Fusaro A, et al. Disentangling the role of Africa in the global spread of H5 highly pathogenic avian influenza. Nat Commun. 2019 Nov 22;10(1):5310.. Abstract
submitted by kickingbird at Nov, 25, 2019 from Nat Commun. 2019 Nov 22;10(1):5310. (via https://www.ncbi.nlm.nih.gov/pubmed/31757953)
The role of Africa in the dynamics of the global spread of a zoonotic and economically-important virus, such as the highly pathogenic avian influenza (HPAI) H5Nx of the Gs/GD lineage, remains unexplored. ...
Gilchuk IM, et al. Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice. Cell Host Microbe. 2019 Nov 1.. Abstract
submitted by kickingbird at Nov, 25, 2019 from Cell Host Microbe. 2019 Nov 1. (via https://www.ncbi.nlm.nih.gov/pubmed/31757769)
H7N9 avian influenza virus causes severe infections and might have the potential to trigger a major pandemic. Molecular determinants of human humoral immune response to N9 neuraminidase (NA) proteins, ...
Zhu X, et al. Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe. 2019 Oct 24. Abstract
submitted by kickingbird at Nov, 25, 2019 from Cell Host Microbe. 2019 Oct 24 (via https://www.ncbi.nlm.nih.gov/pubmed/31757767)
Influenza virus neuraminidase (NA) is a major target for small-molecule antiviral drugs. Antibodies targeting the NA surface antigen could also inhibit virus entry and egress to provide host protection. ...
Chen G, et al. A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus. Nucleic Acids Res. 2019 Nov 22.. Abstract
submitted by kickingbird at Nov, 25, 2019 from Nucleic Acids Res. 2019 Nov 22. (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
Influenza A viruses cause widespread human respiratory disease. The viral multifunctional NS1 protein inhibits host antiviral responses. This inhibition results from the binding of specific cellular antiviral ...
Wang J, Wiltse A, Zand MS. A Complex Dance: Measuring the Multidimensional Worlds of Influenza Virus Evolution and Anti-Influenza Immune Responses. Pathogens. 2019 Nov 15;8(4). Abstract
submitted by kickingbird at Nov, 18, 2019 from Pathogens. 2019 Nov 15;8(4) (via https://www.mdpi.com/2076-0817/8/4/238)
The human antibody response to influenza virus infection or vaccination is as complicated as it is essential for protection against flu. The constant antigenic changes of the virus to escape human herd ...
Londrigan SL, et al. IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages. Virology. 2019 Nov 5;540:17-22.. Abstract
submitted by kickingbird at Nov, 18, 2019 from Virology. 2019 Nov 5;540:17-22. (via https://www.ncbi.nlm.nih.gov/pubmed/31731106)
Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to contribute to effective host defence. Interferon (IFN)-induced transmembrane ...
Harding AT, Haas GD, Chambers BS, Heaton NS. Influenza viruses that require 10 genomic segments as antiviral therapeutics. PLoS Pathog. 2019 Nov 15;15(11):e1008098.. Abstract
submitted by kickingbird at Nov, 18, 2019 from PLoS Pathog. 2019 Nov 15;15(11):e1008098. (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A viruses (IAVs) encode their genome across eight, negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging a mutated segment, renders the resulting ...
Li R, Zhang T, Xu J, Chang J, Xu B. Novel Reassortant Avian Influenza A(H3N8) Virus Isolated from a Wild Bird in Jiangxi, China. Microbiol Resour Announc. 2019 Nov 14;8(46).. Abstract
submitted by kickingbird at Nov, 18, 2019 from Microbiol Resour Announc. 2019 Nov 14;8(46). (via https://mra.asm.org/content/8/46/e01163-19)
Here, we report the detection of a reassortant avian influenza A(H3N8) virus isolated from a wild bird in Poyang Lake, Jiangxi, China, in 2014. Phylogenetic analyses indicated that this virus is most likely ...
Sultan HA, et al. Efficacy of Clade 2.3.2 H5-Recombinant Baculovirus Vaccine in Protecting Muscovy and Pekin Ducks from Clade 184.108.40.206 H5N8 Highly Pathogenic Avian Influenza Infection. Avian Dis. 2019 Mar 1;63(sp1):219-229.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Avian Dis. 2019 Mar 1;63(sp1):219-229. (via https://www.ncbi.nlm.nih.gov/pubmed/31713400)
In late 2016, a highly pathogenic avian influenza (HPAI) virus subtype H5N8 clade 220.127.116.11 was reported in Egypt in migratory birds; subsequently, the virus spread to backyard and commercial poultry in ...
Schreiber A, et al. Type I interferon antagonistic properties of Influenza B virus polymerase proteins. Cell Microbiol. 2019 Nov 11:e13143. Abstract
submitted by kickingbird at Nov, 14, 2019 from Cell Microbiol. 2019 Nov 11:e13143 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13143)
The innate immune system, in particular the type I interferon (IFN) response, is a powerful defense against virus infections. In turn, many if not all viruses have evolved various means to circumvent, ...
Antanasijevic A, Durst MA, Lavie A, Caffrey M. Identification of a pH Sensor in Influenza Hemagglutinin using X-ray Crystallography. J Struct Biol. 2019 Nov 2:107412. Abstract
submitted by kickingbird at Nov, 11, 2019 from J Struct Biol. 2019 Nov 2:107412 (via https://www.ncbi.nlm.nih.gov/pubmed/31689502)
Hemagglutnin (HA) mediates entry of influenza virus through a series of conformational changes triggered by the low pH of the endosome. The residue or combination of residues acting as pH sensors has not ...
Kwon HI, et al. A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus. MBio. 2019 Nov 5;10(6). Abstract
submitted by kickingbird at Nov, 11, 2019 from MBio. 2019 Nov 5;10(6) (via https://mbio.asm.org/content/10/6/e02369-19)
n this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism ...
Coombs KM, et al. Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses. Viruses. 2019 Nov 5;11(11).. Abstract
submitted by kickingbird at Nov, 11, 2019 from Viruses. 2019 Nov 5;11(11). (via https://www.mdpi.com/1999-4915/11/11/1028)
Influenza A viruses (IAVs) are important animal and human emerging and re-emerging pathogens that are responsible for yearly seasonal epidemics and sporadic pandemics. IAVs cause a wide range of clinical ...
Gambaryan AS, et al. Changes in the Receptor-Binding Properties of H3N2 Viruses during Long-Term Circulation in Humans. Biochemistry (Mosc). 2019 Oct;84(10):1177-1185. Abstract
submitted by kickingbird at Nov, 11, 2019 from Biochemistry (Mosc). 2019 Oct;84(10):1177-1185 (via https://www.ncbi.nlm.nih.gov/pubmed/31694513)
It was previously shown that hemagglutinin residues Thr155, Glu158, and Ser228 are crucial for the recognition of Neu5Gc. In this study, we demonstrated that the ability to bind the Neu5Gc-terminated receptor ...
Brown JC, Barclay WS, Galiano M, Harvey R. Passage of influenza A/H3N2 viruses in human airway cells removes artefactual variants associated with neuraminidase-mediated binding. J Gen Virol. 2019 Nov 8.. Abstract
submitted by kickingbird at Nov, 11, 2019 from J Gen Virol. 2019 Nov 8. (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Serological assays with modern influenza A/H3N2 viruses have become problematic due to the progressive reduction in the ability of viruses of this subtype to bind and agglutinate red blood cells (RBCs). ...
Chen F, Liu T, Xu J, Huang Y, Liu S, Yang J. Key amino acid residues of neuraminidase involved in influenza A virus entry. Pathog Dis. 2019 Nov 8.. Abstract
submitted by kickingbird at Nov, 11, 2019 from Pathog Dis. 2019 Nov 8. (via https://academic.oup.com/femspd/advance-article-abstract/doi)
Generally, influenza virus neuraminidase (NA) plays a critical role in the release stage of influenza virus. Recently, it has been found that NA may promote influenza virus to access the target cells. ...
Tapia F, Laske T, Wasik MA, Rammhold M, Genzel Y. Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times-Insights From qPCR Measurements and Viral Dynamics Modeling. Front Bioeng Biotechnol. 2019 Oct 18;7:275. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Bioeng Biotechnol. 2019 Oct 18;7:275 (via https://www.frontiersin.org/articles/10.3389/fbioe.2019.0027)
Defective interfering particles (DIPs) are a natural byproduct of influenza A virus (IAV) replication. DIPs interfere with the propagation and spread of infectious standard virus (STV), reduce virus yields ...
Zhang F, et al. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. Front Immunol. 2019 Oct 11;10:2426. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Immunol. 2019 Oct 11;10:2426 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0242)
Rhesus macaques (Macaca mulatta) are used as a human-relevant animal species for the evaluation of vaccines and as a source for cloning monoclonal antibodies (mAbs) that are highly similar to human-derived ...
Li J, Zhang K, Fan W, Zhang S, Li Y, Gu J, Zhou J,. Transcriptome Profiling Reveals Differential Effect of Interleukin-17A Upon Influenza Virus Infection in Human Cells. Front Microbiol. 2019 Oct 10;10:2344.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Microbiol. 2019 Oct 10;10:2344. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0234)
Influenza A virus (IAV) has developed elegant strategies to utilize cellular proteins and pathways to promote replication and evade the host antiviral response. Identification of these sabotaged host factors ...
Yang J, Li H, Jia L, Lan X, Zhao Y, Bian H, Li Z. High expression levels of influenza virus receptors in airway of the HBV-transgenic mice. Epidemiol Infect. 2019 Nov 4;147:e297.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Epidemiol Infect. 2019 Nov 4;147:e297. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
In the human population, influenza A viruses are associated with acute respiratory illness and are responsible for millions of deaths annually. Avian and human influenza viruses typically have a different ...
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