Zhuang J, Zang N, Ye C, Xu F. Lethal Avian Influenza A (H5N1) Virus Replicates in Pontomedullary Chemosensitive Neurons and Depresses Hypercapnic Ventilatory Response in Mice. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 10. Abstract
submitted by kickingbird at Jan, 14, 2019 from Am J Physiol Lung Cell Mol Physiol. 2019 Jan 10 (via https://www.ncbi.nlm.nih.gov/pubmed/30628490)
The highly pathogenic H5N1 (HK483) viral infection causes a depressed hypercapnic ventilatory response (dHCVR, 20%↓) at 2 days post-infection (dpi) and death at 7 dpi in mice, but the relevant mechanisms ... Lomakina NF, et al. Three Mutations in the Stalk Region of Hemagglutinin Affect the pH of Fusion and Pathogenicity of H5N1 Influenza Virus. Mol Biol (Mosk). 2018 Nov-Dec;52(6):1029-1037. Abstract
submitted by kickingbird at Jan, 14, 2019 from Mol Biol (Mosk). 2018 Nov-Dec;52(6):1029-1037 (via https://www.ncbi.nlm.nih.gov/pubmed/30633245)
Previously, an attenuated variant Ku/at was obtained from the highly pathogenic avian influenza virus A/chicken/Kurgan/3/2005 (H5N1) by a reverse selection method aimed at increasing the virus resistance ... Lam JH, Baumgarth N. The Multifaceted B Cell Response to Influenza Virus. J Immunol. 2019 Jan 15;202(2):351-359. Abstract
submitted by kickingbird at Jan, 9, 2019 from J Immunol. 2019 Jan 15;202(2):351-359 (via https://www.ncbi.nlm.nih.gov/pubmed/30617116)
Protection from yearly recurring, highly acute infections with a pathogen that rapidly and continuously evades previously induced protective neutralizing Abs, as seen during seasonal influenza virus infections, ... Kuroki T, Osari S, Nagata K, Kawaguchi A. Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes. Front Microbiol. 2018 Dec 14;9:3120.. Abstract
submitted by kickingbird at Jan, 9, 2019 from Front Microbiol. 2018 Dec 14;9:3120. (via https://www.ncbi.nlm.nih.gov/pubmed/30619194)
Autophagy is an essential process for cellular metabolism and homeostasis, but also functions as one of innate immune responses against pathogen infection. However, in contrast to cellular metabolism and ... Dadak M, et al. Varying Patterns of CNS Imaging in Influenza A Encephalopathy in Childhood. Clin Neuroradiol. 2019 Jan 4. Abstract
submitted by kickingbird at Jan, 7, 2019 from Clin Neuroradiol. 2019 Jan 4 (via https://www.ncbi.nlm.nih.gov/pubmed/30610262)
PURPOSE: The brain imaging findings in children with neurological complications associated with influenza A infections are presented and analyzed and pathological imaging changes including atypical intracerebral ... Saito S, et al. Development and evaluation of a new real-time RT-PCR assay for detecting the latest H9N2 influenza viruses capable of causing human infection. Microbiol Immunol. 2019 Jan 1.. Abstract
submitted by kickingbird at Jan, 4, 2019 from Microbiol Immunol. 2019 Jan 1. (via https://www.ncbi.nlm.nih.gov/pubmed/30599081)
The H9N2 subtype of avian influenza A viruses (AIVs) has spread among domestic poultry and wild bird worldwide. H9N2 AIV is sporadically transmitted to humans from avian species. A total of 42 laboratory-confirmed ... Zhou X, Yin R, Kwoh CK, Zheng J. A context-free encoding scheme of protein sequences for predicting antigenicity of diverse influenza A viruses. BMC Genomics. 2018 Dec 31;19. Abstract
submitted by kickingbird at Jan, 4, 2019 from BMC Genomics. 2018 Dec 31;19 (via https://www.ncbi.nlm.nih.gov/pubmed/30598102)
BACKGROUND: The evolution of influenza A viruses leads to the antigenic changes. Serological diagnosis of the antigenicity is usually labor-intensive, time-consuming and not suitable for early-stage detection. ... Peng Q, et al. Impact of the variations in potential glycosylation sites of the hemagglutinin of H9N2 influenza virus. Virus Genes. 2018 Dec 29.. Abstract
submitted by kickingbird at Jan, 1, 2019 from Virus Genes. 2018 Dec 29. (via https://www.ncbi.nlm.nih.gov/pubmed/30594968)
Variations in the potential glycosylation sites were observed in hemagglutinin (HA) sequences of H9N2 avian influenza virus isolated in China, deposited in the Influenza Virus Resource of NCBI before 2017, ... Li Z, et al. A novel linear epitope crossing Group 1 and Group 2 influenza A viruses located in the helix A of HA2 derived from H7N9. Vet Microbiol. 2019 Jan;228:39-44.. Abstract
submitted by kickingbird at Dec, 30, 2018 from Vet Microbiol. 2019 Jan;228:39-44. (via https://www.ncbi.nlm.nih.gov/pubmed/30593378)
In this research, four monoclonal antibodies (mAbs) were first generated as an immunogen by using the GST fusion protein that carries the fusion peptide and helix A derived from H7N9 influenza A virus ... Wang Z, et al. Pre-exposure with influenza A virus A/WSN/1933(H1N1) resulted in viral shedding reduction from pigs challenged with either swine H1N1 or H3N2 virus. Vet Microbiol. 2019 Jan;228:26-31. Abstract
submitted by kickingbird at Dec, 30, 2018 from Vet Microbiol. 2019 Jan;228:26-31 (via https://www.ncbi.nlm.nih.gov/pubmed/30593376)
There is an urgent need to develop a broad-spectrum vaccine that can effectively prevent or eliminate the spread of co-circulating swine influenza virus strains in multiple lineages or subtypes. We describe ... An SH, Lee CY, Choi JG, Lee YJ, Kim JH, Kwon HJ. Generation of highly productive and mammalian nonpathogenic recombinant H9N2 avian influenza viruses by optimization of 3´end promoter and NS genome. Vet Microbiol. 2019 Jan;228:213-218.. Abstract
submitted by kickingbird at Dec, 30, 2018 from Vet Microbiol. 2019 Jan;228:213-218. (via https://www.ncbi.nlm.nih.gov/pubmed/30593370)
We developed A/PR/8/34 (PR8) virus-based reverse genetics system in which six internal genes of PR8 and attenuated hemagglutinin and intact neuraminidase genes of field avian influenza viruses (AIVs) have ... Fleming-Canepa X, et al. Duck innate immune responses to high and low pathogenicity H5 avian influenza viruses. Vet Microbiol. 2019 Jan;228:101-111. Abstract
submitted by kickingbird at Dec, 30, 2018 from Vet Microbiol. 2019 Jan;228:101-111 (via https://www.ncbi.nlm.nih.gov/pubmed/30593354)
Ducks are the reservoir host of influenza A viruses, and are permissive for replication of most strains, yet can elicit robust innate immune responses to highly pathogenic strains. Tissue tropism and viral ... Yu Z, He H, Cheng K, Wu J, Gao Y, Chen W, et al. Genetic characterization of an H13N2 low pathogenic avian influenza virus isolated from gulls in China. Transbound Emerg Dis. 2018 Dec 22.. Abstract
submitted by kickingbird at Dec, 25, 2018 from Transbound Emerg Dis. 2018 Dec 22. (via https://www.ncbi.nlm.nih.gov/pubmed/30578616)
Low pathogenic avian influenza viruses circulate in wild birds but are occasionally transmitted to other species, including poultry, mammals, and humans. To date, infections with low pathogenic avian influenza ... Rahim MN, Klewes L, Zahedi-Amiri A, et al. Global Interactomics Connect Nuclear Mitotic Apparatus Protein NUMA1 to Influenza Virus Maturation. Viruses. 2018 Dec 19;10(12). Abstract
submitted by kickingbird at Dec, 24, 2018 from Viruses. 2018 Dec 19;10(12) (via https://www.ncbi.nlm.nih.gov/pubmed/30572664)
Influenza A virus (IAV) infections remain a major human health threat. IAV has enormous genetic plasticity and can rapidly escape virus-targeted anti-viral strategies. Thus, there is increasing interest ... Skibinski DAG, et al. Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine. Sci Rep. 2018 Dec 20;8(1):18007. Abstract
submitted by kickingbird at Dec, 24, 2018 from Sci Rep. 2018 Dec 20;8(1):18007 (via https://www.ncbi.nlm.nih.gov/pubmed/30573748)
Cell mediated immunity plays a vital role in defense against influenza infection in humans. Less is known about the role of vaccine-induced cell mediated immunity and the cytokine responses elicited. We ... Hong BT, Cheng YE, Cheng TJ, Fang JM. Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity. Eur J Med Chem. 2018 Dec 13;163:710-721. Abstract
submitted by kickingbird at Dec, 24, 2018 from Eur J Med Chem. 2018 Dec 13;163:710-721 (via https://www.ncbi.nlm.nih.gov/pubmed/30576902)
Tamiflu readily undergoes endogenous hydrolysis to give oseltamivir carboxylic acid (OC) as the active anti-influenza agent to inhibit the viral neuraminidase (NA). GOC is derived from OC by replacing ... Sealy JE, Yaqub T, Peacock TP, Chang P, et al. Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential. Emerg Infect Dis. 2019 Jan;25(1):63-72. Abstract
submitted by kickingbird at Dec, 23, 2018 from Emerg Infect Dis. 2019 Jan;25(1):63-72 (via https://wwwnc.cdc.gov/eid/article/25/1/18-0616_article)
We characterized 55 influenza A(H9N2) viruses isolated in Pakistan during 2014-2016 and found that the hemagglutinin gene is of the G1 lineage and that internal genes have differentiated into a variety ... Chen H, Alvarez JJS, Ng SH, Nielsen R, Zhai W. Passage adaptation correlates with the reduced efficacy of the influenza vaccine. Clin Infect Dis. 2018 Dec 18.. Abstract
submitted by kickingbird at Dec, 23, 2018 from Clin Infect Dis. 2018 Dec 18. (via https://www.ncbi.nlm.nih.gov/pubmed/30561532)
Background: As a dominant seasonal influenza virus, H3N2 virus rapidly evolves in human and is a constant threat to public health. Despite sustained research efforts, the efficacy of H3N2 vaccine has decreased ... Zhang J, Su R, Jian X, An H, Jiang R, Mok CKP. The D253N Mutation in the Polymerase Basic 2 Gene in Avian Influenza (H9N2) Virus Contributes to the Pathogenesis of the Virus in Mammalian Hosts. Virol Sin. 2018 Dec 19.. Abstract
submitted by kickingbird at Dec, 23, 2018 from Virol Sin. 2018 Dec 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30569291)
Mutations in the polymerase basic 2 (PB2) gene of avian influenza viruses are important signatures for their adaptation to mammalian hosts. Various adaptive mutations have been identified around the 627 ... Rojas-Quintero J, et al. Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection. JCI Insight. 2018 Dec 20;3(24).. Abstract
submitted by kickingbird at Dec, 23, 2018 from JCI Insight. 2018 Dec 20;3(24). (via https://www.ncbi.nlm.nih.gov/pubmed/30568032)
Matrix metalloproteinase-9 (MMP-9) cleaves various proteins to regulate inflammatory and injury responses. However, MMP-9's activities during influenza A viral (IAV) infections are incompletely understood. ... 5328 items, 20/Page, Page[124/267][|<<] [|<] [121] [122] [123] [124] [125] [126] [127] [128] [129] [130] [>|] [>>|] |
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