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2024-3-29 3:07:16
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Lee ACY, To KKW, Zhu H, Chu H, et al. Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes. J Gen Virol 2017 May 30.  Abstract  
submitted by kickingbird at Jun, 5, 2017 from J Gen Virol 2017 May 30 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28555541/)
Most patients with avian influenza A H7N9 virus (H7N9) infection suffer from severe illness, accompanied by dysregulated cytokine/chemokine response, delayed viral clearance and impaired neutralizing antibody ...

Baratelli M, Pedersen LE, Trebbien R, Larsen LE, e. Identification of cross-reacting T-cell epitopes in structural and non-structural proteins of swine and pandemic H1N1 influenza A virus strains in pigs. J Gen Virol 2017 May 30.  Abstract  
submitted by kickingbird at Jun, 5, 2017 from J Gen Virol 2017 May 30 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28555545/)
Heterologous protection against swine influenza viruses (SwIVs) of different lineages is an important concern for the pig industry. Cross-protection between 'avian-like' H1N1 and 2009 pandemic H1N1 lineages ...

Giarola-Silva S, Coelho-Dos-Reis JGA, Mourao MM, C. Distinct patterns of cellular immune response elicited by influenza non-adjuvanted and AS03-adjuvanted monovalent H1N1(pdm09) vaccine. Antiviral Res 2017;144:70-82..  Abstract  
submitted by kickingbird at Jun, 5, 2017 from Antiviral Res 2017;144:70-82. (via https://www.ncbi.nlm.nih.gov/m/pubmed/28549970/)
The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV) and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both vaccines elicited similar levels ...

Lin CY, Chia MY, Chen PL, Yeh CT, et al.. Assessment of pathogenicity and antigenicity of American lineage influenza H5N2 viruses in Taiwan. Virology 2017;508:159-163.  Abstract  
submitted by kickingbird at May, 29, 2017 from Virology 2017;508:159-163 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28549236/)
During December 2003 and March 2004, large scale epidemics of low-pathogenic avian influenza (LPAI) H5N2 occurred in poultry farms in central and southern Taiwan. Based on genomic analysis, these H5N2 ...

Randolph AG, Yip WK, Allen EK, Rosenberger CM, et. Evaluation of IFITM3 rs12252 Association with Severe Pediatric Influenza Infection. J Infect Dis 2017 May 20.  Abstract  
submitted by kickingbird at May, 29, 2017 from J Infect Dis 2017 May 20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28531322/)
Background: Interferon inducible transmembrane protein 3 (IFITM3) restricts endocytic fusion of influenza virus. IFITM3 rs12252_C, a putative alternate splice site, has been associated with influenza severity ...

Hara K, Kashiwagi T, Hamada N, Watanabe H, et al. Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication. J Gen Virol 2017 May 22..  Abstract  
submitted by kickingbird at May, 29, 2017 from J Gen Virol 2017 May 22. (via https://www.ncbi.nlm.nih.gov/m/pubmed/28530165/)
The PB2 subunit of influenza virus RNA polymerase is known to be involved in the initiation of transcription of the virus genome via cap binding. However, other specific roles of PB2 for viral RNA synthesis ...

Zhao D, Liang L, Wang S, Nakao T, et al. Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response. J Virol 2017;91.  Abstract  
submitted by kickingbird at May, 22, 2017 from J Virol 2017;91 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28100622/)
The highly pathogenic avian influenza (HPAI) H5N1 viruses continue to circulate in nature and threaten public health. Although several viral determinants and host factors that influence the virulence of ...

Pereira CF, Read EKC, Wise HM, Amorim MJ, et al. The influenza A virus NS1 protein promotes efficient nuclear export of unspliced viral M1 mRNA. Virol 2017 May 17. pii: JVI.00528-17.  Abstract  
submitted by kickingbird at May, 22, 2017 from Virol 2017 May 17. pii: JVI.00528-17 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28515301/)
Influenza A virus mRNAs are transcribed by the viral RNA-dependent RNA polymerase in the cell nucleus before being exported to the cytoplasm for translation. Segment 7 produces two major transcripts: an ...

Lee N, Cao B, Ke C, Lu H, et al. IFITM3, TLR3, and CD55 Genes SNPs and Cumulative Ge-netic Risks for Severe Outcomes in Chinese Patients with H7N9 / H1N1pdm09 Influenza. J Infect Dis 2017 May 16.  Abstract  
submitted by kickingbird at May, 22, 2017 from J Infect Dis 2017 May 16 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28510725/)
Background: We examined associations between SNPs (single-nucleotide-polymorphisms) of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese patients. Methods: A multicenter-study was ...

Root JJ, Shriner SA, Ellis JW, VanDalen KK, et al. Transmission of H6N2 wild bird-origin influenza A virus among multiple bird species in a stacked-cage setting. Arch Virol 2017 May 16.  Abstract  
submitted by kickingbird at May, 22, 2017 from Arch Virol 2017 May 16 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28508987/)
Live bird markets are common in certain regions of the U.S. and in other regions of the world. We experimentally tested the ability of a wild bird influenza A virus to transmit from index animals to na?ve ...

Liu S, Zhang L, Yao Z, Xing L, et al. In vitro and in vivo characterization of a novel H1N1/2009 influenza virus reassortant with an NS gene from a highly pathogenic H5N1 virus, isolated from a human. Arch Virol 2017 May 18.  Abstract  
submitted by kickingbird at May, 22, 2017 from Arch Virol 2017 May 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28523521/)
The triple-reassortant H1N1/2009 influenza A virus, which caused the first influenza pandemic of the 21(st) century, is generally associated with mild disease and a relatively low mortality rate comparable ...

JA Besler,etc.,al. A novel A(H7N2) influenza virus isolated from a veterinarian caring for cats in a New York City animal shelter causes mild disease and transmits poorly in the ferret model. J Virol May 17.  Abstract  
submitted by kickingbird at May, 19, 2017 from J Virol May 17 (via http://jvi.asm.org/content/early/2017/05/12/JVI.00672-17.abs)
In December 2016, a low pathogenic avian influenza (LPAI) A(H7N2) virus was identified as the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters ...

Bahl K. et al.. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses. Mol Ther. 2017 Apr 11. pii: S1525-0016(17)30156-9..  Abstract  
submitted by kickingbird at May, 15, 2017 from Mol Ther. 2017 Apr 11. pii: S1525-0016(17)30156-9. (via http://www.cell.com/molecular-therapy-family/molecular-thera)
Recently, the World Health Organization confirmed 120 new human cases of avian H7N9 influenza in China resulting in 37 deaths, highlighting the concern for a potential pandemic and the need for an ...

Bui CM. et al.. Influenza A H5N1 and H7N9 in China: A spatial risk analysis. PLoS One. 2017 Apr 4;12(4):e0174980..  Abstract  
submitted by kickingbird at May, 15, 2017 from PLoS One. 2017 Apr 4;12(4):e0174980. (via http://journals.plos.org/plosone/article?id=10.1371/journal.)
Background Zoonotic avian influenza poses a major risk to China, and other parts of the world. H5N1 has remained endemic in China and globally for nearly two decades, and in 2013, a novel zoonotic influenza ...

Hussain M, Galvin HD, Haw TY, Nutsford AN, Husain. Drug resistance in influenza A virus: the epidemiology and management. Infection and Drug Resistance 20 April 2017 Volum.  Abstract  
submitted by kickingbird at May, 15, 2017 from Infection and Drug Resistance 20 April 2017 Volum (via https://www.dovepress.com/drug-resistance-in-influenza-a-vir)
 Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual influenza epidemics in ...

HOFT DF, Lottenbach K, Goll JB, Hill H, et al. Priming Vaccination With Influenza Virus H5 Hemagglutinin Antigen Significantly Increases the Duration of T cell Responses Induced by a Heterologous H5 Booster Vaccination. J Infect Dis. 2016 Oct.  Abstract  
submitted by kickingbird at May, 14, 2017 from J Infect Dis. 2016 Oct (via https://www.ncbi.nlm.nih.gov/pubmed/27443611)
BACKGROUND: Influenza A(H5N1) virus and other avian influenza virus strains represent major pandemic threats. Like all influenza A virus strains, A(H5N1) viruses evolve rapidly. Innovative immunization ...

HIROSE R, Nakaya T, Naito Y, Daidoji T, et al.. Mechanism of human influenza virus RNA persistence and virion survival in feces: mucus protects virions from acid and digestive juices. J Infect Dis. 2017 May 11.  Abstract  
submitted by kickingbird at May, 14, 2017 from J Infect Dis. 2017 May 11 (via https://www.ncbi.nlm.nih.gov/pubmed/28498998)
Although viral RNA or infectious virions have been detected in the feces of individuals infected with human influenza A/B virus (IAV/IBV), the mechanism of viral survival in the gastrointestinal tract ...

Zhu W, Zhou J, Li Z, Yang L, Li X, Huang W, Zou S,. Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017. Euro Surveill. 2017;22(19):pii=30533..  Abstract  
submitted by kickingbird at May, 12, 2017 from Euro Surveill. 2017;22(19):pii=30533. (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 ...

José Carlos Mancera Gracia, etc.,al. A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine. Scientific Reports 7, Article number: 1323 (2017).  Abstract  
submitted by kickingbird at May, 4, 2017 from Scientific Reports 7, Article number: 1323 (2017) (via http://www.nature.com/articles/s41598-017-01512-x)
Avian H9N2 and 2009 pandemic H1N1 (pH1N1) influenza viruses can infect pigs and humans, raising the concern that H9N2:pH1N1 reassortant viruses could emerge. Such reassortants demonstrated increased replication ...

Nakatsukasa A, Kuruma K, Okamatsu M, Hiono T, et a. Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice. Vaccine 2017 Apr 18..  Abstract  
submitted by kickingbird at May, 4, 2017 from Vaccine 2017 Apr 18. (via https://www.ncbi.nlm.nih.gov/m/pubmed/28446669/)
Transdermal vaccination using a microneedle (MN) confers enhanced immunity compared with subcutaneous (SC) vaccination. Here we developed a novel dissolving MN patch for the influenza vaccine. The potencies ...

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