Horman WSJ, Nguyen THO, Kedzierska K, Butler J, Sh. The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection. Front Immunol. 2020 Sep 24;11:559113. Abstract
submitted by kickingbird at 9 days ago from Front Immunol. 2020 Sep 24;11:559113 (via https://www.frontiersin.org/articles/10.3389/fimmu.2020.5591)
As the recent outbreak of SARS-CoV-2 has highlighted, the threat of a pandemic event from zoonotic viruses, such as the deadly influenza A/H7N9 virus subtype, continues to be a major global health concern. ...
Yang J, Huang X, Liu Y, Zhao D, Han K, Zhang L, Li. Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection. Vet Res. 2020 Oct 17;51(1):132. Abstract
submitted by kickingbird at 9 days ago from Vet Res. 2020 Oct 17;51(1):132 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 ...
Hu J, Kong M, Cui Z, Gao Z, Ma C, Hu Z, Jiao X, Li. PA-X protein of H5N1 avian influenza virus inhibits NF-kappaB activity, a potential mechanism for PA-X counteracting the host innate immune responses. Vet Microbiol. 2020 Sep 18;250:108838. Abstract
submitted by kickingbird at 15 days ago from Vet Microbiol. 2020 Sep 18;250:108838 (via https://www.sciencedirect.com/science/article/pii/S037811352)
PA-X is a fusion protein of influenza virus which plays a crucial role in modulating influenza virus-induced host innate immune response and subsequent pathogenicity. However, the potential mechanism of ...
Sitaras I, Spackman E, de Jong MCM, Parris DJ. Selection and Antigenic Characterization of Immune-Escape Mutants of H7N2 Low Pathogenic Avian Influenza Virus Using Homologous Polyclonal Sera. Virus Res. 2020 Oct 9:198188. Abstract
submitted by kickingbird at 15 days ago from Virus Res. 2020 Oct 9:198188 (via https://www.sciencedirect.com/science/article/pii/S016817022)
Understanding the dynamics of the selection of influenza A immune escape variants by serum antibody is critical for designing effective vaccination programs for animals, especially poultry where large ...
Heindel DW, Koppolu S, Zhang Y, Kasper B, Meche L,. Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity. Proc Natl Acad Sci U S A. 2020 Oct 12:202008203. Abstract
submitted by kickingbird at 15 days ago from Proc Natl Acad Sci U S A. 2020 Oct 12:202008203 (via https://www.pnas.org/content/early/2020/10/09/2008203117)
Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5 million cases of severe illness and ～290,000 to 645,000 deaths annually worldwide. The molecular mechanisms underlying ...
Liu Z, Guo Y, Zhao L, Liu Q, Tian M, Huang N, Fan. Analysis of the circRNAs expression profile in mouse lung with H7N9 influenza A virus infection. Genomics. 2020 Oct 10:S0888-7543(20)31961-3. Abstract
submitted by kickingbird at 15 days ago from Genomics. 2020 Oct 10:S0888-7543(20)31961-3 (via https://www.sciencedirect.com/science/article/pii/S088875432)
Influenza A virus is a single-stranded RNA virus that can cause great mortality and economic loss worldwide. Circular RNAs (circRNAs) are non-coding RNAs that have been shown to have important functions ...
Zhang Z, Zhang H, Xu L, Guo X, Wang W, Ji Y, Lin C. Selective usage of ANP32 proteins by influenza B virus polymerase: Implications in determination of host range. PLoS Pathog. 2020 Oct 12;16(10):e1008989. Abstract
submitted by kickingbird at Oct, 13, 2020 from PLoS Pathog. 2020 Oct 12;16(10):e1008989 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The influenza B virus (IBV) causes seasonal influenza and has accounted for an increasing proportion of influenza outbreaks. IBV mainly causes human infections and has not been found to spread in poultry. ...
Zykova AA, Blokhina EA, Kotlyarov RY, Stepanova LA. Highly Immunogenic Nanoparticles Based on a Fusion Protein Comprising the M2e of Influenza A Virus and a Lipopeptide. Viruses. 2020 Oct 6;12(10):E1133. Abstract
submitted by kickingbird at Oct, 12, 2020 from Viruses. 2020 Oct 6;12(10):E1133 (via https://www.mdpi.com/1999-4915/12/10/1133)
The highly conserved extracellular domain of the transmembrane protein M2 (M2e) of the influenza A virus is a promising target for the development of broad-spectrum vaccines. However, M2e is a poor immunogen ...
Guilfoyle K, Major D, Skeldon S, James H, Tingsted. Protective efficacy of a polyvalent influenza A DNA vaccine against both homologous (H1N1pdm09) and heterologous (H5N1) challenge in the ferret model. Vaccine. 2020 Oct 6:S0264-410X(20)31233-0. Abstract
submitted by kickingbird at Oct, 12, 2020 from Vaccine. 2020 Oct 6:S0264-410X(20)31233-0 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
This study describes the protective efficacy of a novel influenza plasmid DNA vaccine in the ferret challenge model. The rationally designed polyvalent influenza DNA vaccine encodes haemagglutinin and ...
Brehony C, Dunford L, Bennett C, O´Donnell J. Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season. J Clin Virol. 2020 Oct 1;132:104653. Abstract
submitted by kickingbird at Oct, 12, 2020 from J Clin Virol. 2020 Oct 1;132:104653 (via https://www.sciencedirect.com/science/article/pii/S138665322)
Neuraminidase inhibitor (NAI) resistance levels globally are currently low. However, as antivirals are increasingly being used, and even in the absence of selective pressure, resistance may increase or ...
Arai Y, Kawashita N, Elgendy EM, Ibrahim MS, Daido. PA mutations inherited during viral evolution act cooperatively to increase replication of contemporary H5N1 influenza virus with an expanded host range. J Virol. 2020 Oct 7:JVI.01582-20. Abstract
submitted by kickingbird at Oct, 11, 2020 from J Virol. 2020 Oct 7:JVI.01582-20 (via https://jvi.asm.org/content/early/2020/10/02/JVI.01582-20)
Adaptive mutations and/or reassortments in avian influenza virus polymerase subunits PA, PB1 and PB2 are one of the major factors enabling the virus to overcome the species barrier to infect humans. The ...
Wei Y, Zeng Y, Zhang X, Xu S, Wang Z, Du Y, Zhang. The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. J Virol. 2020 Oct 7:JVI.01640-20. Abstract
submitted by kickingbird at Oct, 11, 2020 from J Virol. 2020 Oct 7:JVI.01640-20 (via https://jvi.asm.org/content/early/2020/10/02/JVI.01640-20)
H7N9 influenza A virus (IAV) is an emerged contagious pathogen that may cause severe human infections, even death. Understanding the precise cross-talk between virus and host is vital for the development ...
Laleye AT, Abolnik C. Emergence of highly pathogenic H5N2 and H7N1 influenza A viruses from low pathogenic precursors by serial passage in ovo. PLoS One. 2020 Oct 8;15(10):e0240290. Abstract
submitted by kickingbird at Oct, 11, 2020 from PLoS One. 2020 Oct 8;15(10):e0240290 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Highly pathogenic (HPAI) strains emerge from their low pathogenic (LPAI) precursors and cause severe disease in poultry with enormous economic losses, and zoonotic potential. Understanding the mechanisms ...
Herfst S, Zhang J, Richard M, McBride R, Lexmond P. Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe. 2020 Oct 7;28(4):602-613.e7. Abstract
submitted by kickingbird at Oct, 11, 2020 from Cell Host Microbe. 2020 Oct 7;28(4):602-613.e7 (via https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(2)
In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission ...
Chu HY, Boeckh M, Englund JA, Famulare M, Lutz B,. The Seattle Flu Study: a multiarm community-based prospective study protocol for assessing influenza prevalence, transmission and genomic epidemiology. BMJ Open. 2020 Oct 7;10(10):e037295. Abstract
submitted by kickingbird at Oct, 11, 2020 from BMJ Open. 2020 Oct 7;10(10):e037295 (via https://bmjopen.bmj.com/content/10/10/e037295)
Introduction: Influenza epidemics and pandemics cause significant morbidity and mortality. An effective response to a potential pandemic requires the infrastructure to rapidly detect, characterise, and ...
Gulyaeva M, Huettmann F, Shestopalov A, Okamatsu M. Data mining and model-predicting a global disease reservoir for low-pathogenic Avian Influenza (A) in the wider pacific rim using big data sets. Sci Rep. 2020 Oct 8;10(1):16817. Abstract
submitted by kickingbird at Oct, 11, 2020 from Sci Rep. 2020 Oct 8;10(1):16817 (via https://www.nature.com/articles/s41598-020-73664-2)
Avian Influenza (AI) is a complex but still poorly understood disease; specifically when it comes to reservoirs, co-infections, connectedness and wider landscape perspectives. Low pathogenic (Low-path ...
Zhang C, Wang Y, Chen C, Long H, Bai J, Zeng J, Ca. A Mutation Network Method for Transmission Analysis of Human Influenza H3N2. Viruses. 2020 Oct 3;12(10):E1125. Abstract
submitted by kickingbird at Oct, 8, 2020 from Viruses. 2020 Oct 3;12(10):E1125 (via https://www.mdpi.com/1999-4915/12/10/1125)
Characterizing the spatial transmission pattern is critical for better surveillance and control of human influenza. Here, we propose a mutation network framework that utilizes network theory to study the ...
Jiang H, Peng W, Qi J, Chai Y, Song H, Bi Y, Rijal. Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. mBio. 2020 Oct 6;11(5):e02315-20. Abstract
submitted by kickingbird at Oct, 8, 2020 from mBio. 2020 Oct 6;11(5):e02315-20 (via https://mbio.asm.org/content/11/5/e02315-20)
Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins ...
Hu J, Zhang L, Liu X. Role of Post-translational Modifications in Influenza A Virus Life Cycle and Host Innate Immune Response. Front Microbiol. 2020 Sep 4;11:517461. Abstract
submitted by kickingbird at Oct, 6, 2020 from Front Microbiol. 2020 Sep 4;11:517461 (via https://www.frontiersin.org/articles/10.3389/fmicb.2020.5174)
Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system. During infection, influenza virus ...
Li Y, Chai W, Min J, Ye Z, Tong X, Qi D, Liu W, Lu. Neddylation of M1 negatively regulates the replication of influenza A virus. J Gen Virol. 2020 Oct 5. Abstract
submitted by kickingbird at Oct, 6, 2020 from J Gen Virol. 2020 Oct 5 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Post-translational modification plays a critical role in viral replication. Previously we reported that neddylation of PB2 of influenza A virus (IAV) can inhibit viral replication. However, we found that ...
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