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2025-4-1 2:25:20
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Yuncong Yin, etc.,al. Random forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus. Virologica Sinica.  Abstract  
submitted by kickingbird at Jan, 6, 2025 from Virologica Sinica (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
A switch from avian-type α-2,3 to human-type α-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus. Some H9N2 viruses exhibit a preference for binding to ...

Abigail P Paulos, etc.,al. [preprint]Detection of Hemagglutinin H5 influenza A virus RNA and model of potential inputs in an urban California sewershed. https://doi.org/10.1101/2024.12.31.24319823.  Abstract  
submitted by kickingbird at Jan, 5, 2025 from https://doi.org/10.1101/2024.12.31.24319823 (via https://www.medrxiv.org/content/10.1101/2024.12.31.24319823v)
In 2024, the highly pathogenic avian influenza A H5N1 caused outbreaks in wild birds, poultry, cows, and other mammals in the United States with 61 human cases also reported by the CDC. Detection of influenza ...

Zhao Y, Han L, Sang H, Yang P, Hou Y, Xiao Y. Two genotypes of H3N2 swine influenza viruses identified in pigs from Shandong Province, China. Front Cell Infect Microbiol. 2024 Dec 16;14:151702.  Abstract  
submitted by kickingbird at Jan, 3, 2025 from Front Cell Infect Microbiol. 2024 Dec 16;14:151702 (via https://www.frontiersin.org/journals/cellular-and-infection-)
Swine influenza virus (SIV) is a highly contagious pathogen that poses significant economic challenges to the swine industry and carries zoonotic potential, underscoring the need for vigilant surveillance. ...

Maria Ogrzewalska, etc.,al. [preprint]High Pathogenicity Avian Influenza Virus (HPAIV) H5N1 clade 2.3.4.4b recovered from a kelp gull (Larus dominicanus) in the South Shetland Islands, Antarctica. https://doi.org/10.1101/2024.12.29.630510.  Abstract  
submitted by kickingbird at Jan, 1, 2025 from https://doi.org/10.1101/2024.12.29.630510 (via https://www.biorxiv.org/content/10.1101/2024.12.29.630510v1)
Whole-genome analysis of the earliest-detected High Pathogenicity Avian Influenza Virus (HPAIV) H5N1 clade 2.3.4.4b detected in Hannah Point, Antarctica (January 2024) reveals close relatedness to strains ...

Jasmina M. Luczo, Erica Spackman. Molecular Evolution of the H5 and H7 Highly Pathogenic Avian Influenza Virus Haemagglutinin Cleavage Site Motif. Reviews in Medical Virology Volume 35, Issue 1.  Abstract  
submitted by kickingbird at Jan, 1, 2025 from Reviews in Medical Virology Volume 35, Issue 1 (via https://onlinelibrary.wiley.com/doi/10.1002/rmv.70012)
Avian influenza viruses are ubiquitous in the Anatinae subfamily of aquatic birds and occasionally spill over to poultry. Infection with low pathogenicity avian influenza viruses generally leads to subclinical ...

Kevin S. Kuchinski, etc.,al. Detection of a Reassortant Swine- and Human-Origin H3N2 Influenza A Virus in Farmed Mink in British Columbia, Canada. Zoonoses and Public Health.  Abstract  
submitted by kickingbird at Jan, 1, 2025 from Zoonoses and Public Health (via https://onlinelibrary.wiley.com/doi/10.1111/zph.13205)
IntroductionIn December 2021, influenza A viruses (IAV) were detected in a population of farmed mink in British Columbia, Canada. Circulation of IAVs in farmed mink populations has raised public health ...

Lin-Lei Chen, etc.,al. [preprint]Risk assessment of 2024 cattle H5N1 using age-stratified serosurveillance data. https://doi.org/10.1101/2024.12.23.24319580.  Abstract  
submitted by kickingbird at Jan, 1, 2025 from https://doi.org/10.1101/2024.12.23.24319580 (via https://www.medrxiv.org/content/10.1101/2024.12.23.24319580v)
The highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b has caused a human outbreak in North America since March 2024. Here, we conducted a serosurveillance study to determine the risk of A(H5N1) ...

Resende PC, Junqueira DM, Tochetto C, Ogrzewalska. Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023. Nat Commun. 2024 Dec 30;15(1):10748.  Abstract  
submitted by kickingbird at Jan, 1, 2025 from Nat Commun. 2024 Dec 30;15(1):10748 (via https://www.nature.com/articles/s41467-024-53815-z)
Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild ...

Sun L, Guo X, Yu M, Wang XF, Ren H, Wang X. Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction. Nat Commun. 2024 Dec 30;15(1):10805.  Abstract  
submitted by kickingbird at Jan, 1, 2025 from Nat Commun. 2024 Dec 30;15(1):10805 (via https://www.nature.com/articles/s41467-024-55034-y)
Human ANP32A/B (huANP32A/B) poorly support the polymerase activity of avian influenza viruses (AIVs), thereby limiting interspecies transmission of AIVs from birds to humans. The SUMO-interacting motif ...

Good, M.R., Fernández-Quintero, M.L., Ji, W. et al. A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth. Nat Commun 15, 10768 (2024).  Abstract  
submitted by kickingbird at Dec, 31, 2024 from Nat Commun 15, 10768 (2024) (via https://www.nature.com/articles/s41467-024-54934-3)
Clade 2.3.4.4b H5N1 is causing an unprecedented outbreak in dairy cows in the United States. To understand if recent H5N1 viruses are changing their receptor use, we screened recombinant hemagglutinin ...

Daniel Higgins, etc.,al. [preprint]Introducing a framework for within-host dynamics and mutations modelling of H5N1 influenza infection in humans. https://doi.org/10.1101/2024.09.01.24312235.  Abstract  
submitted by kickingbird at Dec, 30, 2024 from https://doi.org/10.1101/2024.09.01.24312235 (via https://www.medrxiv.org/content/10.1101/2024.09.01.24312235v)
Avian influenza A(H5N1) poses a public health risk due to its pandemic potential should the virus mutate to become human-to-human transmissible. To date, reported influenza A(H5N1) human cases have typically ...

Chen X, Kong M, Ma C, Zhang M, Hu Z, Gu M, Wang X,. The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens. Virulence. 2025 Dec;16(1):2445238.  Abstract  
submitted by kickingbird at Dec, 30, 2024 from Virulence. 2025 Dec;16(1):2445238 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2024.2)
Several viruses, including influenza A virus (IAV), encode viral factors to hijack cellular RNA biogenesis processes to direct the degradation of host mRNAs, termed "host shutoff." Host shutoff enables ...

Jaemoo Kim, etc.,al. A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity. Virologica Sinica.  Abstract  
submitted by kickingbird at Dec, 30, 2024 from Virologica Sinica (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Influenza, a highly contagious respiratory infectious disease caused by an influenza virus, is a threat to public health worldwide. Avian influenza viruses (AIVs) have the potential to cause the next pandemic ...

Mostafa A, Barre RS, Allué-Guardia A, Escobedo RA,. Replication Kinetics, Pathogenicity and Virus-induced Cellular Responses of Cattle-origin Influenza A(H5N1) isolates from Texas, United States. Emerg Microbes Infect. 2024 Dec 27:2447614.  Abstract  
submitted by kickingbird at Dec, 28, 2024 from Emerg Microbes Infect. 2024 Dec 27:2447614 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
The host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States (US). Shortly after, human H5N1 infection was reported in a dairy worker in Texas ...

He L, Zhang Y, Si K, Yu C, Shang K, Yu Z, Wei Y, D. Evidence of an emerging triple-reassortant H3N3 avian influenza virus in China. BMC Genomics. 2024 Dec 26;25(1):1249.  Abstract  
submitted by kickingbird at Dec, 27, 2024 from BMC Genomics. 2024 Dec 26;25(1):1249 (via https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286)
The H3 subtype of avian influenza virus (AIV) stands out as one of the most prevalent subtypes, posing a significant threat to public health. In this study, a novel triple-reassortant H3N3 AIV designated ...

Ando H, Murakami M, Kitajima M, Reynolds KA. Wastewater-based estimation of temporal variation in shedding amount of influenza A virus and clinically identified cases using the PRESENS model. Environ Int. 2024 Dec 19;195:109218.  Abstract  
submitted by kickingbird at Dec, 25, 2024 from Environ Int. 2024 Dec 19;195:109218 (via https://www.sciencedirect.com/science/article/pii/S016041202)
Wastewater-based estimation of infectious disease prevalence in real-time assists public health authorities in developing effective responses to current outbreaks. However, wastewater-based estimation ...

Xuyong Li, etc.,al. Novel H16N3 avian influenza viruses isolated from migratory gulls in China in 2023. Front. Microbiol. Volume 15 - 2024.  Abstract  
submitted by kickingbird at Dec, 25, 2024 from Front. Microbiol. Volume 15 - 2024 (via https://www.frontiersin.org/journals/microbiology/articles/1)
As a rare subtype of avian influenza virus, H16 viruses are predominant in gulls but rarely found in domestic birds. The low prevalence of H16 viruses has limited our understanding of their epidemiology ...

Fumiya Kozawa, etc.,al. [preprint]The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection. https://doi.org/10.1101/2024.12.20.629723.  Abstract  
submitted by kickingbird at Dec, 24, 2024 from https://doi.org/10.1101/2024.12.20.629723 (via https://www.biorxiv.org/content/10.1101/2024.12.20.629723v1)
Influenza A viruses (IAVs) initially infect a few host cells, and the infection subsequently spreads to neighboring cells. However, the molecular mechanisms underlying this expansion remain unclear. Here, ...

Sidney J, Kim A-R, de Vries RD, Peters B, Meade PS. Targets of influenza human T-cell response are mostly conserved in H5N1. mBio. 2024 Dec 26:e0347924.  Abstract  
submitted by kickingbird at Dec, 24, 2024 from mBio. 2024 Dec 26:e0347924 (via https://journals.asm.org/doi/10.1128/mbio.03479-24)
Frequent recent spillovers of subtype H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI) virus into poultry and mammals, especially dairy cattle, including several human cases, increased concerns ...

Niedringhaus KD, Chan TC, McDowell A, Maxwell L, S. Surveillance of Highly Pathogenic Avian Influenza Virus in Wild Canids from Pennsylvania, USA. Animals. 2024; 14(24):3700.  Abstract  
submitted by kickingbird at Dec, 23, 2024 from Animals. 2024; 14(24):3700 (via https://www.mdpi.com/2076-2615/14/24/3700)
The avian influenza virus is a global pathogen with significant health and economic implications. While primarily a pathogen of wild and domestic birds, recent outbreaks of the H5N1 highly pathogenic avian ...

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