Chaimayo C, et al. Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity. PLoS Pathog. 2018 Nov 29;14(11):e1007465. Abstract
submitted by kickingbird at Dec, 4, 2018 from PLoS Pathog. 2018 Nov 29;14(11):e1007465 (via https://www.ncbi.nlm.nih.gov/pubmed/30496325)
Influenza A viruses modulate host antiviral responses to promote viral growth and pathogenicity. Through viral PA-X and NS1 proteins, the virus is capable of suppressing host protein synthesis, termed ...
Oladipo EK, Oloke JK, Adeniji JA. Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria. Open Vet J. 2018;8(3):347-350.. Abstract
submitted by kickingbird at Dec, 4, 2018 from Open Vet J. 2018;8(3):347-350. (via https://www.ncbi.nlm.nih.gov/pubmed/30483460)
Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic ...
Imai K, et al. Whole Genome Sequencing of Influenza A and B Viruses With the MinION Sequencer in the Clinical Setting: A Pilot Study. Front Microbiol. 2018 Nov 13;9:2748.. Abstract
submitted by kickingbird at Dec, 4, 2018 from Front Microbiol. 2018 Nov 13;9:2748. (via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243006/)
Introduction: Whole genome sequencing (WGS) of influenza viruses is important for preparing vaccines and coping with newly emerging viruses. However, WGS is difficult to perform using conventional next-generation ...
Rimondi A, et al. Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006-2016). Emerg Microbes Infect. 2018 Nov 28;7(1):194. Abstract
submitted by kickingbird at Dec, 4, 2018 from Emerg Microbes Infect. 2018 Nov 28;7(1):194 (via https://www.ncbi.nlm.nih.gov/pubmed/30482896)
Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n?=?6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza ...
Golovko AO, et al. Aggregation of Influenza A Virus Nuclear Export Protein. Biochemistry (Mosc). 2018 Nov;83. Abstract
submitted by kickingbird at Dec, 4, 2018 from Biochemistry (Mosc). 2018 Nov;83 (via https://www.ncbi.nlm.nih.gov/pubmed/30482152)
Influenza A virus nuclear export protein (NEP) plays an important role in the viral life cycle. Recombinant NEP proteins containing (His)6-tag at either N- or C-terminus were obtained by heterologous expression ...
Ozawa M, et al. Phylogenetic variations of highly pathogenic H5N6 avian influenza viruses isolated from wild birds in the Izumi plain, Japan during the 2016/17 winter season. Transbound Emerg Dis. 2018 Nov 30. Abstract
submitted by kickingbird at Dec, 4, 2018 from Transbound Emerg Dis. 2018 Nov 30 (via https://www.ncbi.nlm.nih.gov/pubmed/30499632)
During the 2016/2017 winter season, we isolated 33 highly pathogenic avian influenza viruses (HPAIVs) of H5N6 subtype and three low pathogenic avian influenza viruses (LPAIVs) from debilitated or dead ...
Huang KA, et al. Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans. Nat Microbiol. 2018 Nov 26.. Abstract
submitted by kickingbird at Nov, 30, 2018 from Nat Microbiol. 2018 Nov 26. (via https://www.ncbi.nlm.nih.gov/pubmed/30478290)
Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive ...
Yan Z, et al. Evolutionary changes of the novel Influenza D virus hemagglutinin-esterase fusion gene revealed by the codon usage pattern. Virulence. 2018 Nov 26. Abstract
submitted by kickingbird at Nov, 27, 2018 from Virulence. 2018 Nov 26 (via https://www.ncbi.nlm.nih.gov/pubmed/30475085)
The codon usage pattern can reveal the adaptive changes that allow virus survival and fitness adaptation to their particular host, as well as the external environment. Although still considered a novel ...
Zhang J, et al. Molecular evolutionary and antigenic characteristics of newly isolated H9N2 avian influenza viruses in Guangdong province, China. Arch Virol. 2018 Nov 24.. Abstract
submitted by kickingbird at Nov, 27, 2018 from Arch Virol. 2018 Nov 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30474753)
Four new H9N2 avian influenza viruses (AIVs) were isolated from domestic birds in Guangdong between December 2015 and April 2016. Nucleotide sequence comparisons indicated that most of the internal genes ...
Abolnik C, Stutchbury S, Hartman MJ. Experimental infection of racing pigeons (Columba livia domestica) with highly pathogenic Clade 220.127.116.11 sub-group B H5N8 avian influenza virus. Vet Microbiol. 2018 Dec;227:127-132.. Abstract
submitted by kickingbird at Nov, 27, 2018 from Vet Microbiol. 2018 Dec;227:127-132. (via https://www.ncbi.nlm.nih.gov/pubmed/30473343)
Reported mass mortalities in wild pigeons and doves during the 2017/2018 Clade 18.104.22.168 HPAI H5N8 outbreaks in South Africa necessitated an investigation of healthy racing pigeons for their susceptibility ...
Wang K, et al. Serological surveillance of avian influenza virus and canine distemper virus in captive Siberian Tigers in Northeastern China. Pol J Vet Sci. 2018 Sep;21(3):491-495.. Abstract
submitted by kickingbird at Nov, 26, 2018 from Pol J Vet Sci. 2018 Sep;21(3):491-495. (via https://www.ncbi.nlm.nih.gov/pubmed/30468333)
In order to understand infection of avian influenza A virus (AIV) and canine distemper virus (CDV) in the Siberian Tiger in Northeast China, 75 Siberian Tiger serum samples from three cap- tive facilities ...
Lin HT, Chen CC, Liu PY, Wu HL, Wu TH, et al. Grail attenuates influenza A virus infection and pathogenesis by inhibiting viral nucleoprotein. Sci Rep. 2018 Nov 22;8(1):17242. Abstract
submitted by kickingbird at Nov, 26, 2018 from Sci Rep. 2018 Nov 22;8(1):17242 (via https://www.ncbi.nlm.nih.gov/pubmed/30467324)
Grail is a well-characterized mediator of metabolic disease, tumour progression, and immune response. However, its role in influenza A virus (IAV) infection remains poorly understood. In this study, we ...
Kupke SY, Riedel D, Frensing T, Zmora P, et al. A novel type of influenza A virus-derived defective interfering particle with nucleotide substitutions in its genome. J Virol. 2018 Nov 21.. Abstract
submitted by kickingbird at Nov, 26, 2018 from J Virol. 2018 Nov 21. (via https://www.ncbi.nlm.nih.gov/pubmed/30463972)
Defective interfering particles (DIPs) replicate at the expense of co-infecting, fully infectious homologous virus. Typically, they contain a highly deleted form of the viral genome. Utilizing single-cell ...
Bolte H, et al. Packaging of the influenza A virus genome is governed by a plastic network of RNA/protein interactions. J Virol. 2018 Nov 21. Abstract
submitted by kickingbird at Nov, 26, 2018 from J Virol. 2018 Nov 21 (via https://www.ncbi.nlm.nih.gov/pubmed/30463968)
The genome of influenza A virus is organized into eight ribonucleoproteins, each composed of a distinct RNA segment bound by the viral polymerase and oligomeric viral nucleoprotein. Packaging sequences ...
Arai Y, etc.,al. Genetic compatibility of reassortants between avian H5N1 and H9N2 influenza viruses with higher pathogenicity in mammals. J Virol. 2018 Nov 21. Abstract
submitted by kickingbird at Nov, 26, 2018 from J Virol. 2018 Nov 21 (via https://www.ncbi.nlm.nih.gov/pubmed/30463961)
The co-circulation of H5N1 and H9N2 avian influenza viruses in birds in Egypt provides reassortment opportunities between these two viruses. However, little is known about the emergence potential of reassortants ...
Kamiki H, et al. A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice. Viruses. 2018 Nov 19;10(11). Abstract
submitted by kickingbird at Nov, 26, 2018 from Viruses. 2018 Nov 19;10(11) (via https://www.ncbi.nlm.nih.gov/pubmed/30463209)
H9N2 avian influenza viruses are present in poultry worldwide. These viruses are considered to have pandemic potential, because recent isolates can recognize human-type receptor and several sporadic human ...
Huo C, et al. H5N1 Influenza a Virus Replicates Productively in Pancreatic Cells and Induces Apoptosis and Pro-Inflammatory Cytokine Response. Front Cell Infect Microbiol. 2018 Nov 6;8:386.. Abstract
submitted by kickingbird at Nov, 26, 2018 from Front Cell Infect Microbiol. 2018 Nov 6;8:386. (via https://www.ncbi.nlm.nih.gov/pubmed/30460207)
The inflammatory response and apoptosis have been proved to have a crucial role in the pathogenesis of the influenza A virus (IAV). Previous studies indicated that while IAV commonly causes pancreatitis ...
Alarcon P, et al. Comparison of 2016~17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe. Emerg Infect Dis. 2018 Dec;24(12):2270-2283.. Abstract
submitted by kickingbird at Nov, 22, 2018 from Emerg Infect Dis. 2018 Dec;24(12):2270-2283. (via https://www.ncbi.nlm.nih.gov/pubmed/30457528)
We analyzed the highly pathogenic avian influenza (HPAI) H5 epizootic of 2016~17 in Europe by epidemiologic and genetic characteristics and compared it with 2 previous epizootics caused by the same H5 ...
Neu KE, et al. Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination. J Clin Invest. 2018 Nov 19. Abstract
submitted by kickingbird at Nov, 22, 2018 from J Clin Invest. 2018 Nov 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30457979)
Vaccines are among the most effective public health tools for combating certain infectious diseases such as influenza. The role of the humoral immune system in vaccine-induced protection is widely appreciated; ...
Ramos-Sevillano E, et al. The Effect of Influenza Virus on the Human Oropharyngeal Microbiome. Clin Infect Dis. 2018 Nov 15.. Abstract
submitted by kickingbird at Nov, 19, 2018 from Clin Infect Dis. 2018 Nov 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30445563)
Background: Secondary bacterial infections are an important cause of morbidity and mortality associated with influenza infections. As bacterial disease can be caused by a disturbance of the host microbiome, ...
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