clade 2.3.4.4b H5N8 subtype high pathogenicity (HP) avian influenza A virus (AIV) infections were detected in poultry and captive birds. During this ... Horwood PF, Horm SV, Yann S, Tok S, Chan M, Suttie. Aerosol exposure of live bird market workers to viable influenza A/H5N1 and A/H9N2 viruses, Cambodia. Zoonoses Public Health. 2022 Nov 21. Abstract
submitted by kickingbird at Nov, 22, 2022 from Zoonoses Public Health. 2022 Nov 21 (via https://onlinelibrary.wiley.com/doi/10.1111/zph.13009)
Live bird markets (LBMs) have been identified as key factors in the spread, persistence and evolution of avian influenza viruses (AIVs). In addition, these settings have been associated with human infections ... Lai KK, Munro JB, Shi G, Majdoul S, Compton AA, Re. Restriction of Influenza A Virus by SERINC5. mBio. 2022 Nov 21:e0292322. Abstract
submitted by kickingbird at Nov, 22, 2022 from mBio. 2022 Nov 21:e0292322 (via https://journals.asm.org/doi/10.1128/mbio.02923-22)
Serine incorporator 5 (Ser5), a transmembrane protein, has recently been identified as a host antiviral factor against human immunodeficiency virus (HIV)-1 and gammaretroviruses like murine leukemia viruses ... 5168 items, 20/Page, Page[27/259][|<<] [|<] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [>|] [>>|] |
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