Bu H, Zhang S, Li P, Liu Z, Liu Y, Li Z, Liu X, Wa. Secreted phospholipase PLA2G2E contributes to regulation of T cell immune response against influenza virus infection. J Virol. 2024 Apr 9:e0019824. Abstract submitted by kickingbird at Apr, 10, 2024 from J Virol. 2024 Apr 9:e0019824 (via https://journals.asm.org/doi/10.1128/jvi.00198-24) The involvement of secreted phospholipase A2s in respiratory diseases, such as asthma and respiratory viral infections, is well-established. However, the specific role of secreted phospholipase A2 group ... Kutkat O, Gomaa M, Aboulhoda BE, Moatasim Y, El Ta. Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt. Arch Virol. 2024 Apr 9;169(5):95. Abstract submitted by kickingbird at Apr, 10, 2024 from Arch Virol. 2024 Apr 9;169(5):95 (via https://link.springer.com/article/10.1007/s00705-024-06022-6) The first detection of a human infection with avian influenza A/H6N1 virus in Taiwan in 2013 has raised concerns about this virus. During our routine surveillance of avian influenza viruses (AIVs) in live-bird ... Alice Fusaro, Bianca Zecchin, Edoardo Giussani, El. High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe – why trends of virus evolution are more difficult to predict. Virus Evolution, 2024;, veae027. Abstract submitted by kickingbird at Apr, 10, 2024 from Virus Evolution, 2024;, veae027 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v) Since 2016, A(H5Nx) high pathogenic avian influenza (HPAI) virus of clade 2.3.4.4b has become one of the most serious global threats not only to wild and domestic birds, but also to public health. In recent ... Koch B, Shehata M, Müller-Ruttloff C, Gouda SA, We. Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients. Front Cell Infect Microbiol. 2024 Mar 25;14:136340. Abstract submitted by kickingbird at Apr, 9, 2024 from Front Cell Infect Microbiol. 2024 Mar 25;14:136340 (via https://www.frontiersin.org/articles/10.3389/fcimb.2024.1363) Introduction: Influenza A virus (IAV) infection can cause the often-lethal acute respiratory distress syndrome (ARDS) of the lung. Concomitantly, acute kidney injury (AKI) is frequently noticed during ... Xiuqin Huang, Weiye Li, Xuewei Cao, Qi Zhang, Yizh. Generation and characterization of a nanobody against the avian influenza virus H7 subtype. International Journal of Biological Macromolecules. Abstract submitted by kickingbird at Apr, 9, 2024 from International Journal of Biological Macromolecules (via https://www.sciencedirect.com/science/article/abs/pii/S01418) Avian influenza virus (AIV) H7N9 diseases have been recently reported, raising concerns about a potential pandemic. Thus, there is an urgent need for effective therapeutics for AIV H7N9 infections. Herein, ... Si YJ, Jang SG, Kim YI, Casel MAB, Kim DJ, Ji HY,. Evolutional dynamics of highly pathogenic avian influenza H5N8 genotypes in wintering bird habitats: Insights from South Korea´s 2020-2021 season. One Health. 2024 Mar 30;18:100719. Abstract submitted by kickingbird at Apr, 9, 2024 from One Health. 2024 Mar 30;18:100719 (via https://www.sciencedirect.com/science/article/pii/S235277142) The winter of 2020-2021 in South Korea witnessed severe outbreaks of Highly Pathogenic Avian Influenza (HPAI) viruses, specifically multiple genotypes of the H5N8 subtype. These outbreaks prompted an extensive ... Unione L, Ammerlaan ANA, Bosman GP, Uslu E, Liang. Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling. Nat Commun. 2024 Apr 6;15(1):2979. Abstract submitted by kickingbird at Apr, 7, 2024 from Nat Commun. 2024 Apr 6;15(1):2979 (via https://www.nature.com/articles/s41467-024-47344-y) Prototypic receptors for human influenza viruses are N-glycans carrying α2,6-linked sialosides. Due to immune pressure, A/H3N2 influenza viruses have emerged with altered receptor specificities that bind ... Du Y, Xia J, Wang Z, Xu J, Ji Y, Jin Y, Pu L, Xu S. Evolution of H6N6 viruses in China between 2014 and 2019 involves multiple reassortment events. Emerg Microbes Infect. 2024 Apr 6:2341142. Abstract submitted by kickingbird at Apr, 7, 2024 from Emerg Microbes Infect. 2024 Apr 6:2341142 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2) H6N6 avian influenza viruses (AIVs) have been widely detected in wild birds, poultry, and even mammals. Recently, H6N6 viruses were reported to be involved in the generation of H5 and H7 subtype viruses. ... Nadeau S, Devaux AJ, Bagutti C, Alt M, Ilg Hampe E. Influenza transmission dynamics quantified from RNA in wastewater in Switzerland. Swiss Med Wkly. 2024 Jan 3;154:3503. Abstract submitted by kickingbird at Apr, 6, 2024 from Swiss Med Wkly. 2024 Jan 3;154:3503 (via https://smw.ch/index.php/smw/article/view/3503) Introduction: Influenza infections are challenging to monitor at the population level due to many mild and asymptomatic cases and similar symptoms to other common circulating respiratory diseases, including ... Bordes, L.; Gonzales, J.L.; Vreman, S.; Venema, S.. In Ovo Models to Predict Virulence of Highly Pathogenic Avian Influenza H5-Viruses for Chickens and Ducks. Viruses 2024, 16, 563. Abstract submitted by kickingbird at Apr, 5, 2024 from Viruses 2024, 16, 563 (via https://www.mdpi.com/1999-4915/16/4/563) Highly pathogenic avian influenza (HPAI) H5-viruses are circulating in wild birds and are repeatedly introduced to poultry causing outbreaks in the Netherlands since 2014. The largest epizootic ever recorded ... Chokkakula S, Oh S, Choi WS, Kim CI, Jeong JH, Kim. Mammalian Adaptation Risk in HPAI H5N8: A Comprehensive Model Bridging Experimental Data with Mathematical Insights. Emerg Microbes Infect. 2024 Apr 4:2339949. Abstract submitted by kickingbird at Apr, 5, 2024 from Emerg Microbes Infect. 2024 Apr 4:2339949 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2) Understanding the mammalian pathogenesis and interspecies transmission of HPAI H5N8 virus hinges on mapping its adaptive markers. We used deep sequencing to track these markers over five passages in murine ... Li T, Spruit CM, Wei N, Liu L, Wolfert MA, de Vrie. Chemoenzymatic Synthesis of Tri-antennary N-glycans Terminating in Sialyl-Lewisx Reveals the Importance of Glycan Complexity for Influenza A Virus Receptor Binding. Chemistry. 2024 Apr 3:e202401108. Abstract submitted by kickingbird at Apr, 4, 2024 from Chemistry. 2024 Apr 3:e202401108 (via https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002) Sialyl-Lewisx (SLex) is involved in immune regulation, human fertilization, cancer, and bacterial and viral diseases. The influence of the complex glycan structures, which can present SLex epitopes, on ... Silva F, Boal-Carvalho I, Williams N, Chabert M, N. Identification of a short sequence motif in the influenza A virus pathogenicity factor PB1-F2 required for inhibition of human NLRP3. J Virol. 2024 Apr 3:e0041124. Abstract submitted by kickingbird at Apr, 4, 2024 from J Virol. 2024 Apr 3:e0041124 (via https://journals.asm.org/doi/10.1128/jvi.00411-24) Influenza A virus infection activates the NLRP3 inflammasome, a multiprotein signaling complex responsible for the proteolytic activation and release of the proinflammatory cytokine IL-1β from monocytes ... Driskell EA, Jones CA, Berghaus RD, Stallknecht DE. Domestic cats are susceptible to infection with low pathogenic avian influenza viruses from shorebirds. Vet Pathol. 2013 Jan;50(1):39-45. Abstract submitted by kickingbird at Apr, 3, 2024 from Vet Pathol. 2013 Jan;50(1):39-45 (via https://journals.sagepub.com/doi/10.1177/0300985812452578) Domestic cats are susceptible to infection with highly pathogenic avian influenza virus H5N1, resulting in pneumonia and in some cases, systemic spread with lesions in multiple organ systems. Recent transmission ... van Riel D, Leijten LM, Kochs G, Osterhaus ADME, K. Decrease of virus receptors during highly pathogenic H5N1 virus infection in humans and other mammals. Am J Pathol. 2013 Nov;183(5):1382-1389. Abstract submitted by kickingbird at Apr, 3, 2024 from Am J Pathol. 2013 Nov;183(5):1382-1389 (via https://ajp.amjpathol.org/article/S0002-9440(13)00521-X/full) Highly pathogenic avian influenza H5N1 virus causes a severe, often fatal, pneumonia in humans. The tropism and pathogenesis of highly pathogenic avian influenza H5N1 virus can partly be explained by the ... Reperant LA, van de Bildt MW, van Amerongen G, Lei. Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats. J Virol. 2012 Jan;86(2):1158-65. Abstract submitted by kickingbird at Apr, 3, 2024 from J Virol. 2012 Jan;86(2):1158-65 (via https://journals.asm.org/doi/10.1128/jvi.06375-11) Highly pathogenic avian influenza virus (HPAIV) H5N1 can infect mammals via the intestine; this is unusual since influenza viruses typically infect mammals via the respiratory tract. The dissemination ... Vahlenkamp TW, Teifke JP, Harder TC, Beer M, Mette. Systemic influenza virus H5N1 infection in cats after gastrointestinal exposure. Influenza Other Respir Viruses. 2010 Nov;4(6):379-. Abstract submitted by kickingbird at Apr, 3, 2024 from Influenza Other Respir Viruses. 2010 Nov;4(6):379- (via https://onlinelibrary.wiley.com/doi/10.1111/j.1750-2659.2010) Background: Highly pathogenic avian influenza virus (HPAIV) H5N1 infections in felids have been reported in several countries. Feeding on infected birds has been suggested as potential source of infection.Objectives: ... van Riel D, Rimmelzwaan GF, van Amerongen G, Oster. Highly pathogenic avian influenza virus H7N7 isolated from a fatal human case causes respiratory disease in cats but does not spread systemically. Am J Pathol. 2010 Nov;177(5):2185-90. Abstract submitted by kickingbird at Apr, 3, 2024 from Am J Pathol. 2010 Nov;177(5):2185-90 (via https://ajp.amjpathol.org/article/S0002-9440(10)60272-6/full) Highly pathogenic avian influenza viruses (HPAIV) of the H5 and H7 subtypes primarily infect poultry but are occasionally transmitted to humans and other mammalian species, often causing severe disease. ... Marschall J, Schulz B, Harder Priv-Doz TC, Vahlenk. Prevalence of influenza A H5N1 virus in cats from areas with occurrence of highly pathogenic avian influenza in birds. J Feline Med Surg. 2008 Aug;10(4):355-8. Abstract submitted by kickingbird at Apr, 3, 2024 from J Feline Med Surg. 2008 Aug;10(4):355-8 (via https://journals.sagepub.com/doi/10.1016/j.jfms.2008.03.007) Natural and experimental infections have shown that cats are susceptible to highly pathogenic avian influenza A virus subtype H5N1 (HPAIV H5N1). Cats can be severely affected and die from the disease, ... Keown J, Baazaoui A, ?ebesta M, ?tefl R, Carrique. Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II. J Virol. 2024 Apr 2:e0013824. Abstract submitted by kickingbird at Apr, 3, 2024 from J Virol. 2024 Apr 2:e0013824 (via https://journals.asm.org/doi/10.1128/jvi.00138-24) Influenza A viruses, causing seasonal epidemics and occasional pandemics, rely on interactions with host proteins for their RNA genome transcription and replication. 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