Sofie Joerg, Rick J Mourits, Katarina L Matthes. [preprint]How the 1918-1920 Influenza Pandemic Spread Across Switzerland - Spatial Patterns and Determinants of Incidence and Mortality. https://doi.org/10.64898/2025.12.15.25342287. Abstract
submitted by kickingbird at 8 hours ago from https://doi.org/10.64898/2025.12.15.25342287 (via https://www.medrxiv.org/content/10.64898/2025.12.15.25342287)
This study shows that the quality of the morbidity data is sufficient to allow for meaningful analyses of spatiotemporal dynamics and provides a significant contribution to understanding the 1918-1920 ... Rouphael N, Tanios R, Traenkner J, Pauly MD, Shett. Feasibility and Safety of Aerosolized Influenza Virus Challenge in Humans Using Two Modern Delivery Systems. J Infect Dis. 2025 Dec 16:jiaf603. Abstract
submitted by kickingbird at 12 hours ago from J Infect Dis. 2025 Dec 16:jiaf603 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Background: Controlled human infection models are widely used to study infectious diseases. Since the 1960s, these studies have primarily relied on intranasal inoculation, as earlier aerosol-based methods ... Lisa Bauer, etc.,al. Attachment and replication of clade 2.3.4.4b influenza A (H5N1) viruses in human respiratory epithelium: an in-vitro study. The Lancet Microbe. Abstract
submitted by kickingbird at 2 days ago from The Lancet Microbe (via https://www.sciencedirect.com/science/article/pii/S266652472)
BackgroundHighly pathogenic avian influenza H5N1 viruses of the A/Goose/Guangdong/1/1996 lineage pose a global threat to wildlife, domestic animals, and humans. Cross-species transmission events to mammals, ... Zhang X, Wang H, Zhao C, Shi W, Wen F, Qiang H, Li. Targeted NanoBiT Screening Identifies a Novel Interaction Between SNAPIN and Influenza A Virus M1 Protei. Biology. 2025; 14(12):1770. Abstract
submitted by kickingbird at 2 days ago from Biology. 2025; 14(12):1770 (via https://www.mdpi.com/2079-7737/14/12/1770)
Influenza A virus (IAV) poses a significant threat due to its rapid evolution through gene mutations and reassortments. Understanding host–virus protein interactions is vital for developing countermeasures. ... Turnbull, M.L., Zakaria, M.K., Upfold, N.S. et al. The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution. Nat Commun 16, 11042 (2025). Abstract
submitted by kickingbird at 2 days ago from Nat Commun 16, 11042 (2025) (via https://link.springer.com/article/10.1038/s41467-025-67234-1)
Avian influenza H5N1 clade 2.3.4.4b viruses caused a global panzootic and, unexpectedly, widespread outbreaks in dairy cattle, therefore representing a pandemic threat. To inform control strategies, it ... Pascua, P. N. Q., Chesnokov, A. P., Nguyen, H. T.,. Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses from humans in the United States, October 2024 to February 2025. Emerging Microbes & Infections. Abstract
submitted by kickingbird at 2 days ago from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Since October 2024, 55 human cases of influenza A(H5N1), clade 2.3.4.4b, were reported in the US. Sequencing of 46 viruses identified genotypes B3.13, D1.1, and D1.3. Genomes of viruses were analyzed for ... Alzua, G.P., León, A.N., Yellin, T. et al. Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin. Nat Commun (2025). Abstract
submitted by kickingbird at 3 days ago from Nat Commun (2025) (via https://link.springer.com/article/10.1038/s41467-025-66829-y)
The highly pathogenic avian influenza H5N1 virus clade 2.3.4.4b has been spreading globally since 2022, causing mortality and morbidity in domestic and wild birds, as well as in mammals, which underscores ... Matias Cardenas, etc.,al. [preprint]Vaccine-induced antigenic drift of a human-origin H3N2 Influenza A virus in swine alters glycan binding and sialic acid avidity. https://doi.org/10.64898/2025.12.10.693614. Abstract
submitted by kickingbird at 4 days ago from https://doi.org/10.64898/2025.12.10.693614 (via https://www.biorxiv.org/content/10.64898/2025.12.10.693614v1)
Interspecies transmission of human influenza A viruses (FLUAV) to swine occurs frequently, yet the molecular factors driving adaptation remain poorly understood. Here we investigated how vaccine-induced ... Anne Günther, etc.,al. [preprint]High pathogenicity avian influenza virus H5N1 (clade 2.3.4.4b) drives mass mortality in Eurasian crane (Grus grus) populations in Germany, 2025. https://doi.org/10.64898/2025.12.08.692485. Abstract
submitted by kickingbird at 4 days ago from https://doi.org/10.64898/2025.12.08.692485 (via https://www.biorxiv.org/content/10.64898/2025.12.08.692485v1)
In autumn 2025, an unprecedented mass mortality event was observed among the western migrating subpopulation of Eurasian cranes (Grus grus) in Germany. Systemic infection with highly pathogenic avian influenza ... van Diemen PM, Ramsay AM, Everett HE, Hurley S, Le. Experimental infection of alpacas (Vicugna pacos) with influenza C or D viruses results in subclinical upper respiratory tract disease. J Gen Virol. 2025 Dec;106(12). Abstract
submitted by kickingbird at 4 days ago from J Gen Virol. 2025 Dec;106(12) (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Influenza D virus (IDV), a new genus within the Orthomyxoviridae family, was initially detected in pigs and cattle. IDV is structurally similar to the influenza C virus (ICV). Influenza A, C and D viruses ... de Paiva Froes Rocha, R., Tomris, I., Bowman, C.A.. Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift. Nat Commun (2025). Abstract
submitted by kickingbird at 4 days ago from Nat Commun (2025) (via https://www.nature.com/articles/s41467-025-66375-7)
The quest for a universal influenza vaccine holds great promise for mitigating the global burden of influenza-related morbidity and mortality. However, challenges persist in identifying conserved epitopes ... Michelle Wille, etc.,al. [preprint]Ecology of low pathogenicity avian influenza virus H7 in wild birds in south-eastern Australia prior to emergence of high pathogenicity avian influenza H7 in poultry. https://doi.org/10.64898/2025.12.08.693062. Abstract
submitted by kickingbird at 6 days ago from https://doi.org/10.64898/2025.12.08.693062 (via https://www.biorxiv.org/content/10.64898/2025.12.08.693062v1)
Adding to the global burden of high pathogenicity avian influenza (HPAI) H5N1, an unprecedented five HPAI H7 outbreaks occurred globally in 2024. Of these, three occurred in southeast Australia, with the ... Sena Mursel, Brian D. Davison, Thomas McAndrew, Bi. Spatiotemporal Dynamics of Avian Influenza: Understanding Avian Influenza Transmission via Mallard Migration Data. Interdisciplinary Perspectives on Infectious Disea. Abstract
submitted by kickingbird at 6 days ago from Interdisciplinary Perspectives on Infectious Disea (via https://onlinelibrary.wiley.com/doi/10.1155/ipid/5555858)
Influenza, categorized as one of the emergent infectious diseases, presents a substantial public health concern due to its capacity to trigger extensive epidemics and global pandemics. Every recent pandemic ... Zhang, L., Shao, Y., Zou, X. et al. A primary oseltamivir-resistant mutation in influenza hemagglutinin and its implications for antiviral resistance surveillance. Nat Commun (2025). Abstract
submitted by kickingbird at 6 days ago from Nat Commun (2025) (via https://www.nature.com/articles/s41467-025-66307-5)
Oseltamivir, a neuraminidase (NA) inhibitor, is currently the most widely used antiviral drug for influenza worldwide. The emergence of primary oseltamivir-resistant mutations in NA protein of seasonally ... Higerd-Rusli GP, Karan A, Hoffman SA, Morante IEA,. One confirmed and one potential human case of influenza A(H5N1) detected through an expanded subtyping protocol. ASM Case Rep 0:e00165-25. Abstract
submitted by kickingbird at 6 days ago from ASM Case Rep 0:e00165-25 (via https://journals.asm.org/doi/10.1128/asmcr.00165-25)
Current U.S. surveillance for highly pathogenic avian influenza A(H5N1) in humans prioritizes individuals with known animal exposures, potentially missing community-acquired infections. To address this ... Kar J, Hirohama M, Nakayama K, Lee S, Kawaguchi A. Microtubule detyrosination links inflammasome activation to apoptotic cell death in macrophages upon influenza A virus infection. J Virol. 2025 Dec 9:e0184725. Abstract
submitted by kickingbird at 7 days ago from J Virol. 2025 Dec 9:e0184725 (via https://journals.asm.org/doi/10.1128/jvi.01847-25)
The tubulin code, defined by diverse post-translational modifications of microtubules, fine-tunes microtubule dynamics, regulating downstream cellular signaling. Among these, detyrosination of α-tubulin ... Ivan Tomic, etc.,al. [preprint]Innate antiviral readiness drives the expansion of protective T stem cell memory against influenza. https://doi.org/10.64898/2025.12.06.692757. Abstract
submitted by kickingbird at 7 days ago from https://doi.org/10.64898/2025.12.06.692757 (via https://www.biorxiv.org/content/10.64898/2025.12.06.692757v1)
The development of T-cell-based influenza vaccines relies on eliciting broad CD8+ T-cell immunity, wherein T stem cell-like memory (TSCM) cells serve as the ultimate long-lived reservoir for immune memory, ... Matteo Chiara, etc.,al. [preprint]Distinctive viral genome signatures are linked to repeated mammalian spillovers of H5N1 in North America. https://doi.org/10.64898/2025.12.09.693147. Abstract
submitted by kickingbird at 7 days ago from https://doi.org/10.64898/2025.12.09.693147 (via https://www.biorxiv.org/content/10.64898/2025.12.09.693147v1)
Highly pathogenic avian influenza H5N1 rarely infects mammals. In 2024-2025, however, genotypes B3.13 and D1.1 caused two independent spillovers into U.S. dairy cattle. By analysing 26,930 complete H5N1 ... Wang X, Liu X, Wang S, Wang Q, Wang J, Wang M, Yao. Identification of the Key Amino Acid Mutations in the PB2 and PA Proteins of Classical Swine H1N1 Influenza A Virus in Mammalian Adaptation. Emerg Microbes Infect. 2025 Dec 9:2602310. Abstract
submitted by kickingbird at 7 days ago from Emerg Microbes Infect. 2025 Dec 9:2602310 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The classical swine (CS) H1N1 influenza virus firstly isolated in 1930 is highly homologous to the 1918 Spanish influenza virus. CS H1N1 virus crossed the interspecies barrier to infect humans has become ... Richard A. Neher, etc.,al. [preprint]Nomenclature for tracking of genetic variation of seasonal influenza viruses. https://doi.org/10.64898/2025.12.06.25341755. Abstract
submitted by kickingbird at 8 days ago from https://doi.org/10.64898/2025.12.06.25341755 (via https://www.medrxiv.org/content/10.64898/2025.12.06.25341755)
Background: Genomic surveillance of human seasonal influenza viruses is an essential component of the Global Influenza Surveillance and Response system (GISRS) and informs the recommendations for the seasonal ... 6499 items, 20/Page, Page[1/325][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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