Chan JCM, Ching RHH, Kock HHM, Long T, Nicholls JM. Evaluation of pandemic potential of the genotype 4 (G4) swine influenza virus using ex vivo and in vitro cultures of the human respiratory tract. J Gen Virol. 2025 Jul;106(7):002133. Abstract
submitted by kickingbird at Aug, 4, 2025 from J Gen Virol. 2025 Jul;106(7):002133 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Recent studies have reported a genotype 4 (G4) reassortant Eurasian avian-like (EA) H1N1 virus in swine, demonstrating a potential pandemic threat in humans. Here, we have compared the tropism, replication ... Jo, G., Yamayoshi, S., Ma, K.M. et al. Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3. Nat Commun 16, 7067 (2025). Abstract
submitted by kickingbird at Aug, 3, 2025 from Nat Commun 16, 7067 (2025) (via https://link.springer.com/article/10.1038/s41467-025-62174-2)
Influenza viruses evolve rapidly, driving seasonal epidemics and posing global pandemic threats. While neuraminidase (NA) has emerged as a vaccine target, shared molecular features of NA antibody responses ... Mansi Sharma, etc.,al. [preprint]Differential modulation of Interferon and Cell Death Responses defines Human vs Avian Influenza A Virus Strain-Specific Virulence and guides Combination Therapy. https://doi.org/10.1101/2025.07.31.667854. Abstract
submitted by kickingbird at Aug, 3, 2025 from https://doi.org/10.1101/2025.07.31.667854 (via https://www.biorxiv.org/content/10.1101/2025.07.31.667854v1)
Influenza A virus (IAV) poses a significant global health risk, with highly pathogenic strains like H5N1 (CFR ~52%) causing severe disease compared to less lethal but more transmissible strains like H1N1 ... Mark A. Power, etc.,al. [preprint]Seasonal Influenza Exposure Elicits Functional Antibody and T-cell Responses to A(H5) Influenza Viruses in Humans. https://doi.org/10.1101/2025.07.31.25331995. Abstract
submitted by kickingbird at Aug, 3, 2025 from https://doi.org/10.1101/2025.07.31.25331995 (via https://www.medrxiv.org/content/10.1101/2025.07.31.25331995v)
Background Highly pathogenic avian influenza A(H5) viruses pose a pandemic threat, with a history of zoonotic spillovers into humans that are presumed immunologically na?ve. Whether the general population ... Oluwatosin Babasola, Mohamed Bakheet, Christina Na. [preprint]A Phylogeny-Informed Mathematical Modeling of H5N1 Transmission Dynamics and Effectiveness of Control Measures. https://doi.org/10.1101/2025.07.29.25331913. Abstract
submitted by kickingbird at Aug, 3, 2025 from https://doi.org/10.1101/2025.07.29.25331913 (via https://www.medrxiv.org/content/10.1101/2025.07.29.25331913v)
The highly pathogenic avian influenza (HPAI) subtype H5N1 is a severe viral disease which continues to pose a significant threat to public health and a rigorous understanding of its transmission dynamics ... Lv K, Li X, Zhu X, Cai JP, Liu S, Sun Y, Liu L, Ca. Broad neuraminidase antibodies confer protection against seasonal and avian influenza viruses. Nat Commun. 2025 Aug 2;16(1):7103. Abstract
submitted by kickingbird at Aug, 3, 2025 from Nat Commun. 2025 Aug 2;16(1):7103 (via https://www.nature.com/articles/s41467-025-62040-1)
Neuraminidase (NA) is a critical target for universal influenza vaccines and therapeutic antibodies, yet its antigenic landscape remains incompletely understood. Here we identify two broadly cross-protective ... Kozawa F, Tamura T, Takahashi N, Kakizuka T, Ichim. The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection. Cell Commun Signal. 2025 Aug 2;23(1):361. Abstract
submitted by kickingbird at Aug, 3, 2025 from Cell Commun Signal. 2025 Aug 2;23(1):361 (via https://biosignaling.biomedcentral.com/articles/10.1186/s129)
Background: Influenza A viruses (IAVs) initially infect a few host cells before spreading to neighboring cells. However, the molecular mechanisms underlying this dissemination remain unclear. We have previously ... Bayoumi M, Barre RS, Escobedo RA, Shivanna V, Jack. Identification of Amino Acid Residues in polymerase PB2 Responsible for Differential Replication and Pathogenicity of Avian Influenza Virus H5N1 Isolated from Human and Cattle in Texas, US. Emerg Microbes Infect. 2025 Aug 1:2542247. Abstract
submitted by kickingbird at Aug, 3, 2025 from Emerg Microbes Infect. 2025 Aug 1:2542247 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Highly pathogenic avian influenza viruses (HPAIV) pose a serious public health concern. In March 2024, a first-time outbreak of HPAIV H5N1 in dairy cattle herds was reported in the United States (US). ... Annie Dosey, etc.,al. [preprint]Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses. https://doi.org/10.1101/2025.07.30.667762. Abstract
submitted by kickingbird at Aug, 3, 2025 from https://doi.org/10.1101/2025.07.30.667762 (via https://www.biorxiv.org/content/10.1101/2025.07.30.667762v1)
Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influenza ... Rongye Ye, Lun Li, Shuhui Song. [preprint]Influ-BERT: An Interpretable Model for Enhancing Low-Frequency Influenza A virus Subtype Recognition. https://doi.org/10.1101/2025.07.31.667841. Abstract
submitted by kickingbird at Aug, 3, 2025 from https://doi.org/10.1101/2025.07.31.667841 (via https://www.biorxiv.org/content/10.1101/2025.07.31.667841v1)
Influenza A Virus (IAV) poses a continuous threat to global public health due to its wide host adaptability, high-frequency antigenic variation, and potential for cross-species transmission. Accurate recognition ... Wu M, Guo L, Kong M, Zou M, Liu X, Li X. Epidemiological and genomic surveillance of influenza A virus (pdm09 H1N1 and H3N2) strains from 2017 to 2025 in Tianjin, China. Virol Sin. 2025 Jul 30:S1995-820X(25)00106-3. Abstract
submitted by kickingbird at Aug, 3, 2025 from Virol Sin. 2025 Jul 30:S1995-820X(25)00106-3 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Influenza A virus (IAV) remains a global public health concern, causing influenza-like illness and severe respiratory tract infections. Two major subtypes, A/pdm09 H1N1 and A/H3N2, circulate globally, ... A.J. Campbell, etc.,al. [preprint]Surveillance on California dairy farms reveals multiple sources of H5N1 transmission. https://doi.org/10.1101/2025.07.31.666798. Abstract
submitted by kickingbird at Aug, 2, 2025 from https://doi.org/10.1101/2025.07.31.666798 (via https://www.biorxiv.org/content/10.1101/2025.07.31.666798v1)
Transmission routes of highly pathogenic H5N1 between cows or to humans remain unclear due to limited data from affected dairy farms. We performed extensive air, farm wastewater, and milk sampling on 14 ... Wang Y, Zhong Q, Meng F, Cheng Z, Zhang Y, Song Z,. Glutamic Acid at Position 343 in PB2 Contributes to the Virulence of H1N1 Swine Influenza Virus in Mice. Viruses. 2025 Jul 20;17(7):1018. Abstract
submitted by kickingbird at Jul, 31, 2025 from Viruses. 2025 Jul 20;17(7):1018 (via https://www.mdpi.com/1999-4915/17/7/1018)
The H1N1 swine influenza viruses CQ91 and CQ445, isolated from pigs in China, exhibited distinct virulence in mice despite sharing similar genomic constellations. CQ91 demonstrated higher pathogenicity ... LIU Zhaosheng, ZHOU Jienan, FU Xiaoqing, ZHAO Xiao. Sequence Analysis of Hemagglutinin Genes of 28 H9N2 Avian Influenza Virus Strains in Yunnan. CHINESE JOURNAL OF VIROLOGY. Abstract
submitted by kickingbird at Jul, 29, 2025 from CHINESE JOURNAL OF VIROLOGY (via http://www.flu.org.cn/scn/article_detail.asp?articleId=22930)
This study investigates the genetic variation of H9N2 subtype avian influenza virus (AIV) in Yunnan Province to provide a basis for further research and efforts in prevention and control. Reverse transcription ... LIU Zhaosheng, FU Xiaoqing, LUO Chunrui, ZHAO Xiao. Whole genomic analysis of 8 strains of H9N2 subtype avian influenza virus isolates from live poultry markets in Yunnan, 2023. China Tropical Medicine, Mar 2025, Vol.25, No.3. Abstract
submitted by kickingbird at Jul, 29, 2025 from China Tropical Medicine, Mar 2025, Vol.25, No.3 (via http://www.flu.org.cn/scn/article_detail.asp?articleId=22871)
ObjectiveTo conduct an in-depth study of the molecular biological characteristics and evolutionary trends of H9N2 avian influenza virus(AIV) in live poultry markets in Yunnan Province in 2023, and to provide ... Gu W, de Carvahlo Madrid DM, Wen Y, Clements S, To. Single-cell antigen receptor sequencing in pigs with influenza. Commun Biol. 2025 Jul 26;8(1):1108. Abstract
submitted by kickingbird at Jul, 29, 2025 from Commun Biol. 2025 Jul 26;8(1):1108 (via https://www.nature.com/articles/s42003-025-08507-9)
Single-cell RNA sequencing (scRNAseq) has accelerated characterizing cellular phenotypes in pigs under healthy and diseased conditions. To pair scRNAseq with immune receptor profiling, we developed porcine-specific ... Sullivan JD, Casazza ML, Poulson RL, Matchett EL,. Potential impacts of 2.3.4.4b highly pathogenic H5N1 avian influenza virus infection on Snow Goose (Anser caerulescens) movement ecology. PLoS One. 2025 Jul 28;20(7):e0328149. Abstract
submitted by kickingbird at Jul, 29, 2025 from PLoS One. 2025 Jul 28;20(7):e0328149 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
While wild waterfowl are known reservoirs of avian influenza viruses and facilitate the movement of these viruses, there are notable differences in the response to infection across species. This study ... Grace K Wenger, etc.,al. [preprint]Primary bovine embryonic fibroblasts support seasonal influenza A virus infection and demonstrate variable fitness of HPAI H5N1. https://doi.org/10.1101/2025.07.26.666677. Abstract
submitted by kickingbird at Jul, 28, 2025 from https://doi.org/10.1101/2025.07.26.666677 (via https://www.biorxiv.org/content/10.1101/2025.07.26.666677v1)
The emergence of highly pathogenic avian influenza (HPAI) H5N1 (clade 2.3.4.4b, genotype B3.13) in dairy cattle presents substantial challenges to the agricultural sector and public health. Mechanistic ... Izel Avkan, etc.,al. [preprint]Controlling avian influenza spillover events: a modelling study. https://doi.org/10.1101/2025.07.22.25331905. Abstract
submitted by kickingbird at Jul, 28, 2025 from https://doi.org/10.1101/2025.07.22.25331905 (via https://www.medrxiv.org/content/10.1101/2025.07.22.25331905v)
Avian influenza is a highly contagious viral disease that affects both domestic and wild birds, with occasional spillover to mammals, including humans. As of June 2025, 117 H5N1 infections in humans have ... LI Yudong, ZHOU Yingchun, DUAN Qianqian, CAO Jie,. Genetic Evolution and Antigenic Analysis of H9N2 Subtype Avian Influenza Virus in Anhui Province in 2024. Chinese Journal of Veterinary Medicine. Abstract
submitted by kickingbird at Jul, 28, 2025 from Chinese Journal of Veterinary Medicine (via http://www.flu.org.cn/scn/article_detail.asp?articleId=23509)
To investigate the genetic evolution and antigenic variation of H9N2 subtype avian influenza virus (AIV) in Anhui Province, China, this study collected oropharyngeal swab samples from poultry in live bird ... 6499 items, 20/Page, Page[19/325][|<<] [|<] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [>|] [>>|] |
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