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2025-12-18 2:23:49
Article

Park ES, Gayashan MK, Kim KH. Thermogenesis dynamics and influenza A virus: unveiling the intriguing interplay. Crit Rev Microbiol. 2025 Aug 12:1-22.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from Crit Rev Microbiol. 2025 Aug 12:1-22 (via https://www.tandfonline.com/doi/full/10.1080/1040841X.2025.2)
Maintaining body temperature is critical, with brown adipose tissue (BAT) and uncoupling protein 1 (UCP1) activation playing pivotal roles in heat generation and metabolism. Modulating thermoregulation ...

Kelvin AA, Baker PH, Ghosh S, Schultz-Cherry S, La. Influenza infection of the mammary gland. J Virol 0:e01940-24.  Abstract  
submitted by kickingbird at Aug, 13, 2025 from J Virol 0:e01940-24 (via https://journals.asm.org/doi/10.1128/jvi.01940-24)
The mammary gland is an essential organ for milk production, providing essential immune and nutritional support to offspring and supplying dairy products for human consumption. In both humans and animals, ...

Bullock TA, Pappas C, Uyeki TM, Brock N, Kieran TJ. The (digestive) path less traveled: influenza A virus and the gastrointestinal tract. mBio 0:e01017-25..  Abstract  
submitted by kickingbird at Aug, 13, 2025 from mBio 0:e01017-25. (via https://journals.asm.org/doi/10.1128/mbio.01017-25)
Influenza A virus (IAV) infection of the respiratory tract can cause both respiratory and non-respiratory symptoms. Gastrointestinal (GI) symptoms such as diarrhea, vomiting, and abdominal pain can occur ...

Yan Y, Xu J, Chen Z, Xu Y, Qin L, Zhao L, Zhang H,. Heat shock protein A1L restricts influenza A virus by ubiquitination of NA. J Virol. 2025 Aug 11:e0077125.  Abstract  
submitted by kickingbird at Aug, 12, 2025 from J Virol. 2025 Aug 11:e0077125 (via https://journals.asm.org/doi/10.1128/jvi.00771-25)
Neuraminidase (NA) protein of influenza A virus (IAV), a tetrameric envelope glycoprotein critical for viral release and spread, has well-characterized enzymatic functions but poorly resolved host-pathogen ...

Maria Giovanna Marotta, etc.,al. [preprint]Development and optimisation of Influenza C and Influenza D pseudotyped viruses. https://doi.org/10.1101/2025.05.26.656172.  Abstract  
submitted by kickingbird at Aug, 11, 2025 from https://doi.org/10.1101/2025.05.26.656172 (via https://www.biorxiv.org/content/10.1101/2025.05.26.656172v2)
To facilitate the study of influenza C (ICV) and influenza D (IDV) viruses, we generated lentiviral pseudotyped viruses (PVs) expressing the hemagglutinin-esterase fusion (HEF) glycoprotein from ICV (C/Minnesota/33/2015) ...

Gonzalez-Ricon RJ, Otero AM, Chalen I, Savas JN, A. Influenza A virus infection during pregnancy increases transfer of maternal bloodborne molecules to fetal tissues. Brain Behav Immun. 2025 Aug 6:106069.  Abstract  
submitted by kickingbird at Aug, 11, 2025 from Brain Behav Immun. 2025 Aug 6:106069 (via https://www.sciencedirect.com/science/article/pii/S088915912)
Influenza A virus (IAV) infection during pregnancy is linked to heightened risk for neurodevelopmental disorders (NDDs) in the offspring. The precise pathophysiological mechanism(s) underling this association ...

Marandino A, Tomás G, Panzera Y, Williman J, Dezor. Converging Transmission Routes of the Highly Pathogenic Avian Influenza H5N1 Clade 2.3.4.4b Virus in Uruguay: Phylogeographic Insights into Its Spread Across South America. Pathogens. 2025; 14(8):793.  Abstract  
submitted by kickingbird at Aug, 9, 2025 from Pathogens. 2025; 14(8):793 (via https://www.mdpi.com/2076-0817/14/8/793)
The highly pathogenic avian influenza H5N1 2.3.4.4b clade virus has caused widespread outbreaks across South America, primarily affecting seabirds, poultry, and marine mammals. The virus likely reached ...

Ran Duan, Jiayi Mao, Xiao Mao, Xinkai Shu, Longhui. Breaking the Sorting Barrier for Directed Single-Source Shortest Paths. DOI: 10.1145/3717823.3718179.  Abstract  
submitted by kickingbird at Aug, 9, 2025 from DOI: 10.1145/3717823.3718179 (via https://dl.acm.org/doi/10.1145/3717823.3718179)
We give a deterministic O(mlog2/3n)-time algorithm for single-source shortest paths (SSSP) on directed graphs with real non-negative edge weights in the comparison-addition model. This is the first result ...

Walters KA, Blatti CA 3rd, Zhu R, Banbury B, Giurg. Nasal and systemic immune responses correlate with viral shedding after influenza challenge in people with complex preexisting immunity. Sci Transl Med . 2025 Aug 6;17(810):eadt1452.  Abstract  
submitted by kickingbird at Aug, 9, 2025 from Sci Transl Med . 2025 Aug 6;17(810):eadt1452 (via https://www.science.org/doi/10.1126/scitranslmed.adt1452)
Each year in the United States, ~50% of adults ≥18 years old are vaccinated against influenza viruses, with protective efficacy averaging 40.5% over the past 20 years. To model annual seasonal influenza, ...

Lei YX, Xu QY, Sun Y, Liu H, Wang X, Zou X, Shu YL. Influenza H7N9 Virus Infection Activated TNF Signaling Pathway in BV2 Cells. J Med Virol . 2025 Aug;97(8):e70545.  Abstract  
submitted by kickingbird at Aug, 9, 2025 from J Med Virol . 2025 Aug;97(8):e70545 (via https://onlinelibrary.wiley.com/doi/10.1002/jmv.70545)
Although patients infected with the avian influenza H7N9 virus primarily present flu-like symptoms, recent clinical studies have found that viral encephalopathy caused by avian influenza H7N9 virus infection ...

Sownthirarajan B, Mason M, Loganathan G, Manivasag. A versatile H5N1-VSV platform for safe influenza virus research applications. J Virol 0:e00975-25.  Abstract  
submitted by kickingbird at Aug, 9, 2025 from J Virol 0:e00975-25 (via https://journals.asm.org/doi/10.1128/jvi.00975-25)
The H5N1 strain of influenza A virus (IAV) continues to cause severe infections in a range of avian and mammalian species, including sporadic but concerning cases in humans. There is growing concern that ...

Pauline M van Diemen, etc.,al. [preprint]Experimental infection of alpacas (Vicugna pacos) with Influenza C and D viruses results in subclinical upper respiratory tract disease. https://doi.org/10.1101/2025.07.28.667103.  Abstract  
submitted by kickingbird at Aug, 9, 2025 from https://doi.org/10.1101/2025.07.28.667103 (via https://www.biorxiv.org/content/10.1101/2025.07.28.667103v1)
Influenza D virus (IDV), a new genus within the Orthomyxoviridae family, was initially detected in pigs and cattle. IDV is structurally similar to influenza C virus (ICV). Influenza A, C and D viruses ...

Carrie L. Byington, Donald Pizzo, Hana Russo, Stev. [preprint]Sialic Acid Receptors in Human Mammary Tissue: Implications for Infection with Novel Influenza Strains. https://doi.org/10.1101/2025.08.06.25333154.  Abstract  
submitted by kickingbird at Aug, 9, 2025 from https://doi.org/10.1101/2025.08.06.25333154 (via https://www.medrxiv.org/content/10.1101/2025.08.06.25333154v)
Importance: Highly pathogenic avian influenza (HPAI) A H5N1 has been recognized for nearly three decades as a threat to avian species and as a virus with pandemic potential if spillover into human populations ...

Zanin M, Flerlage T, Wong S, Vogel P, Piza K, Schr. Inflammatory, transcriptomic, and cell fate responses underlying the mammalian transmission of avian influenza viruses. J Virol 0:e00647-25.  Abstract  
submitted by kickingbird at Aug, 9, 2025 from J Virol 0:e00647-25 (via https://journals.asm.org/doi/10.1128/jvi.00647-25)
Airborne transmissibility of avian influenza viruses (AIVs) in humans is considered an essential component of their pandemic risk. Although several viral factors regulating airborne transmission (AT) have ...

Liu Z, Zhang L, Zhang W, Lai Y, Deng T. The 5′-end segment-specific noncoding region of influenza A virus regulates both competitive multi-segment RNA transcription and selective genome packaging during infection. J Virol 0:e00328-25.  Abstract  
submitted by kickingbird at Aug, 7, 2025 from J Virol 0:e00328-25 (via https://journals.asm.org/doi/10.1128/jvi.00328-25)
The 3′ and 5′ termini of the eight RNA segments of the influenza A virus (IAV) genome contain segment-specific or subtype-specific (in HA and NA segments) noncoding regions (ssNCRs), located between the ...

Hammed Olawale Fatoyinbo, Parul Tiwari, Ryan H.L.. Multivariable analysis of highly pathogenic H5N1 and H5Nx avian influenza in wild birds and poultry in Asian subregions. Comparative Immunology, Microbiology and Infectiou.  Abstract  
submitted by kickingbird at Aug, 7, 2025 from Comparative Immunology, Microbiology and Infectiou (via https://www.sciencedirect.com/science/article/pii/S014795712)
The spread of highly pathogenic avian influenza (HPAI) virus in wild birds, poultry, and other livestock worldwide has caused great concerns, especially in Asia, where the migration routes of many wild ...

Sooksawasdi Na Ayudhya S, Leijten L, Rijnink WF, S. Attachment Patterns of Avian Influenza H5 Clade 2.3.4.4b Virus in Respiratory Tracts of Marine Mammals, North Atlantic Ocean. Emerg Infect Dis. 2025 Sep.  Abstract  
submitted by kickingbird at Aug, 7, 2025 from Emerg Infect Dis. 2025 Sep (via https://wwwnc.cdc.gov/eid/article/31/9/25-0499_article)
Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus infections have caused substantial mortality events in marine mammals in recent years. We hypothesized that the high number of infections ...

Aslam S, Sánchez-Aparicio MT, Siempelkamp BD, Dorn. Influenza A virus NS1 protein mimics oncogenic PI3K resulting in isoform specific cellular redistribution and activation. Proc Natl Acad Sci U S A. 2025 Aug 12;122(32):e242.  Abstract  
submitted by kickingbird at Aug, 6, 2025 from Proc Natl Acad Sci U S A. 2025 Aug 12;122(32):e242 (via https://www.pnas.org/doi/10.1073/pnas.2423066122)
The nonstructural protein 1 (NS1) of influenza A virus performs a broad variety of proviral activities in the infected cell, primarily mediating evasion from the host innate immune response by being the ...

Cavicchio L, Tassoni L, Pastori A, Carrino M, Gagl. Swine influenza surveillance in Italy uncovers regional and farm-based genetic clustering. Front Microbiol. 2025 Jul 21;16:1607204.  Abstract  
submitted by kickingbird at Aug, 6, 2025 from Front Microbiol. 2025 Jul 21;16:1607204 (via https://www.frontiersin.org/journals/microbiology/articles/1)
Introduction: Swine Influenza is a respiratory disease endemic in pigs with implications for animal and public health. Pigs, as mixing vessels for human, avian, and swine influenza strains, contribute ...

Jumpei Ito, etc.,al. [preprint]Integrative modeling of seasonal influenza evolution via AI-powered antigenic cartography. https://doi.org/10.1101/2025.08.04.668423.  Abstract  
submitted by kickingbird at Aug, 6, 2025 from https://doi.org/10.1101/2025.08.04.668423 (via https://www.biorxiv.org/content/10.1101/2025.08.04.668423v1)
Seasonal influenza viruses evade host immunity through rapid antigenic evolution. Antigenicity is assessed by serological assays and typically visualized as antigenic maps, which represent antigenic differences ...

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