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2025-12-18 6:16:40
Article

Coggon A, Lopes S, Simon G, Arendsee Z, Chen K-F,. Quantifying the zoonotic risk profile of European influenza A viruses in swine from 2010 to 2020 inclusive. J Virol. 2025 Jun 4:e0030625.  Abstract  
submitted by kickingbird at Jun, 5, 2025 from J Virol. 2025 Jun 4:e0030625 (via https://journals.asm.org/doi/10.1128/jvi.00306-25)
H1 and H3 influenza A viruses (IAVs) circulating in European pigs are markedly distinct from those circulating in other global swine populations. These viruses exhibit significant genetic diversity, further ...

Singh G, Kafle S, Assato P, Goraya M, Morozov I, R. Single-Cell Analysis of Host Responses in Bovine Milk Somatic Cells (bMSCs) Following HPAIV Bovine H5N1 Influenza Exposure. Viruses. 2025; 17(6):811.  Abstract  
submitted by kickingbird at Jun, 5, 2025 from Viruses. 2025; 17(6):811 (via https://www.mdpi.com/1999-4915/17/6/811)
The 2024 outbreak of highly pathogenic avian influenza virus (HPAIV) H5N1 in U.S. dairy cattle presented an unprecedented scenario where the virus infected bovine mammary glands and was detected in milk, ...

Li Y, Quan X, Chen R, Wang X, Chen Y, Gan Y, Irwin. Adaptive selection of quasispecies during in vivo passaging in chickens, mice, and ferrets results in host-specific strains for the H9N2 avian influenza virus. J Virol 0:e00151-25.  Abstract  
submitted by kickingbird at Jun, 5, 2025 from J Virol 0:e00151-25 (via https://journals.asm.org/doi/10.1128/jvi.00151-25)
Sporadic human infections of avian influenza virus (AIV) raise significant public health concerns. A critical factor limiting the transmission of AIVs is the shift in receptor-binding preference from Siaα2,3 ...

Bingkuan Zhu, etc.,al. [preprint]The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues. https://doi.org/10.1101/2025.06.02.657404.  Abstract  
submitted by kickingbird at Jun, 5, 2025 from https://doi.org/10.1101/2025.06.02.657404 (via https://www.biorxiv.org/content/10.1101/2025.06.02.657404v1)
The global spread of the A/goose/Guangdong/1/96-lineage H5N1 highly pathogenic avian influenza (HPAI) viruses is accompanied by an expanded host range and the establishment of sustained viral transmission ...

Robinson-McCarthy LR, Zirckel KE, Simmons HC, Le S. A replicating recombinant vesicular stomatitis virus model for dairy cattle H5N1 influenza virus glycoprotein evolution. J Virol 0:e00389-25.  Abstract  
submitted by kickingbird at Jun, 5, 2025 from J Virol 0:e00389-25 (via https://journals.asm.org/doi/10.1128/jvi.00389-25)
A panzootic of highly pathogenic avian influenza (HPAI) H5N1 viruses from clade 2.3.4.4b has triggered a multistate outbreak in US dairy cattle and an unknown number of human infections. HPAI viruses are ...

Seibert B, Caceres CJ, Gay LC, Shetty N, Faccin FC. Air-liquid interface model for influenza aerosol exposure in vitro. J Virol. 2025 Jun 3:e0061925.  Abstract  
submitted by kickingbird at Jun, 4, 2025 from J Virol. 2025 Jun 3:e0061925 (via https://journals.asm.org/doi/10.1128/jvi.00619-25)
Airborne transmission is an essential mode of infection and spread of influenza viruses among humans. However, most studies use liquid inoculum for virus infection. To better replicate natural airborne ...

Schlachter AD, Furman N, Byrne AMP, Reid SM, Smith. High pathogenicity avian influenza H5N1 clade 2.3.4.4b natural infection in captive Humboldt penguins (Spheniscus humboldti). Avian Pathol. 2025 Jun 3:1-21.  Abstract  
submitted by kickingbird at Jun, 4, 2025 from Avian Pathol. 2025 Jun 3:1-21 (via https://www.tandfonline.com/doi/full/10.1080/03079457.2025.2)
Between 2020 and 2023, high pathogenicity avian influenza virus (HPAIV) H5Nx clade 2.3.4.4b caused devastating outbreaks across Europe and the United Kingdom among domestic poultry and wild bird populations. ...

Yang, J., Li, J., Sun, J. et al. Genetic diversity of H9N2 avian influenza viruses in poultry across China and implications for zoonotic transmission. Nat Microbiol (2025).  Abstract  
submitted by kickingbird at Jun, 3, 2025 from Nat Microbiol (2025) (via https://link.springer.com/article/10.1038/s41564-025-02002-x)
Nationwide surveillance of avian influenza viruses (AIVs) in live poultry markets across China has occurred since 2014, providing a resource for AIV prevalence and genetic diversity studies. Here we report ...

Mendoza LM, Anderson EM, Leonard AS, McFarland AG,. Antigenic Characterization of H1N1 Influenza Viruses That Circulated During the 2019-2020 Season in Philadelphia, Pennsylvania. Influenza Other Respir Viruses. 2025 Jun;19(6):e70.  Abstract  
submitted by kickingbird at Jun, 3, 2025 from Influenza Other Respir Viruses. 2025 Jun;19(6):e70 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70104)
Background: Multiple clades of H1N1 influenza A viruses (IAVs) circulated during the 2019-2020 season. Here, we completed serological assays to determine the specificities of serum antibodies from humans ...

Dharmayanti NLPI, Nurjanah D, Indriani R, Suyatno. Genomic surveillance of influenza A virus in live bird markets during the COVID-19 pandemic. Vet World. 2025 Apr;18(4):955-968.  Abstract  
submitted by kickingbird at Jun, 3, 2025 from Vet World. 2025 Apr;18(4):955-968 (via https://veterinaryworld.org/Vol.18/April-2025/20.php)
Background and aim: Despite the global focus on coronavirus disease 2019 (COVID-19), the avian influenza virus (AIV) continues to circulate in Indonesia, particularly in traditional live bird markets (LBMs), ...

Nacken, W., Mayr, J., Schreiber, A. et al. Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription. npj Viruses 3, 46 (2025).  Abstract  
submitted by kickingbird at Jun, 2, 2025 from npj Viruses 3, 46 (2025) (via https://www.nature.com/articles/s44298-025-00124-x)
IAV-NS1 proteins that interact with Cleavage and polyadenylation specific factor 30 are known to inhibit host gene expression. Here we report that in both transfection and infection experiments, a strong ...

Lu, X., Zhao, S., Liu, A. et al. Nonlinear Enhanced Prediction of Influenza-Like Illness Using Seasonal-Trend Decomposition and Temporal Dependency. SIViP 19, 681 (2025).  Abstract  
submitted by kickingbird at Jun, 2, 2025 from SIViP 19, 681 (2025) (via https://link.springer.com/article/10.1007/s11760-025-04280-8)
Influenza-like illness (ILI) is a common respiratory infectious disease that puts significant strain on medical resources and leads to numerous fatalities worldwide. Accurate prediction of ILI incidence ...

Norikazu Isoda, etc.,al. Dynamics of high pathogenicity avian influenza virus infection with multiple introductions in a crow flock in an urban park in Hokkaido, Japan. Comparative Immunology, Microbiology and Infectiou.  Abstract  
submitted by kickingbird at Jun, 2, 2025 from Comparative Immunology, Microbiology and Infectiou (via https://www.sciencedirect.com/science/article/abs/pii/S01479)
Since 2021, high pathogenicity avian influenza viruses (HPAIVs) of the H5N1 clade 2.3.4.4b has been circulating globally, not only in domestic poultry but also in wild birds, both migratory and resident ...

Viviani L, Vecchio R, Pariani E, Sandri L, Binda S. Wastewater-based epidemiology of influenza viruses: a systematic review. Sci Total Environ. 2025 May 30;986:179706.  Abstract  
submitted by kickingbird at Jun, 1, 2025 from Sci Total Environ. 2025 May 30;986:179706 (via https://www.sciencedirect.com/science/article/pii/S004896972)
Introduction: Wastewater-based epidemiology (WBE) has emerged as a valuable public health tool for monitoring the circulation of many pathogens, including influenza viruses (IVs). The general aim of this ...

Lombard J, Stenkamp-Strahm C, McCluskey B, Melody. Evidence of Viremia in Dairy Cows Naturally Infected with Influenza A Virus, California, USA. Emerg Infect Dis. 2025 Jul.  Abstract  
submitted by kickingbird at May, 31, 2025 from Emerg Infect Dis. 2025 Jul (via https://wwwnc.cdc.gov/eid/article/31/7/25-0134_article)
We confirmed influenza A virus (IAV) by PCR in serum from 18 cows on 3 affected dairy farms in California, USA. Our findings indicate the presence of viremia and might help explain IAV transmission dynamics ...

Qiong Zhang, etc.,al. [preprint]Preclinical Evaluation of an mRNA Vaccine Developed from the First Human Isolate of Bovine H5N1. https://doi.org/10.21203/rs.3.rs-6758243/v1.  Abstract  
submitted by kickingbird at May, 31, 2025 from https://doi.org/10.21203/rs.3.rs-6758243/v1 (via https://www.researchsquare.com/article/rs-6758243/v1)
Given the ongoing global health threat posed by the zoonotic emergence of H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI), there is an urgent need for the rapid development of effective vaccines. ...

Hassan M, Kaifer B, Christian T, Quaas XT, Mueller. First contact: an interdisciplinary guide into decoding H5N1 influenza virus interactions with glycosaminoglycans in 3D respiratory cell models. Front Cell Infect Microbiol. 2025 May 15;15:159695.  Abstract  
submitted by kickingbird at May, 30, 2025 from Front Cell Infect Microbiol. 2025 May 15;15:159695 (via https://www.frontiersin.org/journals/cellular-and-infection-)
The human respiratory system is vulnerable to viral infections. The influenza virus family alone accounts for one billion reported cases annually, some of which are severe and can be fatal. Among these, ...

Nabeshima, K., Asakura, S., Sakoda, Y. et al. Novel host factors associated with resistance to highly pathogenic avian influenza in wild birds inferred from primary cell culture. Sci Rep 15, 18809 (2025).  Abstract  
submitted by kickingbird at May, 30, 2025 from Sci Rep 15, 18809 (2025) (via https://www.nature.com/articles/s41598-025-01316-4)
Bird species differ in the sensitivity to the highly pathogenic avian influenza virus (HPAIV). Here, we infected fibroblasts from 11 bird species with the H5N1 HPAIV strain A/chicken/Yamaguchi/7/2004. ...

Cao L, Wang T, Ren P, Cheng C, Mao H, Hui X, Lin X. Viral polymerase-host interaction analysis reveals that the association between avian NUP93 and PB1 promotes H5N6 avian influenza virus replication. Microbiol Spectr 0:e03120-24.  Abstract  
submitted by kickingbird at May, 30, 2025 from Microbiol Spectr 0:e03120-24 (via https://journals.asm.org/doi/10.1128/spectrum.03120-24)
The H5N6 avian influenza virus, a highly pathogenic strain, poses a significant threat to poultry production and public health. The RNA-dependent RNA polymerase (comprising PB1, PB2, and PA proteins) and ...

Cong He, etc.,al. A G219A hemagglutinin substitution increases pathogenicity and viral replication of Eurasian avian-like H1N1 swine influenza viruses. Veterinary Microbiology.  Abstract  
submitted by kickingbird at May, 30, 2025 from Veterinary Microbiology (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
The Eurasian avian-like swine (EA) H1N1 virus has been widely prevalent in the Chinese swine population and has caused infections in human. However, knowledge regarding its pathogenic mechanisms remains ...

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