Yang F, Xiao Y, Liu F, Yao H, Wu N, Wu H. Development of a Monoclonal Antibody-Based Antigen Capture Enzyme-Linked Immunosorbent Assay for Detection of H7N9 Subtype Avian Influenza Virus. J Med Virol. 2020;10.1002/jmv.26292. Abstract
submitted by kickingbird at Jul, 12, 2020 from J Med Virol. 2020;10.1002/jmv.26292 (via https://pubmed.ncbi.nlm.nih.gov/32648948/)
In order to establish a rapid detection method for H7N9 avian influenza virus (AIV), monoclonal antibodies (mAbs) against hemagglutinin (HA) of H7N9 were developed to establish an antigen capture enzyme-linked ...
Guk K, Kim H, Lee M, et al.. Development of A4 Antibody for Detection of Neuraminidase I223R/H275Y-associated Antiviral Multidrug-Resistant Influenza Virus. Nat Commun. 2020;11(1):3418. Published 2020 Jul 9.. Abstract
submitted by kickingbird at Jul, 12, 2020 from Nat Commun. 2020;11(1):3418. Published 2020 Jul 9. (via https://pubmed.ncbi.nlm.nih.gov/32647286/)
The emergence and spread of antiviral drug-resistant viruses have been a worldwide challenge and a great concern for patient care. We report A4 antibody specifically recognizing and binding to the mutant ...
Cheng C, Li J, Liu W, Xu L, Zhang Z. Modelling Analysis Revealed the Distinct Global Transmission Patterns of Influenza A Viruses and Their Influencing Factors. Integr Zool. 2020;10.1111/1749-4877.12469. Abstract
submitted by kickingbird at Jul, 11, 2020 from Integr Zool. 2020;10.1111/1749-4877.12469 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/1749-4877.12)
Influenza A virus has caused huge damage to human health and poultry production worldwide, but its global transmission patterns and influencing factors remains unclear. Here, by using the Nearest Genetic ...
Li L, Wu H, Li Q, et al. SOCS3-deficient Lung Epithelial Cells Uptaking Neutrophil-Derived SOCS3 Worsens Lung Influenza Infection. Mol Immunol. 2020;125:51-62. Abstract
submitted by kickingbird at Jul, 10, 2020 from Mol Immunol. 2020;125:51-62 (via https://pubmed.ncbi.nlm.nih.gov/32645550/)
Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether ...
Maier HE, Kuan G, Gresh L, et al. Obesity Is Associated With Increased Susceptibility to Influenza A (H1N1pdm) but Not H3N2 Infection. Clin Infect Dis. 2020;ciaa928. Abstract
submitted by kickingbird at Jul, 10, 2020 from Clin Infect Dis. 2020;ciaa928 (via https://pubmed.ncbi.nlm.nih.gov/32642771/)
Background: Obesity has been shown to increase the risk of severe outcomes and death for influenza virus infections. However, we don't understand the influence of obesity on susceptibility to infection ...
Arai Y, Elgendy EM, Daidoji T, et al. H9N2 Influenza Virus Infections in Human Cells Require a Balance Between NA Sialidase Activity and HA Receptor Affinity. J Virol. 2020;JVI.01210-20.. Abstract
submitted by kickingbird at Jul, 10, 2020 from J Virol. 2020;JVI.01210-20. (via https://pubmed.ncbi.nlm.nih.gov/32641475/)
Some avian influenza (AI) viruses have a deletion of up to 20-30 amino acids in their NA stalk. This has been associated with changes in virus replication and host range. Currently prevalent H9N2 AI viruses ...
Zanin M, DeBeauchamp J, Vangala G, Webby RJ, Husai. Histone Deacetylase 6 Knockout Mice Exhibit Higher Susceptibility to Influenza A Virus Infection. Viruses. 2020;12(7):E728. Abstract
submitted by kickingbird at Jul, 10, 2020 from Viruses. 2020;12(7):E728 (via https://pubmed.ncbi.nlm.nih.gov/32640546/)
The host innate defence against influenza virus infection is an intricate system with a plethora of antiviral factors involved. We have identified host histone deacetylase 6 (HDAC6) as an anti-influenza ...
Chen C, Liu Z, Liu L, Wang J, Jin Q. Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design. Front Microbiol. 2020;11:1313. Abstract
submitted by kickingbird at Jul, 9, 2020 from Front Microbiol. 2020;11:1313 (via https://pubmed.ncbi.nlm.nih.gov/32636820/)
H7N9 influenza virus was first isolated in 2013 and has caused five epidemic waves among humans to date. Treatment opinions are currently limited. Previously, we characterized a human neutralizing antibody, ...
Feng Z, Zhu W, Yang L, et al. Epidemiology and Genotypic Diversity of Eurasian Avian-Like H1N1 Swine Influenza Viruses in China. Virol Sin. 2020;10.1007/s12250-020-00257-8. Abstract
submitted by kickingbird at Jul, 9, 2020 from Virol Sin. 2020;10.1007/s12250-020-00257-8 (via https://pubmed.ncbi.nlm.nih.gov/32638231/)
Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) outside European countries was first detected in Hong Kong Special Administrative Region (Hong Kong, SAR) of China in 2001. Afterwards, EA ...
Gupta SD, Hoque MA, Fournié G, Henning J. Patterns of Avian Influenza A (H5) and A (H9) Virus Infection in Backyard, Commercial Broiler and Layer Chicken Farms in Bangladesh. ransbound Emerg Dis. 2020;10.1111/tbed.13657. Abstract
submitted by kickingbird at Jul, 9, 2020 from ransbound Emerg Dis. 2020;10.1111/tbed.13657 (via https://pubmed.ncbi.nlm.nih.gov/32639112/)
In order to control Highly Pathogenic Avian Influenza (HPAI) H5N1 and Low Pathogenic Avian Influenza (LPAI) H9N2 virus spread in endemically infected countries, a detailed understanding of infection patterns ...
Sieben C, Sezgin E, Eggeling C, Manley S. Influenza A Viruses Use Multivalent Sialic Acid Clusters for Cell Binding and Receptor Activation. PLoS Pathog. 2020;16(7):e1008656. Abstract
submitted by kickingbird at Jul, 9, 2020 from PLoS Pathog. 2020;16(7):e1008656 (via https://pubmed.ncbi.nlm.nih.gov/32639985/)
Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment ...
Phipps KL, Ganti K, Jacobs NT, et al. Collective Interactions Augment Influenza A Virus Replication in a Host-Dependent Manner. Nat Microbiol. 2020;10.1038/s41564-020-0749-2. Abstract
submitted by kickingbird at Jul, 8, 2020 from Nat Microbiol. 2020;10.1038/s41564-020-0749-2 (via https://pubmed.ncbi.nlm.nih.gov/32632248/)
Infection with a single influenza A virus (IAV) is only rarely sufficient to initiate productive infection. Instead, multiple viral genomes are often required in a given cell. Here, we show that the reliance ...
Arevalo CP, Le Sage V, Bolton MJ, et al. Original Antigenic Sin Priming of Influenza Virus Hemagglutinin Stalk Antibodies. Proc Natl Acad Sci U S A . 2020 Jul 6;201920321. Abstract
submitted by kickingbird at Jul, 8, 2020 from Proc Natl Acad Sci U S A . 2020 Jul 6;201920321 (via https://pubmed.ncbi.nlm.nih.gov/32631992/)
Immunity to influenza viruses can be long-lived, but reinfections with antigenically distinct viral strains and subtypes are common. Reinfections can boost antibody responses against viral strains first ...
Müller NF, Stolz U, Dudas G, Stadler T, Vaughan TG. Bayesian Inference of Reassortment Networks Reveals Fitness Benefits of Reassortment in Human Influenza Viruses. Proc Natl Acad Sci U S A. 2020;201918304. Abstract
submitted by kickingbird at Jul, 8, 2020 from Proc Natl Acad Sci U S A. 2020;201918304 (via https://pubmed.ncbi.nlm.nih.gov/32631984/)
Reassortment is an important source of genetic diversity in segmented viruses and is the main source of novel pathogenic influenza viruses. Despite this, studying the reassortment process has been constrained ...
Kim HM, Lee N, Kim MS, Kang C, Chung YS. Characterization of Neuraminidase Inhibitor-Resistant Influenza Virus Isolates From Immunocompromised Patients in the Republic of Korea. Virol J. 2020;17(1):94. Abstract
submitted by kickingbird at Jul, 8, 2020 from Virol J. 2020;17(1):94 (via https://pubmed.ncbi.nlm.nih.gov/32631440/)
Background: The emergence of influenza viruses resistant to anti-influenza drugs is a threat to global public health. The Korea Centers for Disease Control and Prevention operates the Korea Influenza and ...
Tsai SK, Shih CH, Chang HW, et al. Replication of a Dog-Origin H6N1 Influenza Virus in Cell Culture and Mice. Viruses. 2020;12(7):E704. Abstract
submitted by kickingbird at Jul, 8, 2020 from Viruses. 2020;12(7):E704 (via https://pubmed.ncbi.nlm.nih.gov/32629810/)
The world's first natural avian-origin H6N1 influenza A virus infection case in dogs was confirmed in Taiwan in 2014. The H6N1 virus in chickens has been endemic in Taiwan since 1972. Whether the dog H6N1 ...
Scolamacchia F, Mulatti P, Mazzucato M, et al. Different Environmental Gradients Associated to the Spatiotemporal and Genetic Pattern of the H5N8 Highly Pathogenic Avian Influenza Outbreaks in Poultry in Italy. Transbound Emerg Dis. 2020;10.1111/tbed.13661. Abstract
submitted by kickingbird at Jul, 3, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13661 (via https://pubmed.ncbi.nlm.nih.gov/32613724/)
Comprehensive understanding of the patterns and drivers of avian influenza outbreaks is pivotal to inform surveillance systems and heighten nations' ability to quickly detect and respond to the emergence ...
Zeng Z, Yau LF, Lin Z, et al. Characterization and Evolutionary Analysis of a Novel H3N2 Influenza A Virus Glycosylation Motif in Southern China. Front Microbiol. 2020;11:1318. Abstract
submitted by kickingbird at Jul, 3, 2020 from Front Microbiol. 2020;11:1318 (via https://pubmed.ncbi.nlm.nih.gov/32612596/)
An influenza A (H3N2) virus epidemic occurred in China in 2017 and the causative strain failed to bind red blood cells (RBCs), which may affect receptor binding and antibody recognition. The objective ...
Belser JA, Sun X, Brock N, et al. Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models. J Virol. 2020;JVI.00451-20. Abstract
submitted by kickingbird at Jul, 3, 2020 from J Virol. 2020;JVI.00451-20 (via https://pubmed.ncbi.nlm.nih.gov/32611751/)
Low pathogenicity avian influenza A(H9N2) viruses, enzootic in poultry populations in Asia, are associated with fewer confirmed human infections but higher rates of seropositivity compared to A(H5) or ...
Zhang RH, Li PY, Xu MJ, et al. Molecular Characterization and Pathogenesis of H9N2 Avian Influenza Virus Isolated From a Racing Pigeon. Vet Microbiol. 2020;246:108747. Abstract
submitted by kickingbird at Jul, 2, 2020 from Vet Microbiol. 2020;246:108747 (via https://pubmed.ncbi.nlm.nih.gov/32605760/)
H9N2 avian influenza viruses (AIVs) can cross species barriers and expand from birds tomammals and humans. It usually leads to economic loss for breeding farms and poses a serious threat to human health.This ...
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