Liao HY, Wang SC, Ko YA, et al. Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes. Proc Natl Acad Sci U S A. 2020;202004783. Abstract
submitted by kickingbird at Jul, 18, 2020 from Proc Natl Acad Sci U S A. 2020;202004783 (via https://pubmed.ncbi.nlm.nih.gov/32669430/)
Vaccination has been used to control the spread of seasonal flu; however, the virus continues to evolve and escape from host immune response through mutation and increasing glycosylation. Efforts have ...
Ge Z, Gu M, Cai T, et al. Phylogenetic tracing and biological characterization of a novel clade 126.96.36.199 reassortant of H5N6 subtype avian influenza virus in China. Transbound Emerg Dis. 2020;10.1111/tbed.13736. Abstract
submitted by kickingbird at Jul, 18, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13736 (via https://pubmed.ncbi.nlm.nih.gov/32677729/)
In recent years in China, clade 188.8.131.52 H5N6 plus clade 184.108.40.206 H5N1 subtype highly pathogenic avian influenza (HPAI) viruses have gradually become endemic in poultry, and their co-circulation could inevitably ...
Sha TW, Weber M, Kasumba DM, et al. Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner. Virol J. 2020;17(1):107. Abstract
submitted by kickingbird at Jul, 18, 2020 from Virol J. 2020;17(1):107 (via https://pubmed.ncbi.nlm.nih.gov/32677963/)
Background: The non-structural protein 1 (NS1) of influenza A virus (IAV) is a key player in inhibiting antiviral response in host cells, thereby facilitating its replication. However, other roles of NS1, ...
Sultankulova K, Orynbayev M, Kozhabergenov N, et a. Complete Coding Genome Sequence of an Avian Influenza A/H3N8 Virus Strain Detected in North Kazakhstan in 2018. Microbiol Resour Announc. 2020;9(29):e00441-20. Abstract
submitted by kickingbird at Jul, 18, 2020 from Microbiol Resour Announc. 2020;9(29):e00441-20 (via https://pubmed.ncbi.nlm.nih.gov/32675181/)
We report the complete coding genome sequence of the influenza A/H3N8 virus, isolated from Anas querquedula in northern Kazakhstan in 2018. Phylogenetic analysis of the surface antigens of strain A/garganey/North-Kazakhstan/45/2018 ...
Horwood PF, Fabrizio T, Horm SV, et al. Transmission experiments support clade-level differences in the transmission and pathogenicity of Cambodian influenza A/H5N1 viruses. Emerg Microbes Infect. 2020;1-36. Abstract
submitted by kickingbird at Jul, 16, 2020 from Emerg Microbes Infect. 2020;1-36 (via https://pubmed.ncbi.nlm.nih.gov/32666894/)
Influenza A/H5N1 has circulated in Asia since 2003 and is now enzootic in many countries in that region. In Cambodia, the virus has circulated since 2004 and has intermittently infected humans. During ...
Tricoche AD, Wagner AL, Balmaseda A, et al. Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections. J Infect Dis. 2020;jiaa426. Abstract
submitted by kickingbird at Jul, 16, 2020 from J Infect Dis. 2020;jiaa426 (via https://pubmed.ncbi.nlm.nih.gov/32668454/)
Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses. This study examines the relationship between influenza symptoms and serological response. Influenza-positive ...
Wang M, Huang Y, Gu W, Wang H. Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice. J Vis Exp. 2020;(160):10.3791/60523. Abstract
submitted by kickingbird at Jul, 15, 2020 from J Vis Exp. 2020;(160):10.3791/60523 (via https://pubmed.ncbi.nlm.nih.gov/32658200/)
T Follicular Helper (Tfh) cells are an independent CD4+ T cell subset specialized in providing help for germinal center (GC) development and generation of high-affinity antibodies. In influenza virus infection, ...
Nguyen-Van-Tam JS, Killingley B, Enstone J, et al. Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment. PLoS Pathog. 2020;16(7):e1008704. Abstract
submitted by kickingbird at Jul, 14, 2020 from PLoS Pathog. 2020;16(7):e1008704 (via https://pubmed.ncbi.nlm.nih.gov/32658939/)
Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising ...
Yang F, Xiao Y, Liu F, Yao H, Wu N, Wu H. Development of a Monoclonal Antibody-Based Antigen Capture Enzyme-Linked Immunosorbent Assay for Detection of H7N9 Subtype Avian Influenza Virus. J Med Virol. 2020;10.1002/jmv.26292. Abstract
submitted by kickingbird at Jul, 12, 2020 from J Med Virol. 2020;10.1002/jmv.26292 (via https://pubmed.ncbi.nlm.nih.gov/32648948/)
In order to establish a rapid detection method for H7N9 avian influenza virus (AIV), monoclonal antibodies (mAbs) against hemagglutinin (HA) of H7N9 were developed to establish an antigen capture enzyme-linked ...
Guk K, Kim H, Lee M, et al.. Development of A4 Antibody for Detection of Neuraminidase I223R/H275Y-associated Antiviral Multidrug-Resistant Influenza Virus. Nat Commun. 2020;11(1):3418. Published 2020 Jul 9.. Abstract
submitted by kickingbird at Jul, 12, 2020 from Nat Commun. 2020;11(1):3418. Published 2020 Jul 9. (via https://pubmed.ncbi.nlm.nih.gov/32647286/)
The emergence and spread of antiviral drug-resistant viruses have been a worldwide challenge and a great concern for patient care. We report A4 antibody specifically recognizing and binding to the mutant ...
Cheng C, Li J, Liu W, Xu L, Zhang Z. Modelling Analysis Revealed the Distinct Global Transmission Patterns of Influenza A Viruses and Their Influencing Factors. Integr Zool. 2020;10.1111/1749-4877.12469. Abstract
submitted by kickingbird at Jul, 11, 2020 from Integr Zool. 2020;10.1111/1749-4877.12469 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/1749-4877.12)
Influenza A virus has caused huge damage to human health and poultry production worldwide, but its global transmission patterns and influencing factors remains unclear. Here, by using the Nearest Genetic ...
Li L, Wu H, Li Q, et al. SOCS3-deficient Lung Epithelial Cells Uptaking Neutrophil-Derived SOCS3 Worsens Lung Influenza Infection. Mol Immunol. 2020;125:51-62. Abstract
submitted by kickingbird at Jul, 10, 2020 from Mol Immunol. 2020;125:51-62 (via https://pubmed.ncbi.nlm.nih.gov/32645550/)
Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether ...
Maier HE, Kuan G, Gresh L, et al. Obesity Is Associated With Increased Susceptibility to Influenza A (H1N1pdm) but Not H3N2 Infection. Clin Infect Dis. 2020;ciaa928. Abstract
submitted by kickingbird at Jul, 10, 2020 from Clin Infect Dis. 2020;ciaa928 (via https://pubmed.ncbi.nlm.nih.gov/32642771/)
Background: Obesity has been shown to increase the risk of severe outcomes and death for influenza virus infections. However, we don't understand the influence of obesity on susceptibility to infection ...
Arai Y, Elgendy EM, Daidoji T, et al. H9N2 Influenza Virus Infections in Human Cells Require a Balance Between NA Sialidase Activity and HA Receptor Affinity. J Virol. 2020;JVI.01210-20.. Abstract
submitted by kickingbird at Jul, 10, 2020 from J Virol. 2020;JVI.01210-20. (via https://pubmed.ncbi.nlm.nih.gov/32641475/)
Some avian influenza (AI) viruses have a deletion of up to 20-30 amino acids in their NA stalk. This has been associated with changes in virus replication and host range. Currently prevalent H9N2 AI viruses ...
Zanin M, DeBeauchamp J, Vangala G, Webby RJ, Husai. Histone Deacetylase 6 Knockout Mice Exhibit Higher Susceptibility to Influenza A Virus Infection. Viruses. 2020;12(7):E728. Abstract
submitted by kickingbird at Jul, 10, 2020 from Viruses. 2020;12(7):E728 (via https://pubmed.ncbi.nlm.nih.gov/32640546/)
The host innate defence against influenza virus infection is an intricate system with a plethora of antiviral factors involved. We have identified host histone deacetylase 6 (HDAC6) as an anti-influenza ...
Chen C, Liu Z, Liu L, Wang J, Jin Q. Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design. Front Microbiol. 2020;11:1313. Abstract
submitted by kickingbird at Jul, 9, 2020 from Front Microbiol. 2020;11:1313 (via https://pubmed.ncbi.nlm.nih.gov/32636820/)
H7N9 influenza virus was first isolated in 2013 and has caused five epidemic waves among humans to date. Treatment opinions are currently limited. Previously, we characterized a human neutralizing antibody, ...
Feng Z, Zhu W, Yang L, et al. Epidemiology and Genotypic Diversity of Eurasian Avian-Like H1N1 Swine Influenza Viruses in China. Virol Sin. 2020;10.1007/s12250-020-00257-8. Abstract
submitted by kickingbird at Jul, 9, 2020 from Virol Sin. 2020;10.1007/s12250-020-00257-8 (via https://pubmed.ncbi.nlm.nih.gov/32638231/)
Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) outside European countries was first detected in Hong Kong Special Administrative Region (Hong Kong, SAR) of China in 2001. Afterwards, EA ...
Gupta SD, Hoque MA, Fournié G, Henning J. Patterns of Avian Influenza A (H5) and A (H9) Virus Infection in Backyard, Commercial Broiler and Layer Chicken Farms in Bangladesh. ransbound Emerg Dis. 2020;10.1111/tbed.13657. Abstract
submitted by kickingbird at Jul, 9, 2020 from ransbound Emerg Dis. 2020;10.1111/tbed.13657 (via https://pubmed.ncbi.nlm.nih.gov/32639112/)
In order to control Highly Pathogenic Avian Influenza (HPAI) H5N1 and Low Pathogenic Avian Influenza (LPAI) H9N2 virus spread in endemically infected countries, a detailed understanding of infection patterns ...
Sieben C, Sezgin E, Eggeling C, Manley S. Influenza A Viruses Use Multivalent Sialic Acid Clusters for Cell Binding and Receptor Activation. PLoS Pathog. 2020;16(7):e1008656. Abstract
submitted by kickingbird at Jul, 9, 2020 from PLoS Pathog. 2020;16(7):e1008656 (via https://pubmed.ncbi.nlm.nih.gov/32639985/)
Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment ...
Phipps KL, Ganti K, Jacobs NT, et al. Collective Interactions Augment Influenza A Virus Replication in a Host-Dependent Manner. Nat Microbiol. 2020;10.1038/s41564-020-0749-2. Abstract
submitted by kickingbird at Jul, 8, 2020 from Nat Microbiol. 2020;10.1038/s41564-020-0749-2 (via https://pubmed.ncbi.nlm.nih.gov/32632248/)
Infection with a single influenza A virus (IAV) is only rarely sufficient to initiate productive infection. Instead, multiple viral genomes are often required in a given cell. Here, we show that the reliance ...
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