Motta FC, Born PS, Resende PC, Brown D, et al. A cheap and accurate RT-PCR-melting temperature assay for real time Influenza B lineages discrimination. J Clin Microbiol. 2019 Sep 25.. Abstract
submitted by kickingbird at Sep, 29, 2019 from J Clin Microbiol. 2019 Sep 25. (via https://jcm.asm.org/content/early/2019/09/19/JCM.00602-19)
In this work, we describe a SYBR-Green one-step RT-PCR protocol coupled with a melting temperature analysis (RT-PCR-Tm), which allows the discrimination of influenza B lineages Yamagata and Victoria. The ...
Feng H, et al. Food Additives as Novel Influenza Vaccine Adjuvants. Vaccines (Basel). 2019 Sep 24;7(4).. Abstract
submitted by kickingbird at Sep, 29, 2019 from Vaccines (Basel). 2019 Sep 24;7(4). (via https://www.mdpi.com/2076-393X/7/4/127)
Influenza is a major threat to public health. Vaccination is an effective strategy to control influenza; however, the current inactivated influenza vaccine has mild immunogenicity and exhibits suboptimal ...
Roosenhoff R, et al. Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS). Clin Infect Dis. 2019 Sep 27. Abstract
submitted by kickingbird at Sep, 29, 2019 from Clin Infect Dis. 2019 Sep 27 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
BACKGROUND: The effect of age, baseline viral load, vaccination status, antiviral therapy and emergence of drug resistance on viral shedding in children infected with influenza A or B virus was studied.METHODS: ...
Hillman AE, et al. Serological surveillance reveals patterns of exposure to H5 and H7 influenza A viruses in European poultry. Transbound Emerg Dis. 2019 Sep 24. Abstract
submitted by kickingbird at Sep, 27, 2019 from Transbound Emerg Dis. 2019 Sep 24 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13371)
Influenza A viruses of H5 and H7 subtype in poultry can circulate subclinically, and subsequently mutate from low to high pathogenicity with potentially devastating economic and welfare consequences. European ...
Sisteré-Oró M, et al. DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs. PLoS One. 2019 Sep 25;14(9):e0222201. Abstract
submitted by kickingbird at Sep, 27, 2019 from PLoS One. 2019 Sep 25;14(9):e0222201 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Swine influenza virus (SIVs) infections cause a significant economic impact to the pork industry. Moreover, pigs may act as mixing vessel favoring genome reassortment of diverse influenza viruses. Such ...
Hirst JC, Hutchinson EC. Single-particle measurements of filamentous influenza virions reveal damage induced by freezing. J Gen Virol. 2019 Sep 25.. Abstract
submitted by kickingbird at Sep, 27, 2019 from J Gen Virol. 2019 Sep 25. (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Clinical isolates of influenza virus produce pleiomorphic virions, ranging from small spheres to elongated filaments. The filaments are seemingly adaptive in natural infections, but their basic functional ...
Ramage W, et al. Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin. Antibodies (Basel). 2019 Feb 10;8(1). Abstract
submitted by kickingbird at Sep, 25, 2019 from Antibodies (Basel). 2019 Feb 10;8(1) (via https://www.mdpi.com/2073-4468/8/1/14)
Influenza B virus (IBV) circulates in the human population and causes considerable disease burden worldwide, each year. Current IBV vaccines can struggle to mount an effective cross-reactive immune response, ...
Patel H, Kukol A. Prediction of ligands to universally conserved binding sites of the influenza a virus nuclear export protein. Virology. 2019 Aug 14;537:97-103. Abstract
submitted by kickingbird at Sep, 24, 2019 from Virology. 2019 Aug 14;537:97-103 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The nuclear export protein (NEP) of the influenza A virus exports viral ribonucleoproteins to the host cell cytoplasm following nuclear transcription. In this work conservation analysis of 3000 protein ...
Chesnokov A, et al. Replicative fitness of seasonal influenza A viruses with decreased susceptibility to baloxavir. J Infect Dis. 2019 Sep 21.. Abstract
submitted by kickingbird at Sep, 23, 2019 from J Infect Dis. 2019 Sep 21. (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Susceptibility of influenza A viruses to baloxavir can be affected by changes at amino acid residue 38 in polymerase acidic (PA) protein. Information on replicative fitness of PA-I38-substituted viruses ...
Bekking C, et al. Evaluation of bioaerosol samplers for the detection and quantification of influenza virus from artificial aerosols and influenza virus-infected ferrets. Influenza Other Respir Viruses. 2019 Sep 21. Abstract
submitted by kickingbird at Sep, 23, 2019 from Influenza Other Respir Viruses. 2019 Sep 21 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12678)
BACKGROUND: Bioaerosol sampling devices are necessary for the characterization of infectious bioaerosols emitted by naturally-infected hosts with acute respiratory virus infections. Assessment of these ...
Chastagner A, Enouf V, Peroz D, et al. Bidirectional Human-Swine Transmission of Seasonal Influenza A(H1N1)pdm09 Virus in Pig Herd, France, 2018. Emerg Infect Dis. 2019;25(10):1940-1943. Abstract
submitted by kickingbird at Sep, 22, 2019 from Emerg Infect Dis. 2019;25(10):1940-1943 (via https://wwwnc.cdc.gov/eid/article/25/10/19-0068_article)
In 2018, a veterinarian became sick shortly after swabbing sows exhibiting respiratory syndrome on a farm in France. Epidemiologic data and genetic analyses revealed consecutive human-to-swine and swine-to-human ...
Wille M, Lisovski S, Risely A, et al. Serologic Evidence of Exposure to Highly Pathogenic Avian Influenza H5 Viruses in Migratory Shorebirds, Australia. Emerg Infect Dis. 2019;25(10):1903-1910. Abstract
submitted by kickingbird at Sep, 22, 2019 from Emerg Infect Dis. 2019;25(10):1903-1910 (via https://wwwnc.cdc.gov/eid/article/25/10/19-0699_article)
Highly pathogenic avian influenza (HPAI) H5Nx viruses of the goose/Guangdong/96 lineage continue to cause outbreaks in poultry and wild birds globally. Shorebirds, known reservoirs of avian influenza viruses, ...
Bai R, et al. Antigenic Variation of Avian Influenza A(H5N6) Viruses, Guangdong Province, China, 2014-2018. Emerg Infect Dis. 2019 Oct;25(10):1932-1945. Abstract
submitted by kickingbird at Sep, 22, 2019 from Emerg Infect Dis. 2019 Oct;25(10):1932-1945 (via https://wwwnc.cdc.gov/eid/article/25/10/19-0274_article)
Market surveillance showed continuing circulation of avian influenza A(H5N6) virus in live poultry markets in Guangdong Province in 2017, despite compulsory vaccination for avian influenza A(H5Nx) and ...
Pohlmann A, et al. Genetic Characterization and Zoonotic Potential of Highly Pathogenic Avian Influenza Virus A(H5N6/H5N5), Germany, 2017-2018. Emerg Infect Dis. 2019 Oct;25(10):1973-1976.. Abstract
submitted by kickingbird at Sep, 22, 2019 from Emerg Infect Dis. 2019 Oct;25(10):1973-1976. (via https://wwwnc.cdc.gov/eid/article/25/10/18-1931_article)
We genetically characterized highly pathogenic avian influenza virus A(H5N6) clade 188.8.131.52b isolates found in Germany in 2017-2018 and assessed pathogenicity of representative H5N5 and H5N6 viruses in ...
Sheng T, Sun Y, Sun J, Prinz RA, Peng D, et al. Role of TGF-β-activated kinase 1 (TAK1) activation in H5N1 influenza A virus-induced c-Jun terminal kinase activation and virus replication. Virology. 2019 Sep 10;537:263-271. Abstract
submitted by kickingbird at Sep, 22, 2019 from Virology. 2019 Sep 10;537:263-271 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Activation of c-Jun terminal kinase (JNK) by the nonstructural protein 1 (NS1) of the H5N1 subtype of influenza A virus (IAV) plays an important role in inducing autophagy and virus replication. However, ...
Yu Z, Cheng K, He H, Wu J. A novel reassortant influenza A (H1N1) virus infection in swine in Shandong Province, eastern China. Transbound Emerg Dis. 2019 Sep 19.. Abstract
submitted by kickingbird at Sep, 21, 2019 from Transbound Emerg Dis. 2019 Sep 19. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13360)
Influenza A (H1N1) viruses are distributed worldwide and pose a threat to public health. Swine, as a natural host and mixing vessel of influenza A (H1N1) virus, play a critical role in the transmission ...
Blackburn RM, et al. Nosocomial transmission of influenza: A retrospective cross-sectional study using next generation sequencing at a hospital in England (2012-2014). Influenza Other Respir Viruses. 2019 Sep 19. Abstract
submitted by kickingbird at Sep, 21, 2019 from Influenza Other Respir Viruses. 2019 Sep 19 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12679)
BACKGROUND: The extent of transmission of influenza in hospital settings is poorly understood. Next generation sequencing may improve this by providing information on the genetic relatedness of viral strains.OBJECTIVES: ...
Gao S, Zhang W, Lu C, Cao M, Cen S, Peng Y, Deng T. Identification of a type-specific promoter element that differentiates between influenza A and B viruses. J Virol. 2019 Sep 18. Abstract
submitted by kickingbird at Sep, 21, 2019 from J Virol. 2019 Sep 18 (via https://jvi.asm.org/content/early/2019/09/12/JVI.01164-19)
Type A and type B influenza viruses (FluA and FluB) are two major human pathogens that share common structural and functional features. FluA and FluB could reassort within each type but never between them. ...
Ciminski K, et al. Bat influenza viruses transmit among bats but are poorly adapted to non-bat species. Nat Microbiol. 2019 Sep 16.. Abstract
submitted by kickingbird at Sep, 21, 2019 from Nat Microbiol. 2019 Sep 16. (via https://www.nature.com/articles/s41564-019-0556-9)
Major histocompatibility complex class II (MHC-II) molecules of multiple species function as cell-entry receptors for the haemagglutinin-like H18 protein of the bat H18N11 influenza A virus, enabling tropism ...
Nemoto M, et al. Mutated influenza A virus exhibiting reduced susceptibility to baloxavir marboxil from an experimentally infected horse.. J Gen Virol. 2019 Sep 17.. Abstract
submitted by kickingbird at Sep, 21, 2019 from J Gen Virol. 2019 Sep 17. (via https://www.ncbi.nlm.nih.gov/pubmed/31526451)
Baloxavir marboxil (BXM), an inhibitor of the cap-dependent endonuclease of the influenza virus polymerase acidic protein (PA), exerts an antiviral effect against influenza A virus. It has been available ...
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