Basu Thakur P, Bullock HA, Stevens J, Kumar A, Mai. Heterogeneity across mammalian- and avian-origin A(H1N1) influenza viruses influences viral infectivity following incubation with host bacteria from the human respiratory tract. Microbiol Spectr. 2025 Aug 18:e0097725. Abstract
submitted by kickingbird at Aug, 19, 2025 from Microbiol Spectr. 2025 Aug 18:e0097725 (via https://journals.asm.org/doi/10.1128/spectrum.00977-25)
Influenza A viruses (IAVs) are primarily transmitted between mammals by the respiratory route and encounter bacteria in the respiratory tract before infecting susceptible epithelial cells. Previous studies ... Meseko C, Edet UO, Henshaw O, Mkpuma N, Olawuyi KA. Bibliometric analysis of highly pathogenic avian influenza research globally from 2003 to 2023. Germs. 2025 Mar 31;15(1):11-25. Abstract
submitted by kickingbird at Aug, 19, 2025 from Germs. 2025 Mar 31;15(1):11-25 (via https://www.germs.ro/en/Articles/Bibliometric-analysis-of-hi)
Introduction: Despite decades of research on highly pathogenic avian influenza, especially H5N1, an understanding of the impact of research outputs on policy, the impact of funding and policies, collaboration ... Andersen, Hanne et al. Immunopathogenesis of lethal H5N1 avian influenza virus clade 2.3.4.4b infection in macaques. Immunity. Abstract
submitted by kickingbird at Aug, 19, 2025 from Immunity (via https://www.cell.com/immunity/fulltext/S1074-7613(25)00329-2)
The H5N1 avian influenza virus clade 2.3.4.4b outbreak represents a major pandemic threat for humans, with some reported cases of severe and fatal respiratory illness. A key unanswered question is the ... Ashraf M, Stein AN, Youhanna J, Rockman S, McMahon. The impact of egg adaptation and immune imprinting on influenza vaccine effectiveness. Vaccine. 2025 Aug 13;62:127393. Abstract
submitted by kickingbird at Aug, 18, 2025 from Vaccine. 2025 Aug 13;62:127393 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Most influenza vaccines are produced in hens' eggs and may undergo 'egg adaptation', whereby mutations within the haemagglutinin protein that result in adaptation to the avian cells undergo positive selection. ... Rawi R, Morano NC, Cheung CS, Du H, Gorman J, Prab. The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody. Structure. 2025 Aug 6:S0969-2126(25)00264-3. Abstract
submitted by kickingbird at Aug, 18, 2025 from Structure. 2025 Aug 6:S0969-2126(25)00264-3 (via https://www.cell.com/structure/fulltext/S0969-2126(25)00264-)
The N terminus of the H3 subtype of influenza virus hemagglutinin is ～10 residues longer than the N termini of most other hemagglutinins. As conserved, exposed, and linear regions may be good vaccine targets, ... Thomas MN, Janzen GM, Markin A, Sharma A, Hewitt K. Active surveillance for influenza A virus in swine reveals within-farm reassortment and cocirculation of distinct subtypes and genetic clades. Vet Microbiol. 2025 Aug 11;309:110681. Abstract
submitted by kickingbird at Aug, 18, 2025 from Vet Microbiol. 2025 Aug 11;309:110681 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Influenza A virus (IAV) is one of the most frequently detected respiratory pathogens in swine. A passive surveillance system in the United States (U.S.) provides aggregated metrics to quantify spatial ... Shanshan Guan, etc.,al. Optimization of the Monoclonal Antibody 3E1 through W32I Mutation Enhances Antiviral Efficacy against Influenza Virus Subtypes H1N1 and H3N2. Antiviral Research. Abstract
submitted by kickingbird at Aug, 17, 2025 from Antiviral Research (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
The influenza virus has caused a global pandemic with significant morbidity and mortality, underscoring the need to optimize antibodies for improved antiviral efficacy. The monoclonal antibody 3E1 effectively ... Lorin Adams, etc.,al. Improved Resolution of Influenza Vaccination Responses With High-Throughput Live Virus Microneutralisation. Influenza and Other Respiratory Viruses. Abstract
submitted by kickingbird at Aug, 16, 2025 from Influenza and Other Respiratory Viruses (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70140)
BackgroundInfluenza remains a significant threat to human and animal health. Assessing serological protection against influenza has relied upon haemagglutinin inhibition (HAI) assays, which are used to ... Hu, S., & Cui, J.. Cattle H5N1 Outbreak in US Driven by Cow’s ´Cross-Nursing´ Behavior: Elucidating a Novel Transmission Mechanism. Emerging Microbes & Infections. Abstract
submitted by kickingbird at Aug, 16, 2025 from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The emergence of highly pathogenic avian influenza A(H5N1) in US dairy cattle represents an unprecedented zoonotic event with critical pandemic implications. As of June 2025, over 1,070 dairy farms across ... Eduard Puente-Massaguer, etc.,al. [preprint]A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoprotein. https://doi.org/10.1101/2025.08.14.670375. Abstract
submitted by kickingbird at Aug, 16, 2025 from https://doi.org/10.1101/2025.08.14.670375 (via https://www.biorxiv.org/content/10.1101/2025.08.14.670375v1)
The continuous evolution and widespread dissemination of highly pathogenic avian influenza (HPAI) H5N1 viruses, particularly clade 2.3.4.4b, pose critical challenges to global pandemic preparedness. In ... Cárdenas Parra AK, Barón Vera JP, Calixto-Botía IF. A Broad Wildlife Survey of Influenza A Virus in the Orinoco Flooded Savannas from Colombia: New Reports and Perspectives. Animals (Basel). 2025 Jul 26;15(15):2201. Abstract
submitted by kickingbird at Aug, 15, 2025 from Animals (Basel). 2025 Jul 26;15(15):2201 (via https://www.mdpi.com/2076-2615/15/15/2201)
Influenza A virus (IAV) poses a significant threat to animal and public health due to its wide host range and potential for interspecies transmission. This study aimed to conduct a comprehensive survey ... Vidhi Dholakia, etc.,al. [preprint]Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals. https://doi.org/10.1101/2025.01.06.631435. Abstract
submitted by kickingbird at Aug, 15, 2025 from https://doi.org/10.1101/2025.01.06.631435 (via https://www.biorxiv.org/content/10.1101/2025.01.06.631435v3)
In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. As of mid-2025 the epidemic is ongoing, resulting in spillbacks into poultry, ... Albert Perlas Puente, etc.,al. [preprint]From feather to fur: gull and mink H5N1 clade 2.3.4.4b HPAIV in their original hosts and their spillover and spillback potential. https://doi.org/10.21203/rs.3.rs-7357485/v1. Abstract
submitted by kickingbird at Aug, 15, 2025 from https://doi.org/10.21203/rs.3.rs-7357485/v1 (via https://www.researchsquare.com/article/rs-7357485/v1)
The ongoing panzootic of H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus (HPAIV) increasingly involves non-traditional hosts such as seabirds and mammals. To assess their role in viral-host ... Xu Y, Anirudhan V, Gaisina IN, Du H, Alqarni S, Mo. Mechanistic insights into the small-molecule inhibition of influenza A virus entry. Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e250. Abstract
submitted by kickingbird at Aug, 14, 2025 from Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e250 (via https://www.pnas.org/doi/10.1073/pnas.2503899122)
Influenza A virus (IAV) is a zoonotic pathogen responsible for seasonal and pandemic flu. The extensive genetic and antigenic diversity within and between IAV phylogenetic groups presents major challenges ... Mo J, Ferreri LM, Geiger G, Perez DR, Rajao DS. Passage of human-origin influenza A virus in swine tracheal epithelial cells selects for adaptive mutations in the hemagglutinin gene. PLoS One. 2025 Aug 13;20(8):e0327096. Abstract
submitted by kickingbird at Aug, 14, 2025 from PLoS One. 2025 Aug 13;20(8):e0327096 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Frequent spillover of influenza A viruses from humans to swine contributes to the increasing diversity of influenza viruses circulating in pigs. Although these events are common, little is known about ... Cho, Andrew Y., Kim, Tae-Hyeon, Lee, Heesu, Lee, S. Evolution and Spread of Y280-Lineage H9N2 Low Pathogenicity Avian Influenza Viruses in Korea, 2020–2023. Transboundary and Emerging Diseases, 2025, 8009335. Abstract
submitted by kickingbird at Aug, 14, 2025 from Transboundary and Emerging Diseases, 2025, 8009335 (via https://onlinelibrary.wiley.com/doi/10.1155/tbed/8009335)
In 2020, Y280-lineage H9N2 low pathogenic avian influenza was detected in South Korea for the first time. Active surveillance from live bird markets (LBMs) and farms revealed the continuous circulation ... León, F., Le Bohec, C., Pizarro, E.J. et al. Tracking HPAIV H5 through a geographic survey of Antarctic seabird populations. Sci Rep 15, 29499 (2025). Abstract
submitted by kickingbird at Aug, 14, 2025 from Sci Rep 15, 29499 (2025) (via https://link.springer.com/article/10.1038/s41598-025-14651-3)
An extensive survey for the detection of Highly Pathogenic Avian Influenza virus (HPAIV) H5 in seabird species is reported here. It was conducted between December 2023 and January 2024, in thirteen breeding ... Markin A, Macken CA, Baker AL, Anderson TK. Revealing Reassortment in Influenza A Viruses with TreeSort. Mol Biol Evol. 2025 Jul 30;42(8):msaf133. Abstract
submitted by kickingbird at Aug, 13, 2025 from Mol Biol Evol. 2025 Jul 30;42(8):msaf133 (via https://academic.oup.com/mbe/article/doi/10.1093/molbev/msaf)
Reassortment among influenza A viruses (IAV) facilitates evolution and has been associated with interspecies transmission and pandemics. We introduce a novel tool called TreeSort that accurately identifies ... Cecilia Di Genova, etc.,al. [preprint]Pigeons exhibit low susceptibility and poor transmission capacity for H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus. https://doi.org/10.1101/2025.05.02.651910. Abstract
submitted by kickingbird at Aug, 13, 2025 from https://doi.org/10.1101/2025.05.02.651910 (via https://www.biorxiv.org/content/10.1101/2025.05.02.651910v2)
The ongoing panzootic of H5N1 high pathogenicity avian influenza virus (HPAIV) has caused the deaths of over half a billion wild birds and poultry, and has led to spillover events in both wild and domestic ... Sharp CP, Thompson BH, Hoque AF, Diebold O, Tesla. Understanding off-target growth defects introduced to influenza A virus by synonymous recoding. RNA. 2025 Aug 12:rna.080675. Abstract
submitted by kickingbird at Aug, 13, 2025 from RNA. 2025 Aug 12:rna.080675 (via https://rnajournal.cshlp.org/content/early/2025/08/12/rna.08)
CpG dinucleotides are under-represented in the genomes of most RNA viruses. Synonymously increasing CpG content of a range of RNA virus genomes reliably causes replication defects due to the recognition ... 6499 items, 20/Page, Page[17/325][|<<] [|<] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [>|] [>>|] |
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