Haag R, et., al. Exploring rigid and flexible core trivalent sialosides for influenza virus inhibition. Chemistry. 2018 Oct 8.. Abstract
submitted by kickingbird at Oct, 10, 2018 from Chemistry. 2018 Oct 8. (via https://www.ncbi.nlm.nih.gov/pubmed/30295350)
We describe the chemical synthesis and binding analysis of functionalizable rigid and flexible core trivalent sialosides bearing oligoethylene glycol (OEG) spacers interacting with spike proteins of influenza ...
Hayden FG. et al. Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents. N Engl J Med. 2018 Sep 6;379(10):913-923. Abstract
submitted by kickingbird at Oct, 10, 2018 from N Engl J Med. 2018 Sep 6;379(10):913-923 (via https://www.nejm.org/doi/full/10.1056/NEJMoa1716197)
BackgroundBaloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains ...
Chang P, Sealy JE, Sadeyen JR, Iqbal M. Amino acid residue 217 in the hemagglutinin glycoprotein is a key mediator of avian influenza H7N9 virus antigenicity. J Virol. 2018 Oct 3. pii: JVI.01627-18. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Virol. 2018 Oct 3. pii: JVI.01627-18 (via https://www.ncbi.nlm.nih.gov/pubmed/30282714)
Avian influenza viruses continue to evolve and acquire mutations that facilitate antigenic drift and virulence change. In 2017, low pathogenicity H7N9 avian influenza viruses evolved to a high pathogenicity ...
Wang S, etc.,al. Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function. Vet Res. 2018 Oct 1;49(1):98. Abstract
submitted by kickingbird at Oct, 6, 2018 from Vet Res. 2018 Oct 1;49(1):98 (via https://www.ncbi.nlm.nih.gov/pubmed/30285871)
The emerging avian-origin H7N9 influenza A virus, which causes mild to lethal human respiratory disease, continues to circulate in China, posing a great threat to public health. Influenza NS1 protein plays ...
Mirzaei SG, Shoushtari A, Nouri A. Development and Evaluation of Real-Time RT-PCR Test for Quantitative and Qualitative Recognition of Current H9N2 Subtype Avian Influenza Viruses in Iran. Arch Razi Inst. 2018 Sep;73(3):177-182. Abstract
submitted by kickingbird at Oct, 6, 2018 from Arch Razi Inst. 2018 Sep;73(3):177-182 (via https://www.ncbi.nlm.nih.gov/pubmed/30280837)
Avian influenza H9N2 subtype viruses have had a great impact on Iranian industrial poultry production economy since introduction in the country. To approach Rapid and precise identification of this viruses ...
Hatayama K, etc.,al. Combined effect of anti-high-mobility group box-1 monoclonal antibody and peramivir against influenza A virus-induced pneumonia in mice. J Med Virol. 2018 Oct 3. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Med Virol. 2018 Oct 3 (via https://www.ncbi.nlm.nih.gov/pubmed/30281823)
Human pandemic H1N1 2009 influenza virus causes significant morbidity and mortality with severe acute lung injury (ALI) due to excessive inflammatory reaction, even with neuraminidase inhibitor use. The ...
Okamoto M, etc.,al. MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses to influenza whole-virus vaccine. J Biol Chem. 2018 Oct 3.. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Biol Chem. 2018 Oct 3. (via https://www.ncbi.nlm.nih.gov/pubmed/30282637)
The innate immune system is important for the efficacy of vaccines, but excessive innate immune responses can cause adverse reactions after vaccination. Extracellular vesicles (EVs) are enriched in the ...
Fay EJ, etc.,al. Engineered small molecule control of influenza A virus replication. J Virol. 2018 Oct 3.. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Virol. 2018 Oct 3. (via https://www.ncbi.nlm.nih.gov/pubmed/30282710)
Influenza A virus (IAV) remains a global health concern despite the availability of a seasonal vaccine. It is difficult to predict which strains will circulate during influenza season, and therefore extremely ...
Jang Y, etc.,al. Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function. J Virol. 2018 Oct 3. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Virol. 2018 Oct 3 (via https://www.ncbi.nlm.nih.gov/pubmed/30282713)
Screening of chemical libraries with 2,000 synthetic compounds identified salinomycin as a hit against influenza A and B viruses with 50% effective concentrations ranging from 0.4 to 4.3 μM in cells. This ...
Lee JJ, etc.,al. The clinical utility of point-of-care tests for influenza in ambulatory care: A systematic review and meta-analysis. Clin Infect Dis. 2018 Oct 4.. Abstract
submitted by kickingbird at Oct, 6, 2018 from Clin Infect Dis. 2018 Oct 4. (via https://www.ncbi.nlm.nih.gov/pubmed/30285232)
Background: Point-of-care tests (POCTs) for influenza are diagnostically superior to clinical diagnosis, but their impact on patient outcomes is unclear.Methods: A systematic review of influenza POCTs ...
Trinh P, etc.,al. Temporal and spatial associations between influenza and asthma hospitalisations in New York City from 2002 to 2012: a longitudinal ecological study. BMJ Open. 2018 Sep 28;8(9):e020362.. Abstract
submitted by kickingbird at Oct, 3, 2018 from BMJ Open. 2018 Sep 28;8(9):e020362. (via https://www.ncbi.nlm.nih.gov/pubmed/30269061)
OBJECTIVES: To determine whether asthma hospitalisations of children and adults in the five boroughs of New York City are correlated with influenza hospitalisations temporally and spatially.DESIGN: A longitudinal ...
Reid SM, etc.,al. Detection of non-notifiable H4N6 avian influenza virus in poultry in Great Britain. Vet Microbiol. 2018 Oct;224:107-115.. Abstract
submitted by kickingbird at Oct, 3, 2018 from Vet Microbiol. 2018 Oct;224:107-115. (via https://www.ncbi.nlm.nih.gov/pubmed/30269784)
A 12-month pilot project for notifiable avian disease (NAD) exclusion testing in chicken and turkey flocks in Great Britain (GB) offered, in partnership with industry, opportunities to carry out differential ...
Yamazaki W, Makino R, Nagao K, etc.,al. New Micro-amount of Virion Enrichment Technique (MiVET) to Detect Influenza A Virus in the Duck Feces. Transbound Emerg Dis. 2018 Sep 29. Abstract
submitted by kickingbird at Oct, 3, 2018 from Transbound Emerg Dis. 2018 Sep 29 (via https://www.ncbi.nlm.nih.gov/pubmed/30267611)
Transboundary animal diseases, including highly pathogenic avian influenza, cause vast economic losses throughout the world. While it is important to identify the sources and propagation routes of the ...
Strohmidel P, Sperling M, Karst U. Investigations on the binding of ethylmercury from thiomersal to proteins in influenza vaccines. J Trace Elem Med Biol. 2018 Dec;50:100-104. Abstract
submitted by kickingbird at Oct, 3, 2018 from J Trace Elem Med Biol. 2018 Dec;50:100-104 (via https://www.ncbi.nlm.nih.gov/pubmed/30262265)
This study investigates the binding of ethylmercury (EtHg+) released from the preservative thiomersal by hydrolysis to proteins in influenza vaccines via ultrafiltration and subsequent total reflection ...
Henritzi D, Hoffmann B, Wacheck S, Pesch S. A newly developed tetraplex real time RT-PCR for simultaneous screening of influenza virus types A, B, C and D. Influenza Other Respir Viruses. 2018 Sep 28. Abstract
submitted by kickingbird at Oct, 3, 2018 from Influenza Other Respir Viruses. 2018 Sep 28 (via https://www.ncbi.nlm.nih.gov/pubmed/30264926)
BACKGROUND: Human- or avian-to-swine transmissions have founded several autonomously circulating influenza A virus (IAV) lineages in swine populations that cause economically important respiratory disease. ...
Liu J, Gong LF, Xu YC, Sun ZL, Gao Q, Dong ZJ. Genetic and antigenic characterization of influenza A(H1N1)pdm09 in Yantai, China, during the 2009-2017 influenza season. J Med Virol. 2018 Sep 29.. Abstract
submitted by kickingbird at Oct, 3, 2018 from J Med Virol. 2018 Sep 29. (via https://www.ncbi.nlm.nih.gov/pubmed/30267587)
OBJECTIVE: This study was performed to determine the antigenic and genetic characteristics and evaluate potential vaccine efficacy of influenza A(H1N1)pdm09 in Yantai from August 2009 to August 2017.MATERIALS ...
Allen JD, Ray S, Ross TM. Split inactivated COBRA vaccine elicits protective antibodies against H1N1 and H3N2 influenza viruses. PLoS One. 2018 Sep 28;13(9):e0204284. Abstract
submitted by kickingbird at Oct, 3, 2018 from PLoS One. 2018 Sep 28;13(9):e0204284 (via https://www.ncbi.nlm.nih.gov/pubmed/30265682)
Development of broadly reactive or universal influenza vaccines will be a paradigm shifting event for the influenza vaccine field. These next generation vaccines could replace the current standard of care ...
Liu K, etc.,al. Genetic and biological characterization of two reassortant H5N2 avian influenza A viruses isolated from waterfowl in China in 2016. Vet Microbiol. 2018 Oct;224:8-16. Abstract
submitted by kickingbird at Oct, 3, 2018 from Vet Microbiol. 2018 Oct;224:8-16 (via https://www.ncbi.nlm.nih.gov/pubmed/30269795)
Two reassortant H5N2 viruses in which hemagglutinin (HA) was clustered into clade 126.96.36.199, were isolated from apparently healthy waterfowl in live poultry markets in Eastern China in 2016. We used specific ...
Rohaim MA, etc.,al. Chickens Expressing IFIT5 Ameliorate Clinical Outcome and Pathology of Highly Pathogenic Avian Influenza and Velogenic Newcastle Disease Viruses. Front Immunol. 2018 Sep 14;9:2025. Abstract
submitted by kickingbird at Oct, 3, 2018 from Front Immunol. 2018 Sep 14;9:2025 (via https://www.ncbi.nlm.nih.gov/pubmed/30271403)
Innate antiviral immunity establishes first line of defense against invading pathogens through sensing their molecular structures such as viral RNA. This antiviral potential of innate immunity is mainly ...
Bernasconi V, etc.,al. Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections. Front Immunol. 2018 Sep 12;9:2060. Abstract
submitted by kickingbird at Oct, 3, 2018 from Front Immunol. 2018 Sep 12;9:2060 (via https://www.ncbi.nlm.nih.gov/pubmed/30271406)
Due to the high risk of an outbreak of pandemic influenza, the development of a broadly protective universal influenza vaccine is highly warranted. The design of such a vaccine has attracted attention ...
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