Diefenbacher M, Sun J, Brooke CB. The parts are greater than the whole: the role of semi-infectious particles in influenza A virus biology. Curr Opin Virol. 2018 Jul 24;33:42-46. Abstract
submitted by kickingbird at Aug, 2, 2018 from Curr Opin Virol. 2018 Jul 24;33:42-46 (via https://www.ncbi.nlm.nih.gov/pubmed/30053722)
The influenza A virus (IAV) genome is incorporated into newly produced virions through a tightly orchestrated process that is one of the best studied examples of genome packaging by a segmented virus. ... Guo Z, Wilson JR, York IA, Stevens J. Biosensor-based epitope mapping of antibodies targeting the hemagglutinin and neuraminidase of influenza A virus. J Immunol Methods. 2018 Jul 24. pii: S0022-1759(17. Abstract
submitted by kickingbird at Aug, 2, 2018 from J Immunol Methods. 2018 Jul 24. pii: S0022-1759(17 (via https://www.ncbi.nlm.nih.gov/pubmed/30053389)
Characterization of the epitopes on antigen recognized by monoclonal antibodies (mAb) is useful for the development of therapeutic antibodies, diagnostic tools, and vaccines. Epitope mapping also provides ... Yogaratnam J, etc.,al. Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study. J Infect Dis. 2018 Jul 26.. Abstract
submitted by kickingbird at Aug, 2, 2018 from J Infect Dis. 2018 Jul 26. (via https://www.ncbi.nlm.nih.gov/pubmed/30053042)
Background: AL-794 is an orally active prodrug of ALS-033719, which selectively inhibits the endonuclease domain of influenza virus A and B polymerase.Methods: In a phase 1, double-blinded, randomized, ... Jasmina M. Luczo, etc.,al. Evolution of high pathogenicity of H5 avian influenza virus: haemagglutinin cleavage site selection of reverse-genetics mutants during passage in chickens. Scientific Reports volume 8, Article number: 1151. Abstract
submitted by kickingbird at Aug, 2, 2018 from Scientific Reports volume 8, Article number: 1151 (via https://www.nature.com/articles/s41598-018-29944-z)
Low pathogenicity avian influenza viruses (LPAIVs) are generally asymptomatic in their natural avian hosts. LPAIVs can evolve into highly pathogenic forms, which can affect avian and human populations ... Kumar A, etc.,al. MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2. J Virol. 2018 Jul 25. Abstract
submitted by kickingbird at Jul, 29, 2018 from J Virol. 2018 Jul 25 (via https://www.ncbi.nlm.nih.gov/pubmed/30045983)
MicroRNAs (miRNAs) are small non-coding RNAs that are crucial post-transcriptional regulator for host mRNAs. Recent studies indicate that miRNAs may modulate host response during RNA viruses infection. ... Nachbagauer R, Krammer F, Albrecht RA. A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study. Vaccines (Basel). 2018 Jul 25;6(3).. Abstract
submitted by kickingbird at Jul, 29, 2018 from Vaccines (Basel). 2018 Jul 25;6(3). (via https://www.ncbi.nlm.nih.gov/pubmed/30044403)
Influenza viruses cause severe diseases and mortality in humans on an annual basis. The current influenza virus vaccines can confer protection when they are well-matched with the circulating strains. However, ... Patel U, etc.,al. Susceptibility of influenza viruses to hypothiocyanite and hypoiodite produced by lactoperoxidase in a cell-free system. PLoS One. 2018 Jul 25;13(7):e0199167.. Abstract
submitted by kickingbird at Jul, 29, 2018 from PLoS One. 2018 Jul 25;13(7):e0199167. (via https://www.ncbi.nlm.nih.gov/pubmed/30044776)
Lactoperoxidase (LPO) is an enzyme found in several exocrine secretions including the airway surface liquid producing antimicrobial substances from mainly halide and pseudohalide substrates. Although the ... Oishi K, Yamayoshi S, Kozuka-Hata H, Oyama M. N-Terminal Acetylation by NatB Is Required for the Shutoff Activity of Influenza A Virus PA-X. Cell Rep. 2018 Jul 24;24(4):851-860. Abstract
submitted by kickingbird at Jul, 29, 2018 from Cell Rep. 2018 Jul 24;24(4):851-860 (via https://www.ncbi.nlm.nih.gov/pubmed/30044982)
N-terminal acetylation is a major posttranslational modification in eukaryotes catalyzed by N-terminal acetyltransferases (NATs), NatA through NatF. Although N-terminal acetylation modulates diverse protein ... Yip TF, Selim ASM, Lian I, Lee SM.. Advancements in Host-Based Interventions for Influenza Treatment. Front Immunol. 2018 Jul 10;9:1547.. Abstract
submitted by kickingbird at Jul, 29, 2018 from Front Immunol. 2018 Jul 10;9:1547. (via https://www.ncbi.nlm.nih.gov/pubmed/30042762)
Influenza is a major acute respiratory infection that causes mortality and morbidity worldwide. Two classes of conventional antivirals, M2 ion channel blockers and neuraminidase inhibitors, are mainstays ... Smith AP, Moquin DJ, Bernhauerova V, Smith AM.. Influenza Virus Infection Model With Density Dependence Supports Biphasic Viral Decay. Front Microbiol. 2018 Jul 10;9:1554.. Abstract
submitted by kickingbird at Jul, 29, 2018 from Front Microbiol. 2018 Jul 10;9:1554. (via https://www.ncbi.nlm.nih.gov/pubmed/30042759)
Mathematical models that describe infection kinetics help elucidate the time scales, effectiveness, and mechanisms underlying viral growth and infection resolution. For influenza A virus (IAV) infections, ... Chan MC, etc.,al. First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome. J Formos Med Assoc. 2018 Jul 3.. Abstract
submitted by kickingbird at Jul, 29, 2018 from J Formos Med Assoc. 2018 Jul 3. (via https://www.ncbi.nlm.nih.gov/pubmed/30041997)
BACKGROUNDS: Severe influenza infection causes substantial morbidity and mortality worldwide and remains an important threat to global health. This study addressed factors related to treatment outcomes ... Kühnl A, etc.,al. Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus. MBio. 2018 Jul 24;9(4). pii: e01345-18.. Abstract
submitted by kickingbird at Jul, 29, 2018 from MBio. 2018 Jul 24;9(4). pii: e01345-18. (via https://www.ncbi.nlm.nih.gov/pubmed/30042202)
To transfer the viral genome into the host cell cytoplasm, internalized influenza A virus (IAV) particles depend on the fusion of the IAV envelope with host endosomal membranes. The antiviral host interferon ... Qin J, Zhang Y, Shen X, Gong L, Peng O, Liu Y. H7 virus-like particles assembled by hemagglutinin containing H3N2 transmembrane domain and M1 induce broad homologous and heterologous protection in mice. Vaccine. 2018 Aug 9;36(33):5030-5036.. Abstract
submitted by kickingbird at Jul, 29, 2018 from Vaccine. 2018 Aug 9;36(33):5030-5036. (via https://www.ncbi.nlm.nih.gov/pubmed/30037418)
Influenza A H7N9 virus has caused five outbreak waves of human infections in China since 2013 and posed a dual challenge to public health and poultry industry. There is an urgent need to develop an effective ... Jang J, Bae SE. Comparative Co-Evolution Analysis Between the HA and NA Genes of Influenza A Virus. Virology (Auckl). 2018 Jul 19;9:1178122X18788328.. Abstract
submitted by kickingbird at Jul, 29, 2018 from Virology (Auckl). 2018 Jul 19;9:1178122X18788328. (via https://www.ncbi.nlm.nih.gov/pubmed/30038490)
Influenza A virus subtypes are determined based on envelope proteins encoded by the hemagglutinin (HA) gene and the neuraminidase (NA) gene, which are involved in attachment to the host, pathogenicity, ... Melnichuk N, etc.,al. Complexes of Oligoribonucleotides with d-Mannitol Modulate the Innate Immune Response to Influenza A Virus H1N1 (A/FM/1/47) In Vivo. Pharmaceuticals (Basel). 2018 Jul 22;11(3).. Abstract
submitted by kickingbird at Jul, 29, 2018 from Pharmaceuticals (Basel). 2018 Jul 22;11(3). (via https://www.ncbi.nlm.nih.gov/pubmed/30037133)
Rapid replication of the influenza A virus and lung tissue damage caused by exaggerated pro-inflammatory host immune responses lead to numerous deaths. Therefore, novel therapeutic agents that have anti-influenza ... Correia V, Abecasis AB, Rebelo-de-Andrade H. Molecular footprints of selective pressure in the neuraminidase gene of currently circulating human influenza subtypes and lineages. Virology 2018;522:122-130. Abstract
submitted by kickingbird at Jul, 29, 2018 from Virology 2018;522:122-130 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30029011/)
Influenza neuraminidase (NA) is under selective pressure (SP) of both host immune system and drug use. Here, we assembled large datasets of NA sequences of worldwide circulating viruses to estimate the ... Davis AKF, McCormick K, Gumina ME, Petrie JG, et a. Sera from individuals with narrowly focused influenza virus antibodies rapidly select viral escape mutations in ovo. J Virol 2018 Jul 25. Abstract
submitted by kickingbird at Jul, 29, 2018 from J Virol 2018 Jul 25 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30045982/)
Influenza viruses use distinct antibody escape mechanisms depending on the overall complexity of the antibody response that is encountered. When grown in the presence of a hemagglutinin (HA) monoclonal ... Li L, Bowman AS, DeLiberto TJ, Killian ML, et al. Genetic evidence supports sporadic and independent introductions of subtype H5 low pathogenic avian influenza A viruses from wild birds to domestic poultry in North America. J Virol 2018 Jul 25. Abstract
submitted by kickingbird at Jul, 29, 2018 from J Virol 2018 Jul 25 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30045988/)
Wild bird-origin influenza A viruses (IAVs or avian influenza) have led to sporadic outbreaks among domestic poultry in the United States (US) and Canada, resulting in economic losses through the implementation ... Broecker F, Liu STH, Sun W, Krammer F, et al.. Immunodominance of Antigenic Site B in the Hemagglutinin of the Current H3N2 Influenza Virus in Humans and Mice. J Virol 2018 Jul 25.. Abstract
submitted by kickingbird at Jul, 29, 2018 from J Virol 2018 Jul 25. (via https://www.ncbi.nlm.nih.gov/m/pubmed/30045991/)
The hemagglutinin protein of H3N2 influenza viruses is the major target of neutralizing antibodies induced by infection and vaccination. However, the virus frequently escapes antibody-mediated neutralization ... Maegawa K, Shibata T, Yamaguchi R, Hiroike K, et a. Overexpression of a virus-like particle influenza vaccine in Eri silkworm pupae, using Autographa californica nuclear polyhedrosis virus and host-range expansion. Arch Virol 2018 Jul 19. Abstract
submitted by kickingbird at Jul, 29, 2018 from Arch Virol 2018 Jul 19 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30027487/)
Ecological investigations of silkworms have revealed that Eri silkworms (Samia cynthia ricini) possess useful morphological and ecological characteristics for virus-like particle (VLP) production, namely ... 5165 items, 20/Page, Page[136/259][|<<] [|<] [131] [132] [133] [134] [135] [136] [137] [138] [139] [140] [>|] [>>|] |
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