De Vlugt C, Sikora D, Rocheleau L, Pelchat M. Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA. Virology. 2019 Aug 2;536:91-100.. Abstract
submitted by kickingbird at Aug, 15, 2019 from Virology. 2019 Aug 2;536:91-100. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Initiation of influenza A virus (IAV) transcription depends on RNA primers derived from host RNAs. During this process, some primers are elongated by a few nucleotides, realigned on the viral RNA templates ... Xiong J, Zhao P, Yang P, Yan Q, Jiang L. Evolutionary dynamics of the H7N9 avian influenza virus based on large-scale sequence analysis. PLoS One. 2019 Aug 12;14(8):e0220249.. Abstract
submitted by kickingbird at Aug, 15, 2019 from PLoS One. 2019 Aug 12;14(8):e0220249. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Since 2013, epidemics caused by novel H7N9 avian influenza A viruses (AIVs) have become a considerable public health issue. This study investigated the evolution of these viruses at the population level. ... Khan S, et al. Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes. J Vis Exp. 2019 Jul 26;(149).. Abstract
submitted by kickingbird at Aug, 15, 2019 from J Vis Exp. 2019 Jul 26;(149). (via https://www.jove.com/video/59973/use-an-influenza-antigen-mi)
The influenza virus remains a significant cause of mortality worldwide due to the limited effectiveness of currently available vaccines. A key challenge to the development of universal influenza vaccines ... Li X, et al. Characterization of avian influenza H5N3 reassortants isolated from migratory waterfowl and domestic ducks in China from 2015 to 2018. Transbound Emerg Dis. 2019 Aug 11.. Abstract
submitted by kickingbird at Aug, 15, 2019 from Transbound Emerg Dis. 2019 Aug 11. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13324)
Wild and domestic aquatic birds are the natural reservoirs of avian influenza viruses (AIVs). All subtypes of AIVs, including 16 hemagglutinin (HA) and nine neuraminidase (NA), have been isolated from ... Trost JF, et al. A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity. Virology. 2019 Aug 6;536:78-90.. Abstract
submitted by kickingbird at Aug, 15, 2019 from Virology. 2019 Aug 6;536:78-90. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A viruses enter host cells through the endocytic pathway, where acidification triggers conformational changes of the viral hemagglutinin (HA) to drive membrane fusion. During this process, the ... Ge Y, et al. The evolution and characterization of influenza A(H7N9) virus under the selective pressure of peramivir. Virology. 2019 Aug 6;536:58-67.. Abstract
submitted by kickingbird at Aug, 15, 2019 from Virology. 2019 Aug 6;536:58-67. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Human infection with H7N9 virus has provoked global public health concern due to the substantial morbidity and mortality. Neuraminidase inhibitors (NAIs) are used as first-line drugs to treat the infection. ... Chang J, et al. octoFLU: Automated Classification for the Evolutionary Origin of Influenza A Virus Gene Sequences Detected in U.S. Swine. Microbiol Resour Announc. 2019 Aug 8;8(32).. Abstract
submitted by kickingbird at Aug, 11, 2019 from Microbiol Resour Announc. 2019 Aug 8;8(32). (via https://mra.asm.org/content/8/32/e00673-19)
The diversity of the 8 genes of influenza A viruses (IAV) in swine reflects introductions from nonswine hosts and subsequent antigenic drift and shift. Here, we curated a data set and present a pipeline ... Nelson SW, et al. Madin-Darby canine kidney cell sialic acid receptor modulation induced by culture medium conditions: Implications for the isolation of influenza A virus. Influenza Other Respir Viruses. 2019 Aug 7. Abstract
submitted by kickingbird at Aug, 11, 2019 from Influenza Other Respir Viruses. 2019 Aug 7 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12671)
BACKGROUND: The influenza A virus (IAV) binds to α-2,3- and α-2,6-linked sialic acid (SA) receptors expressed by Madin-Darby canine kidney (MDCK) cells. The receptor distribution may therefore be important ... Limburg H, et al. TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes. J Virol. 2019 Aug 7. Abstract
submitted by kickingbird at Aug, 11, 2019 from J Virol. 2019 Aug 7 (via https://jvi.asm.org/content/early/2019/08/05/JVI.00649-19)
Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus infectivity and spread. We previously demonstrated in vitro that the transmembrane protease TMPRSS2 cleaves ... Jin F, et al. A Single Mutation N166D in Hemagglutinin Affects Antigenicity and Pathogenesis of H9N2 Avian Influenza Virus. Viruses. 2019 Aug 2;11(8).. Abstract
submitted by kickingbird at Aug, 8, 2019 from Viruses. 2019 Aug 2;11(8). (via https://www.mdpi.com/1999-4915/11/8/709)
Some immune escape mutants of H9N2 virus and the corresponding mutations in hemagglutinin (HA) have been documented, but little is known about the impact of a single mutation on the antigenicity and pathogenesis ... Ren X, et al. Avian Influenza A Virus Polymerase Recruits Cellular RNA Helicase eIF4A3 to Promote Viral mRNA Splicing and Spliced mRNA Nuclear Export. Front Microbiol. 2019 Jul 16;10:1625.. Abstract
submitted by kickingbird at Aug, 8, 2019 from Front Microbiol. 2019 Jul 16;10:1625. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0162)
The influenza A virus replicates in a broad range of avian and mammalian species by hijacking cellular factors and processes. Avian influenza A viruses (AIVs) generally propagated poorly in mammalian cells, ... Yang J, Wang Z, Du Y, Jia Y, Wang L, Xu S, Zhu Q. Clade 2.3.2.1 H5N1 avian influenza viruses circulate at the interface of migratory and domestic birds around Qinghai Lake in China. Vet Microbiol. 2019 Aug;235:234-242. Abstract
submitted by kickingbird at Aug, 8, 2019 from Vet Microbiol. 2019 Aug;235:234-242 (via https://www.sciencedirect.com/science/article/pii/S037811351)
During 2012-2015, six H5N1 avian influenza viruses were isolated from domestic birds and the environment around Qinghai Lake. Phylogenetic analysis of HA genes revealed that A/chicken/Gansu/XG2/2012 (CK/GS/XG2/12) ... Yang J, Müller NF, Bouckaert R, Xu B, Drummond AJ. Bayesian phylodynamics of avian influenza A virus H9N2 in Asia with time-dependent predictors of migration. PLoS Comput Biol. 2019 Aug 6;15(8):e1007189.. Abstract
submitted by kickingbird at Aug, 8, 2019 from PLoS Comput Biol. 2019 Aug 6;15(8):e1007189. (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Model-based phylodynamic approaches recently employed generalized linear models (GLMs) to uncover potential predictors of viral spread. Very recently some of these models have allowed both the predictors ... Shi W, et al. Co-circulation and persistence of multiple A/H3N2 influenza variants in China. Emerg Microbes Infect. 2019;8(1):1157-1167. Abstract
submitted by kickingbird at Aug, 4, 2019 from Emerg Microbes Infect. 2019;8(1):1157-1167 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The spread of influenza A/H3N2 variants possessing the hemagglutinin 121?K mutation and the unexpectedly high incidence of influenza in the 2017-2018 northern hemisphere influenza season have raised serious ... Yang Y, et al. Clinical and virological characteristics of human infections with H7N9 avian influenza virus in Shenzhen, China, 2013~2017. J Infect. 2019 Jul 30.. Abstract
submitted by kickingbird at Aug, 4, 2019 from J Infect. 2019 Jul 30. (via https://www.journalofinfection.com/article/S0163-4453(19)302)
Recent articles in this Journal have reported the human infections with highly pathogenic (HP) H7N9 avian influenza virus (AIV) in Shenzhen city of China, and compared the clinical and virological characteristics ... Weng CF, et al. Association between the Risk of Lung Cancer and Influenza: A Population-Based Nested Case-Control Study. Int J Infect Dis. 2019 Jul 30.. Abstract
submitted by kickingbird at Aug, 4, 2019 from Int J Infect Dis. 2019 Jul 30. (via https://www.ijidonline.com/article/S1201-9712(19)30315-7/pdf)
BACKGROUND: Previous animal studies have shown that certain respiratory oncoviruses can lead to tumorigenesis, especially influenza virus. However, no clinical studies other than animal studies have been ... Komadina N, et al. Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. Epidemiol Infect. 2019 Jan;147:e213.. Abstract
submitted by kickingbird at Aug, 2, 2019 from Epidemiol Infect. 2019 Jan;147:e213. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The ... Lin RW, et al. Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability. J Biomed Sci. 2019 Jul 31;26(1):55. Abstract
submitted by kickingbird at Aug, 2, 2019 from J Biomed Sci. 2019 Jul 31;26(1):55 (via https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929)
BACKGROUND: Mutations in the PB1 subunit of RNA-dependent RNA polymerase (RdRp) of influenza A virus can affect replication fidelity. Before the influenza A/H1N1 pandemic in 2009, most human influenza ... ?wi?toń E, et al. Evolution of H9N2 low pathogenic avian influenza virus during passages in chickens. Infect Genet Evol. 2019 Jul 24:103979.. Abstract
submitted by kickingbird at Jul, 30, 2019 from Infect Genet Evol. 2019 Jul 24:103979. (via https://www.sciencedirect.com/science/article/pii/S156713481)
The process of avian influenza virus (AIV) evolution in a new host was investigated in the experiment in which ten serial passages of a turkey-derived H9N2 AIV were carried out in specific pathogen free ... Andrews SF, et al. Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin. Immunity. 2019 Jul 16. Abstract
submitted by kickingbird at Jul, 30, 2019 from Immunity. 2019 Jul 16 (via https://www.cell.com/immunity/fulltext/S1074-7613(19)30294-8)
Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of ... 5328 items, 20/Page, Page[104/267][|<<] [|<] [101] [102] [103] [104] [105] [106] [107] [108] [109] [110] [>|] [>>|] |
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