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2019-3-22 19:30:04
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Pan M, Yang HP, Jian J, et al. Association of meteorological factors with seasonal activity of influenza A subtypes and B lineages in subtropical western China. Epidemiol Infect. 2019 Jan;147:e72.  Abstract  
submitted by kickingbird at 7 days ago from Epidemiol Infect. 2019 Jan;147:e72 (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
The seasonality of individual influenza subtypes/lineages and the association of influenza epidemics with meteorological factors in the tropics/subtropics have not been well understood. The impact of the ...

Amanat F, Meade P, Strohmeier S, Krammer F. Cross-reactive antibodies binding to H4 hemagglutinin protect against a lethal H4N6 influenza virus challenge in the mouse model. Emerg Microbes Infect. 2019;8(1):155-168.  Abstract  
submitted by kickingbird at 7 days ago from Emerg Microbes Infect. 2019;8(1):155-168 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
Influenza viruses of the H4 subtype are widespread in wild birds, circulate in domestic poultry, readily infect mammals, and tolerate the insertion of a polybasic cleavage site. In addition, serological ...

Bao L, et al. Diverse biological characteristics and varied virulence of H7N9 from Wave 5. Emerg Microbes Infect. 2019;8(1):94-102..  Abstract  
submitted by kickingbird at 7 days ago from Emerg Microbes Infect. 2019;8(1):94-102. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic ...

Yao Y, et al. Protection against homo and hetero-subtypic in?uenza A virus by optimized M2e DNA vaccine. Emerg Microbes Infect. 2019;8(1):45-54.  Abstract  
submitted by kickingbird at 7 days ago from Emerg Microbes Infect. 2019;8(1):45-54 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
Current influenza vaccines provide hemagglutinin strain-specific protection, but rarely provide cross-protection against divergent strains. It is, therefore, particularly important to develop a universal ...

Njifon HLM, et al. Genetic diversity of influenza A(H3N2) viruses in Northern Cameroon during the 2014-2016 influenza seasons. J Med Virol. 2019 Mar 13.  Abstract  
submitted by kickingbird at 7 days ago from J Med Virol. 2019 Mar 13 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25456)
In Cameroon, genome characterization of influenza virus has been performed only in the Southern regions meanwhile genetic diversity of this virus varies with respect to locality. The Northern region characterized ...

Quan L, Ji C, Ding X, Peng Y, Liu M, Sun J, et al. Cluster-transition determining sites underlying the antigenic evolution of seasonal influenza viruses. Mol Biol Evol. 2019 Mar 9.  Abstract  
submitted by kickingbird at 8 days ago from Mol Biol Evol. 2019 Mar 9 (via https://academic.oup.com/mbe/advance-article-abstract/doi/10)
Seasonal influenza viruses undergo frequent mutations on their surface hemagglutinin (HA) proteins to escape the host immune response. In these mutations, a few key amino acid sites are associated with ...

Karunakaran AC, et al. Survivability of Highly Pathogenic Avian Influenza Virus (H5N1) in naturally preened Duck Feathers at different temperatures. Transbound Emerg Dis. 2019 Mar 12..  Abstract  
submitted by kickingbird at 9 days ago from Transbound Emerg Dis. 2019 Mar 12. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13148)
Ducks are the "Trojan Horses" for Asian H5N1 avian influenza viruses (AIV) and attain carrier status without displaying overt infection. These birds help in the spread of the virus among the poultry and ...

Cueno ME, et al. Structural significance of residues 158-160 in the H3N2 hemagglutnin globular head: A computational study with implications in viral evolution and infection. J Mol Graph Model. 2019 Feb 25;89:33-40..  Abstract  
submitted by kickingbird at 12 days ago from J Mol Graph Model. 2019 Feb 25;89:33-40. (via https://www.sciencedirect.com/science/article/pii/S109332631)
Influenza A H3N2 has been linked to annual outbreaks within the human population attributable to continuous structural changes. H3N2 HA contains well identified antigenic sites and receptor-binding sites ...

Liu J, Zhou L, Lv J, Zou Y, Wang T. Two novel reassortant H11N8 avian influenza viruses occur in wild birds found in East Dongting Lake, China. Arch Virol. 2019 Mar 8.  Abstract  
submitted by kickingbird at 12 days ago from Arch Virol. 2019 Mar 8 (via https://link.springer.com/article/10.1007%2Fs00705-019-04168)
During the surveillance of avian influenza viruses in East Dongting Lake, China (2014-2015), two H11N8 avian influenza viruses were detected in the bean goose (Anser fabalis) and the falcated teal (Anas ...

Michalak P, et al. Secondary structure of the segment 5 genomic RNA of influenza A virus and its application for designing antisense oligonucleotides. Sci Rep. 2019 Mar 7;9(1):3801.  Abstract  
submitted by kickingbird at 12 days ago from Sci Rep. 2019 Mar 7;9(1):3801 (via https://www.nature.com/articles/s41598-019-40443-7)
Influenza virus causes seasonal epidemics and dangerous pandemic outbreaks. It is a single stranded (-)RNA virus with a segmented genome. Eight segments of genomic viral RNA (vRNA) form the virion, which ...

van Dongen MJP, et al. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science. 2019 Mar 8;363(6431)..  Abstract  
submitted by kickingbird at 12 days ago from Science. 2019 Mar 8;363(6431). (via http://science.sciencemag.org/content/363/6431/eaar6221)
Recent characterization of broadly neutralizing antibodies (bnAbs) against influenza virus identified the conserved hemagglutinin (HA) stem as a target for development of universal vaccines and therapeutics. ...

Jacqueline M. Nolting Scott D. Scheer Andrew S.. Perceptions and attitudes of swine exhibitors towards recommendations for reducing zoonotic transmission of influenza A viruses. Zoonoses and Public Health 06 Mar 2019.  Abstract  
submitted by kickingbird at 12 days ago from Zoonoses and Public Health 06 Mar 2019 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/zph.12574)
Since 2011, there have been 468 cases of variant influenza A virus (IAV) reported in the United States, many of which were associated with youth swine exhibition. In an effort to mitigate risk associated ...

Mandala VS, Liao SY, Gelenter MD, Hong M. The Transmembrane Conformation of the Influenza B Virus M2 Protein in Lipid Bilayers. Sci Rep. 2019 Mar 6;9(1):3725..  Abstract  
submitted by kickingbird at 12 days ago from Sci Rep. 2019 Mar 6;9(1):3725. (via https://www.nature.com/articles/s41598-019-40217-1)
Influenza A and B viruses cause seasonal flu epidemics. The M2 protein of influenza B (BM2) is a membrane-embedded tetrameric proton channel that is essential for the viral lifecycle. BM2 is a functional ...

Liu Y, et al. CRISPR-Cas13a Nanomachine Based Simple Technology for Avian Influenza A (H7N9) Virus On-Site Detection. J Biomed Nanotechnol. 2019 Apr 1;15(4):790-798.  Abstract  
submitted by kickingbird at 12 days ago from J Biomed Nanotechnol. 2019 Apr 1;15(4):790-798 (via https://www.ingentaconnect.com/content/asp/jbn/2019/00000015)
It is urgent to find an avian influenza A H7N9 detection simple method which is suitable for on-site detection. The Cas13a protein just likes a nanomachine, when specifically bound to target RNA by single-stranded ...

Yamaya M, et al. Effects of high temperature on pandemic and seasonal human influenza viral replication and infection-induced damage in primary human tracheal epithelial cell cultures. Heliyon. 2019 Feb 5;5(2):e01149.  Abstract  
submitted by kickingbird at 14 days ago from Heliyon. 2019 Feb 5;5(2):e01149 (via https://www.heliyon.com/article/e01149)
High temperature reduces influenza viral replication; however, the treatment of fevers is thought to be necessary to improve patients' conditions. We examined the effects of high temperature on viral replication ...

Teo SHC, Wu JP, Mok CK, Tan YJ. A NS1-Binding Monoclonal Antibody Interacts with Two Residues that are Highly Conserved in Seasonal as well as Newly-Emerged Influenza A Virus. Pathog Dis. 2019 Mar 6.  Abstract  
submitted by kickingbird at 14 days ago from Pathog Dis. 2019 Mar 6 (via https://academic.oup.com/femspd/advance-article-abstract/doi)
The non-structural protein 1 (NS1) of influenza A virus (IAV) is a multifunctional protein that antagonizes host antiviral responses, modulating virus pathogenesis. As such, it serves as a good target ...

Krammer F. The human antibody response to influenza A virus infection and vaccination. Nat Rev Immunol. 2019 Mar 5..  Abstract  
submitted by kickingbird at 14 days ago from Nat Rev Immunol. 2019 Mar 5. (via https://www.nature.com/articles/s41577-019-0143-6)
The adaptive immune response to influenza virus infection is multifaceted and complex, involving antibody and cellular responses at both systemic and mucosal levels. Immune responses to natural infection ...

Bajic G, et al. Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies. Sci Rep. 2019 Mar 5;9(1):3492..  Abstract  
submitted by kickingbird at 14 days ago from Sci Rep. 2019 Mar 5;9(1):3492. (via https://www.nature.com/articles/s41598-019-40175-8)
Epitope-focused approaches for selective clonal induction of broadly neutralizing antibodies (bnAbs) inform most current vaccine strategies for influenza virus and other rapidly evolving pathogens. The ...

Taniguchi K, et al. Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil. Sci Rep. 2019 Mar 5;9(1):3466..  Abstract  
submitted by kickingbird at 14 days ago from Sci Rep. 2019 Mar 5;9(1):3466. (via https://www.nature.com/articles/s41598-019-39683-4)
Human infections with avian-origin influenza A(H7N9) virus represent a serious threat to global health; however, treatment options are limited. Here, we show the inhibitory effects of baloxavir acid (BXA) ...

Nu?ez IA, Ross TM. A review of H5Nx avian influenza viruses. Ther Adv Vaccines Immunother. 2019 Feb 22;7:251513.  Abstract  
submitted by kickingbird at 15 days ago from Ther Adv Vaccines Immunother. 2019 Feb 22;7:251513 (via https://journals.sagepub.com/doi/10.1177/2515135518821625)
Highly pathogenic avian influenza viruses (HPAIVs), originating from the A/goose/Guangdong/1/1996 H5 subtype, naturally circulate in wild-bird populations, particularly waterfowl, and often spill over ...

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