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2024-7-17 3:37:56
Article

Karakus, U., Sempere Borau, M., Martínez-Barragán, P. et al. MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses. Nat Microbiol. 2024 Jul 15.  Abstract  
submitted by kickingbird at 13 hours ago from Nat Microbiol. 2024 Jul 15 (via https://www.nature.com/articles/s41564-024-01771-1)
Influenza A viruses (IAV) pose substantial burden on human and animal health. Avian, swine and human IAV bind sialic acid on host glycans as receptor, whereas some bat IAV require MHC class II complexes ...

Cheng-Shun Hsueh, etc.,al. Histopathologic Features and Viral Antigen Distribution of H5N1 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4b from the 2022–2023 Outbreak in Iowa Wild Birds. Avian Dis (2024).  Abstract  
submitted by kickingbird at 13 hours ago from Avian Dis (2024) (via https://meridian.allenpress.com/avian-diseases/article-abstr)
In 2022, a new epornitic of H5N1 highly pathogenic avian influenza (HPAI) virus clade 2.3.4.4b emerged in U.S. domestic poultry with high prevalence in wild bird populations. We describe pathological findings ...

Singh G, Trujillo JD, McDowell CD, Matias-Ferreyra. Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm. Virus Genes. 2024 Jul 15.  Abstract  
submitted by kickingbird at 17 hours ago from Virus Genes. 2024 Jul 15 (via https://link.springer.com/article/10.1007/s11262-024-02085-4)
The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle, emphasizes the critical need for better epidemiological monitoring ...

Hu X, Saxena A, Magstadt DR, Gauger PC, Burrough E. Genomic Characterization of Highly Pathogenic Avian Influenza A H5N1 Virus Newly Emerged in Dairy Cattle. Emerg Microbes Infect. 2024 Jul 15:2380421.  Abstract  
submitted by kickingbird at 17 hours ago from Emerg Microbes Infect. 2024 Jul 15:2380421 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
In March 2024, the emergence of highly pathogenic avian influenza (HPAI) A (H5N1) infections in dairy cattle was detected in United States for the first time. We genetically characterize HPAI viruses from ...

Roach SN, Shepherd FK, Mickelson CK, Fiege JK, Thi. Tropism for ciliated cells is the dominant driver of influenza viral burst size in the human airway. PNAS 2024 Jul 30;121(31):e2320303121.  Abstract  
submitted by kickingbird at 17 hours ago from PNAS 2024 Jul 30;121(31):e2320303121 (via https://www.pnas.org/doi/10.1073/pnas.2320303121)
Influenza viruses pose a significant burden on global human health. Influenza has a broad cellular tropism in the airway, but how infection of different epithelial cell types impacts replication kinetics ...

Jiayun Yang, etc.,al. [preprint]The Haemagglutinin Genes of the UK Clade 2.3.4.4b H5N1 Avian Influenza Viruses from 2020 to 2022 Retain Strong Avian Phenotype. https://doi.org/10.1101/2024.07.09.602706.  Abstract  
submitted by kickingbird at 2 days ago from https://doi.org/10.1101/2024.07.09.602706 (via https://www.biorxiv.org/content/10.1101/2024.07.09.602706v1)
Since 2020, the United Kingdom (UK) has suffered repeated epizootics of clade 2.3.4.4b H5 high pathogenicity avian influenza viruses (HPAIVs) in wild birds and poultry, resulting in substantial economic ...

Ryota Tanaka, etc.,al. [preprint]In vitro one-pot construction of influenza viral genomes for virus particle synthesis based on reverse genetics system. https://doi.org/10.1101/2024.07.12.603202.  Abstract  
submitted by kickingbird at 2 days ago from https://doi.org/10.1101/2024.07.12.603202 (via https://www.biorxiv.org/content/10.1101/2024.07.12.603202v1)
The reverse genetics system, which allows the generation of influenza viruses from plasmids encoding viral genome, is a powerful tool for basic research on viral infection mechanisms and application research ...

Amy L. Baker, etc.,al. [preprint]Experimental reproduction of viral replication and disease in dairy calves and lactating cows inoculated with highly pathogenic avian influenza H5N1 clade 2.3.4.4b. https://doi.org/10.1101/2024.07.12.603337.  Abstract  
submitted by kickingbird at 2 days ago from https://doi.org/10.1101/2024.07.12.603337 (via https://www.biorxiv.org/content/10.1101/2024.07.12.603337v1)
Highly pathogenic avian influenza (HPAI) H5N1 of the hemagglutinin clade 2.3.4.4b was detected in the United States in late 2021 and continues to circulate in all four North American flyways to date. In ...

Hang Gong, Ganping Cai, Chunyan Chen, Feng Chen, C. Construction of a monoclonal molecular imprinted sensor with high affinity for specific recognition of influenza A virus subtype. Talanta 2024, 126568.  Abstract  
submitted by kickingbird at 2 days ago from Talanta 2024, 126568 (via https://www.sciencedirect.com/science/article/abs/pii/S00399)
Although molecular imprinting technology has been widely used in the construction of virus sensors, it is still a great challenge to identify subtypes viruses specifically because of their high similarity ...

Shubin Li, Xuebin Peng, MinJie Wang, Wenqian Wa. Influenza A Virus Utilizes the Nasolacrimal System to Establish Respiratory Infection after Ocular Exposure in the Swine Model. Transboundary and Emerging Diseases Vol 2024.  Abstract  
submitted by kickingbird at 2 days ago from Transboundary and Emerging Diseases Vol 2024 (via https://onlinelibrary.wiley.com/doi/10.1155/2024/8192499)
Influenza A virus (IAV) can rapidly disseminate among animals through various transmission routes, with emerging evidence suggesting the ocular surface as an important entrance. However, it remains unclear ...

Minghui Li, etc.,al. Spatiotemporal and Species-Crossing Transmission Dynamics of Subclade 2.3.4.4b H5Nx HPAIVs. Transboundary and Emerging Diseases Vol 2024.  Abstract  
submitted by kickingbird at 2 days ago from Transboundary and Emerging Diseases Vol 2024 (via https://onlinelibrary.wiley.com/doi/10.1155/2024/2862053)
Subclade 2.3.4.4b H5Nx highly pathogenic avian influenza (HPAI) viruses, emerged in 2013 with multiple subtypes of H5N8, H5N1, and H5N6, had unprecedently caused a global epizootic by H5N1 since 2021, ...

Konstantin Andreev, Jeremy C. Jones, Patrick Seile. Genotypic and phenotypic susceptibility of emerging avian influenza A viruses to neuraminidase and cap-dependent endonuclease inhibitors. Antiviral Research, 2024, 105959.  Abstract  
submitted by kickingbird at 2 days ago from Antiviral Research, 2024, 105959 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Avian influenza outbreaks, including ones caused by highly pathogenic A(H5N1) clade 2.3.4.4b viruses, have devastated animal populations and remain a threat to humans. Risk elements assessed for emerging ...

Cassidy N.G. Erdelyan, Ahmed Kandeil, Anthony V. S. Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals. Cell Reports, Vol 43, Issue 7, 2024, 114479.  Abstract  
submitted by kickingbird at 2 days ago from Cell Reports, Vol 43, Issue 7, 2024, 114479 (via https://www.sciencedirect.com/science/article/pii/S221112472)
Highly pathogenic avian influenza (HPAI) viruses have spread at an unprecedented scale, leading to mass mortalities in birds and mammals. In 2023, a transatlantic incursion of HPAI A(H5N5) viruses into ...

Chowdhury D, Nayeem M, Vanderven HA, Sarker S. Role of miRNA in Highly Pathogenic H5 Avian Influenza Virus Infection: An Emphasis on Cellular and Chicken Models. Viruses. 2024; 16(7):1102.  Abstract  
submitted by kickingbird at 2 days ago from Viruses. 2024; 16(7):1102 (via https://www.mdpi.com/1999-4915/16/7/1102)
The avian influenza virus, particularly the H5N1 strain, poses a significant and ongoing threat to both human and animal health. Recent outbreaks have affected domestic and wild birds on a massive scale, ...

de Vos CJ, Elbers ARW. Quantitative Risk Assessment of Wind-Supported Transmission of Highly Pathogenic Avian Influenza Virus to Dutch Poultry Farms via Fecal Particles from Infected Wild Birds in the Environment. Pathogens. 2024; 13(7):571.  Abstract  
submitted by kickingbird at 2 days ago from Pathogens. 2024; 13(7):571 (via https://www.mdpi.com/2076-0817/13/7/571)
A quantitative microbial risk assessment model was developed to estimate the probability that the aerosolization of fecal droppings from wild birds in the vicinity of poultry farms would result in the ...

Zhao Y, Han L, Sang H, Liu S, Yang P, Hou Y, Xiao. Swine Influenza Viruses Isolated from 2019 to 2022 in Shandong Province, China, Exemplify the Dominant Genotype. Genes. 2024; 15(7):849.  Abstract  
submitted by kickingbird at 2 days ago from Genes. 2024; 15(7):849 (via https://www.mdpi.com/2073-4425/15/7/849)
Swine influenza viruses (SIVs) have been circulating in swine globally and are potential threats to human health. During the surveillance of SIVs in Shandong Province, China, from 2019 to 2022, 21 reassortant ...

Graaf-Rau A, Schmies K, Breithaupt A, Ciminski K,. Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets. NPJ Vaccines. 2024 Jul 13;9(1):127.  Abstract  
submitted by kickingbird at 2 days ago from NPJ Vaccines. 2024 Jul 13;9(1):127 (via https://www.nature.com/articles/s41541-024-00916-x)
Swine influenza A viruses (swIAV) cause an economically important respiratory disease in modern pig production. Continuous virus transmission and antigenic drift are difficult to control in enzootically ...

Chen D, Su W, Choy KT, Chu YS, Lin CH, Yen HL. High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro. Antiviral Res. 2024 Jul 11:105961.  Abstract  
submitted by kickingbird at 2 days ago from Antiviral Res. 2024 Jul 11:105961 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Baloxavir acid (BXA) is a pan-influenza antiviral that targets the cap-dependent endonuclease of the polymerase acidic (PA) protein required for viral mRNA synthesis. To gain a comprehensive understanding ...

Fan Q, Xie Z, Zhao J, Hua J, Wei Y, Li X, Li D, Lu. Simultaneous differential detection of H5, H7 and H9 subtypes of avian influenza viruses by a triplex fluorescence loop-mediated isothermal amplification assay. Front. Vet. Sci. 11:1419312.  Abstract  
submitted by kickingbird at 2 days ago from Front. Vet. Sci. 11:1419312 (via https://www.frontiersin.org/journals/veterinary-science/arti)
H5, H7, and H9 are pivotal avian influenza virus (AIV) subtypes that cause substantial economic losses and pose potential threats to public health worldwide. In this study, a novel triplex fluorescence ...

Andreev K, Jones JC, Seiler P, Kandeil A, Webby RJ. Genotypic and phenotypic susceptibility of emerging avian influenza A viruses to neuraminidase and cap-dependent endonuclease inhibitors. Antiviral Res. 2024 Jul 8:105959.  Abstract  
submitted by kickingbird at 5 days ago from Antiviral Res. 2024 Jul 8:105959 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Avian influenza outbreaks, including ones caused by highly pathogenic A(H5N1) clade 2.3.4.4b viruses, have devastated animal populations and remain a threat to humans. Risk elements assessed for emerging ...

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