Acosta E, et al. Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016. Demography. 2019 Sep 9. Abstract
submitted by kickingbird at Sep, 12, 2019 from Demography. 2019 Sep 9 (via https://link.springer.com/article/10.1007%2Fs13524-019-00809)
This study examines the roles of age, period, and cohort in influenza mortality trends over the years 1959-2016 in the United States. First, we use Serfling models based on Lexis surfaces to highlight ...
Li J, et al. Delayed peak of human infections and ongoing reassortment of H7N9 avian influenza virus in the newly affected western Chineses provinces during Wave Five. Int J Infect Dis. 2019 Sep 6.. Abstract
submitted by kickingbird at Sep, 11, 2019 from Int J Infect Dis. 2019 Sep 6. (via https://www.ijidonline.com/article/S1201-9712(19)30363-7/pdf)
OBJECTIVES: Eight additional provinces in western China reported human infections for the first time during the fifth wave of human H7N9 infections. Our study aimed to analyze the epidemiological and virological ...
Zhang H, et al. Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection. Bioorg Med Chem Lett. 2019 Aug 24:126639.. Abstract
submitted by kickingbird at Sep, 10, 2019 from Bioorg Med Chem Lett. 2019 Aug 24:126639. (via https://www.sciencedirect.com/science/article/pii/S0960894X1)
Exploration of the chemical space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds 16a and 16b, two novel thienopyrimidine derivatives ...
Olguin-Perglione C, et al. Multifocal outbreak of equine influenza in vaccinated horses in Argentina in 2018: Epidemiological aspects and molecular characterisation of the involved virus strains. Equine Vet J. 2019 Sep 8.. Abstract
submitted by kickingbird at Sep, 10, 2019 from Equine Vet J. 2019 Sep 8. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/evj.13176)
BACKGROUND: Equine influenza is an important cause of respiratory disease of horses worldwide. The equine influenza virus (EIV) undergoes antigenic drift through the accumulation of amino acid substitutions ...
Adlhoch C, et al. Estimation of the number of exposed people during highly pathogenic avian influenza virus outbreaks in EU/EEA countries, October 2016-September 2018. Zoonoses Public Health. 2019 Sep 6.. Abstract
submitted by kickingbird at Sep, 9, 2019 from Zoonoses Public Health. 2019 Sep 6. (via https://onlinelibrary.wiley.com/doi/full/10.1111/zph.12629)
We estimated that more than 11,000 people were exposed to highly pathogenic avian influenza viruses in EU/EEA countries over the outbreak period October 2016-September 2018 by cross-linking data submitted ...
Jané M, et al. Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016. Sci Rep. 2019 Sep 6;9(1):12853.. Abstract
submitted by kickingbird at Sep, 9, 2019 from Sci Rep. 2019 Sep 6;9(1):12853. (via https://www.nature.com/articles/s41598-019-49273-z)
Influenza produces annual epidemics that affect 5-15% of the world population. Complications and hospitalizations are more frequent in childhood. This study describes and analyses the epidemiological and ...
Palekar RS, et al. Burden of influenza-associated respiratory hospitalizations in the Americas, 2010-2015. PLoS One. 2019 Sep 6;14(9):e0221479.. Abstract
submitted by kickingbird at Sep, 9, 2019 from PLoS One. 2019 Sep 6;14(9):e0221479. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
BACKGROUND: Despite having influenza vaccination policies and programs, countries in the Americas underutilize seasonal influenza vaccine, in part because of insufficient evidence about severe influenza ...
Radonovich LJ Jr, et al. N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial. JAMA. 2019 Sep 3;322(9):824-833.. Abstract
submitted by kickingbird at Sep, 5, 2019 from JAMA. 2019 Sep 3;322(9):824-833. (via https://jamanetwork.com/journals/jama/article-abstract/27492)
Importance: Clinical studies have been inconclusive about the effectiveness of N95 respirators and medical masks in preventing health care personnel (HCP) from acquiring workplace viral respiratory infections.Objective: ...
Jeevan T, et al. A(H9N2) influenza viruses associated with chicken mortality in outbreaks in Algeria 2017. Influenza Other Respir Viruses. 2019 Sep 3. Abstract
submitted by kickingbird at Sep, 5, 2019 from Influenza Other Respir Viruses. 2019 Sep 3 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12675)
In late 2017, increased mortality was detected in chicken farms in Algeria undergoing A(H9N2) influenza outbreaks. Analysis of viruses isolated from affected farms showed that they were monophyletic, were ...
Liu H, Li J, Chen M, Su J. Glucocorticoid treatment of suspected organizing pneumonia after H7N9 infection: A case report. Medicine (Baltimore). 2019 Aug;98(34):e16839.. Abstract
submitted by kickingbird at Aug, 25, 2019 from Medicine (Baltimore). 2019 Aug;98(34):e16839. (via https://insights.ovid.com/crossref?an=00005792-201908230-000)
RATIONALE: H7N9 infection causes acute respiratory distress syndrome with high mortality. The use of glucocorticoids in the acute phase lessened inflammatory responses. Some case reports suggested that ...
Gou X, Wu X, Shi Y, Zhang K, Huang J. A systematic review and meta-analysis of cross-reactivity of antibodies induced by H7 influenza vaccine. Hum Vaccin Immunother. 2019 Aug 16. Abstract
submitted by kickingbird at Aug, 18, 2019 from Hum Vaccin Immunother. 2019 Aug 16 (via https://www.tandfonline.com/doi/abs/10.1080/21645515.2019.16)
Inoculation with vaccine is the major intervention currently used to prevent influenza infections. However, it will be a challenge to produce and implement a new vaccine when a novel highly pathogenic ...
Ang JC, et al. Comparative Immunogenicity of the 2014-2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children. Vaccines (Basel). 2019 Aug 12;7(3).. Abstract
submitted by kickingbird at Aug, 15, 2019 from Vaccines (Basel). 2019 Aug 12;7(3). (via https://www.mdpi.com/2076-393X/7/3/87)
Both inactivated influenza vaccines (IIV) and live-attenuated influenza vaccines (LAIV) have been recommended for administration to children. Children are a high-risk group for severe influenza, and a ...
Lai CC, et al. Evaluation of novel disposable bioreactors on pandemic influenza virus production. PLoS One. 2019 Aug 12;14(8):e0220803.. Abstract
submitted by kickingbird at Aug, 15, 2019 from PLoS One. 2019 Aug 12;14(8):e0220803. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Since 1997, the highly pathogenic influenza H5N1 virus has spread from Hong Kong. According to the WHO bulletin report, the H5N1 virus is a zoonotic disease threat that has infected more than 850 humans, ...
Gouma S, Weirick M, Hensley SE. Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine. Clin Infect Dis. 2019 Aug 11.. Abstract
submitted by kickingbird at Aug, 15, 2019 from Clin Infect Dis. 2019 Aug 11. (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. ...
Garvey MI, et al. Lessons learnt from influenza POCT implementation in an AMU. J Hosp Infect. 2019 Aug 6. Abstract
submitted by kickingbird at Aug, 15, 2019 from J Hosp Infect. 2019 Aug 6 (via https://www.journalofhospitalinfection.com/article/S0195-670)
Influenza point of care tests (POCT) can speed up diagnosis and improve management of patients with influenza.1-3 Young et al discussed the impact of a POCT for influenza in an emergency department.4 The ...
Van Bennekom CM, Kerr SM, Mitchell AA. Oseltamivir exposure in pregnancy and the risk of specific birth defects. Birth Defects Res. 2019 Aug 8. Abstract
submitted by kickingbird at Aug, 11, 2019 from Birth Defects Res. 2019 Aug 8 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/bdr2.1563)
BACKGROUND: Influenza during pregnancy contributes to maternal morbidity and mortality. Neuraminidase inhibitors, including oseltamivir, are recommended for treating women with influenza during pregnancy.METHODS: ...
Chambers CD, et al. Oseltamivir use in pregnancy: Risk of birth defects, preterm delivery, and small for gestational age infants. Birth Defects Res. 2019 Aug 8. Abstract
submitted by kickingbird at Aug, 11, 2019 from Birth Defects Res. 2019 Aug 8 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/bdr2.1566)
BACKGROUND: Influenza infection during pregnancy increases risks for adverse outcomes for both mother and fetus. For this reason, treatment for infection or postexposure prophylaxis with a neuraminidase ...
Chang KH, et al. Gulllain-Barre Syndrome After Trivalent Influenza Vaccination in Adults. Front Neurol. 2019 Jul 24;10:768.. Abstract
submitted by kickingbird at Aug, 11, 2019 from Front Neurol. 2019 Jul 24;10:768. (via https://www.frontiersin.org/articles/10.3389/fneur.2019.0076)
Lines of evidence suggest trivalent influenza vaccination may be associated with Guillain-Barre syndrome (GBS), an immune-mediated acute inflammatory neuropathy. On the other hand, this vaccination protects ...
Palekar R, et al. Patterns of influenza B circulation in Latin America and the Caribbean, 2010~2017. PLoS One. 2019 Aug 8;14(8):e0219595. Abstract
submitted by kickingbird at Aug, 11, 2019 from PLoS One. 2019 Aug 8;14(8):e0219595 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
OBJECTIVE: There are limited published data about the circulation of influenza B/Victoria and B/Yamagata in Latin America and the Caribbean (LAC) and most countries have a vaccine policy that includes ...
Jha A, et al. Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza. Eur Respir J. 2019 Aug 7.. Abstract
submitted by kickingbird at Aug, 11, 2019 from Eur Respir J. 2019 Aug 7. (via https://erj.ersjournals.com/content/early/2019/07/31/1399300)
BACKGROUND: Patients with asthma are at risk of hospitalisation with influenza, but the reasons for this predisposition are unknown.STUDY SETTING: A prospective observational study of adults with PCR-confirmed ...
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