Nachbagauer R, Feser J, Naficy A, Bernstein DI, Gu. A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial. Nat Med. 2020 Dec 7. Abstract
submitted by kickingbird at Dec, 9, 2020 from Nat Med. 2020 Dec 7 (via https://www.nature.com/articles/s41591-020-1118-7)
Seasonal influenza viruses constantly change through antigenic drift and the emergence of pandemic influenza viruses through antigenic shift is unpredictable. Conventional influenza virus vaccines induce ...
Toy R, Keenum MC, Pradhan P, Phang K, Chen P, Chuk. TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccinatio. J Control Release. 2020 Nov 4:S0168-3659(20)30641-. Abstract
submitted by kickingbird at Nov, 9, 2020 from J Control Release. 2020 Nov 4:S0168-3659(20)30641- (via https://www.sciencedirect.com/science/article/abs/pii/S01683)
Although the existing flu vaccines elicit strong antigen-specific antibody responses, they fail to provide effective, long term protection - partly due to the absence of robust cellular memory immunity. ...
Kotomina T, Isakova-Sivak I, Kim KH, Park BR, Jung. Generation and Characterization of Universal Live-Attenuated Influenza Vaccine Candidates Containing Multiple M2e Epitopes. Vaccines (Basel). 2020 Nov 3;8(4):E648. Abstract
submitted by kickingbird at Nov, 7, 2020 from Vaccines (Basel). 2020 Nov 3;8(4):E648 (via https://www.mdpi.com/2076-393X/8/4/648)
Influenza viruses constantly evolve, reducing the overall protective effect of routine vaccination campaigns. Many different strategies are being explored to design universal influenza vaccines capable ...
Shinde V, Cai R, Plested J, Cho I, Fiske J, Pham X. Induction of Cross-reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine. Clin Infect Dis. 2020 Nov 4:ciaa1673. Abstract
submitted by kickingbird at Nov, 5, 2020 from Clin Infect Dis. 2020 Nov 4:ciaa1673 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
Background: Recurrent reports of suboptimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protective influenza vaccines. Here, we evaluated the safety and immunogenicity ...
Correia R, Fernandes B, Alves PM, Carrondo MJT, Ro. Improving Influenza HA-Vlps Production in Insect High Five Cells via Adaptive Laboratory Evolution. Vaccines (Basel). 2020 Oct 7;8(4):E589. Abstract
submitted by kickingbird at Oct, 12, 2020 from Vaccines (Basel). 2020 Oct 7;8(4):E589 (via https://www.mdpi.com/2076-393X/8/4/589)
The use of non-standard culture conditions has proven efficient to increase cell performance and recombinant protein production in different cell hosts. However, the establishment of high-producing cell ...
Bedford JG, Caminschi I, Wakim LM. Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8 + T Cells That Are Protective against Influenza Virus Infection. Vaccines (Basel). 2020 Oct 1;8(4):E572. Abstract
submitted by kickingbird at Oct, 8, 2020 from Vaccines (Basel). 2020 Oct 1;8(4):E572 (via https://www.mdpi.com/2076-393X/8/4/572)
Rapid antigen clearance from the nasal mucosa is one of the major challenges in the development of intranasal vaccines. Here, we tested whether intranasal immunization with a chitosan-hydrogel vaccine, ...
Takahashi H, Fujimoto T, Horikoshi F, Uotani T, Ok. Determination of the potency of a cell-based seasonal quadrivalent influenza vaccine using a purified primary liquid standard. Biologicals. 2020 Oct 3:S1045-1056(20)30111-1. Abstract
submitted by kickingbird at Oct, 8, 2020 from Biologicals. 2020 Oct 3:S1045-1056(20)30111-1 (via https://www.sciencedirect.com/science/article/pii/S104510562)
In Japan, the practical application of completely cell-based seasonal influenza vaccines is under consideration. Considering the good correlation between the immunogenicity of egg-based influenza vaccines ...
Bruce-Staskal PJ, Woods RM, Borisov OV, Massare MJ. Hemagglutinin from multiple divergent influenza A and B viruses bind to a distinct branched, sialylated poly-LacNAc glycan by surface plasmon resonance. Vaccine. 2020;S0264-410X(20)31078-1. Abstract
submitted by kickingbird at Sep, 17, 2020 from Vaccine. 2020;S0264-410X(20)31078-1 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Influenza viruses initiate infection via specific interactions of hemagglutinin (HA) with host cell surface sialic acid-containing glycans. Antigenic drift has resulted in HA amino acid sequence changes ...
Liu Z, Geng X, Cui Z, Li W, Ou X, Liao G. Construction and identification of influenza plasmid pool imparting high yields to candidate vaccine viruses in Vero cell at low temperature. J Cell Mol Med. 2020;10.1111/jcmm.15672. Abstract
submitted by kickingbird at Sep, 11, 2020 from J Cell Mol Med. 2020;10.1111/jcmm.15672 (via https://pubmed.ncbi.nlm.nih.gov/32902192/)
We generated plasmid pools for the rapid preparation of candidate vaccine strains, which could grow in the Vero cells at low temperature. Firstly, we cloned in the pHW2000 plasmid each of the eight gene ...
Mehaffey MR, Lee J, Jung J, et al. Mapping a Conformational Epitope of Hemagglutinin A Using Native Mass Spectrometry and Ultraviolet Photodissociation. Anal Chem. 2020;92(17):11869-11878. Abstract
submitted by kickingbird at Sep, 1, 2020 from Anal Chem. 2020;92(17):11869-11878 (via https://pubs.acs.org/doi/10.1021/acs.analchem.0c02237)
As the importance of effective vaccines and the role of protein therapeutics in the drug industry continue to expand, alternative strategies to characterize protein complexes are needed. Mass spectrometry ...
Wei J, Li Z, Yang Y, et al. A biomimetic VLP influenza vaccine with interior NP/exterior M2e antigens constructed through a temperature shift-based encapsulation strategy. Vaccine. 2020;S0264-410X(20)30915-4. Abstract
submitted by kickingbird at Jul, 28, 2020 from Vaccine. 2020;S0264-410X(20)30915-4 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Here we present a biomimetic strategy towards an influenza vaccine design based on hepatitis B virus core virus-like particles (HBc VLP). To this end, a temperature-shift based encapsulation process based ...
Wei J, Li Z, Yang Y, Ma G, Su Z, Zhang S. An apoferritin-haemagglutinin conjugate vaccine with encapsulated nucleoprotein antigen peptide from influenza virus confers enhanced cross protection. Bioconjug Chem. 2020;10.1021/acs.bioconjchem.0c00. Abstract
submitted by kickingbird at Jul, 18, 2020 from Bioconjug Chem. 2020;10.1021/acs.bioconjchem.0c00 (via https://pubmed.ncbi.nlm.nih.gov/32678574/)
Naturally occurring self-assembling ferritin nanoparticles have become widely appreciated for vaccine design. In this study, an apoferritin (AFt) nanocage was used as a carrier to construct a biomimetic ...
Paillot R, Regourd E, Behr-Gross ME. Establishment of a candidate equine influenza Florida Clade 2 strain A/eq/Richmond/1/07 horse antiserum as Ph. Eur. Biological Reference Preparation/OIE International Reference Reagent. Bio Sci Notes. 2020;2020:125-140. Abstract
submitted by kickingbird at Jul, 18, 2020 from Bio Sci Notes. 2020;2020:125-140 (via https://pubmed.ncbi.nlm.nih.gov/32677612/)
Equine influenza (EI) is an important respiratory disease of horses, with welfare and economic consequences. Vaccination remains one of the most efficient prevention methods available. Equine influenza ...
Yang G, Wang X, Yang Y, Yang R, Gowetski DB, Paula. Quantitation of residual valproic acid in flu vaccine drug substance. J Chromatogr B Analyt Technol Biomed Life Sci. 202. Abstract
submitted by kickingbird at Jul, 16, 2020 from J Chromatogr B Analyt Technol Biomed Life Sci. 202 (via https://pubmed.ncbi.nlm.nih.gov/32668376/)
Quantitative measurement of process-related impurities is a critical safety requirement for the production of drug substances of vaccine and therapeutic biologics. A simple and sensitive HPLC method has ...
Ellebedy AH, Nachbagauer R, Jackson KJL, et al. Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans. Proc Natl Acad Sci U S A. 2020;201906613. Abstract
submitted by kickingbird at Jul, 15, 2020 from Proc Natl Acad Sci U S A. 2020;201906613 (via https://pubmed.ncbi.nlm.nih.gov/32661157/)
There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus nonadjuvanted H5N1 avian influenza virus inactivated ...
Mo J, Spackman E, Stephens CB. Identification of Optimal Sample Collection Devices and Sampling Locations for the Detection Environmental Viral Contamination in Wire Poultry Cages. Transbound Emerg Dis. 2020;10.1111/tbed.13721. Abstract
submitted by kickingbird at Jul, 10, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13721 (via https://pubmed.ncbi.nlm.nih.gov/32643291/)
Environmental testing of poultry premises after an outbreak of an infectious disease like avian influenza (AI) or Newcastle disease, is essential to promptly verify virus-free status and subsequently return ...
Endo M, Tanishima M, Ibaragi K, et al. Clinical Phase II and III Studies of an AS03-adjuvanted H5N1 Influenza Vaccine Produced in an EB66 ? Cell Culture Platform. Influenza Other Respir Viruses. 2020;10.1111/irv.. Abstract
submitted by kickingbird at Jun, 26, 2020 from Influenza Other Respir Viruses. 2020;10.1111/irv. (via https://pubmed.ncbi.nlm.nih.gov/32579785/)
Background: We have developed an AS03-adjuvanted H5N1 influenza vaccine produced in an EB66? cell culture platform (KD-295). Objectives: In accordance with Japanese guidelines for development of pandemic ...
Lu PH, Ma YD, Fu CY, Lee GB. A structure-free digital microfluidic platform for detection of influenza a virus by using magnetic beads and electromagnetic forces. Lab Chip. 2020 Jan 20. Abstract
submitted by kickingbird at Jan, 21, 2020 from Lab Chip. 2020 Jan 20 (via https://www.ncbi.nlm.nih.gov/pubmed/31956865)
H1N1, a subtype of influenza A virus, has emerged as a global threat in the past decades. Due to its highly infectious nature, an accurate and rapid detection assay is urgently required. Therefore, this ...
Poh ZW, et al. Modification of neutralizing epitopes of hemagglutinin for the development of broadly protective H9N2 vaccine.. Vaccine. 2020 Jan 7. Abstract
submitted by kickingbird at Jan, 13, 2020 from Vaccine. 2020 Jan 7 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
The H9N2 avian influenza viruses cause significant economic losses in poultry worldwide and could potentially cause human pandemic. Currently, the available vaccines have limited efficacy due to antigenic ...
Guo J, et al. Development and fit-for-purpose verification of an LC-MS method for quantitation of hemagglutinin and neuraminidase proteins in influenza virus-like particle vaccine candidates. Anal Biochem. 2020 Jan 8:113577.. Abstract
submitted by kickingbird at Jan, 13, 2020 from Anal Biochem. 2020 Jan 8:113577. (via https://www.sciencedirect.com/science/article/pii/S000326971)
Recombinant influenza Virus-Like Particle (VLP) vaccines are promising vaccine candidates to prevent influenza, contain two major viral antigenic glycoproteins, Hemagglutinin (HA) and Neuraminidase (NA), ...
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