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2024-3-28 20:19:41
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Lyons DM, Lauring AS. Mutation and Epistasis in Influenza Virus Evolution. Viruses. 2018 Aug 3;10(8)..  Abstract  
submitted by kickingbird at Aug, 11, 2018 from Viruses. 2018 Aug 3;10(8). (via https://www.ncbi.nlm.nih.gov/pubmed/30081492)
Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. ...

Liu J, Ren Z, Wang H, Zhao Y, Wilker PR, Yu Z. Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses. Int Immunopharmacol. 2018 Aug 3;63:119-128..  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Int Immunopharmacol. 2018 Aug 3;63:119-128. (via https://www.ncbi.nlm.nih.gov/pubmed/30081250)
Influenza viruses cause significant morbidity and mortality and pose a substantial threat to public health. Vaccination represents the principle means of preventing influenza virus infection. Current vaccine ...

Chen TH, Liu WC, Lin CY, Liu CC, Jan JT, Spearman. Glycan-masking hemagglutinin antigens from stable CHO cell clones for H5N1 avian influenza vaccine development. Biotechnol Bioeng. 2018 Aug 6..  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Biotechnol Bioeng. 2018 Aug 6. (via https://www.ncbi.nlm.nih.gov/pubmed/30080931)
Refocusing of B cell responses can be achieved by preserving the overall fold of the antigen structure but selectively mutating the undesired antigenic sites with additional N-linked glycosylation motifs ...

Ruan BY, Wen F, Gong XQ, Liu XM, Wang Q, Yu L. Protective efficacy of a high-growth reassortant H1N1 influenza virus vaccine against the European Avian-like H1N1 swine influenza virus in mice and pigs. Vet Microbiol. 2018 Aug;222:75-84..  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Vet Microbiol. 2018 Aug;222:75-84. (via https://www.ncbi.nlm.nih.gov/pubmed/30080677)
Swine influenza A viruses (SIVs) causing outbreaks of acute, highly contagious respiratory disease in pigs also pose a potential threat to public health. European avian-like H1N1 (EA H1N1) SIVs are the ...

Li X, Liu B, Ma S, Cui P, Liu W, Li Y, Guo J, Chen. High frequency of reassortment after co-infection of chickens with the H4N6 and H9N2 influenza A viruses and the biological characteristics of the reassortants. Vet Microbiol. 2018 Aug;222:11-17.  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Vet Microbiol. 2018 Aug;222:11-17 (via https://www.ncbi.nlm.nih.gov/pubmed/30080665)
H4 and H9 avian influenza viruses (AIVs) are two of the most prevalent influenza viruses worldwide. The co-existence of H4 and H9 viruses in multiple avian species provides an opportunity for the generation ...

Cooper GE, Ostridge K, Khakoo SI, Wilkinson T. Human CD49a+ Lung Natural Killer Cell Cytotoxicity in Response to Influenza A Virus. Front Immunol. 2018 Jul 20;9:1671..  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Front Immunol. 2018 Jul 20;9:1671. (via https://www.ncbi.nlm.nih.gov/pubmed/30079068)
Influenza A virus (IAV) is a major global public health burden due to its routine evasion of immunization strategies. Natural killer (NK) cells are innate cytotoxic cells with important antiviral activity ...

Dou D, Revol R, ?stbye H, Wang H, Daniels R. Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement. Front Immunol. 2018 Jul 20;9:1581.  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Front Immunol. 2018 Jul 20;9:1581 (via https://www.ncbi.nlm.nih.gov/pubmed/30079062)
Influenza viruses replicate within the nucleus of the host cell. This uncommon RNA virus trait provides influenza with the advantage of access to the nuclear machinery during replication. However, it also ...

Lubna NJ, Nakamura Y, Hagiwara-Nagasawa M. Electropharmacological characterization of microminipigs as a laboratory animal using anti-influenza virus drug oseltamivir. J Toxicol Sci. 2018;43(8):507-512.  Abstract  
submitted by kickingbird at Aug, 8, 2018 from J Toxicol Sci. 2018;43(8):507-512 (via https://www.ncbi.nlm.nih.gov/pubmed/30078836)
We analyzed electropharmacological characteristics of microminipigs under halothane-anesthesia using anti-influenza virus drug oseltamivir, which has been known to possess multi-channel blocking properties, ...

Xu J, Li S, Wang X, Liu J, Shan P, Zhou Y. Systemic and mucosal humoral immune responses induced by the JY-adjuvanted nasal spray H7N9 vaccine in mice. Emerg Microbes Infect. 2018 Aug 3;7(1):140.  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Emerg Microbes Infect. 2018 Aug 3;7(1):140 (via https://www.ncbi.nlm.nih.gov/pubmed/30076293)
Since the first case of human avian influenza A (H7N9) virus infection in 2013, five H7N9 epidemics have occurred in China, all of which caused severe diseases, including pneumonia and acute respiratory ...

Suttie A, etc.,al. Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets. Virology. 2018 Jul 31;523:22-26.  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Virology. 2018 Jul 31;523:22-26 (via https://www.ncbi.nlm.nih.gov/pubmed/30075357)
Live bird market surveillance for avian influenza viruses in Cambodia in 2015 has led to the detection of two 7:1 reassortant influenza A(H5N1) clade 2.3.2.1c viruses. These reassortant strains, designated ...

Yamasaki M, Okada T, Sumimoto Y, Hattori N. Influenza infection presenting with pulmonary congestion: influenza myocarditis. Respirol Case Rep. 2018 Jul 30;6(7):e00352.  Abstract  
submitted by kickingbird at Aug, 8, 2018 from Respirol Case Rep. 2018 Jul 30;6(7):e00352 (via https://www.ncbi.nlm.nih.gov/pubmed/30073086)
Influenza myocarditis is a rare but life-threatening complication of influenza infection. Pneumonitis is a well-known complication of influenza infection, and chest computed tomography (CT) is useful for ...

Agustiningsih A, Trimarsanto H, etc.,al. Evolutionary study and phylodynamic pattern of human influenza A/H3N2 virus in Indonesia from 2008 to 2010. PLoS One. 2018 Aug 1;13(8):e0201427..  Abstract  
submitted by kickingbird at Aug, 5, 2018 from PLoS One. 2018 Aug 1;13(8):e0201427. (via https://www.ncbi.nlm.nih.gov/pubmed/30067808)
Influenza viruses are by nature unstable with high levels of mutations. The sequential accumulation of mutations in the surface glycoproteins allows the virus to evade the neutralizing antibodies. The ...

Moheimani F, etc.,al. Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics. Respir Res. 2018 Aug 2;19(1):145..  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Respir Res. 2018 Aug 2;19(1):145. (via https://www.ncbi.nlm.nih.gov/pubmed/30068332)
BACKGROUND: Specific microRNAs (miRNAs) play essential roles in airway remodeling in asthma. Infection with influenza A virus (IAV) may also magnify pre-existing airway remodeling leading to asthma exacerbation. ...

Kim YJ, etc.,al. Complement C3 Plays a Key Role in Inducing Humoral and Cellular Immune Responses to Influenza Virus Strain Specific HA or Cross Protective M2e vaccination. J Virol. 2018 Aug 1. pii: JVI.00969-18..  Abstract  
submitted by kickingbird at Aug, 5, 2018 from J Virol. 2018 Aug 1. pii: JVI.00969-18. (via https://www.ncbi.nlm.nih.gov/pubmed/30068650)
The complement pathway is involved in eliminating antigen immune complexes. However, the role of the C3 complement system remains largely unknown in influenza virus M2 extracellular (M2e) domain or hemagglutinin ...

Mehta K, Goneau LW, Wong J, L´Huillier AG. Zoonotic Influenza and Human Health-Part 2: Clinical Features, Diagnosis, Treatment, and Prevention Strategies. Curr Infect Dis Rep. 2018 Aug 1;20(10):38.  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Curr Infect Dis Rep. 2018 Aug 1;20(10):38 (via https://www.ncbi.nlm.nih.gov/pubmed/30069787)
PURPOSE OF REVIEW: Zoonotic influenza viruses are those influenza viruses that cross the animal-human barrier and can cause disease in humans, manifesting from minor respiratory illnesses to multiorgan ...

Goneau LW, Mehta K, Wong J, L´Huillier AG. Zoonotic Influenza and Human Health-Part 1: Virology and Epidemiology of Zoonotic Influenzas. Curr Infect Dis Rep. 2018 Aug 1;20(10):37..  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Curr Infect Dis Rep. 2018 Aug 1;20(10):37. (via https://ww.ncbi.nlm.nih.gov/pubmed/30069735)
PURPOSE OF REVIEW: Zoonotic influenza viruses are those that cross the animal-human barrier and can cause disease in humans, manifesting from minor respiratory illnesses to multiorgan dysfunction. They ...

Lin YJ, Shih YJ, Chen CH, Fang CT. Aluminum salts as an adjuvant for pre-pandemic influenza vaccines: a meta-analysis. Sci Rep. 2018 Jul 30;8(1):11460..  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Sci Rep. 2018 Jul 30;8(1):11460. (via https://www.ncbi.nlm.nih.gov/pubmed/30061656)
Avian-origin H5/H7 influenza has the potential to cause the next influenza pandemic. Availability of effective vaccines is an essential part of pre-pandemic preparedness. However, avian influenza surface ...

Elliott S, Keaton AA, Chu JD, Reed CC, Garman. A Synthetic Micro-Consensus DNA Vaccine Generates Comprehensive Influenza-A H3N2 Immunity and Protects Mice Against Lethal Challenge by Multiple H3N2 Viruses. Hum Gene Ther. 2018 Jul 31.  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Hum Gene Ther. 2018 Jul 31 (via https://www.ncbi.nlm.nih.gov/pubmed/30062926)
Influenza-A H3N2 viruses circulate globally, leading to substantial morbidity and mortality. Commercially-available, antigen-matched influenza vaccines must be updated frequently to match dynamic sequence ...

Wang J, Liu M, Ding N, Li Y, Shao J, Zhu M. Vaccine based on antibody-dependent cell-mediated cytotoxicity epitope on the H1N1 influenza virus increases mortality in vaccinated mice. Biochem Biophys Res Commun. 2018 Jul 28..  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Biochem Biophys Res Commun. 2018 Jul 28. (via https://www.ncbi.nlm.nih.gov/pubmed/30064910)
Antibody-dependent cell-mediated cytotoxicity bridges humoral immunity and cellular immunity. Thus vaccine candidates which can elicit both broadly neutralizing antibodies and potent antibody-dependent ...

Deng L, Chang TZ, Wang Y, Li S, Wang S, Matsu. Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice. PNAS 2018 Jul 31. pii: 201805713.  Abstract  
submitted by kickingbird at Aug, 5, 2018 from PNAS 2018 Jul 31. pii: 201805713 (via https://www.ncbi.nlm.nih.gov/pubmed/30065113)
Influenza is a persistent threat to public health. Here we report that double-layered peptide nanoparticles induced robust specific immunity and protected mice against heterosubtypic influenza A virus ...

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