Yang W, Schountz T, Ma W. Bat Influenza Viruses: Current Status and Perspective. Viruses. 2021 Mar 25;13(4):547. Abstract
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 25;13(4):547 (via https://www.mdpi.com/1999-4915/13/4/547)
Bats are natural reservoirs for many viruses, including several that are zoonotic. Two unusual H17N10 and H18N11 influenza viruses have been found in New World bats. Although neither of these viruses have ...
Ilyicheva T, Marchenko V, Pyankova O, Moiseeva A,. Antibodies to Highly Pathogenic A/H5Nx (Clade 22.214.171.124) Influenza Viruses in the Sera of Vietnamese Residents. Pathogens. 2021 Mar 25;10(4):394. Abstract
submitted by kickingbird at Apr, 4, 2021 from Pathogens. 2021 Mar 25;10(4):394 (via https://www.mdpi.com/2076-0817/10/4/394)
To cause a pandemic, an influenza virus has to overcome two main barriers. First, the virus has to be antigenically new to humans. Second, the virus has to be directly transmitted from humans to humans. ...
Nemanichvili N, Berends AJ, Wubbolts RW, Gr?ne A,. Tissue Microarrays to Visualize Influenza D Attachment to Host Receptors in the Respiratory Tract of Farm Animals. Viruses. 2021 Mar 31;13(4):586. Abstract
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 31;13(4):586 (via https://www.mdpi.com/1999-4915/13/4/586)
The trimeric hemagglutinin-esterase fusion protein (HEF) of influenza D virus (IDV) binds 9-O-acetylated sialic acid receptors, which are expressed in various host species. While cattle are the main reservoir ...
Zhou Y, Pu J, Wu Y. The Role of Lipid Metabolism in Influenza A Virus Infection. Pathogens. 2021 Mar 5;10(3):303. Abstract
submitted by kickingbird at Apr, 4, 2021 from Pathogens. 2021 Mar 5;10(3):303 (via https://www.mdpi.com/2076-0817/10/3/303)
Influenza A virus (IAV) is an important zoonotic pathogen that can cause disease in animals such as poultry and pigs, and it can cause infection and even death in humans, posing a serious threat to public ...
Ganti K, Bagga A, DaSilva J, Shepard SS, Barnes JR. Avian Influenza A Viruses Reassort and Diversify Differently in Mallards and Mammals. Viruses. 2021 Mar 19;13(3):509. Abstract
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 19;13(3):509 (via https://www.mdpi.com/1999-4915/13/3/509)
Reassortment among co-infecting influenza A viruses (IAVs) is an important source of viral diversity and can facilitate expansion into novel host species. Indeed, reassortment played a key role in the ...
Park BJ, Park MS, Lee JM, Song YJ. Specific Detection of Influenza A and B Viruses by CRISPR-Cas12a-Based Assay. Biosensors (Basel). 2021 Mar 19;11(3):88. Abstract
submitted by kickingbird at Apr, 4, 2021 from Biosensors (Basel). 2021 Mar 19;11(3):88 (via https://www.mdpi.com/2079-6374/11/3/88)
A rapid and accurate on-site diagnostic test for pathogens including influenza viruses is critical for preventing the spread of infectious diseases. Two types of influenza virus, A and B cause seasonal ...
Baek YG, Lee YN, Lee DH, Shin JI, Lee JH, Chung DH. Multiple Reassortants of H5N8 Clade 126.96.36.199b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020-2021. Viruses. 2021 Mar 16;13(3):490. Abstract
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 16;13(3):490 (via https://www.mdpi.com/1999-4915/13/3/490)
During October 2020-January 2021, we isolated a total of 67 highly pathogenic avian influenza (HPAI) H5N8 viruses from wild birds and outbreaks in poultry in South Korea. We sequenced the isolates and ...
McKellar J, Rebendenne A, Wencker M, Moncorgé O, G. Mammalian and Avian Host Cell Influenza A Restriction Factors. Viruses. 2021 Mar 22;13(3):522. Abstract
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 22;13(3):522 (via https://www.mdpi.com/1999-4915/13/3/522)
The threat of a new influenza pandemic is real. With past pandemics claiming millions of lives, finding new ways to combat this virus is essential. Host cells have developed a multi-modular system to detect ...
Michalak P, Piasecka J, Szutkowska B, Kierzek R, B. Conserved Structural Motifs of Two Distant IAV Subtypes in Genomic Segment 5 RNA. Viruses. 2021 Mar 22;13(3):525. Abstract
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 22;13(3):525 (via https://www.mdpi.com/1999-4915/13/3/525)
The functionality of RNA is fully dependent on its structure. For the influenza A virus (IAV), there are confirmed structural motifs mediating processes which are important for the viral replication cycle, ...
Mengual-Chuliá B, Alonso-Cordero A, Cano L, Del Ma. Surveillance of Influenza A resistance to polymerase complex inhibitors by whole genome analysis, 2016-17, 2017-18 and 2018-19 Seasons, Eastern Spain. Antimicrob Agents Chemother. 2021 Mar 29:AAC.02718. Abstract
submitted by kickingbird at Mar, 31, 2021 from Antimicrob Agents Chemother. 2021 Mar 29:AAC.02718 (via https://aac.asm.org/content/early/2021/03/23/AAC.02718-20)
Molecular surveillance by whole genome sequencing was used to monitor the susceptibility of circulating Influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions ...
Marriott AC, Gooch KE, Brown PJ, Ryan KA, Jones NJ. Severity of heterosubtypic influenza virus infection in ferrets is reduced by live attenuated influenza vaccine. NPJ Vaccines. 2021 Mar 29;6(1):43.. Abstract
submitted by kickingbird at Mar, 31, 2021 from NPJ Vaccines. 2021 Mar 29;6(1):43. (via https://www.nature.com/articles/s41541-021-00306-7)
Live attenuated influenza vaccine (LAIV) is widely used to protect humans from seasonal influenza infection, particularly in children. In contrast to inactivated vaccines, the LAIV can induce both mucosal ...
Tang YS, Xu S, Chen YW, Wang JH, Shaw PC. Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. Nucleic Acids Res. 2021 Mar 30:gkab203. Abstract
submitted by kickingbird at Mar, 31, 2021 from Nucleic Acids Res. 2021 Mar 30:gkab203 (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
The nucleoprotein (NP) of influenza virus is the core component of the ribonucleoprotein (RNP) and performs multiple structural and functional roles. Structures of the influenza A, B and D NP molecules ...
Xie XT, Yitbarek A, Astill J, Singh S, Khan SU, Sh. Within-host model of respiratory virus shedding and antibody response to H9N2 avian influenza virus vaccination and infection in chickens. Infect Dis Model. 2021 Mar 4;6:490-502. Abstract
submitted by kickingbird at Mar, 30, 2021 from Infect Dis Model. 2021 Mar 4;6:490-502 (via https://www.sciencedirect.com/science/article/pii/S246804272)
Avian influenza virus (AIV) H9N2 subtype is an infectious pathogen that can affect both the respiratory and gastrointestinal systems in chickens and continues to have an important economic impact on the ...
Heo GB, Kye SJ, Sagong M, Lee EK, Lee KN, Lee YN,. Genetic characterization of H9N2 avian influenza virus previously unrecognized in Korea. J Vet Sci. 2021 Mar;22(2):e21. Abstract
submitted by kickingbird at Mar, 29, 2021 from J Vet Sci. 2021 Mar;22(2):e21 (via https://vetsci.org/DOIx.php?id=10.4142/jvs.2021.22.e21)
In this study, we describe the isolation and characterization of previously unreported Y280-lineage H9N2 viruses from two live bird markets in Korea in June 2020. Genetic analysis revealed that they were ...
Wang X, Lin X, Zheng Z, Lu B, Wang J, Tan AH, Zhao. Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection. Nat Commun. 2021 Mar 26;12(1):1914. Abstract
submitted by kickingbird at Mar, 28, 2021 from Nat Commun. 2021 Mar 26;12(1):1914 (via https://www.nature.com/articles/s41467-021-22242-9)
Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate ...
Wu M, Su R, Gu Y, Yu Y, Li S, Sun H, Pan L, Cui X,. Molecular Characteristics, Antigenicity, Pathogenicity, and Zoonotic Potential of a H3N2 Canine Influenza Virus Currently Circulating in South China. Front Microbiol. 2021 Mar 9;12:628979.. Abstract
submitted by kickingbird at Mar, 28, 2021 from Front Microbiol. 2021 Mar 9;12:628979. (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.6289)
Canine influenza viruses (CIVs) could be a source of influenza viruses which infect humans because canine are important companion pets. To assess the potential risk of H3N2 CIVs currently circulating in ...
Krischuns T, Lukarska M, Naffakh N, Cusack S. Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus. Annu Rev Biochem. 2021 Mar 26. Abstract
submitted by kickingbird at Mar, 28, 2021 from Annu Rev Biochem. 2021 Mar 26 (via https://www.annualreviews.org/doi/10.1146/annurev-biochem-07)
Influenza virus RNA-dependent RNA polymerase (FluPol) transcribes the viral RNA genome in the infected cell nucleus. In the 1970s, researchers showed that viral transcription depends on host RNA polymerase ...
Slaine PD, Kleer M, Duguay BA, Pringle ES, Kadijk. Thiopurines activate an antiviral unfolded protein response that blocks influenza A virus glycoprotein accumulation. J Virol. 2021 Mar 24:JVI.00453-21. Abstract
submitted by kickingbird at Mar, 26, 2021 from J Virol. 2021 Mar 24:JVI.00453-21 (via https://jvi.asm.org/content/early/2021/03/18/JVI.00453-21)
Influenza A viruses (IAVs) utilize host shutoff mechanisms to limit antiviral gene expression and redirect translation machinery to the synthesis of viral proteins. Previously, we showed that IAV replication ...
Chen L, Zhu L, Chen J. Human Interferon Inducible Transmembrane Protein 3 (IFITM3) Inhibits Influenza Virus A Replication and Inflammation by Interacting with ABHD16A. Biomed Res Int. 2021 Mar 3;2021:6652147. Abstract
submitted by kickingbird at Mar, 26, 2021 from Biomed Res Int. 2021 Mar 3;2021:6652147 (via https://www.hindawi.com/journals/bmri/2021/6652147/)
Studies have shown that human interferon inducible transmembrane protein (hIFITMs) family proteins have broad-spectrum antiviral capabilities. Preliminary studies in our laboratory have tentatively proved ...
Fusade-Boyer M, Djegui F, Batawui K, Byuragaba DK,. Antigenic and Molecular Characterization of Low Pathogenic Avian Influenza A(H9N2) Viruses in Sub-Saharan Africa from 2017 through 2019. Emerg Microbes Infect. 2021 Mar 23:1-32. Abstract
submitted by kickingbird at Mar, 24, 2021 from Emerg Microbes Infect. 2021 Mar 23:1-32 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Sub-Saharan Africa was historically considered an animal influenza cold spot, with only sporadic highly pathogenic H5 outbreaks detected over the last 20 years. However, in 2017, low pathogenic avian influenza ...
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